肠道微生态在儿童变应性鼻炎中的研究现状

doi:10.6040/j.issn.1673-3770.0.2021.496

摘要/Abstract

摘要： 随着对肠道微生态结构与功能研究的不断深入,肠道菌群与变应性疾病的发生、发展与病情转归的联系被证实。在儿童的生长发育过程中,肠道内各种菌群不断发生动态演变,不同年龄阶段肠道微生态的不同特征及其与变应性鼻炎(AR)之间都有其相对应的互动关系。AR作为最为常见的儿童慢性呼吸道疾病之一,针对其治疗的临床药物种类有限,而免疫治疗方式疗程长被接受度低。除以上两种主要治疗模式外,目前已有学者开展了以探究调整肠道微生态对AR儿童进行干预的有效收益评估的临床研究。综述对儿童群体中与AR相关的肠道微生物群临床研究与干预进展进行整理总结,以期评估肠道微生物群在AR发生、治疗方面的相关理论与机制的应用价值。

关键词: 肠道微生态, 变应性鼻炎, 粪菌移植, 儿童

Abstract: With increasing awareness of the specialization of the structure and function of microbiota, the relationship between gut microbiota and the occurrence, development, and outcome of allergic diseases has been explored. The development of gut microbiota during childhood is a highly dynamic process and the characteristics of gut microbiota in children of different ages closely correlate with allergic rhinitis(AR). Although AR is the most common chronic respiratory disease in children, it currently has poor clinical outcomes with drug treatment and low acceptability of long-term immunotherapy treatment. Numerous clinical studies have been conducted to explore the benefits of adjusting the gut microbiota in children with AR. This review summarizes the progress in the clinical research of gut microbiota and potential interventions and evaluates the feasibility of fecal microbiota transplantation in treating allergic diseases.

Key words: Gut microbiome, Allergic rhinitis, Fecal microbiota transplantation, Pediatric

中图分类号:

R765.21

林一杭,李幼瑾. 肠道微生态在儿童变应性鼻炎中的研究现状[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 116-122.

LIN Yihang,LI Youjin. Research progress on gut microbiome in children with allergic rhinitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 116-122.

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