山东大学耳鼻喉眼学报 ›› 2023, Vol. 37 ›› Issue (2): 122-127.doi: 10.6040/j.issn.1673-3770.0.2021.518

• 综述 • 上一篇    下一篇

OSAHS与耳鸣的相关性研究现状

王楠1,黄晶1,彭涛1,冯勃2   

  1. 1.川北医学院临床医学系/川北医学院第二临床医学院耳鼻咽喉头颈外科/南充市中心医院耳鼻咽喉头颈外科, 四川 南充 637000;
    2.中国人民解放军总医院耳鼻咽喉头颈外科/解放军耳鼻咽喉研究所/国家耳鼻咽喉疾病临床医学研究中心/聋病教育部重点实验室/聋病防治北京市重点实验室/中国人民解放军总医院医疗大数据应用技术国家工程实验室, 北京 100853
  • 发布日期:2023-03-30
  • 通讯作者: 冯勃. E-mail:fbo301@163.com
  • 基金资助:
    耳鼻咽喉头颈外科住院患者多疾病数据库构建和疾病谱深度分析(2017ZMBD-018)

Current research on the relationship between obstructive sleep apnea hypopnea syndrome and tinnitus

WANG Nan1, HUANG Jing1, PEN Tao1, FENG Bo2   

  1. 1. Department of Clinical Medicine, North Sichuan Medical College, Department of Otorhinolaryngology, Head and Neck Department of Otorhinolaryngology, Second Clinical College of North Sichuan Medical College, Department of Otorhinolaryngology, Nanchong Central Hospital, Nanchong 637000, Sichuan, China;
    2. Otorhinolaryngology Head and Neck Surgery Chinese People's Liberation Army General Hospital, PLA Otorhinolaryngology Research Institute, National Otorhinolaryngology Clinical Research Center, Key Laboratory of Deafness Ministry of Education, Beijing Key Laboratory for Deafness Prevention and Treatment;
    big data National Engineering Laboratory of Medical Technology, General Hospital of Chinese PLA, Beijing 100853, China
  • Published:2023-03-30

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摘要： 阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是睡眠障碍性疾病的常见类型,长期的呼吸暂停和低通气可引起不同程度的低氧血症,继发组织缺血缺氧,引起中枢及周围听觉系统损伤,使听觉传导通路异常、中枢听觉皮层产生适应性变化,进而导致耳鸣的感知。OSAHS患者体内5-羟色胺(5-HT)神经递质增多,激活受5-HT控制的听觉核团,影响听觉核团的神经电活动,继发耳鸣的产生。OSAHS患者自主交感神经系统兴奋,刺激耳蜗神经纤维诱发耳鸣;同时激活边缘系统和自主植物神经系统,进而产生焦虑、抑郁等不良情绪加重耳鸣。OSAHS患者长期睡眠结构紊乱形成睡眠剥夺,大脑内有毒代谢物质堆积,使耳鸣的中枢代偿障碍,继发耳鸣的产生。

关键词: 阻塞性睡眠呼吸暂停低通气综合征, 耳鸣, 相关性, 研究现状

Abstract: Obstructive sleep apnea hypopnea syndrome(OSAHS)is a common type of sleep disorder. Long-term Obstructive sleep apnea and hypopnea can cause different degrees of hypoxemia, followed by tissue ischemia and hypoxia. Cause central and surrounding auditory system damage, auditory conduction pathway abnormalities, central auditory cortex adaptive changes, and then lead to tinnitus perception. The increase of 5-hydroxytryptamine(5-HT)neurotransmitter in OSAHS patients activates the auditory nucleus controlled by 5-HT and affects the neural electrical activity of the auditory nucleus, resulting in secondary tinnitus. The autonomic sympathetic nervous system of OSAHS patients excites and stimulates cochlear nerve fibers to induce tinnitus. At the same time activate limbic system and plant nervous system, and then produce anxiety, depression and other adverse emotions aggravate tinnitus. OSAHS patients suffer from long-term sleep structure disorder, resulting in sleep deprivation and accumulation of toxic metabolites in the brain, leading to central compensation disorder of tinnitus and secondary tinnitus.

Key words: Obstructive sleep apnea hypopnea syndrome, Tinnitus, Correlation, Research situation

中图分类号: 

  • R762
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