氨基糖苷类抗生素耳毒性影响因素研究进展

doi:10.6040/j.issn.1673-3770.0.2021.097

摘要/Abstract

摘要： 氨基糖苷类抗生素是一类广泛使用的治疗严重细菌感染的关键药物,耳毒性为药物的严重并发症,其主要病因是药物触发的内耳感觉毛细胞死亡。介导感觉毛细胞死亡的分子事件一直以来被广泛研究。近年来关于增加药物毒性的外在因素及导致个体敏感性增加的遗传因素不断被揭示,为氨基糖苷类抗生素耳毒性的预防及个体化治疗提供可能。现对氨基糖苷类抗生素内耳损害机制、影响药物耳毒性的多个因素及预防氨基糖苷类药物耳毒性的潜在干预策略的最新研究进展进行综述。

关键词: 氨基糖苷类抗生素, 耳毒性, 基因易感性, 炎症, 糖皮质激素

Abstract: Aminoglycoside antibiotics are potent and widely used primarily in the treatment of serious bacterial infections.A serious complication from using these antibiotics is ototoxicity.The main cause of ototoxicity is drug-triggered sensory hair cell damage in the inner ear.Molecular events that engender aminoglycoside-induced sensory hair cell death have been extensively studied.Recent reports have revealed the external factors that increase drug toxicity and the genetic factors that lead to increased sensitivity in individuals, which may provide prospective approach for individualized treatment and prevention of ototoxicity. In this review,we discuss the ototoxicity mechanism of aminoglycoside antibiotics, factors affecting drug ototoxicity,and potential intervention strategies to prevent ototoxicity.

Key words: Aminoglycoside antibiotics, Ototoxicity, Genetic susceptibility, Inflammation, Glucocorticoid

中图分类号:

R764

李聪,李玲,刘亭彦, 陈良. 氨基糖苷类抗生素耳毒性影响因素研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(2): 128-134.

LI Cong, LI Ling, LIU Tingyan, CHEN Liang. Research progress on influencing factors of aminoglycoside antibiotic ototoxicity[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 128-134.

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