宏基因组二代测序技术在坏死性颈筋膜炎中应用进展

doi:10.6040/j.issn.1673-3770.0.2022.319

摘要/Abstract

摘要： 宏基因组二代测序技术是一种新型病原微生物学检验方法,其不依赖于病原体分离培养,理论上可以快速检测出样本中的所有病原体信息,在多种感染性疾病中均有应用。坏死性颈筋膜炎是一种致命的感染性疾病,病死率高,是耳鼻咽喉头颈外科的急危重症之一。如何快速出检测其感染病原体种类,是提高抢救成功率及改善预后的关键。论文分析了宏基因组二代测序技术在坏死性颈筋膜炎的应用进展,旨在为早期坏死性颈筋膜炎诊断提供新的依据。

关键词: 坏死性颈筋膜炎, 颈部, 宏基因组二代测序技术, 诊断

Abstract: Metagenomic next generation sequencing is a novel microbiological diagnostic technique that does not rely on isolation and cultivation of pathogens. In theory, it can promptly detect all pathogen information in samples and has been used to diagnose many infectious diseases. Cervical necrotizing fasciitis is a fatal infectious disease with a high mortality rate. Cervical necrotizing fasciitis is one of the critical diseases in otorhinolaryngology head and neck surgery. Rapid detection of the infection causing pathogens is essential in improving the rescue success rate and prognosis. This article analyzes the application progress of the metagenomic next generation sequencing in necrotizing cervical fasciitis, to provide a new diagnostic basis for the early detection of the infection.

Key words: Necrotizing fasciitis, Cervical, Metagenomic next generation sequencing, Diagnosis

中图分类号:

R762

秦念,肖禹,张锟艺,李京鲲,肖旭平. 宏基因组二代测序技术在坏死性颈筋膜炎中应用进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 192-197.

QIN Nian, XIAO Yu, ZHANG Kunyi, LI Jingkun, XIAO Xuping. Application of metagenomic next-generation sequencing in cervical necrotizing fasciitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 192-197.

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