山东大学耳鼻喉眼学报 ›› 2026, Vol. 40 ›› Issue (5): 37-52.doi: 10.6040/j.issn.1673-3770.0.2025.383

• 儿童耳鼻咽喉头颈外科 • 上一篇    

儿童慢性鼻窦炎研究的现状与前沿:基于CiteSpace的可视化分析

朱斌1,2,刘迪1,焦成1,2,严齐1,2,王莹1,2,关兵1,2,马伟1,徐丽1,2,曹清1   

  1. 1. 江苏省苏北人民医院 耳鼻咽喉头颈外科, 江苏 扬州 225001;
    2. 扬州大学附属苏北人民医院 耳鼻咽喉头颈外科, 江苏 扬州 225001
  • 发布日期:2026-09-07
  • 通讯作者: 曹清. E-mail:ufo-43@163.com
  • 基金资助:
    扬州市市级计划社会发展项目(YZ2025390;YZ2024100);苏北人民医院青年托举专项(SBQN24006;SBQN24010);苏北人民医院院级扶持技术项目(FCJS202539)

The current situation and frontiers of chronic sinusitis research in children: visual analysis based on CiteSpace

ZHU Bin1,2, LIU Di1, JIAO Cheng1,2, YAN Qi1,2, WANG Ying1,2, GUAN Bing1,2, MA Wei1, XU Li1,2, CAO Qing1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Northern Jiangsu People's Hospital, Yangzhou 225001, Jiangsu, China2. Department of Otorhinolaryngology & Head and Neck Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu, China
  • Published:2026-09-07

摘要: 目的 研究旨在利用CiteSpace科学知识图谱工具,系统性地梳理国内外儿童慢性鼻窦炎(chronic rhinosinusitis, CRS)领域的研究脉络。通过对文献知识结构、研究热点及演进趋势的深度剖析,为优化临床诊疗方案、指引未来科研方向提供数据驱动的循证参考。 方法 分别检索中国知网、万方、维普生物医学数据库和Web of Science核心合集数据库自建库至2024年12月31日发表的相关文献,筛选后利用CiteSpace 6.4.R1对作者、机构、关键词进行共现、聚类和突现分析,绘制知识图谱,探讨研究热点与发展趋势。 结果 共纳入中文文献1 374篇,英文文献286篇,发文量上中文研究历经增长后进入平台期,而英文文献虽发文总量较低,但整体保持稳定态势。中文研究的作者与机构合作网络密度显著低于英文。研究内容上关键词与聚类分析表明中文文献聚焦于具体治疗手段(如鼻内镜手术、药物、鼻腔冲洗)及疗效评估、并发症及机制研究,并凸显了中医中药特色;而英文文献则更侧重于内镜手术、疾病综合管理、共病关联(如囊性纤维化、胃食管反流)及基础机制探索。 结论 国内外儿童CRS研究热度持续,研究热点聚焦于治疗方法、疗效评估、并发症和共病管理、疾病基础机制,研究前沿是治疗策略的精准化与微创化、疗效评估的深化以及发病机制的多组学研究。

关键词: 儿童, 慢性鼻窦炎, 可视化分析, CiteSpace

Abstract: Objective The objective of this study is to employ the CiteSpace knowledge mapping tool ato systematically map the research landscape of paediatric chronic rhinosinusitis(CRS). A comprehensive analysis of the extant literature was conducted to ascertain the knowledge structure, research hotspots; and evolutionary trends. The analysis yielded data-driven, evidence-based references to optimise clinical diagnosis and treatment plans and guide future research directions. Methods A comprehensive search of the China National Knowledge Infrastructure(CNKI), Wanfang Data, VIP databases and Web of Science Core Collection databases was conducted up to 31 December 2024, to retrieve all all relevant literature. Following the screening process, the CiteSpace 6.4.R1 software was utilised to conduct co-occurrence, clustering, and burst analyses of authors, institutions, and keywords. This process yielded a series of knowledge graphs, which were utilised to explore research hotspots and developmental trends. Results The corpus comprised a total of 1,374 Chinese and 286 English artieles. As demonstrated in Chinese articles an initial increase was observed, which was subsequently followed by a plateau. While the total number of English publications is relatively low, it has maintained a stable trend overall. A significant finding of the present study was that collaboration networks among authors and institutions were considerably more dense in English articles than in Chinese articles. A review of the extant literature reveals that research in the field of Chinese medicine has been primarily focused on specific treatments, including endoscopic sinus surgery, medication and nasal irrigation. In addition, research has focused on the evaluation of efficacy, the identification of complications and the exploration of the mechanisms underpinning the treatment. By contrast, international research has placed a greater emphasis on endoscopic surgery, comprehensive disease management, comorbidities(e.g.cystic fibrosis and gastroesophageal reflux)and the exploration of underlying mechanisms. Conclusion Globally, research interest in paediatric CRS remains strong. The following research areas are currently receiving significant attention: treatment methods, efficacy evaluation, complication and comorbidity management, and disease mechanisms. Recent developments in the field have seen a shift inresearch priorities towards precision and minimally invasive treatment strategies, in-depth efficacy assessment, and multi-omics studiesof pathogenesis.

Key words: Children, Chronic rhinosinusitis, Visual analysis, CiteSpace

中图分类号: 

  • R766.9
[1] 付勇, 刘佳, 李静, 等. 儿童慢性鼻窦炎的诊断和治疗中国专家共识(杭州, 2024)[J]. 临床耳鼻咽喉头颈外科杂志, 2024, 38(12): 1091-1099. DOI:10.13201/j.issn.2096-7993.2024.12.001
[2] 王紫燕, 王方. 基于CiteSpace近10年单纯疱疹病毒性角膜炎的可视化分析[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 108-115. DOI: 10.6040/j.issn.1673-3770.0.2023.495
[3] Wei NM, Xu Y, Li YN, et al. A bibliometric analysis of T cell and atherosclerosis[J]. Front Immunol, 2022, 13: 948314. DOI:10.3389/fimmu.2022.948314
[4] 王佳慧, 刘学勤. 全球近10年干眼相关生活质量研究: 基于VOSviewer和CiteSpace的文献计量学及可视化分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 61-72. DOI:10.6040/j.issn.1673-3770.0.2023.035
[5] 黎鉴瑶, 周方伟, 张田, 等. 慢性鼻窦炎研究文献的计量学分析[J]. 中国眼耳鼻喉科杂志, 2023, 23(6): 488-495. DOI:10.14166/j.issn.1671-2420.2023.06.015
[6] 陈娜, 刘芳, 王蕊, 等. 儿童变应性鼻炎的可视化分析和热点研究[J]. 中国耳鼻咽喉颅底外科杂志, 2022, 28(1): 33-37. DOI:10.11798/j.issn.1007-1520.202221409
[7] 叶建. 消风宣窍汤联合阿奇霉素分散片治疗儿童慢性鼻窦炎风热犯肺证58例临床观察[J]. 中医儿科杂志, 2021, 17(4): 62-66. DOI:10.16840/j.issn1673-4297.2021.04.17
[8] Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020[J]. Rhinology, 2020, 58(Suppl S29): 1-464. DOI:10.4193/Rhin20.600
[9] Chandy Z, Ference E, Lee JT. Clinical guidelines on chronic rhinosinusitis in children[J]. Curr Allergy Asthma Rep, 2019, 19(2): 14. DOI:10.1007/s11882-019-0845-7
[10] Ge M, Liu DH, Ference EH. Pediatric chronic sinusitis: diagnosis and management[J]. Curr Opin Otolaryngol Head Neck Surg, 2022, 30(1): 68-77. DOI:10.1097/MOO.0000000000000778
[11] Venturini E, Del Bene M, Fusani L, et al. Treatment of sinusitis in children: an Italian intersociety consensus(SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-SIM-FIMMG)[J]. Ital J Pediatr, 2025, 51(1): 102. DOI:10.1186/s13052-025-01868-1
[12] Brietzke SE, Shin JJ, Choi S, et al. Clinical consensus statement: pediatric chronic rhinosinusitis[J]. Otolaryngol Head Neck Surg, 2014, 151(4): 542-553. DOI:10.1177/0194599814549302
[13] Wei JL, Sykes KJ, Johnson P, et al. Safety and efficacy of once-daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis[J]. Laryngoscope, 2011, 121(9): 1989-2000. DOI:10.1002/lary.21923
[14] Pecoraro L, Di Muri E, Lezzi G, et al. Nasal irrigations: a 360-degree view in clinical practice[J]. Medicina, 2025, 61(8): 1402. DOI:10.3390/medicina61081402
[15] 沈李, 罗庆, 叶菁. 儿童慢性鼻窦炎外科治疗的研究进展[J]. 中华耳鼻咽喉头颈外科杂志, 2025, 60(5): 566-571. DOI:10.3760/cma.j.cn115330-20240531-00329
[16] 刘佳, 付勇. 儿童鼻窦炎治疗新技术[J]. 中国实用儿科杂志, 2025, 40(2): 117-121. DOI:10.19538/j.ek2025020607
[17] 马晶影, 周兵, 孙炎. 伴或不伴慢性鼻窦炎的腺样体肥大患儿微生物群研究[J]. 中国耳鼻咽喉头颈外科, 2023, 30(7): 434-437. DOI:10.16066/j.1672-7002.2023.07.006
[18] Liu J, Zhao ZG, Chen Y, et al. Clinical curative effect and safety of balloon sinuplasty in children with chronic rhinosinusitis[J]. Int J Pediatr Otorhinolaryngol, 2017, 100: 204-210. DOI:10.1016/j.ijporl.2017.06.026
[19] Ramadan HH. Pediatric chronic rhinosinusitis[J]. Eur Arch Otorhinolaryngol, 2024, 281(3): 1131-1137. DOI:10.1007/s00405-023-08307-z
[20] Purrinos JA, Younis R. Pediatric endoscopic sinus surgery: Revisited 35 years later[J]. Am J Otolaryngol, 2025, 46(1): 104567. DOI:10.1016/j.amjoto.2024.104567
[21] Mirza AA, Shawli HY, Alandejani TA, et al. Efficacy and safety of paranasal sinus balloon catheter dilation in pediatric chronic rhinosinusitis: a systematic review[J]. J Otolaryngol Head Neck Surg, 2020, 49(1): 69. DOI:10.1186/s40463-020-00463-0
[22] 王曼, 王俊阁, 闫新宇, 等. 漏芦连翘汤治疗儿童慢性鼻窦炎的临床评价[J]. 中国药物应用与监测, 2025, 22(6): 1120-1124. DOI:10.3969/j.issn.1672-8157.2025.06.035
[23] 李云凤, 胡晓静. 呋麻滴鼻液鼻负压吸引冲洗联合苍耳子散加减方治疗儿童鼻渊的临床疗效观察[J]. 中国处方药, 2024, 22(10): 147-150. DOI:10.3969/j.issn.1671-945X.2024.10.044
[24] Latek M, Lacwik P, Molinska K, et al. Effect of an intranasal corticosteroid on quality of life and local microbiome in young children with chronic rhinosinusitis: a randomized clinical trial[J]. JAMA Pediatr, 2023, 177(4): 345-352. DOI:10.1001/jamapediatrics.2022.6172
[25] Lai WY, Kay DJ, Wei CC, et al. Validation of the traditional Chinese version of the Sinus and Nasal Quality of Life Survey(SN-5)for children[J]. Pediatr Neonatol, 2022, 63(4): 410-417. DOI:10.1016/j.pedneo.2022.01.008
[26] Terrell AM, Ramadan HH. Correlation between SN-5 and computed tomography in children with chronic rhinosinusitis[J]. Laryngoscope, 2009, 119(7): 1394-1398. DOI:10.1002/lary.20250
[27] Krajewska J, Zub K, Sowikowski A, et al. Chronic rhinosinusitis in cystic fibrosis: a review of therapeutic options[J]. Eur Arch Oto Rhino Laryngol, 2022, 279(1): 1-24. DOI:10.1007/s00405-021-06875-6
[28] Stapleton AL, Kimple A, Goralski JL, et al. Elexacaftor-tezacaftor-ivacaftor improves sinonasal outcomes in young children with cystic fibrosis[J]. Int Forum Allergy Rhinol, 2025, 15(7): 706-714. DOI:10.1002/alr.23555
[29] Nation J, Kaufman M, Allen M, et al. Incidence of gastroesophageal reflux disease and positive maxillary antral cultures in children with symptoms of chronic rhinosinusitis[J]. Int J Pediatr Otorhinolaryngol, 2014, 78(2): 218-222. DOI:10.1016/j.ijporl.2013.10.057
[30] Mahdavinia M, Grammer LC 3rd. Chronic rhinosinusitis and age: is the pathogenesis different?[J]. Expert Rev Anti Infect Ther, 2013, 11(10): 1029-1040. DOI:10.1586/14787210.2013.839380
[31] Ryu G, Min CY, Park B, et al. Bidirectional association between asthma and chronic rhinosinusitis: Two longitudinal follow-up studies using a national sample cohort[J]. Sci Rep, 2020, 10(1): 9589. DOI:10.1038/s41598-020-66479-8
[32] Rosati MG, Peters AT. Relationships among allergic rhinitis, asthma, and chronic rhinosinusitis[J]. Am J Rhinol Allergy, 2016, 30(1): 44-47. DOI:10.2500/ajra.2016.30.4252
[33] Zhang CX, Zhang H, Tang QP, et al. Allergic rhinitis as an independent risk factor for postoperative recurrence of children chronic sinusitis[J]. Children, 2023, 10(7): 1207. DOI:10.3390/children10071207
[34] 张薇, 葛文彤, 唐力行, 等. 儿童慢性鼻窦炎合并腺样体肥大菌谱及预后相关因素分析[J]. 中国耳鼻咽喉颅底外科杂志, 2021, 27(2): 151-156. DOI:10.11798/j.issn.1007-1520.202121057
[35] 徐浪, 刘璐, 张薇, 等. 腺样体切除术对儿童难治性慢性鼻窦炎伴腺样体肥大预后的影响[J]. 中国耳鼻咽喉头颈外科, 2025, 32(8): 529-533, 537. DOI:10.16066/j.1672-7002.2025.08.011
[36] 李琳, 高正文, 崔楠, 等. 儿童慢性鼻窦炎基因表达谱的生物信息学分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 171-180. DOI:10.6040/j.issn.1673-3770.0.2021.556
[37] Stapleton AL, Shaffer AD, Morris A, et al. The microbiome of pediatric patients with chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2021, 11(1): 31-39. DOI:10.1002/alr.22597
[38] Lim SJ, Jithpratuck W, Wasylik K, et al. Associations of microbial diversity with age and other clinical variables among pediatric chronic rhinosinusitis(CRS)patients[J]. Microorganisms, 2023, 11(2): 422. DOI:10.3390/microorganisms11020422
[39] Liu KT, Pereira N, Subramanian T, et al. Microbiome of the middle meatus, tonsils, and adenoids in pediatric chronic rhinosinusitis[J]. Otolaryngol Head Neck Surg, 2025, 172(2): 642-650. DOI:10.1002/ohn.1014
[40] Saieg A, Brown KJ, Pena MT, et al. Proteomic analysis of pediatric sinonasal secretions shows increased MUC5B mucin in CRS[J]. Pediatr Res, 2015, 77(2): 356-362. DOI:10.1038/pr.2014.187
[41] Chen YC, Wang X, Pan YW, et al. Distinct and shared molecular mechanisms in pediatric antrochoanal polyps and chronic rhinosinusitis with nasal polyps: a proteomic and metabolomic integrative analysis[J]. J Inflamm Res, 2025, 18: 4435-4447. DOI:10.2147/JIR.S507475
[42] Alekseenko SI, Skalny AV, Karpischenko SA, et al. Serum, whole blood, hair, and mucosal essential trace element and mineral levels in children with verified chronic rhinosinusitis undergoing functional endoscopic sinus surgery[J]. Biol Trace Elem Res, 2021, 199(6): 2112-2120. DOI:10.1007/s12011-020-02333-2
[43] Fokkens WJ, Viskens AS, Backer V, et al. EPOS/EUFOREA update on indication and evaluation of Biologics in Chronic Rhinosinusitis with Nasal Polyps 2023[J]. Rhinology, 2023, 61(3): 194-202. DOI:10.4193/Rhin22.489
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