山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (6): 55-60.doi: 10.6040/j.issn.1673-3770.0.2023.343

• 研究进展 • 上一篇    

胃蛋白酶与咽喉反流性疾病:从致病机制到咽喉鳞状细胞癌的潜在风险因素

周诗侗1,2,杨艳艳1,杨玉成2,方红雁1   

  1. 1.重庆市人民医院 耳鼻咽喉头颈外科, 重庆 401147;
    2.重庆医科大学附属第一医院 耳鼻咽喉头颈外科, 重庆 400016
  • 发布日期:2024-12-13
  • 通讯作者: 方红雁. E-mail: guosl999@sina.com;杨玉成. E-mail: yychxh@163.com

Pepsin and laryngopharyngeal reflux disease: from pathogenic mechanisms to potential risk factors for pharyngeal and laryngeal squamous cell carcinoma

ZHOU Shitong1,2, YANG Yanyan1, YANG Yucheng2, FANG Hongyan1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, Chongqing General Hospital, Chongqing 401147, China2. Department of Otorhinolaryngology & Head and Neck Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Published:2024-12-13

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摘要： 咽喉反流性疾病(laryngopharyngeal reflux disease, LPRD)是由胃十二指肠内容物反流的直接或间接作用引起的上呼吸消化道组织的一种炎症疾病,胃蛋白酶是其主要致病因子。近年来,越来越多研究发现咽喉反流与咽喉鳞状细胞癌关系密切,但咽喉反流是否咽喉鳞状细胞癌的危险因素尚存争议。胃蛋白酶作为LPRD的主要致病因子,可能在咽喉鳞状细胞癌的发生发展中有重要作用,其机制包含咽喉黏膜上皮损伤、上皮防御屏障的破坏、诱导炎症、诱导基因及miRNA改变等。论文针对胃蛋白酶与LPRD,从致病机制及咽喉鳞状细胞癌的潜在风险因素方面进行综述,旨在为探寻咽喉鳞状细胞癌新的致病机制和治疗手段提供新的研究思路。

关键词: 咽喉反流, 胃蛋白酶, 鳞状细胞癌, 黏膜损伤, 致病机制

Abstract: Laryngopharyngeal reflux disease(LPRD)is an inflammatory disease of the tissues of the upper aerodigestive tract caused by the direct or indirect action of reflux of gastroduodenal contents, with pepsin as the main causative agent. Numerous studies have shown a strong association between laryngeal reflux and squamous cell carcinoma of the pharynx and larynx. Nonetheless, the ongoing debate as to whether laryngeal reflux is a risk factor for laryngeal squamous cell carcinoma remains inconclusive. Pepsin, the main pathogenic factor of LPRD, has been shown to play a crucial role in the oncogenesis of squamous cell carcinoma of the pharynx and larynx. Possible mechanisms include damage to the epithelium of the pharyngeal and laryngeal mucosa, disruption of the epithelial defense barrier, induction of inflammation, and alterations in genes and miRNA. This article provides a comprehensive review of the role and mechanism of LPRD, with a special focus on pepsin, in terms of pathogenic mechanisms and potential risk factors for pharyngeal and laryngeal squamous cell carcinoma, with the aim of facilitating the explanation of oncogenesis and inspiring innovative therapeutic approaches in this disease.

Key words: Laryngopharyngeal reflux, Pepsin, Squamous cell carcinoma, Mucosal injury, Pathogenesis

中图分类号: 

  • R767.6
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