声带白斑组织中胃蛋白酶的表达分析

doi:10.6040/j.issn.1673-3770.0.2024.073

摘要/Abstract

摘要： 目的研究胃蛋白酶在不同病理类型的声带白斑组织中的表达,探讨声带白斑与咽喉反流的相关性。方法回顾性分析71例声带白斑患者的临床资料。采用免疫组织化学染色的方法,分析胃蛋白酶在不同病理类型声带白斑中的表达。采用多因素分析明确咽喉反流与声带白斑的关系。结果 71例患者中,男63例、女8例;40~75岁,平均(58.6±8.6)岁。声带白斑低级别异型增生组和高级别异型增生组中,胃蛋白酶染色阳性的比例分别为23.4%(11/47)和75%(18/24),具有统计学意义。在调整了患者年龄、性别、吸烟及饮酒高危因素后,胃蛋白酶阳性亦增加了高级别异型增生的风险,其OR值为9.64(95%CI为2.96-31.38)。结论作为咽喉反流标志物的胃蛋白酶是声带白斑高级别异型增生的独立危险因素。咽喉反流可能是声带白斑高级别异型增生的潜在危险因素之一。

关键词: 咽喉反流, 声带白斑, 低级别异型增生, 高级别异型增生, 胃蛋白酶

Abstract: Objective To investigate the expression of pepsin in different pathological types of vocal cord leukoplakia tissues and to explore the relationship between vocal cord leukoplakia and laryngopharyngeal reflux(LPR), providing evidence for the prevention and treatment of vocal cord leukoplakia. Methods Clinical data of 71 patients with vocal cord leukoplakia were retrospectively analyzed. Immunohistochemical staining was used to analyze the expression of pepsin in vocal cord leukoplakia tissues. Multivariate analysis was performed to clarify the relationship between laryngopharyngeal reflux and vocal cord leukoplakia. Results Among the 71 patients, there were 63 males and 8 females. The age ranged from 40 to 75 years with a mean age of 58.6±8.6 years. The proportions of positive pepsin staining in the low-grade dysplasia group and the high-grade dysplasia group of vocal cord leukoplakia were 23.4%(11/47)and 75%(18/24), respectively, with statistical significance. After adjustment for possible risk factors such as age, gender, smoking and alcohol consumption, positive pepsin expression also increased the risk of high-grade dysplasia with an odds ratio of 9.64(95%CI:2.96-31.38). Conclusion Pepsin, as a biomarker of LPR, is an independent risk factor for high-grade dysplasia of vocal cord leukoplakia. LPR may be one of the potential risk factors for high-grade dysplasia of vocal cord leukoplakia.

Key words: Laryngopharyngeal reflux, Vocal cord leukoplakia, Low-grade dysplasia, High-grade dysplasia, Pepsin

中图分类号:

R766.5

牛燕燕,顾伟,金晓峰,霍红,杨大海,崔婷婷,王剑. 声带白斑组织中胃蛋白酶的表达分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 66-70.

NIU Yanyan, GU Wei, JIN Xiaofeng, HUO Hong, YANG Dahai, CUI Tingting, WANG Jian. Expression analysis of pepsin in vocal cord leukoplakia tissues[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6): 66-70.

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