嗜酸性粒细胞与嗅觉功能障碍

doi:10.6040/j.issn.1673-3770.0.2021.533

摘要/Abstract

摘要： 慢性鼻-鼻窦炎(CRS)是一种难治性疾病,发病机制非常复杂,嗅觉功能障碍是其重要的临床症状之一。尽管有药物和外科干预,但复发率高,患者的嗅觉功能障碍有时不能得到改善,严重影响患者的生活质量。嗜酸性粒细胞(EOS)是嗅区黏膜炎症重要的细胞之一。嗜酸性粒细胞的降解和积聚、细胞因子的释放和黏液分泌在不同类型的慢性鼻窦炎发病机制中起着重要作用。多数学者认为组织EOS与外周血EOS与CRS导致的嗅觉功能障碍密切相关,但也有学者对此持有不同观点。

关键词: 嗜酸性粒细胞, 嗅觉功能障, 慢性鼻窦炎, 嗅区黏膜

Abstract: Chronic rhinosinusitis(CRS)is a refractory disease with a very complex pathogenesis. Olfactory dysfunction is an important clinical symptoms of CRS.Despite drug and surgical intervention, the recurrence rate of CRS is high, and the olfactory dysfunction of patients sometimes cannot be improved, which may seriously affects a patient's quality of life.Eosinophils(EOS)are an important cell type.The degradation and accumulation of eosinophils, the release of cytokines and mucus secretion play important roles in the pathogenesis of different types of chronic rhinosinusitis. While many scholars consider that tissue EOS to be closely related to olfactory dysfunction caused by peripheral blood EOS and CRS, but some scholars hold different views.

Key words: Eosinophils, Olfactory dysfunction, Chronic rhinosinusitis, Olfactory Mucosa

中图分类号:

R765.4

宜若男,陈福权. 嗜酸性粒细胞与嗅觉功能障碍[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 50-55.

YI Ruonan,CHEN Fuquan. Eosinophils and Olfactory Dysfunction[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 50-55.

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