喉癌患者术前中性粒细胞/淋巴细胞比值与淋巴结转移的相关性研究

doi:10.6040/j.issn.1673-3770.0.2019.546

摘要/Abstract

摘要： 目的研究探讨喉癌患者术前中性粒细胞/淋巴细胞比值(NLR)与淋巴结转移的关系。方法选取2008年1月至2017年12月广西医科大学附属肿瘤医院收治的102例喉癌患者,以术前NLR为因变量对喉癌临床病理分期及淋巴结检测结果进行分析。结果术前NLR>2.2患者的转移度和转移率高于NLR≤2.2的患者(P<0.001);术前NLR>2.2组的患者中,淋巴结分期(N+)>N0者多于术前NLR≤2.2组(P<0.001)。肿瘤早期(T1,T2)患者的NLR均值较局晚期(T3,T4)的低,后者的淋巴结转移率和转移度较高(P<0.001);临床Ⅳ期患者NLR的均值、淋巴结转移率和转移度明显较Ⅲ期的高(P<0.05)。声门上型、声门型的患者中,术前NLR>2.2组的淋巴结转移率及转移度高于NLR≤2.2组(P<0.05);声门下型的患者中,淋巴结转移率差异比较无统计学意义(P>0.05),而淋巴结转移度差异比较有统计学意义(P<0.05)。结论喉癌患者术前NLR的高低与淋巴结转移之间有相关性,能在一定程度上反映淋巴结转移的程度,可为临床治疗提供有价值的参考依据。

关键词: 喉癌, 临床病理, 术前中性粒细胞/淋巴细胞比值, 淋巴结转移

Abstract: Objective To investigate the relationship between preoperative neutrophil-to-lymphocyte ratio(NLR)and lymph node metastasis in patients with laryngeal cancer. Methods A total of 102 patients with laryngeal cancer admitted to the Affiliated Cancer Hospital of Guangxi Medical University from January 2008 to December 2017 were enrolled. The preoperative NLR was used as the dependent variable to analyze the clinical pathological staging and lymph node test results of laryngeal cancer. Results The patients with preoperative NLR>2.2 has higher transfer rate and metastasis than the patients with preoperative NLR≤2.2 and the difference was significant(P<0.001).The lymph node stage of patients with preoperative NLR>2.2 was significantly higher than that of the patients with preoperative NLR≤2.2, and the difference was significant(P<0.001).The mean NLR of patients with early tumor(T1,T2)was lower than that of patients with late tumor(T3,T4), the latter had higher lymph node transfer rate and metastasis, and the difference was statistically significant(P<0.001).The mean value of NLR in clinical stage IV patients with transfer rate and metastasis were significantly higher than that of stage III, and the difference was also statistically significant(P<0.05). Among patients with supraglottic and glottic carcinoma, the preoperative NLR>2.2 group had higher lymph node metastasis rate and metastasis than NLR≤2.2 group, and the difference was statistically significant(P<0.05); There was no significant difference in lymph node metastasis for subglottic patients(P>0.05), whereas the difference in lymph node metastasis was statistically significant(P<0.05). Conclusion There is a correlation between the preoperative NLR level and lymph node metastasis in patients with laryngeal cancer, which can reflect the degree of lymph node metastasis to some extent, and provide a valuable reference for clinical treatment.

Key words: laryngeal carcinoma, clinical pathology, preoperative NLR, lymph node metastasis.

中图分类号:

R765.4

庞振文,黄愉峰,杨爱芳,曾先捷. 喉癌患者术前中性粒细胞/淋巴细胞比值与淋巴结转移的相关性研究[J]. 山东大学耳鼻喉眼学报, 2020, 34(6): 58-62.

PANG Zhenwen, HUANG Yufeng, YANG Aifang, ZENG Xianjie. Correlation between Preoperative neutrophil/lymphocyte ratio and lymph node metastasis in patients with laryngeal cancer[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(6): 58-62.

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