山东大学耳鼻喉眼学报 ›› 2021, Vol. 35 ›› Issue (5): 70-74.doi: 10.6040/j.issn.1673-3770.0.2021.043

• • 上一篇    下一篇

肿瘤异常蛋白在喉癌临床诊断中的价值研究

李艳杰1, 贾建2,杨萍2,万保罗1   

  1. 1. 郑州大学人民医院/河南省人民医院 耳鼻咽喉头颈外科, 河南 郑州 450000;
    2. 息县人民医院 耳鼻喉科, 河南 息县 464300
  • 发布日期:2021-09-29
  • 通讯作者: 万保罗. E-mail:wanbaoluo2013@ 126.com

Study on the value of tumor abnormal protein in clinical diagnosis of laryngeal carcinoma

LI Yanjie1, JIA Jian2, YANG Ping2, WAN Baoluo1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, The People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou 450003, Henan, China;
    2. Department of Otolaryngology, People's Hospital of Xixian, Xixian 464300, Henan, China
  • Published:2021-09-29

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摘要： 目的 对喉癌患者和健康者进行肿瘤异常蛋白检测,分析肿瘤异常蛋白在喉癌诊疗中的价值。 方法 选取耳鼻咽喉头颈外科2017年9月至2019年9月经病理科确诊的95例喉癌病人为实验组,同期选取95例健康者为对照组,对所有研究对象进行外周血肿瘤异常蛋白检测,探究其在喉癌患者临床诊断中的应用价值。 结果 喉癌患者中肿瘤异常蛋白阳性率为83.16%,高于健康人群(15.79%),差异具有统计学意义(P<0.001)。有淋巴结转移、Ⅲ+Ⅳ期喉癌患者外周血TAP阳性表达率较高,差异具有统计学意义(P<0.05)。不同性别、不同年龄喉癌患者的外周血清肿瘤异常蛋白表达水平比较,差异无统计学意义(P>0.05)。 结论 在喉癌患者外周血中肿瘤异常蛋白表达具有较高的灵敏性,肿瘤异常蛋白对喉癌的临床诊断有较高的应用价值。

关键词: 肿瘤异常蛋白, 喉癌, 价值研究

Abstract: Objective Detection of tumor abnormal protein in patients with laryngeal cancer and healthy people was conducted to analyze the clinical value of tumor abnormal protein in the diagnosis of laryngeal cancer. Methods A total of 95 patients with laryngeal cancer diagnosed in pathology department, People's Hospital from September 2017 to September 2019 were selected as the experimental group, while 95 healthy patients were selected as the control group. All subjects were tested for tumor abnormal protein to explore its application value in the clinical diagnosis of patients with laryngeal cancer. Results The positive rate of tumor abnormal protein in patients with laryngeal cancer was 83.16%, which was higher than that in healthy people(15.79%), and the difference was statistically significant(P<0.001).The positive expression rate of TAP in peripheral blood of patients with lymph node metastasis and stage Ⅲ+Ⅳ laryngeal cancer was higher, and the difference was statistically significant(P<0.05).There was no significant difference in the expression level of abnormal tumor protein in peripheral blood of laryngeal cancer patients with different genders and ages(P>0.05). Conclusion The expression of tumor abnormal protein in peripheral blood of patients with laryngeal cancer has high sensitivity, and tumor abnormal protein has high application value in the clinical diagnosis of laryngeal cancer.

Key words: Tumor abnormal protein, Laryngeal cancer, The value of research

中图分类号: 

  • R739.65
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