上皮屏障在慢性鼻窦炎伴鼻息肉中的研究进展

doi:10.6040/j.issn.1673-3770.0.2021.583

Abstract

Abstract: Chronic rhinosinusitis with nasal polyps(CRSwNP)is a common disease in otorhinolaryngology characterized by the highly heterogeneous chronic inflammation of the nasal and sinonasal mucosa. Recently, CRSwNP has been reported to have substantially affected the quality of life of patients and increased social and economic burdens due to the increase in its worldwide incidence, frequent recurrence, and poor therapeutic outcomes. As a gatekeeper, the epithelial barrier, which is composed of epithelial cells, is the first line of defense against the invasion of pathogens and allergens in the nasal cavity. It maintains the homeostasis within hosts by initiating defense mechanisms, activating various physicochemical factors, and regulating immune responses. Studies have shown that epithelial barrier dysfunction is closely related to the occurrence of CRSwNP; this is currently one of the major focuses of CRSwNP-associated research. Therefore, it is crucial to elucidate the molecular biological mechanisms underlying CRSwNP-associated epithelial barrier dysfunction. This review summarizes the progress of current research regarding the functions and the mechanisms underlying the action of, and the factors damaging, the epithelial barrier during CRSwNP. Our review will provide insights into the pathological mechanism of CRSwNP and shed light on new directions for research regarding its diagnosis and treatment.

Key words: Epithelial barrier, Chronic rhinosinusitis, Nasal polyp, Epithelial-mesenchymal transition, Heterogeneous chronic inflammation

CLC Number:

R765.4

HUANG Danyi, ZHANG Ting,CHEN Jing, ZHANG Wei. Progress of research regarding the role of the epithelial barrier in chronic rhinosinusitis with nasal polyps[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 78-83.

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Progress of research regarding the role of the epithelial barrier in chronic rhinosinusitis with nasal polyps

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