Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (5): 160-164.doi: 10.6040/j.issn.1673-3770.0.2023.153

• Review • Previous Articles    

Research progress on the role of M receptor signaling pathway in the occurrence and development of myopia

ZHANG Jinmu1, GUO Bin1,2, JIANG Wenjun3, LIU Dongmei4   

  1. 1. College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China2.Postdoctoral Station of Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China3.Shandong Academy of Eye Disease Prevention and Therapy/Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Eye Disease, Jinan 250002, Shandong, China4. Department of Cataract, Eye Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong, China
  • Published:2024-09-25

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Abstract: M receptors participate in regulating numerous physiological activities in eye tissues. Studies have shown that M receptors can regulate ciliary muscle contraction, regulate the expression of myopia-related neurotransmitters(such as dopamine)and growth factors(such as transforming growth factor β2)in the retina and choroid, and affect scleral fibroblast proliferation and matrix metalloproteinase-2 expression, which in turn affects scleral remodeling and axial growth, ultimately affecting the occurrence and development of myopia. In recent years, a large number of animal experiments and clinical studies have confirmed that M receptor antagonists effectively delay the progression of myopia.This article provides a brief review of the role of the M receptor signaling pathway in the occurrence and development of myopia in different eye tissues(ciliary muscle, retina, choroid, and sclera), to provide ideas for the studing of myopia-related mechanisms and clinical treatment.

Key words: Myopia, M receptor, Ciliary muscle, Retina, Choroid, Sclera

CLC Number: 

  • R778.1+1
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