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Pathogenesis and treatment of vasomotor rhinitis CUI Zhe-zhu,HAN Yu,YE Hui,JIANG Xian,CUI Chun-lian,JIN Shun-ji JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （2697）      PDF（pc） （112KB）（4833）       Save Objective To investigate the pathogenesis and therapy of vasomotor rhinitis. Method One hundred and seventysix patients with vasomotor rhinitis were randomly divided into three groups: the autonomic nerve regulation group (n=62 ), the laser therapy for single inferior turbinate group (n=50) and the drug therapy group (n=64). Results The effect of laser therapy for the single inferior turbinate group was better than that of the autonomic nerve regulation group, but there was no significant difference between the two groups statistically. The effect of laser therapy for the single inferior turbinate group and the autonomic nerve regulation group was better than that for the drug therapy group (P=0.004, P= 0.041). Conclusion Laser therapy for the single inferior turbinate and autonomic nerve regulation are all effective for vasomotor rhinitis. Vasomotor rhinitis is probably caused by regional vegetosis of the nasal mucosa. Related Articles | Metrics

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Diagnosis and treatment of neck space infection of 4 cases and review of the literature LONG Meihui, MU Yanyun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 94-95.   DOI: 10.6040/j.issn.1673-3770.0.2015.023 Abstract （1619）      PDF（pc） （899KB）（1285）       Save Reference | Related Articles | Metrics

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Postnasal drip syndrome in 300 cases LI Jia,LI Duo-xian,CHEN Kai, YE Bao-xiang,ZHANG Zhi-xiong,LI Xiong-wen,YE Yuan-hang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （4026）      PDF（pc） （275KB）（5103）       Save ObjectiveTo study the etiopathogenisis and clinical manifestations of postnasal drip syndrome. MethodsThe clinic manifestations, treatments and follow-up results of 300 cases in our hospital in recent years were retrospectively analyzed. Postnasal drip is mainly complicated with sinus nasalis and nasopharynx diseases and it often induces chronic cough and various kinds of discomforts in the pharyngeal portion. ResultsAll cases mainly had chronic and various kinds of discomfort in the pharyngeal portion related to sinus nasalis and nasopharynx diseases. Of the total, 243 cases related to diseases in the nasal cavity and the sinus nasalis, of which rhinitis happened in 30, periodic rhinitis in 59, nasosinusitis in 64, nasosinusitis polypus in 77 and tumor in the nasal cavity and the sinus nasalis in 13. Also, 57 cases related to nasopharynx diseases, including 50 cases of inflammatory diseases and 7 cases of neoplastic diseases. The misdiagnosis rate was up to 78.7 percent. After anti-infective treatment, anti-allege, necessary surgeries and radiotherapies, the cough symptoms of 290 cases disappeared and of 10 cases apparently improved. During a 1-2 year follow-up, 8 cases relapsed, but the same treatment measures still had an effect. ConclusionsStrengthening the knowledge of postnasal drip syndrome is an important step to diagnose, reduce the rate of misdiagnosis and guide therapy. In order to reduce the misdiagnosis rate, it is necessary to use the standard check. Also the all-round treatments according to the causes are guarantees for curative effects. Related Articles | Metrics

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Outcomes of sinus balloon catheter dilation in treatment of pediatric chronic rhinosinusitis: a systematic review and meta-analysis. LIN Xing, LIN Zongtong, SHEN Ling. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (6): 79-86.   DOI: 10.6040/j.issn.1673-3770.0.2017.373 Abstract （1876）      PDF（pc） （5045KB）（588）       Save Objective To estimate the safety, feasibility, and efficacy of sinus balloon catheter dilation in the treatment of pediatric chronic rhinosinusitis. Methods PubMed, Embase, CNKI, Wanfang Data, CBM, and VIP databases were systematically searched for prospective studies from the date of establishment of the databases to June, 2017, on the therapeutic effects of sinus balloon catheter dilation in the treatment of pediatric chronic rhinosinusitis. Two reviewers independently conducted the literature search, study selection, data extraction, and quality assessment of the included studies. The meta-analysis was conducted using statistical package R. Results A total of 8 prospective studies were included. Feasibility study: 7 prospective studies involving 235 patients(549 sinuses)were included. The results of the meta-analysis showed that sinus balloon catheter dilation was successful in 98% of the cases(95%CI［0.95-1.00］). Effectiveness study: 5 prospective studies involving 172 patients were included. The SN-5 score was used to assess postoperative improvement in symptoms. The meta-analysis showed that the procedure improved symptoms in 89% of patients(95%CI［0.84 - 0.93］); and the SN-5 score decreased by 1.87 at follow-up, compared to baseline values(P<0.01). Safety study: Only one study reported a patient who experienced periorbital swelling without hematoma postoperatively; it resolved within one week with no specific treatment. Conclusion Sinus balloon catheter dilation is a safe, feasible, and effective treatment for pediatric chronic rhinosinusitis. Due to the low quality of the included studies, the conclusion should be verified by more strictly-designed, large-scale, and high-quality studies in the future. Reference | Related Articles | Metrics

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A simple repair of partical iridoialysis in 16 cases ZHANG Ning, TIAN Jie, ZHAO Jun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2008, 22 (6): 547-548.   Abstract （1867）      PDF（pc） （244KB）（1591）       Save To discuss a microsurgical repair method of partical iridodialysis.  MethodsUnder microscopy 16 cases (16 eye) of partical iridodialysis were repaired by puncturing tunnels on the scleras. ResultAfter the operations, all the pupils became circular and eyesight was improved. ConclusionIt is simple, safe and effective to repair partical iridodialysis by puncturing tunnels on the scleras. Related Articles | Metrics

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Nasal endoscopic surgery in the treatment of isolated sphenoid sinus lesions KANG Wen-jun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （1970）      PDF（pc） （254KB）（2217）       Save The clinical data of fifteen patients with isolated sphenoid sinus lesions treated by nasal endoscopic surgery were retrospectively analyzed. ResultsAll cases were cured without serious complications. None recurred during six months after the operations. ConclusionNasal endoscopic surgery is convenient, safe and effective for isolated sphenoid sinus lesions. Related Articles | Metrics

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Application of HRT-II in the diagnosis of chronic primary angle-closure glaucoma QU Hong-Bo, TANG Gui-Lan, LIU Shao-Jun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2008, 22 (6): 538-540.   Abstract （1631）      PDF（pc） （250KB）（1460）       Save To investigate the diagnostic value of HRT-II for chronic primary angle-closure glaucoma（CPACG）. MethodsThirty cases (60 eyes) of CPACG were detected by HRT-II and auto visual field examination. The sensitivity， characteristics of different disk section, and correlation between optic disc parameters and mean defect of the visual field were analyzed. Results1. Fifty-three eyes were abnormal by visual field detection and fifty-four eyes abnormal by HRT-II. The corresponding ratio between visual field detection and HRT-II was 98.15%. In the group of single eye abnormal in the visual field, there were 2 eyes which were normal in the visual field but abnormal in HRT-II and 5 eyes were normal in both the visual field and HRT-II; 1 eye was abnormal in the visual field but normal in HRT-II. The Rim area of the abnormal ratio in the temporal inferior section was the highest in HRT-II.  2. Mean defection showed a statistically significant correlation with rim area, rim volume, cup/disc (C/D) area and cup shape (P＜0.05). ConclusionHRT-II is sensitive and is related to the visual field result. HRT-II can probably be used for follow-up and early diagnosis of CPACG. Related Articles | Metrics

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Research of eustachian tube dysfunction and the application of balloon dilation eustachian tuboplasty ZHAO Xinxing, ZHANG Longcheng JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 83-86.   DOI: 10.6040/j.issn.1673-3770.0.2015.091 Abstract （1886）      PDF（pc） （926KB）（2113）       Save Eustachian tube dysfunction (ETD) is a major factor resulting in middle ear diseases. There are many methods for judgement and treatment of ETD in clinic. Balloon dilation eustachian tuboplasty(BET) was found to be a simple, minimally invasive and effective new method in the treatment of ETD. Reference | Related Articles | Metrics

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Initial clinical observation of Smart Plug lacrimal plug in the treatment of aqueous tear deficiency dry eye GUO Li1, YUAN Fang2, LI Bin1 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (1): 63-66.   Abstract （1640）      PDF（pc） （390KB）（2185）       Save Objective    To evaluate the clinical efficacy of SmartPlug lacrimal plug in the treatment of aqueous tear deficiency dry eye.  Methods    SmartPlug lacrimal plugs were inserted to treat 42 cases of aqueous tear deficiency dry eye (84 eyes). All patients were followed-up for 5-15 months（average 8.3 months）. Schirmer I test (SIT) ，tear breakup time (TBUT), and fluorescent of cornea (FL) were used to evaluate the clinical efficacy. Results     ①Pre- and posttreatment SIT  were 3.41±0.60mm and 5.75±0.44mm(P<0.05), respectively; ② Pre- and post-treatment  TBUT  were 3.75±1.26 seconds and 6.46±1.47 seconds (P<0.05), respectively; ③Pre- and posttreatment FL were 2.45±0.06 and 0.04±0.02 (P<0.05), respectively;④The subjective symptoms improved in most patients. Conclusions    The SmartPlug lacrimal plug is effective in the treatment of aqueous tear deficiency dry eye. Moreover, it is recommended that lacrimal punctual occlusion should be done before irreversible damages of the ocular surface. Related Articles | Metrics

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Sphenoid sinus open surgeries for sphenoid sinus related diseases ZHONG Zhao-tang, LIANG Min-zhi, CHEN Ze J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (3): 39-41.   DOI: 10.6040/j.issn.1673-3770.0.2012.376 Abstract （2213）      PDF（pc） （912KB）（1401）       Save Objective   To improve the understanding of sphenoidotomy for sphenoid sinus and related diseases. Methods   The clinical data of 42 cases of sphenoidotomy treated in our department were retrospectively analyzed. There were type 1 sphenoidotomy for 18 cases of bacterial sphenoiditis, type 2 sphenoidotomy for 19 cases related of sphenoid sinus mycoses, submucosal cyst and papillary tumor, type 3 sphenoidotomy for 5 cases related for adjusting ethmoid sinus mucocele, pituitary tumor, rock peak cholesteatoma and rock peak cholesterol granulation cyst. Results   All patients were cured and did not relapse during a followup of six months to 3 years. One case of pituitary tumor had post-operative cerebrospinal fluid rhinorrhea was cured after conservative treatment. Conclusion   Different types of sphenoid sinus open surgery can be used to treat different sphenoid sinus diseases, also can be used as the nasal endoscopic skull base surgery approach. Related Articles | Metrics

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Current progress of exosome research in allergic diseases ZHANG Xuping, LIU Xuexia,ZHANG Hua Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (2): 136-140.   DOI: 10.6040/j.issn.1673-3770.0.2020.285 Abstract （1799）      PDF（pc） （966KB）（2194）       Save Exosomes are closed vesicles with a lipid bilayer membrane that are produced from late endosomes. They can carry and secrete cargo such as intracellular proteins and nucleic acids, and they can be transported to recipient cells. Exosomes are used for signal transduction and intercellular communication. These carriers play an important role in various physiological and pathological processes. Recent studies have found that exosomes can regulate immune responses, transmit inflammatory signals, and release cytokines, which play a key role in allergic diseases. Since exosomes exist in a variety of body fluids, they are expected to aid early disease screening, efficacy evaluation, and prognostic analysis. Therefore, this study reviews the research progress regarding exosomes in allergic diseases, hoping to provide new ideas and effective targets for the diagnosis and treatment of diseases. Reference | Related Articles | Metrics

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Advances in single-cell RNA sequencing in the retina YANG Songyue, ZHANG Meixia Journal of Otolaryngology and Ophthalmology of Shandong University    2025, 39 (1): 162-170.   DOI: 10.6040/j.issn.1673-3770.0.2023.222 Abstract （530）      PDF（pc） （3340KB）（1261）       Save The retina is a heterogeneous tissue. This intricate structure is composed of various types of cells with distinct transcriptomes. The traditional bulk RNA sequencing has quantified the global transcriptome of retinal cells. In recent years, single-cell RNA sequencing(scRNA-seq)methods have enabled profiling the transcriptome of retinal cells at a single-cell resolution, improving our understanding of cell classification, physiology, and developmental patterns of the retina. Currently, scRNA-seq is mainly focused on exploring the mechanism of retinal diseases. This review provides a comprehensive overview of the utilization of scRNA-seq in retinal research. It encompasses the delineation of cell subtypes, identification of specific markers, insights into retinal disease pathogenesis, developmental patterns, interspecies and interregional retinal tissue comparisons, as well as a concise introduction to scRNA-seq methodologies and prospective advancements in the field. Reference | Related Articles | Metrics

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A follow-up study of quality of life of 120 cases of chronic nasalsinusitis after endoscopic sinus surgery. ZHANG Xia1, XIA Li-jun2 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 51-54.   Abstract （1378）      PDF（pc） （1042KB）（2178）       Save Objective   To investigate the clinical significance of regular follow-up of chronic nasal-sinusitis symptom improvement and quality of life impact after endoscopic sinus surgery. Methods   From December 2009 to September 2010 120 patients with sinusitis according to chronic nose-sinusitis diagnosis and treatment guidelines of the 2008 Nanchang standard were enrolled in our department and were divided into chronic nose not associated with sinusitis and chronic nasal polyps and sinusitis associated with nasal polyp groups (n=60). Two groups of patients were on regular follow-up dressing for one year. The main symptom status and quality of life improvement of all patients were evaluated before and after 1, 3, 6 and 12 months. Results   Of 60 patients without nasal polyps, at 6 months 36 cases were cured, 20 cases improved, and 4 cases were invalid. At 12 months 50 patients were cured, 7 cases improved, and 3 cases invalid. Of the nasal polyps group, at 6 months 30 cases recovered, 27 cases improved, and 3 cases were invalid. At 12 months 37 cases were cured, 20 cases improved, and 3 cases were invalid. The two groups had statistically significant differences between disease outcomes. At 1, 3, 6, and 12 months after endoscopic sinus surgery, the first major symptom scores decreased (P<0.01); Compared with the preoperative, the 20 items and 5 items scores rated from 1 month also declined (P<0.01). Conclusion    Endoscopic sinus surgery with regular follow-up dressing can significantly improve surgical outcome. Related Articles | Metrics

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Research progress of Copper complexes for antitumor therapy YANG Yuyun, HUANG Yanli, LI Junzhen Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (5): 145-152.   DOI: 10.6040/j.issn.1673-3770.0.2023.117 Abstract （800）      PDF（pc） （2178KB）（1729）       Save Copper is one of the essential elements required by the human body, being widely involved in various activities. Copper homeostasis is strictly regulated in prolcaryotic and eukaryotic cells to ensure sufficient copper availability for protein biosynthesis and the inhibition of oxidative stress and resulting toxicity. Copper is a limiting factor in the development and progression of cancer, including growth, angiogenesis and metastasis; Therefore, regulating tumor occurrence and development by varying the copper content in the human body has become a popular research topic in tumor treatment. The method adopted for this can be divided into those that increase the copper concentration in tumor cells by administering copper compounds or copper ionophores and those that reduce the copper concentration to physiological levele using copper complexing agents, thereby achieving antitumor therapy. In this paper, the current status and progress of copper complexes in tumor therapy are briefly reviewed, including the known mechanism of action and molecular targets, Furthermore, the related clinical trials are discussed, and the prospects for copper complexes in this field are outlined. Reference | Related Articles | Metrics

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Research advances on Argonaute2 and its role in human tumors. ZHANG Yanhui, DONG Pin JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (3): 95-99.   DOI: 10.6040/j.issn.1673-3770.0.2016.485 Abstract （2916）      PDF（pc） （1052KB）（4985）       Save With the rapid development of proteomics, proteins related to tumorigenesis and progression have been continuously discovered and applied to clinical diagnosis. By constituting RNA-induced silencing complex(RISC), selfcatalysis and overexpression, Argonaute2 plays an important role in human tumorigenesis and progression, and is becoming a research focus. In this article, we will review the research advances on the structure, function and mechanism of Argonaute2 in tumor development. Reference | Related Articles | Metrics

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ZHOU Yu-jiao,YIN Ji-wei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （1897）      PDF（pc） （167KB）（2426）       Save Related Articles | Metrics

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Net Meta-analysis and data mining of patients with acute pharyngitis managed with Chinese medicine LI Zepeng, LI Wenjian, SUN Zhijia Journal of Otolaryngology and Ophthalmology of Shandong University    2023, 37 (4): 111-118.   DOI: 10.6040/j.issn.1673-3770.0.2022.173 Abstract （1137）      PDF（pc） （683KB）（1001）       Save Objective This study aimed to explore the use of Chines- patent medicines in managing patients with acute pharyngitis, and to compare their efficacy against commonly used drugs. Methods Clinical studies of Chinese-patent medicines for acute pharyngitis, published until April 20, 2022, were collected from PubMed, Embase, Cochrane Library, web of science, CNKI, Wanfang, Sinomed, and VIP. Meta-analysis and data mining were done with the Stata software and R software. Results A total of 202 clinical studies and 141 types of Chinese-patent medicines were collected. Of which, a watermelon cream preparation was the most frequently studied Chinese-patent medicine, followed by Shufengjiedu capsules. The main symptoms of exuberant lung-stomach heat included sore swollen throat, dry throat and thirst, and gum swelling and pain. On the other hand, the main symptoms of wind-heat assailing the outer body included pharyngeal redness and swelling, dry throat, hoarseness, hissing, and fever. A total of 33 randomized control trials, 14 interventions, and eight types of Chinese-patent medicines were included in our meta-analysis, which showed that Sufengjiedu capsules combined with antibiotics, watermelon cream preparation, Qingyan drops combined with antibiotics, Guaizijin, and Yinhuang preparations were more effective than single vse antibiotics. Moreover, our net meta-analysis revealed that the Yinhuang preparation(SUCRA=0.87), sufengjiedu capsule combined with antiviral drugs(SUCRA=0.85), and watermelon cream preparation(SUCRA=0.72)had the greatest efficiency rates. Conclusion At present, the most used clinical research on the treatment of acute pharyngitis with Chinese-patent medicine involves the use of watermelon cream preparation. The most common pattern is wind-heat assailing the outer body. Our metanalysis revealed that the efficacy of Chinese patent medicines was non-inferior to that of antibiotics alone. Of which, the Yinhuang preparation displayed the best efficacy. Reference | Related Articles | Metrics

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Cytoskeleton-associated protein in the inner ear and gene mutations cause hereditary deafness YANG Xia, GAO Xia JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 80-84.   Abstract （1501）      PDF（pc） （1006KB）（4003）       Save The correlated hereditary deafness-associated genes include cytoskeletal proteins, extracellular matrix proteins, channels and gap junction proteins, transcription factor genes, mitochondrial genes and other unknown function genes. Most of the cloned genes are cytoskeletal molecules.This paper makes a summary about major structural protein associated with hair cells and the pathogenesis of gene mutations lead to hereditary deafness. Related Articles | Metrics

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Prediction model of cardiovascular disease risk in people with dual sensory impairment: analysis based on CHARLS LYU Yong, FENG Yun Journal of Otolaryngology and Ophthalmology of Shandong University    2025, 39 (3): 122-128.   DOI: 10.6040/j.issn.1673-3770.0.2024.638 Abstract （322）      PDF（pc） （3227KB）（286）       Save Objective To establish a prediction model of cardiovascular disease(CVD)in people with dual sensory impairment based on the data of CHARLS database. Methods A cohort from China Longitudinal Study on Health and Retirement(CHARLS)in 2011 was included. The baseline population was people over 45 years of age with dual sensory impairment and no CVD, and the follow-up CVD in 2013, 2015, 2018 and 2020 was used as the outcome variable. LASSO regression and Logistic regression were used to screen the best predictors in the model, and a prediction model was constructed. Then, the research population was randomly divided into training set and verification set at the ratio of 75% to 25%. The prediction performance is evaluated by ROC curve, calibration curve and decision curve analysis. Results A total of 5866 participants with double sensory impairment were included, and the incidence of CVD was 16%(938/5866). Lasso regression and multivariate logistic regression selected age, sex, sleep duration, dyslipidemia, nephropathy, waist circumference, BMI and diabetes as predictors to build a prediction model, and the formula was: 0.027 40×age-0.052 52×gender-0.073 61×sleep duration+0.153 26×BMI-0.372 05×dyslipidemia -0.057 37×diabetes -0.252 30×nephropathy-0.014 67×waist circumference. The AUC value of the model was 0.729 in the training set and 0.692 in the verification set. Conclusion In this study, a prediction model was established to evaluate the risk of CVD in people with double sensory impairment. Reference | Related Articles | Metrics

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Detection of serum total IgE and allergen-specific IgE in healthy adults and its significance. YUAN Yuan, WU Zhongfei, CHAO Changjiang, LU Meiping, TIAN Huiqin, CHENG Lei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 34-38.   DOI: 10.6040/j.issn.1673-3770.0.2016.259 Abstract （5219）      PDF（pc） （1217KB）（5065）       Save Objective To explore the scientific significance and practical application of serum levels of total IgE(tIgE)and allergen-specific IgE(sIgE)in excluding allergen sensitization. Methods A total of 536 volunteers including 347 males and 189 females, aged 19-60 years with median age of 38 years old received the healthy physical examination were recruited in the study. All the subjects had no history and symptoms of allergic diseases as well as systemic diseases. Serum tIgE was detected by the capture enzyme-linked immunosorbent assay. The tIgE level ≤100 kU/L represented negative while >100 kU/L positive. Serum sIgE was assessed by means of the Phadiatop test using the fluoroimmunoassay. The Phadiatop class 0 means negative and class ≥1 positive. Results Serum level of tIgE among healthy adults was 1.14-1 703.70(median 37.18)kU/L, and it was significantly higher in males than in females(P=0.001). The negative and positive rates of serum tIgE were 72.52% and 27.48%, respectively. Serum level of sIgE(Phadiatop)among healthy adults was 0.01-59.50(median 0.05)kU/L, which had no significant significance between the male and the female(P=0.154). The negative and positive rates of Phadiatop were 82.09% and 17.91%, respectively. There were no statistically significant differences in serum tIgE and sIgE levels among different age groups(P=0.119 and P=0.225, respectively). The Spearman rank correlation coefficient between serum tIgE and sIgE levels was 0.683 with statistical significance(positive correlation, P<0.001). There were 368 subjects(94.85%)with negative Phadiatop and 20 subjects(5.15%)with positive Phadiatop in the serum tIgE negative subjects(n=388), while 75 山东大学耳鼻喉眼学报30卷4期 -袁源,等.健康成人血清总IgE和变应原特异性IgE检测及意义 \=-subjects(51.02%)with positive Phadiatop and 72 subjects(48.98 %)with negative Phadiatop in the serum tIgE positive subjects(n=147). Conclusion More than one fourth subjects among healthy adults have a serum tIgE level higher than 100 kU/L, while less than one fifth subjects have a sensitization to inhaled allergens. There is an obvious correlation between the serum levels of tIgE and sIgE. The serum tIgE level below 100 kU/L may have a clinical value to exclude allergen sensitization; however, the sensitized status may not be confirmed when the tIgE level is higher than 100 kU/L, and case history and clinical manifestations also should be considered. Reference | Related Articles | Metrics

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The application of artificial intelligence in screening, diagnosis and prognosis of diabetic macular edema SHEN Jiaqi, LI Xiaosa, BI Yanlong, ZHANG Jingfa Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (5): 153-159.   DOI: 10.6040/j.issn.1673-3770.0.2024.084 Abstract （882）      PDF（pc） （1094KB）（2140）       Save Artificial intelligence(AI)has shown promising applications in the early screening, diagnosis, assessment, and treatment decision-making of clinical diseases. Diabetic macular edema(DME)is a significant cause of visual impairment among the working-age population. Given the complexity of DME imaging data, high rate of blindness, and treatment challenges associated with the disease, exploration of AI in the diagnosis and treatment of DME is of great importance. This review summarizes the advancements of AI technology in the early screening, accurate diagnosis, and prognosis prediction of DME, analyzes the challenges faced by AI solutions in practical DME applications, and offers insights into future directions, with the aim of providing valuable guidance for achieving personalized and precise diagnosis and treatment of DME. Reference | Related Articles | Metrics

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Measurements of corneal thickness in the clinic YANG Xue-qiu1, ZHAO Jing-jing1, ZHUANG Wen-juan2 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 80-82.   Abstract （3518）      PDF（pc） （1007KB）（2971）       Save The corneal thickness parameter is one of the major examination data of the anterior segment. It is used in the diagnosis of ophthalmological diseases, and it is very important in pre-operative assessment for excimer laser refractive surgery. With the development from contact to non-contact measurements, the corneal thickness measurement becomes more and more accurate and secure. In this review, we summarized the recent advances of different corneal thickness measurements in the clinic. Related Articles | Metrics

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MA Jing, AN Fei, LI Gong-Bao JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2009, 23 (3): 54-.   Abstract （1487）      PDF（pc） （295KB）（1986）       Save Related Articles | Metrics

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Postoperative parageusia following self-retaining laryngoscopic operations LI De-Sheng, LI Gong-Xia JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2009, 23 (3): 65-.   Abstract （1610）      PDF（pc） （247KB）（2380）       Save Objective   To explore causes and prevention of parageusia under self-retaining laryngoscopic operations. Methods   112 cases of self-retaining laryngoscopy in the past  6 years were retrospectively reviewed. Causes, prevention and treatment of 5 cases were analyzed. Results  Compression of the corpora linguae and radices linguae by a self-retaining laryngoscope might be the main cause of post-operative parageusia, 4 cases of tongue numbness were cured within 2 weeks, and 1 case of tongue deviation recovered in 5 weeks after prompt treatments. Conclusion   Improvement of operative skills， careful protection during the operations and avoidance of unnecessary injuries may reduce postoperative parageusia． Once parageusia has occurred， prompt and rational treatments can reverse parageusia without consequences. Related Articles | Metrics

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （1471）      PDF（pc） （185KB）（2006）       Save Related Articles | Metrics

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The law of medication for the treatment of endogenous eye disease in chinese medical code based on data mining WANG Shushu, FU Yahui, YU Ruoyu, HOU Yi, YANG Jiguo Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (4): 81-87.   DOI: 10.6040/j.issn.1673-3770.0.2021.020 Abstract （2457）      PDF（pc） （4397KB）（1756）       Save Objective To collect the prescription of Chinese Medical Code the treatment of cataract, and to summarize the clinical application of traditional Chinese medicine in the treatment of cataract by using the cloud platform(V2.3.5)database of ancient and modern medical records. Methods To search the prescription of Chinese Medical Code for treating cataract, to select the prescription for treating cataract according to the inclusion and exclusion criteria, to establish a Excel database, and to import the cloud platform of ancient and modern medical records(V2.3.5)in batches. Results A total of 249 prescriptions were selected, Contains 244 herbs, The total frequency was 2 596 times; efficacy 396, Total efficacy frequency 5 486 times; Four, properties 9 times. Total frequency 2 922 times; Five tastes,11 times. The total frequency is 3 697 times; The total frequency was 3 750. The top 3 drugs with high frequency of cataract treatment were Fangfeng, Angelica sinensis and Glycyrrhiza uralensis; The drug with high correlation was the highest in people participating in windbreak. Four properties 9 with cold, warm, slightly cold, flat. Conclusion Using the cloud platform(V1.4.5)of ancient and modern medical records to analyze the data, to show the law of drug use in the treatment of cataract eye disease in Chinese Medical Code, and to provide a reference for the summary of clinical practice of traditional Chinese medicine in the treatment of cataract eye disease. Reference | Related Articles | Metrics

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Analysis of anti-IL-4Rα monoclonal antibody and endoscopic sinus surgery in the treatment of eosinophilic chronic rhinosinusitis with nasal polyps CHEN Xingxue, ZHANG Guangling, WU Tianyi, WANG Weiwei, SUN Zhanwei, LI Shichao, WANG Guangke Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (4): 43-54.   DOI: 10.6040/j.issn.1673-3770.0.2024.093 Abstract （698）      PDF（pc） （4671KB）（1845）       Save Objective To observe and analyse the short-term efficacy of anti-IL-4Rα monoclonal antibody and endoscopic sinus surgery(ESS)in the treatment of eosinophilic chronic rhinosinusitis with nasal polyps(ECRSwNP). Methods Twenty-one patients diagnosed with bilateral ECRSwNP were treated with endoscopic sinus surgery(surgery group), anti-IL-4Rα monoclonal antibody(monoclonal antibody group)and intranasal corticosteroids(control group)respectively. To observe the difference in subjective and objective scores after treatment at 1 month, 3 months and 6 months compared with baseline, to evaluate the therapeutic effect of the two interventions, and then the efficacy of each group was compared to analyse whether there were differences. Results Nasal polyp scores(NPS), sino-nasal outcome test-22(SNOT-22)score, SNOT-22 nasal obstruction score and olfactory score, and Lund-Mackay score at 6 months post-treatment in monoclonal antibody group and surgery group were compared with the baseline data before treatment. The differences were statistically significant(P<0.05). There was a statistically significant difference in NPS(P=0.02), and no significant difference in SNOT-22(P=0.57), nasal obstruction score(P=0.94), olfactory score(P=0.11)and Lund-Mackay score(P=0.08)between monoclonal antibody group and surgery group. There were statistically significant differences in FEV1%(P=0.04)and FEV1/FVC%(P=0.01)in monoclonal antibody group and surgery group before and after treatment in patients with comorbid asthma, but there was no significant difference between the two groups(P=0.25, P=0.74).There was no statistically significant difference in changes in eosinophil count(F=1.73, P=0.21)and eosinophil percentage(F=0.03, P=0.87)before and after treatment among the three groups. The differences between the three were not significant(P=0.18, P=0.07). Conclusion Both anti-IL-4Rα monoclonal antibodies and endoscopic sinus surgery can not only significantly improve nasal symptoms, olfactory levels, and lung function in patients with ECRSwNP, but also reduce the extent of sinusitis lesions and improve patients' quality of life. Olfactory improvement in anti-IL-4Rα monoclonal antibody patients was more significant than in ESS patients, while polyp burden and nasal symptoms were significantly improved in ESS patients. Reference | Related Articles | Metrics

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (3): 1-4.   Abstract （994）      PDF（pc） （443KB）（1983）       Save Related Articles | Metrics

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Endoscopic electrocoagulation in 29 cases of epistaxis QI Jian-wei, XU Jin-jing, WU Yuan-qing J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (4): 9-10.   DOI: 10.6040/j.issn.1673-3770.0.2013.128 Abstract （2102）      PDF（pc） （849KB）（1478）       Save Related Articles | Metrics

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Lamellar coronal sectional anatomy for endoscopic sphenoidotomy ZHAO Zhenhua1, WANG Qirong1, LIU Shuwei2, HAN Fei1, GU Lintao1, Li Xiao1, Chen Zhipeng1 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2010, 24 (2): 35-37.   Abstract （2000）      PDF（pc） （484KB）（1921）       Save Objective  To provide lamellar sectional anatomy data of coronal for endoscopic sphenoidotomy.  Methods  A digital freezing milling technique was used to obtain continuous sectional data of coronal as thin as 0.1mm.of 10 cadaver heads(20 sides) without organic lesions. The sphenoid sinus and some surrounding structures were observed on typical and continuous coronal sectional images.  Results  75% of the sphenoid sinus was sellae type,  only 15% of the septum located in the median sagittal section,  60% of the optical nerve canal and 75% of the internal carotid bulge on the area of the lateral sphenoid sinus. Conclusion  The lamellar coronal sectional image obtained from digital freezing milling technique offers a better understanding of the complex anatomic structures and provides sectional anatomy data for sphenoidotomy. Related Articles | Metrics

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （1612）      PDF（pc） （116KB）（1204）       Save Related Articles | Metrics

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Advancements in olfactory testing for early diagnosis of mild cognitive impairment in patients ZHOU Chunyi, HU Hui, ZHANG Ailin, WANG Yuncui Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (5): 119-125.   DOI: 10.6040/j.issn.1673-3770.0.2023.134 Abstract （564）      PDF（pc） （1095KB）（1224）       Save Mild cognitive impairment(MCI)serves as a transitional state between the typical ageing process and the onset of Alzheimer's disease. Emerging research indicates that MCI patients exhibit pathological alterations such as olfactory bulb atrophy and neuronal loss. Moreover, the severity of these pathological changes correlates with the degree of cognitive impairment. Hence, olfactory testing holds potential as a supplementary tool for MCI screening. Despite being in its nascent stages in China, research on early MCI diagnosis through olfactory tests is gaining momentum. In this study, we conduct a comprehensive review of pertinent literature, encompassing olfactory function, test content, characteristics, and current applications. Our aim is to furnish healthcare practitioners with insights into selecting suitable olfactory test instruments to enhance the early detection rate of MCI. Reference | Related Articles | Metrics

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null SUN Hai-ying1, WANG Zhi-bin2, YU Yang2, LI Da3, CUI Xin3 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 27-29.   Abstract （1443）      PDF（pc） （1611KB）（1835）       Save null Related Articles | Metrics

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Effect of 577 nm subthreshold micropulse laser photocoagulation combined with anti-VEGF on the treatment of refractory diabetic macular edema ZHOU Jinglin, LI Jinxiang, ZENG Qi Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (2): 18-25.   DOI: 10.6040/j.issn.1673-3770.0.2023.313 Abstract （708）      PDF（pc） （2900KB）（879）       Save Objective We compared the clinical efficacy of subthreshold micropulse laser photocoagulation(SMLP)with a threshold of 577 nm, combined with intravitreal injection of compacept(intravitreal conbercept, IVC), with that of IVC alone in the treatment of refractory diabetic macular edema(DME). Methods We designed and performed a non-randomized controlled study. Patients with refractory DME who were admitted to the Department of Ophthalmology, Hunan Provincial People's Hospital from January 2022 to December 2022 were selected and divided into an experimental group(10 cases, 16 eyes)and a control group(12 cases, 17 eyes). The experimental group received 577 nm SMLP combined with IVC treatment, and the control group received IVC alone. The changes in best corrected visual acuity(BCVA), central macular retinal thickness(CMT), hard exudates(HE)area, microangioma(MA), and the number of intravitreal injections were collected after 6 months of treatment in the two groups. The incidence of complications was recorded after treatment. Results After 6 months of treatment, the respective Log MAR BCVA values in the experimental and control groups were 0.300(0.100, 0.400)and 0.400(0.300, 0.600), respectively. The difference between these two groups was statistically significant(t=-2.575, P=0.015). The respective CMT values were 237.00(230.75, 254.75)μm and 263.00(237.00, 341.50)μm, and the difference was statistically significant(t=-2.252, P=0.035). No significant difference was observed between HE ［411.50(72.25, 8 757.50)pixels2］ vs. ［3 000.00(10.00, 6 604.00)pixels2］ and MA ［1.00(0.00, 7.25)vs.(4.55±4.78)］(t=0.766, P=0.452; t=-0.861, P=0.400). The numbers of injections in the experimental and control groups were(4.6±0.2)and(5.3±0.2), respectively. This difference was statistically significant(t=-2.182, P=0.039). After 6 months of treatment, no obvious pigment deposition or sign of laser scar was observed in the fundus examination of the affected eyes in the experimental group. No obvious complications were observed in the experimental group or the control group after 6 months of treatment. Conclusion SMLP at 577 nm demonstrated good safety. Compared with simple IVC treatment, 577 nm SMLP combined with IVC treatment improves HE area, number of bleeding points, and MA with the same efficacy in patients with refractory DME. However, combined treatment can better reduce macular edema in some patients in the short term, improve BCVA, prolong the interval of intravitreal injection, and reduce the frequency of intravitreal injection, offering promising prospects for clinical application. Reference | Related Articles | Metrics

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Causes and treatment of secondary hemorrhage after Uvulopalatopharyngoplasty   ZHAO Xin, ZHANG Qing-quan, WANG Qiang, LIU Zhong-lu JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (6): 1-3.   Abstract （2349）      PDF（pc） （364KB）（2511）       Save Objective   To discuss the causes and preventive methods of secondary hemorrhage after Uvulopalatopharyngoplasty(UPPP). Methods   476 UPPP procedures ,performed from August 2002 to December 2010, were reviewed according to the Windfuhr J bleeding classification system. Results   26 patients suffered from postoperative bleeding, including 17 cases of secondary bleeding.We found that grade 1 bleeding occurred in 5 cases(1%), grade 2 in 7 cases(1.47%), grade 3 in 2 cases(0.42%), grade 4 in 3 cases(0.63%) and there was no grade 5 bleeding. The causes of secondary hemorrhage included failed suture in the operation, poorly controlled blood pressure, postoperative cough, and wound infection. All patients were cured with proper treatment. Conclusion   According to our findings, it is important to decide surgical hemostatic intervention in time. Preventing secondary postoperative hemorrhage  can be achieved by proper measures. Related Articles | Metrics

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Expressions and significance of TNF-α and IL-8 in serum and peripheral blood mononuclear cells from patients with sudden sensorineural hearing loss. HENG Weiwei, HOU Jie, WEI Xianmei, SHE Wandong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (2): 40-45.   DOI: 10.6040/j.issn.1673-3770.0.2015.473 Abstract （1573）      PDF（pc） （1488KB）（893）       Save Objective To explore the expressions of tumor necrosis factor-α(TNF-α)and intedeukik-8(IL-8)in serum and peripheral blood mononuclear cells(PBMCs)from patients with sudden sensorineural hearing loss(SSNHL)and their clinical significance. Methods A total of 44 patients with SSNHL and 32 age-matched controls were enrolled in the study. The expressions of TNF-α and IL-8 in the serum and PBMCs were detected respectively. Results The expressions of TNF-α and IL-8 in the serum from patients with SSNHL were not much different from those in normal controls(P>0.05). However, they were significantly higher in PBMCs(P<0.05). Conclusion The elevated expressions of TNF-α and IL-8 in patients with SSNHL are closely related to the inner ear immune-mediation, indicating that inflammation may play an important role in the pathogenesis of the disease. The expressions of TNF-α and IL-8 may serve as novel diagnostic and therapeutic targets of SSNHL. Reference | Related Articles | Metrics

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （1560）      PDF（pc） （254KB）（2980）       Save Related Articles | Metrics

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Analysis of middle ear resonance frequencies in  patients with different types of tympanograms LIU Qi-ming, MA Zhao-en, ZHAI Jin-ming, QIU Li-zi, MAO Min, ZHANG Jian-guo JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (4): 29-31.   Abstract （2560）      PDF（pc） （313KB）（2687）       Save Objective       To investigate the degree and characteristic of hearing loss and analyze the corresponding middle ear resonance frequencies in  patients with different types of tympanograms. Methods        30 normal ears and 116 abnormal ears were tested by GSI60 pure tone audiometry and GSI-Tympstar middle ear analyzer. Based on the results of tympanograms,116 abnormal ears were divided into 30 type A,22 type Ad,21  type As and 43 type C. All groups were tested by multiple frequency tympanometry and their middle ear resonance frequencies were compared. Results      The average resonance frequency of normal ears was 951±198.85,while it was 861±137.60Hz (P<0.01) for type A, 725±158.14Hz(P<0.01) for type Ad, 499±146.27Hz(P<0.01) for type C, and 1088±199.38Hz(P<0.05) for type As. The average resonance frequency of type A, type Ad and the type C group was lower than the normal group, but the type As group was higher. Conclusion        Clinical testing of resonance frequency is helpful for  the diagnosis and treatment of middle ear pathologies. Related Articles | Metrics

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Four surgical treatments of pterygium on 168 eyes WANG Yuxia, XIAO Ying， SUN Hongyi, GAO Xue， LIU Jing， CHEN Guoling, YANG Lixia JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2010, 24 (3): 64-66.   Abstract （1969）      PDF（pc） （351KB）（1666）       Save Objectiv  eTo compare the therapeutic effects of simple pterygium excision,  pterygium excision combined with mitomycin C, limbus corneae stem cell transplantation, or amniotic membrane transportation on pterygium.  Methods  168 eyes of 158 patients were divided into four groups, i.e.  groups A，B, C and D, in terms of  applied treatments．41 eyes (group A)，42 eyes (group B), 44 eyes (group C)  and 41 eyes ( group D) were treated with simple pterygium excision, pterygium excision combined with mitomycin C, limbus corneae stem cell transplantation, or  amniotic membrane transportation,  respectively．The patients were followed up from 6 months to one year．Results  The recurrence rates of pterygium in groups A，B, C and D were 17.1%，9.5%, 4.5% and 4.9%，respectively．The difference between group A and the other three groups(B,C and D)was statistically significant (P<0．05)，whereas there was no statistical significance between group B & C ，group  B & D and group C & D. Group C had fewer complications than the other three groups. Conclusion  Pterygium excision combined with limbus corneae stem cell transplantation is the preferable methods while it demonstrates better costeffectiveness, lowere recurrence rate, shorter corneal epithelial healing time and fewer complications. Related Articles | Metrics

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Sexual behavior and HPV infection in squamous cell carcinoma of the oropharynx Guojun Li1,2, MD, PhD, Xinliang Pan3, MD, PhD, Dapeng Lei3, MD, PhD et al J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (1): 1-7.   DOI: 10.6040/j.issn.1673-3770.1.2012.015 Abstract （2497）      PDF（pc） （1107KB）（1387）       Save High risk human papillomavirus (HR HPV) infection is associated with a significant portion of squamous carcinoma of the head and neck, particularly for the oropharynx and for those lacking the other risk factors of tobacco and alcohol.  The link between HR HPV and carcionoma of the oropharynx have been suggested based on the identification of HR HPV in oropharyngeal tumors and association of HR HPV with the risk of oropharyngeal cancer from casecontrol epidemiologic studies. This review highlights the roles of sexual behavior characteristics in patients with oropharyngeal cancer compared with patients with non-oropharyngeal cancers at sites of oral cavity, larynx, and hypopharynx. Determining the behavioral risk factors for head and neck cancer is imperative for future cancer prevention efforts and for understanding the potential role of the HPV vaccine currently available.  This review also expands our understanding of the roles of sexual behavior as a risk factor for oropharyngeal cancer and its role as a marker of HPV exposure and emphasizes that HR HPV is sexually transmitted to the upper aerodigestive tract and that certain sexual behaviors increase the risk for HPV-associated oropharyngeal cancer. Related Articles | Metrics

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Injury of the eustachian tube and middle ear by sinusitis in children JIANG Ke-liang,WANG Jing,CHAI Mao-wen,NIU Shan-li,ZHAO Xun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （2216）      PDF（pc） （250KB）（2516）       Save Objective: To investigate injury of the eustachian tube and middle ear by sinusitis in children and observe the recovery of the acoustic dysfunction after treatment for sinusitis. Methods: Examination of the ear, observation of the pharyngeal ostium of the eustachian tube， acoustic impedance tests, and pure tone audiometry were performed on 100 children with chronic sinusitis and 50 normal children. Of them, in 128 ears of 68 children sinusitis was found combined with ear diseases and then treated. Results: In children with sinusitis, the abnormal rate of the eardrum, the pharyngeal ostium of the eustachian tube , the function of the eustachian tube and the acoustic impedance tests was 64%, 62%, 63.5%, and 62.5%,respectively, and the rate of hearing loss was 47.5%. Compared with the normal children, the differences were statistically significant(P＜0.01). The differences of the incidence of middle ear disease and acute sinusitis, subacute sinusitis and chronic sinusitis were statistically significant between the two groups (P＜0.05). The acoustic dysfunction had a significant improvement after the treatment for sinusitis. Conclusion: The changes of the eustachian tube function caused by sinusitis lead to a significantly high incidence of middle ear disease. Related Articles | Metrics

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Volume sinus osteomas： clinical analysis and operative method in 21 cases ZHENG Kuan-yi1, LI Zhi-feng1, SHI Guang-gang2, YANG Ming2 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2010, 24 (6): 27-28.   Abstract （1598）      PDF（pc） （316KB）（1261）       Save Objective    To explore the clinical characteristic and surgery method for frontal sinus osteoma. Methods     Based on the volume and position of the tumor body, 21 cases of volume sinus osteoma were removed en-nose, ex-nose or en-and ex-nose jointly. Results    Followed up for 1 to 3 years post-operative, headache symptom disappeared, and no osteoma relapsed. Conclusion     Different operative routes based on the volume and position of the tumor are convenient and  helpful in reducing operative complications. Related Articles | Metrics

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Endoscopic intranasal structure reconstruction surgery  in treating rhinogenic headache SUN Yiqing, PENG Bengang, WANG Xin, MIAO Xutao JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (4): 50-52.   Abstract （1056）      PDF（pc） （468KB）（1715）       Save  Objective      To explore the effect of endoscopic intranasal structure reconstruction surgery for rhinogenic headache. Methods        50 patients were treated with endoscopic intranasal structure reconstruction surgery. Lesions in the nasal cavity and the sinus were removed and the sinus ostium was opened, the anatomic abnormality was corrected, nasal septal and middle turbinate and inferior turbinate were reconstructed and sinusitis dissipated. Results      Followed up from 3 to 18months postoperatively, 30 cases (60%)were cured, 12cases were obviously recovered(24%)， and 5 cases were effectively recovered(10%). The clinical effective rate was 94%. 3 cases had no recovery. Conclusion       Endoscopic intranasal structure reconstruction surgery can accurately and clearly remove the ill tissue with a good therapeutic effect and has important clinical value.  Related Articles | Metrics

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Application of acellular dermal matrix in otorhinolaryngological reconstructive surgery QIN He, SUN Jian-jun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 75-77.   Abstract （1226）      PDF（pc） （903KB）（3727）       Save The unique features of acellular dermal matrix make it one of excellent material for repairing tissue defects. This article reviews the histological characteristics of acellular dermal matrix and its application in otolaryngological reconstructive surgery. Related Articles | Metrics

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Transnasal endoscopic submucous inferior turbinate resection in treatment of chronic hypertrophic rhinitis LIU Jun,YU Shao-qing,FAN Yong-jiu,GUO Jun-guang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （2184）      PDF（pc） （249KB）（2208）       Save Objective： To sum up the experience of submucous inferior turbinate resection by transnasal endoscopy for treatment of chronic hypertrophic rhinitis(HR). Methods： Twentyfive cases of HR were treated by transnasal endoscopic submucous inferior turbinate resection with the XPS3000 surgery synthetic dynamic system and specialpurpose tool bit(group A) and 22 cases were treated with the traditional partial inferior turbinectomy(group B). The amount of hemorrhage, time of surgery, nasal ventilation and mucosa recovery of the two groups were compared. Results: The amount of hemorrhage, time of surgery, nasal ventilation and mucosa recovery of group A were significantly lower and shorter than those of group B (P＜0.05). Followed up over three months, the response rates of group A and B were 92% and 86% respectively. Conclusion： Transnasal endoscopic submucous inferior turbinate resection is superior to traditional partial inferior turbinectomy in trauma and response for HR. Related Articles | Metrics

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2009, 23 (3): 38-.   Abstract （1915）      PDF（pc） （874KB）（2263）       Save Related Articles | Metrics

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The clinical application of sinus CT and MRI in unilateral benign sphenoid sinus lesions. JI Zao, YAN Aihui JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (3): 75-79.   DOI: 10.6040/j.issn.1673-3770.0.2017.074 Abstract （2459）      PDF（pc） （1841KB）（1059）       Save Objective To discuss the clinical application value through retrospective analysis of the CT and MRI imaging findings of unilateral benign sphenoid sinus lesions. Methods The imaging characteristics of 21 inpatients were analyzed who had had nasal endoscopic surgery and whose unilateral benign sphenoid sinus lesions had been pathologically proved. Results Of the 21 cases of unilateral benign sphenoid sinus lesions, there are 7 cases of cyst. CT manifestations: circular or ovoid soft tissue opacity with relatively homogeneous density in sphenoid sinus. The cases with sphenoid sinus cavity expansion may be accompanied by bone absorption attenuation. MRI manifestations: long T1 and long T2 irregular spherical signal shadow; 8 cases of fungal disease. CT manifestations: in sphenoid sinus, there are irregular patchy calcification spots or puffy-cloud density increase, ground-glass opacity in change. MRI manifestations: in sphenoid sinus, there are mixed signals, inflammation flake effusion in high signal, fungi the nodules are low T2WI signal; 3 cases of cerebrospinal fluid rhinorrhea, CT manifestations: pure soft tissue density in sphenoid sinus, MRI manifestations: there is linear high signal shadow between cerebrospinal fluid high signal shadow and high signal liquid film in sinuses. other organizations(brain tissue, nasal mucous membrane)has low signal; 3 cases of inverting papilloma, CT manifestations: soft tissue density shadow with heterogeneous density in sphenoid sinus. MRI manifestations: Neoplasm has uneven reinforcement, presenting a sample or a different degree of “gyrus” sign. Conclusion CT can show bone changes around the lesions very well. MRI can show the invaded range by lesions more clearly. A combination of both CT and MRI can provide more comprehensive imaging information for diagnosis and clinical treatment of unilateral benign sphenoid sinus lesions. CT combined with enhanced magnetic resonance imaging(MRI)analysis is more valuable in differential diagnosis than merely depending on CT scan. Reference | Related Articles | Metrics

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null YOU Jian-qiang, CHAO Chang-jiang, WANG Kai, WANG Xiao-ye, QIU Jian-he JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 43-46.   Abstract （1058）      PDF（pc） （919KB）（1138）       Save null Related Articles | Metrics

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Misdiagnosis of upper airway cough syndrome in children (140 cases report) HE Cheng J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (6): 69-71.   DOI: 10.6040/j.issn.1673-3770.0.2013.107 Abstract （2083）      PDF（pc） （920KB）（1388）       Save Objective    To investigate the clinical features, diagnosis and treatment of upper airway cough syndrome (UACS) in children. Methods    A retrospective analysis of 140 cases of juvenile UACS was performed. Among the patients, there were 102 cases misdiagnosed as chronic bronchitis, 25 cases as cough variant asthma, and 13 cases as Tourette′s syndrome. After the diagnosis were corrected,  all the patients underwent the treatment for nasal diseases. Results        After one 14-day course of treatment,  cough in the patients disappeared or ameliorated, with total remission rate at 92.1% (129/140).  Conclusion    UACS is prone to be misdiagnosed. Nasopharyngeal endoscopy (endoscopic or electronic nasopharyngoscope) is a useful tool to diagnose UACS and  the  prognosis of  UACS is good. Related Articles | Metrics

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Comparison of high order aberrations in pseudophakia with spherical intraocular lens and aspheric intraocular lens implantation. TIAN Jing, LIAO Xuan, LAN Changjun, TAN Qingqing, LIN Jia, WEN Baiwei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 13-17.   DOI: 10.6040/j.issn.1673-3770.1.2017.031 Abstract （2242）      PDF（pc） （902KB）（1873）       Save Objective To compare the corneal, internal, and ocular high order aberrations(HOAs)in pseudophakia of spherical intraocular lens(IOL)with aspheric IOL implantation, and to provide evidence for individual selection of aspheric IOL. Methods A prospective, non-randomized, controlled clinical study was conducted on 112 age-matched cataract patients(160 eyes). Patients were divided into four groups, and implanted with AMO Sensor AR40 IOL(group AR40, 40 eyes of 26 patients), AMO Tecnis ZA9003 IOL(group ZA9003, 40 eyes of 31 patients), Bausch & Lomb SofPort AO IOL(group AO, 40 eyes of 28 patients), or Alcon SN60WF IQ IOL(group IQ, 40 eyes of 27 patients). The corneal, internal, and ocular HOAs including total HOA(tHOA), spherical aberration(SA), coma, and trefoil were measured at three months postoperatively with a pupil diameter(PD)of 4 mm or 6 mm. Result There were no statistically significant differences in postoperative uncorrected visual acuity and best corrected visual acuity, and in postoperative corneal tHOA, SA, coma, and trefoil at 4 mm or 6 mm PD among the four groups. At 4 mm PD, there were significant differences in internal SA and coma but no differences in tHOA and trefoil; at 6 mm PD, there were significant differences in internal tHOA, SA, and coma but no differences in trefoil. In addition, there were significant differences in ocular tHOA and SA but no differences in coma and trefoil at 4 mm or 6 mm PD among the four groups. Conclusion Phacoemulsification of the cataract and implantation of an aspheric IOL can reduce corneal SA, resulting in enhanced visual quality. For aspheric IOLs with other SAs, the predictability of corneal SA is exact, which provides a clinical basis for personalized implantation of aspheric IOLs. Reference | Related Articles | Metrics