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Clinical features and diagnosis of allergic rhinitis. YAN Aihui, HAN Jiali JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 7-9.   DOI: 10.6040/j.issn.1673-3770.0.2016.243 Abstract （1598）      PDF（pc） （979KB）（1263）       Save Reference | Related Articles | Metrics

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Effects of 01% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome ZHANG Ju, WU Xin-yi JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (1): 49-51.   DOI: 10.6040/j.issn.1673-3770.0.2014.342 Abstract （4053）      PDF（pc） （929KB）（1482）       Save Objective To evaluate the effects of 0.1% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome. Methods A total of 60 patients (120 eyes) with dry eye syndrome were randomly divided into the experimental group (60 eyes) treated by 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops and the control group (60 eyes) treated by bysodium hyaluronate eye drops. Both groups were measured the Schirmer I test(SIt), tear film break-up time(BUT) and corneal fluorescein staining(FLs) before and after a month. Results There were no significant differences between the experimental group and the control group in SIt, BUT and FLs before treatment (P>0.05). After treatment, all the indicators of SIt, BUT and FLs of the experimental group and the control group were better than before (P<0.05). The experimental group was superior to the control group in the three indicators (SIt, BUT and FLs)(P<0.05). Conclusion 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops is effective in treatment of dry eye, and is superior to bysodium hyaluronate eye drops alone. Reference | Related Articles | Metrics

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Application of acellular dermal matrix in otorhinolaryngological reconstructive surgery QIN He, SUN Jian-jun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 75-77.   Abstract （972）      PDF（pc） （903KB）（1990）       Save The unique features of acellular dermal matrix make it one of excellent material for repairing tissue defects. This article reviews the histological characteristics of acellular dermal matrix and its application in otolaryngological reconstructive surgery. Related Articles | Metrics

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Treatment experience of preservation of laryngeal function in surgical management of pyriform sinus carcinoma. SONG Xicheng, ZHANG Hua, LIU Zhonglu, WANG Yunqiang, WANG Yan, ZHANG Qiang, WANG Qiang, KANG Shasha, SONG Yipeng JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2016.262 Abstract （1916）      PDF（pc） （1040KB）（1612）       Save Objective To investigate preservation and reconstruction of larynx function in surgical treatment of pyriform sinus carcinoma. Methods A retrospective analysis of 102 cases of pyriform cancer treated in June 2004 to October 2015 underwent surgeries with laryngeal functions preserved was carried out. There were 9 cases of stage Ⅰ, 11 cases of stage Ⅱ, 47 cases of stage Ⅲ and 35 stage Ⅳ, according to the 2002 UICC staging. Pharyngeal lateral wall approach, hyoid region approach and paraglottic space approach were chosen respectively to remove the tumor as per preoperative evaluation, followed by repairing of surgical defects and reconstruction of laryngeal and pharyngeal functions. 93 cases of postoperative radiotherapy were implemented. Results All patients recovered well after surgery except 1 patient with pharyngeal fistula and infection. All repairing materials of different methods survived and the average time of postoperative oral intake was 12.47 days. All patients retained good laryngeal functions with 95 decannulations and the 3-year and 5-year survival rates were 59.3% and 40.7% respectively. Conclusion Comprehensive preoperative investigations as laryngoscopy and radiological assessment may give good suggestions in selecting appropriate surgical approaches; good surgical approach may help provide good feasibility and visibility, and ensure complete removal of the tumors with safety margins; through the epiglottis flipping and/or thyroid reinforcement repairing methods, the incidence of accidental swallowing and pharyngeal fistula can be reduced; pyriform sinus carcinoma are found mostly in advanced stages, single treatment is often ineffective in controlling the lesion, and radiotherapy is necessary as a comprehensive treatment to improve the local control rate and survival rate. Appropriate surgical approaches and repairing methods can help surgeons to completely remove the tumor, and preserve or rebuild laryngeal and pharyngeal functions in managing chosen patients with pyriform sinus cancer. Reference | Related Articles | Metrics

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Progress in diabetic retinopathy mechanisms and cellular models WANG Jiaojiao, LI MiaoOverview,SONG ZongmingGuidance Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (5): 93-99.   DOI: 10.6040/j.issn.1673-3770.0.2021.203 Abstract （1559）      PDF（pc） （473KB）（768）       Save Diabetic retinopathy is the leading cause of poor vision and blindness in adults. A reasonable model for diabetic retinopathy can not only simulate its pathogenic mechanism, but also reduce economic investment. Therefore, screening and constructing suitable cell models is the core of research. In this paper, the mechanisms of inflammatory response, apoptosis, vascular dysfunction, and neurovascular unit dysfunction in diabetic retinopathy were discussed. Moreover, several models of endothelial cells, pericytes, retinal pigment epithelial cells, and glial cells were summarized to provide a useful reference for further studies on the mechanism of diabetic retinopathy and the development of relevant drugs. Reference | Related Articles | Metrics

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Minimally invasive otoendoscopic surgery: a new path for ear surgery Dengyuan WANG, Zhibin CHEN, Guangqian XING Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 27-30.   DOI: 10.6040/j.issn.1673-3770.1.2019.020 Abstract （1718）   HTML （26）    PDF（pc） （807KB）（908）       Save This article reviews the history, advantages and disadvantages, and current applications of otoendoscopic ear surgery. The otoendoscopic approach has unique advantages over the microscopic approach; it allows the surgeon to visualize the surgical site more clearly from multiple angles and at various magnifications, enabling completion of procedures using the transcanal approach, thereby reducing the need for endoauricular or postauricular incisions and avoiding the associated morbidity. Otoendoscopes also reduce the rates of cholesteatoma recidivism in chronic ear surgery. Otoendoscopic ear surgery appears to be a promising new technique and a reliable alternative to traditional microscopic surgery. Reference | Related Articles | Metrics

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The groove behind the palatovaginal canal: a landmark for identification of the palatovaginal canal MENG Qingguo, LU Yongtian, WU Xiaoliu, LI Jianxing, SUN Huanji, ZHANG Baoying, XIE Chang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 55-61.   DOI: 10.6040/j.issn.1673-3770.0.2015.124 Abstract （2320）      PDF（pc） （4366KB）（1159）       Save Objective To explore the groove behind the palatovaginal canal (PVC) is a critical landmark for safe identification of the PVC during endoscopic endonasal transpterygoid approaches and transfer CT scan of the pterygopalatine fossa. Methods Probes were inserted thorough the PVC of 20 dry skulls. The PVC and the groove behind it were proved on MSCT, meanwhile a comparative study was also carried out by the traditional method to identificate the PVC. Dissection of two skulls and cadaveric heads was performed to demonstrate the endoscopic anatomy of the PV canal and tbe groove. Results The grooves can be found in all 20 dry skulls and appeared as groof near the posterior opening of PV canal. 26 sids were deep while 14 sides were dimple. Mainly appeared as tube-shaped (24 sides) or ovoid dimple-shaped (16 sides). In CT scan, the average angle between PVS and the hard palate was 53.14±5.48°, while between the groove and the hard palate was 20.93±6.28°. There was also statistical difference for identification of the PVC in transfer CT between the traditional method and the method assisting with the groove. Anatomic steps and foundations for dissection of the PVC while using the groove as a landmark were described. Conclusion Anatomic investigation, radiologic studies and comparison between the methods for identification of the PVC demonstrate the important anatomic relationship of the PVC with the groove, and reveal the groove as a landmark in endoscopic endonasal transpterygoid approaches and transfer CT scan of the pterygopalatine fossa. Reference | Related Articles | Metrics

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Establishment and application of model of chronic rhinosinusitis in mice WANG Zhiyuan, ZHANG Gehua JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 76-78.   DOI: 10.6040/j.issn.1673-3770.0.2015.184 Abstract （2209）      PDF（pc） （954KB）（1845）       Save Chronic rhinosinusitis(CRS) is a common chronic inflammatory disease of the upper respiratory tract, which seriously affects the patients' quality of life. Because of its uncertain pathogenesis, the curative effect is not satisfactory. Animal model of CRS is the ideal means for study of the human CRS pathological mechanism and curative effect. Mice are currently common CRS animals. The main content of the review includes research progress of the mice CRS-building methods, the evaluation index and application status of the model. Reference | Related Articles | Metrics

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Detection of serum total IgE and allergen-specific IgE in healthy adults and its significance. YUAN Yuan, WU Zhongfei, CHAO Changjiang, LU Meiping, TIAN Huiqin, CHENG Lei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 34-38.   DOI: 10.6040/j.issn.1673-3770.0.2016.259 Abstract （4417）      PDF（pc） （1217KB）（2449）       Save Objective To explore the scientific significance and practical application of serum levels of total IgE(tIgE)and allergen-specific IgE(sIgE)in excluding allergen sensitization. Methods A total of 536 volunteers including 347 males and 189 females, aged 19-60 years with median age of 38 years old received the healthy physical examination were recruited in the study. All the subjects had no history and symptoms of allergic diseases as well as systemic diseases. Serum tIgE was detected by the capture enzyme-linked immunosorbent assay. The tIgE level ≤100 kU/L represented negative while >100 kU/L positive. Serum sIgE was assessed by means of the Phadiatop test using the fluoroimmunoassay. The Phadiatop class 0 means negative and class ≥1 positive. Results Serum level of tIgE among healthy adults was 1.14-1 703.70(median 37.18)kU/L, and it was significantly higher in males than in females(P=0.001). The negative and positive rates of serum tIgE were 72.52% and 27.48%, respectively. Serum level of sIgE(Phadiatop)among healthy adults was 0.01-59.50(median 0.05)kU/L, which had no significant significance between the male and the female(P=0.154). The negative and positive rates of Phadiatop were 82.09% and 17.91%, respectively. There were no statistically significant differences in serum tIgE and sIgE levels among different age groups(P=0.119 and P=0.225, respectively). The Spearman rank correlation coefficient between serum tIgE and sIgE levels was 0.683 with statistical significance(positive correlation, P<0.001). There were 368 subjects(94.85%)with negative Phadiatop and 20 subjects(5.15%)with positive Phadiatop in the serum tIgE negative subjects(n=388), while 75 山东大学耳鼻喉眼学报30卷4期 -袁源,等.健康成人血清总IgE和变应原特异性IgE检测及意义 \=-subjects(51.02%)with positive Phadiatop and 72 subjects(48.98 %)with negative Phadiatop in the serum tIgE positive subjects(n=147). Conclusion More than one fourth subjects among healthy adults have a serum tIgE level higher than 100 kU/L, while less than one fifth subjects have a sensitization to inhaled allergens. There is an obvious correlation between the serum levels of tIgE and sIgE. The serum tIgE level below 100 kU/L may have a clinical value to exclude allergen sensitization; however, the sensitized status may not be confirmed when the tIgE level is higher than 100 kU/L, and case history and clinical manifestations also should be considered. Reference | Related Articles | Metrics

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Relationship between Friedman OSA staging and ZPPP plus GAHM SUN Xiao-qiang1, YI Hong-liang2, CAO Zhen-yu2, ZHANG Yu-jun2 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 8-9.   Abstract （1843）      PDF（pc） （1023KB）（2759）       Save Objective To explore the relationship between Friedman OSA staging and genioglossus advancement and hyoid suspension(GAHM) plus Z-palatopharyngoplasty(ZPPP). Methods 26 patients with severe OSAHS (AHI>40)were performed GAHM plus ZPPP. The obstructive sites were identified in both oropharynx and hypopharynx. The follow up lasted at least 6 months postoperatively. The Chi square test was used to compare the preoperative and postoperative results. Results Satistying clinic results for the patients with Friedman OSA stages Ⅱ were 100%, while the overall success rate of Friedman OSA stages Ⅲ was 22.2%. Conclusion ZPPP plus GAHM is an effective method for patients with Friedman OSA stages Ⅱ. Related Articles | Metrics

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J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (2): 1-4.   DOI: 10.6040/j.issn.1673-3770.1.2012.016 Abstract （1548）      PDF（pc） （1279KB）（1591）       Save Related Articles | Metrics

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SUN Ziwen1, CUI Hongwei2, SUN XilingEtiology, pathogenesis, and management of dry eye SUN Ziwen, CUI Hongwei, SUN Xiling, CHEN Chen, ZHANG Lu, HU Zhulin Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (2): 159-166.   DOI: 10.6040/j.issn.1673-3770.0.2018.411 Abstract （2294）      PDF（pc） （533KB）（922）       Save Due to multiple influences of internal factors(tear film destruction, sex hormone disorders)and external factors(environment, surgery, and drugs), patients with dry eye disease have been encountered much more frequently and are presenting at a younger age. Dry eye disease has become one of the most common diseases of the ocular surface, with a multifactorial etiology. This paper reviews the newer reports on etiology, pathogenesis, and management of dry eye. Reference | Related Articles | Metrics

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Progress in the research of intraocular lens power calculation formulas TAN Yan, LI Can Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (6): 95-98.   DOI: 10.6040/j.issn.1673-3770.0.2019.275 Abstract （2537）      PDF（pc） （311KB）（1029）       Save With the development of phacoemulsification surgery, the calculation of intraocular lens power has been paid greater attention. Various intraocular lens power formulas have been presented to optimize the visual quality after surgery. This paper comprehensively describes the progress in the research of various intraocular lens power formulas, such as the first-generation intraocular lens formula, the second-generation formula, Hill-RBF, Barrett True-K, and so on. Reference | Related Articles | Metrics

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Interpretation of “The Third Edition of the International Classification of Sleep Disorders(ICSD)”. SHANG Wei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2016.386 Abstract （3516）      PDF（pc） （1002KB）（2557）       Save The third edition of the International Classification of Sleep Disorders(ICSD-3)is the key reference for the diagnosis of sleep disorders. ICSD-3 is built on the same basic outline as ICSD-2, preserving the major diagnostic classifications. Significant modifications have been made to the nosology of insomnia, narcolepsy, and sleep-related breathing disorders. Major changes of the manual are reviewed in this article. Reference | Related Articles | Metrics

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Establishment and morphological assessment of the T-cell immune deficiency  mouse model with facial nerve axotomy QUAN Shi-ming1, PENG Ben-gang1, GAO Zhi-qiang2 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2010, 24 (6): 5-9.   Abstract （1403）      PDF（pc） （1377KB）（687）       Save Objective    To establish a stable and reliable T-cell immune deficiency mouse model with facial nerve axotomy by the application and assessment with morphological methods  on the immune deficiency mouse with facial nerve transection, so as to provide an experimental foundation for revealing the latent neuroimmunological mechanism of traumatic facial paralysis. Methods    The T-cell deficiency mice were subjected to a right facial nerve axotomy. Fluorogold retrotracer was used at a designated time. Two weeks after the operation, the slices of the brain stem were collected and the facial moto-neurons were observed and counted. Also, the injured facial nerve of axotomy nude mice was assessed with osmic acid staining. Results     All the mice presented typical facial paralysis after the transection of the facial nerve. Remarkable degenerations were observed in the distal end of the transected facial nerve on the 14th day after the operation. There was different status among the motoneurons in the facial nuclus, such as healthful, injured or dead. Significant difference in the number of facial moto-neurons between the nude mouse group and the wild type mouse group was noticed. Conclusion    The T-cell immune deficiency mouse model with facial nerve axotomy is effectiveand feasible. It provides an experimental foundation for revealing the latent neuroimmunological mechanism centering on T cell behavior of the pathogenesis and progression of facial nerve trauma. Related Articles | Metrics

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Diagnosis and treatment of parapharyngeal space neoplasms HU Juan-juan, HONG Yu-ming JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 85-90.   DOI: 10.6040/j.issn.1673-3770.0.2014.159 Abstract （2264）      PDF（pc） （972KB）（1388）       Save Anatomy of parapharyneal space is very complicated. Many types of parapharyngeal space neoplasms can occur, and all of them demonstrate different clinical manifestations. Therefore, it is more difficult to diagnose and treat the parapharyngeal space neoplasms than other head and neck neoplasms. Common diagnostics methods include bimanual examination, imaging studies, cytopathology, transoral and transcervical biopsy. All these methods can help doctor determine the nature and blood supply of tumors and understand the relationship between neoplasms and adjacent structure, which provide a reliable basis for the ensuing treatment. This paper aims to state the diagnosis and treatment of parapharyngeal space neoplasms, especially how to select surgical procedures. Reference | Related Articles | Metrics

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Cytoskeleton-associated protein in the inner ear and gene mutations cause hereditary deafness YANG Xia, GAO Xia JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 80-84.   Abstract （1184）      PDF（pc） （1006KB）（1558）       Save The correlated hereditary deafness-associated genes include cytoskeletal proteins, extracellular matrix proteins, channels and gap junction proteins, transcription factor genes, mitochondrial genes and other unknown function genes. Most of the cloned genes are cytoskeletal molecules.This paper makes a summary about major structural protein associated with hair cells and the pathogenesis of gene mutations lead to hereditary deafness. Related Articles | Metrics

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Pathogenesis, diagnosis, and treatment of chronic rhinosinusitis LI Huabin, LAI Yuting JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2018, 32 (3): 4-9.   DOI: 10.6040/j.issn.1673-3770.1.2018.004 Abstract （1835）      PDF（pc） （739KB）（1102）       Save Chronic rhinosinusitis(CRS)is a multifactorial otolaryngologic disease, often requiring surgical intervention. The diagnosis of CRS is relatively clear based on the patients symptoms, and nasal endoscopy and sinus CT scan findings. However, the pathogenesis is complex with multiple treatment methods. Hence, the type of intrinsic pathologic mechanism and its target treatment method should be given greater consideration, in order to achieve the best therapeutic effects. Reference | Related Articles | Metrics

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A review of squamous cell lines originating from the nasopharynx, oropharynx, laryngopharynx and larynx FENG Chengmin, JIN Yidan,LIU Hai, WANG Bing Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (6): 113-124.   DOI: 10.6040/j.issn.1673-3770.0.2020.478 Abstract （4243）      PDF（pc） （470KB）（749）       Save Larynx squamous cell carcinoma is a common malignant tumor of the head and neck region. The head and neck have complicated anatomical structure, and squamous cell carcinomas with different primary sites have different incidences, strategies of diagnosis and therapy, and even molecular pathogeneses. Therefore, selecting the suitable squamous cell carcinoma cell lines is important for researchers to determine appropriate preclinical research models and to have a better understanding of the mechanisms of tumorigenesis and progression. To provide a reference for researchers, this study summarizes the currently available squamous cell carcinoma cell lines originating from the nasopharynx, oropharynx, laryngopharynx and larynx. Reference | Related Articles | Metrics

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Localization diagnosis of obstructive sleep apnea hypopnea syndrome. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (1): 4-7.   DOI: 10.6040/j.issn.1673-3770.0.2017.007 Abstract （1580）      PDF（pc） （1064KB）（1078）       Save The localization diagnosis of obstructive sleep apnea hypopnea syndrome(OSAHS)is important for selecting the appropriate surgical treatment, and improving curative effect. However, there still remains some confusion. Although there exist many commonly used localization diagnosis methods, including nose throat routine examination, endoscopy plus MULLER, upper-airway-esophageal continuous pressure measurement, upper-airway imaging examination, drug inducing sleep endoscopy, and so on, none of them can provide accurate evidence for surgical treatment or predict the outcome comparatively precisely. Based on relevant literature and the authors clinical experience and research, the author puts forward that elaborate localization diagnosis is not necessarily listed as a routine examination, and it applies only to cases with unknown causes or cases which need to be furthered studied. In the future, studies on the pathogenesis of OSAHS should be strengthened. The localization diagnosis is important, but what is more important is to detect the causes for airway stenosis and blockage, in order to develop more precise treatment plan, and achieve satisfactory outcomes by minimally invasive surgery. Reference | Related Articles | Metrics

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (4): 65-66.   Abstract （884）      PDF（pc） （986KB）（1524）       Save Related Articles | Metrics

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Meta-analysis of clinical intradermal acupuncture efficacy for treatment of allergic rhinitis ZHAI Rui, LI Yuan, YU Jinglong, CHEN Xi, ZHENG Youyou, LIU Zhaolan, WANG Junhong Journal of Otolaryngology and Ophthalmology of Shandong University    2023, 37 (3): 35-45.   DOI: 10.6040/j.issn.1673-3770.0.2022.364 Abstract （572）      PDF（pc） （1352KB）（339）       Save Objective To systematically evaluate the clinical efficacy and safety of intradermal acupuncture in the treatment of allergic rhinitis using Meta-analysis. Methods PubMed, The Cochrane Library, Web of Science, SinoMed, VIP, CNKI, and Wanfang databases were searched for randomized controlled trials which used intradermal acupuncture to treat allergic rhinitis from database inception to October 1, 2022. Two researchers conducted independent screening, data extraction, bias risk assessment, and meta-analysis of the literature. Results This study included 29 clinical trials and 2342 patients. Compared with the positive control group, the intradermal acupuncture combined therapy group showed improvements in clinical total effective rate ［RR=1.24, 95%CI(1.16, 1.33), P<0.001］, quantitative scores of symptoms and signs ［MD=-0.67, 95%CI(-1.12, -0.22), P=0.003］, visual analogue score of nasal symptoms ［MD=-0.62, 95%CI(-0.97, -0.28), P<0.001］, number of recurrences ［RR=0.58, 95%CI(0.41, 0.82), P=0.002］, nasal resistance ［MD=-0.13, 95%CI(-0.21, -0.05), P=0.001］, and quality of life score for nasal conjunctivitis［MD=-4.17, 95%CI(-6.06, -2.29), P<0.001］. Compared with antihistamines, there was no significant difference in clinical total effective rate［RR=1.01, 95%CI(0.92, 1.11), P=0.78］ and quality of life score for nasal conjunctivitis［MD=0.43, 95%CI(-1.78, 2.65), P=0.70］ after treatment. No serious adverse reactions occurred after intradermal acupuncture treatment. Conclusion Using intradermal acupuncture to treat allergic rhinitis shows good curative effects and safety, and can reduce recurrence rates and nasal resistance, as well as improve quality of life. Due to the limits of our experimental design and issues related to the quantity and quality of original literature, the results of our meta-analysis still need to be further verified. In the future, relevant research should utilize other methodologies and strict experimental designs to provide more powerful, high-quality evidence-based data for the development of clinical diagnosis and treatment guidelines. Reference | Related Articles | Metrics

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Detection and clinical application of nasal nitric oxide Zhiwen CHEN,Lei CHENG Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 124-128.   DOI: 10.6040/j.issn.1673-3770.1.2019.026 Abstract （4526）   HTML （43）    PDF（pc） （437KB）（2146）       Save Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO）examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable. Reference | Related Articles | Metrics

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Application and progress of three-dimensional-printing technology in rhinology CHENG Xiqiao, QU Shenhong Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (2): 128-136.   DOI: 10.6040/j.issn.1673-3770.0.2023.270 Abstract （120）      PDF（pc） （1123KB）（323）       Save Three-dimensional(3D)-printing technology is based on a digital model and 3D-printed structures from powdered metal or other materials printed layer by layer. The application of 3D-printing-technology in the medical field, combined with advanced imaging technology and artificial intelligence, facilitates clinical teaching, preoperative planning, and doctor-patient communication, and enhances tissue and organ repair and reconstruction. The nasal anatomy is fine, the adjacent structure is complex, the individual differences are evident, and the operation is difficult. With the improvement of quality of life, the demand for defect repair caused by rhinoplasty and other diseases have increased gradually, and conventional surgery cannot fully satisfy various needs. The combination of 3D-printing and various technologies is consistent with this trend and has become a hot topic in rhinology and other disciplines in recent years. Therefore, this review summarizes the 3D-printing technology methods in this research direction, and presents recent progress in rhinology in nasal reconstruction and plastic surgery, 3D-printing nasal bones, postoperative tissue reconstruction, improvement of nasal ventilation function, assisted surgery, teaching and anatomical training, and drug delivery. Furthermore, future research directions and prospects for practical applications are highlighted. Reference | Related Articles | Metrics

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Research of the relationship between adenoid hypertrophy and the common diseases of pediatric otolaryngology LIU Yan, WEI Ping, KOU Wei, HU Sijie, WU Xiaofang, LIU Mengya, CHEN Cheng, YAO Hongbing Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (4): 149-154.   DOI: 10.6040/j.issn.1673-3770.0.2018.266 Abstract （2180）      PDF（pc） （430KB）（442）       Save Adenoid hypertrophy(AH)is a common and frequently occurring disease in pediatric otorhinolaryngology. The etiology, clinical symptoms, and treatment methods of AH have been studied thoroughly and a consensus has been largely reached. However, the relationship between AH and otorhinolaryngology-related diseases has not been widely investigated. AH and allergic rhinitis(AR), acute and chronic rhinosinusitis(ARS/CRS), acute otitis media(AOM), otitis media effusion(OME), cholesteatoma otitis media(COM), acute and chronic tonsillitis(AT/CT), tonsillar hypertrophy(TH), obstructive sleep apnea syndrome(OSAS), and other pharyngeal diseases are inextricably linked. This article mainly discusses the relationship between AH and common pediatric otolaryngology diseases through the interaction and influence of AH on these diseases. Reference | Related Articles | Metrics

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Imaging anatomy of the apertura of the sphenoidal sinus JIANG Shao-hong,LIU Feng-chun,ZHANG Qing-quan,L Yong-bin ,WANG Qiang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （2567）      PDF（pc） （301KB）（1444）       Save To measure the imaging anatomical data of the apertura of sphenoidal sinuses and their surrounding structure and to provide clinical guidance for surgeons. Methods30 adults with a normal sphenoidal sinus were subjected to lamella CT scanning of rhino-sinuses. Axial and frontal reconstructions were performed. The apertura of sphenoidal sinuses and their surrounding structures were measured. ResultsThe maximal vertical longitude of sphenoidal sinuses was (2.28±0.52)mm and the maximal horizontal longitude was (2.06±0.32)mm. Distance between the apertura of the sphenoidal sinus and the anterior naris was (72.34±3.67)mm， the maximal distances between the apertura and hanging wall, posterior wall, inferior wall and lateral wall of the sphenoidal sinus were (10.64±3.99), (17.68±2.78), (13.25±3.50) and (8.76±3.79)mm, respectively. ConclusionsThe apertura of the sphenoidal sinus is the vital anatomic landmark for per-sphenoidal operations, and it should be intero-inferiorly oriented not exceeding 10.64±3.99mm upwards and 8.76±3.79mm laterally. Related Articles | Metrics

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Clinical individual case analysis of poor cases after cataract surgery LI Jian-ping，ZHU Wei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 1-1.   Abstract （1041）      PDF（pc） （1036KB）（1828）       Save Related Articles | Metrics

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Research progress of dry eye animal model. HU Jindong, LIU Xinquan JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 109-113.   DOI: 10.6040/j.issn.1673-3770.0.2016.420 Abstract （2009）      PDF（pc） （899KB）（1361）       Save Dry eye is the most common ocular surface disease; however, its pathogenesis has not yet been fully elucidated. Therefore, the establishment of a dry eye model is particularly important for research into the conditions origins and its possible treatments. The current models used to establish tear deficiency either make use of an autoimmune reaction, involve the removal of the lacrimal gland(i.e., extirpation)or blockage of the lacrimal nerve, or use drugs that inhibit parasympathetic activity. Other methods of inducing dry eye involve burning the meibomian gland, decreasing the blink rate, reducing vitamin A intake, using preservatives, changing sex hormone levels, increasing tear osmolality, or carefully controlling the system environment. Meanwhile, some researchers combine the aforementioned models to produce dry eye, including combining parasympathetic inhibitory drugs with a controlled environmental system or using preservatives following removal of the lacrimal gland. In this article, we summarize the commonly used dry eye models. Reference | Related Articles | Metrics

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null WENG Yong-cai, GU Dong-sheng, CHEN Yu-wu, ZENG Dong-qian, WANG Tian-sheng J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (1): 93-94.   DOI: 10.6040/j.issn.1673-3770.0.2012.253 Abstract （1687）      PDF（pc） （970KB）（989）       Save null Related Articles | Metrics

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Assessment ofquality of life in children with adenoid hypertrophy by OSA-18 questionnaire LONG Chaoqing, YAN Yongyi, RONG Qingfeng JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (3): 13-15.   DOI: 10.6040/j.issn.1673-3770.0.2014.419 Abstract （3787）      PDF（pc） （1197KB）（1093）       Save Objective To investigate the value of OSA-18 questionnaire in assessment of quality of life in the children with adenoid hypertrophy. Methods Electronic nasopharyngoscopy and polysomnography (PSG) were underwent in 56 children with adenoid hypertrophy, and their quality of life were evaluated by OSA-18 questionnaire. The correlations between adenoid hypertrophy and OSA-18 scores were analyzed. Results The quality of life in 80.36% children with adenoid hypertrophy were significantly affected.Their OSA-18 total score were moderate and severe. There was significant correlation between OSA-18 total score and apneahypopneaindex(AHI), lowestoxygen saturation(LSaO2), and adenoid size. Conclusion There is an obvious correlation between adenoid size and OSA-18 score. OSA-18 questionnaire can be used asan indicatorin assessment of quality of life in the children with adenoid hypertrophy. Reference | Related Articles | Metrics

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Multifocal intraocular lens: progress in clinical application. WEI Chao, ZHANG Han JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 29-35.   DOI: 10.6040/j.issn.1673-3770.1.2017.027 Abstract （1084）      PDF（pc） （918KB）（821）       Save The incidence of cataract, which is a common eye disease, is increasing every year. Phacoemulsification and intraocular lens implantation is an effective method to treat cataract. A monofocal intraocular lens can provide adequate distance visual acuity, but spectacles should be used to compensate for near visual acuity deficiency. With the development of technology, the use of multifocal intraocular lens(MIOL)is increasing. The aim of this review is to summarize the principle, characteristics, and current research progress regarding use of MIOL for treating visual acuity deficiency. Reference | Related Articles | Metrics

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Effect of dry eye on refractive cataract surgery DUAN Lian, MENG FanlanReview,DANG GuangfuGuidance Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (6): 1-6.   DOI: 10.6040/j.issn.1673-3770.0.2022.381 Abstract （608）      PDF（pc） （995KB）（301）       Save Dry eye is an ocular surface disease characterized by tear film homeostasis imbalance due to various factors. Dry eye is often accompanied by tear film instability, elevated tear osmolality, ocular surface inflammatory damage, and ocular surface nerve sensory abnormalities. With the environmental pollution, the popularity of video terminals, and the change in lifestyle, dry eye has become one of the most common ophthalmic diseases in clinical practice significantly affecting the visual health and quality of life. The incidence of dry eye has increased annually, and more commonly affects the younger population. With the continuous development in cataract surgery technology and intraocular lenses, refractive cataract surgery has been accepted by more doctors and patients and has achieved satisfactory results. However, in clinical practice, there are still some disgruntled patients. Dry eye is an important and common reason for the reduction in satisfaction. Different interventions for dry eye in the perioperative period of patients undergoing refractive cataract surgery directly affect the accuracy of intraocular lens measurement and the stability of the postoperative refractive state. This paper reviews the incidence of dry eye in cataract patients, the risk factors for dry eye, the impact of dry eye on refractive cataract surgery, the impact of preoperative dry eye intervention on refractive cataract surgery, and therapy for postoperative patients with dry eye. This study highlights the importance of dry eye in refractive cataract surgery and the scientific and reasonable way of dealing with this condition. It is an efficient measure to improve the safety, accuracy, and patient satisfaction of refractive cataract surgery. Reference | Related Articles | Metrics

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Rabbit′s middle ear approach and its anatomic structure WANG Xiao-yan1， YE Qing1， SHEN Fan1， XIE Shu-sen2， ZHANG Xian-zeng2， ZHAN Zhen-lin2 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (6): 37-40.   Abstract （1704）      PDF（pc） （1253KB）（1377）       Save Objective   To study the surgical approach to middle ears and middle ear structure in rabbits and to provide experimental data for a rabbit model used in otological study. Methods   Eight healthy New Zealand rabbits (sixteen ears) were used in this study. The middle ear surgical approach and the landmarks were studied.  Middle ears of the rabbit were anatomized and observed under a microscope. Results   The retroauricular surgical approach was a fast and better way into a rabbit′s middle ears, but it was important to have a suitable position of the rabbit during the experiment. Some anatomical landmarks such as the facial nerve were useful for fast and correct approaching into middle ears. The rabbit′s middle ear anatomical structures are complex and similar to human′s. Conclusions   The retroauricular surgical approach is the choice of way to a rabbit′s middle ears，and the rabbit has similar anatomic structures with human′s in middle ear， so the rabbit model can be used in otological experiments. Related Articles | Metrics

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Interpretation of the clinical practice guidelines for diagnostic testing for adult obstructive sleep apnea: an update for 2016. An American Academy of Sleep Medicine Clinical Practice Guideline. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (1): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2017.084 Abstract （1259）      PDF（pc） （919KB）（1261）       Save Reference | Related Articles | Metrics

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Application and prospect of artificial intelligence in otolaryngology ZHU Zhiling, LI SongOverview,GUAN GuofangGuidance Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (2): 115-120.   DOI: 10.6040/j.issn.1673-3770.0.2019.598 Abstract （2334）      PDF（pc） （443KB）（569）       Save With the development of artificial intelligence(AI)technology in recent years, it has gradually penetrated into various fields of medicine. Further, through deep learning of big data, AI technology has increasingly been applied in some medical fields. Although the literature on AI in otolaryngology has increased rapidly over recent years, most otolaryngologists are still unfamiliar with this technology. In this study, we will briefly introduce the fundamental principles of AI, enumerate and analyze the main applications in otolaryngology, and discuss the application limitations and possible applications of AI technology in otolaryngology in the future. Through discussion of the problems above, AI technology can be more clearly understood by otolaryngologists. Reference | Related Articles | Metrics

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Prospect and progress of allergic rhinitis. ZHANG Ruxin JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 3-6.   DOI: 10.6040/j.issn.1673-3770.0.2016.241 Abstract （1514）      PDF（pc） （1102KB）（1217）       Save Reference | Related Articles | Metrics

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Hyperbaric oxygen therapy for 9 cases of sudden hearing loss with large vestibular aqueduct syndrome. WANG Jiefeng, WANG Huige JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 84-85.   DOI: 10.6040/j.issn.1673-3770.0.2016.107 Abstract （1408）      PDF（pc） （951KB）（834）       Save Objective To investigate the clinical efficacy of hyperbaric oxygen therapy in with sudden hearing loss patients with large vestibular aqueduct syndrome. Methods A total of 9 cases(11 ears)of sudden hearing loss with large vestibular aqueduct syndrome were treated with ten times of hyperbaric oxygen therapy in two weeks. Results The therapy was well tolerated. Pure tone audiometry revealed significant improvement after therapy. Conclusion All cases present good tolerance and significant effect. Hyperbaric oxygen therapy can be one of the therapeutic methods for sudden hearing loss patients with large vestibular aqueduct syndrome. Reference | Related Articles | Metrics

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Diagnosis and treatment of choroidal neovascularization in pathologic myopia Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (5): 157-162.   DOI: 10.6040/j.issn.1673-3770.0.2019.545 Abstract （2088）      PDF（pc） （436KB）（628）       Save Pathologic myopia(PM)is a major cause of vision loss worldwide, particularly in Asian countries. Choroidal neovascularization(CNV)is a severe complication of PM, which can cause macular disorders, leading to central scotoma, metamorphopsia, visual field loss, and finally blindness if not treated. The advents of optical coherence topography(OCT), OCT angiography, and fundus fluorescein angiography are helpful in diagnosing CNV due to PM, which can show the position and size of CNV, whether active or passive. For the treatment, photodynamic and anti-vascular endothelial growth factor(anti-VEGF)therapies are widely applied. In recent years, administering the intravitreal anti-VEGF injection has become the first-line treatment for CNV secondary to PM. Many clinical studies have indicated that intravitreal anti-VEGF injections affect antagonizing neovascularization and reduce macular edema, thereby contributing to visual improvements and better long-term outcomes. This article provides an overview of the current diagnosis and treatment options for myopic CNV. Reference | Related Articles | Metrics

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Advances in the pathological study of artificial intelligence in the lymph node metastasis of head and neck squamous cell carcinoma XIE Yulin, LEI Dapeng Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (3): 124-129.   DOI: 10.6040/j.issn.1673-3770.0.2023.037 Abstract （105）      PDF（pc） （1429KB）（101）       Save Artificial intelligence(AI)has developed rapidly in the field of medicine and is widely used in the diagnosis and prognosis evaluation of diseases. Head and neck cancer is one of the most common malignant tumors in the world, most of which are squamous cell carcinoma. Cervical lymph node metastasis of head and neck squamous cell carcinoma(HNSCC)is an important prognostic factor. The accuracy of the assessment of cervical lymph node metastasis is highly dependent on clinical diagnosis and treatment. At present, many studies have been conducted to develop models that can be used to predict cervical lymph node metastasis of HNSCC, and different clinical and pathological parameters were used in these predictive models. In order to progress development, we need to determine the optimum method to analyze the clinical and pathological data of HNSCC patients in a more comprehensive manner, as well as establish a prediction model with better precision. In this paper, we describe the progress of AI in the field of pathology and discuss the current status of its use in HNSCC research. Additionally, we have conducted an in-depth consideration and prospect on building an accurate and efficient AI prediction model for HNSCC lymph node metastasis to continuously improve the diagnosis and treatment of HNSCC. Reference | Related Articles | Metrics

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Physiological characteristics of voice and care of vocal health in the elderly Jiejie XU Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 14-18.   DOI: 10.6040/j.issn.1673-3770.1.2019.022 Abstract （1630）   HTML （20）    PDF（pc） （665KB）（1286）       Save Degenerative age-related changes in the body organs can affect the structure and physiological function of the vocal cords and cause senescence of voice in the elderly. This paper summarizes the changes in laryngeal structure, glottis appearance, and physiological vocal characteristics of aged subjects, and states the steps that need to be taken to care for vocal health of patients at an advanced age. This will be helpful to distinguish between the physiological and pathological changes of the larynx in the elderly and carry out appropriate and reasonable voice protection measures, thereby improving the quality of life in the aged population.Degenerative age-related changes in the body organs can affect the structure and physiological function of the vocal cords and cause senescence of voice in the elderly. This paper summarizes the changes in laryngeal structure, glottis appearance, and physiological vocal characteristics of aged subjects, and states the steps that need to be taken to care for vocal health of patients at an advanced age. This will be helpful to distinguish between the physiological and pathological changes of the larynx in the elderly and carry out appropriate and reasonable voice protection measures, thereby improving the quality of life in the aged population. Reference | Related Articles | Metrics

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Experience of clinical teaching in otorhinolaryngology for MBBS international students Xinjie ZHU,Ruoxi CHEN,Xiaolu LI,Lei CHENG Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 157-159.   DOI: 10.6040/j.issn.1673-3770.1.2019.033 Abstract （1282）   HTML （4）    PDF（pc） （354KB）（366）       Save Reference | Related Articles | Metrics

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Progress of research of oxidative stress in the pathogenesis of presbycusis ZHOU Yingdong, ZHANG Mengxian, WANG Qingling, KANG Haoran, GUO Xiangdong Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 72-78.   DOI: 10.6040/j.issn.1673-3770.0.2022.518 Abstract （238）      PDF（pc） （1196KB）（226）       Save Presbycusis is a sensorineural hearing loss caused by senescence of the inner ear and auditory cortex. Oxidative stress plays a key role in the occurrence and development of presbycusis. During aging, mitochondrial damage and the release of reactive oxygen species(ROS)promote each other, leading to oxidative stress and a variety of subsequent pathophysiological processes such as an imbalance in mitochondrial quality control, ubiquitin-proteasome system disorders, and programmed cell death. Antioxidants play a role in scavenging ROS, regulating mitochondrial function and inhibiting programmed cell death, and have shown great potential in the prevention and treatment of presbycusis. This review focuses on the progress of research of oxidative stress and subsequent cellular processes in the pathogenesis of presbycusis and antioxidants in delaying presbycusis in order to provide a theoretical basis for its treatment. Reference | Related Articles | Metrics

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Postnasal drip syndrome in 300 cases LI Jia,LI Duo-xian,CHEN Kai, YE Bao-xiang,ZHANG Zhi-xiong,LI Xiong-wen,YE Yuan-hang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （3556）      PDF（pc） （275KB）（2650）       Save ObjectiveTo study the etiopathogenisis and clinical manifestations of postnasal drip syndrome. MethodsThe clinic manifestations, treatments and follow-up results of 300 cases in our hospital in recent years were retrospectively analyzed. Postnasal drip is mainly complicated with sinus nasalis and nasopharynx diseases and it often induces chronic cough and various kinds of discomforts in the pharyngeal portion. ResultsAll cases mainly had chronic and various kinds of discomfort in the pharyngeal portion related to sinus nasalis and nasopharynx diseases. Of the total, 243 cases related to diseases in the nasal cavity and the sinus nasalis, of which rhinitis happened in 30, periodic rhinitis in 59, nasosinusitis in 64, nasosinusitis polypus in 77 and tumor in the nasal cavity and the sinus nasalis in 13. Also, 57 cases related to nasopharynx diseases, including 50 cases of inflammatory diseases and 7 cases of neoplastic diseases. The misdiagnosis rate was up to 78.7 percent. After anti-infective treatment, anti-allege, necessary surgeries and radiotherapies, the cough symptoms of 290 cases disappeared and of 10 cases apparently improved. During a 1-2 year follow-up, 8 cases relapsed, but the same treatment measures still had an effect. ConclusionsStrengthening the knowledge of postnasal drip syndrome is an important step to diagnose, reduce the rate of misdiagnosis and guide therapy. In order to reduce the misdiagnosis rate, it is necessary to use the standard check. Also the all-round treatments according to the causes are guarantees for curative effects. Related Articles | Metrics

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Research progress of miRNA in head and neck cancers ZHOU Juan, ZHENG Jiafa JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 79-82.   DOI: 10.6040/j.issn.1673-3770.0.2015.170 Abstract （1435）      PDF（pc） （928KB）（480）       Save A microRNA, abbreviated miRNA, is a non-coding single-stranded small molecular RNA. Through incomplete or complete complementary pairing with target mRNA 3' UTR (3' end untranslated region), it plays an important role in the occurrence and development of tumors. This paper reviews the role of miRNA in the diagnosis, prognosis and treatment of head and neck cancers. Reference | Related Articles | Metrics

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Improvement of the olfaction and quality of life of the chronic rhinosinusitis patients with olfactory disorders. ZI Xiaoxue, ZHAO Li, JIN Peng, TU Yanyi, LI Ang, SHI Li. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (1): 21-25.   DOI: 10.6040/j.issn.1673-3770.0.2015.512 Abstract （1444）      PDF（pc） （1270KB）（567）       Save Objective To explore the improvements of olfaction and quality of life(QOL)of the chronic rhinosinusitis(CRS)patients(with / without nasal polyps)with olfactory disorders. Methods 44 CRS patients with olfactory disorders were involved in this study and accepted CT scanning and Lund-Mackay CT score investigation before treatments. VAS score, SNOT-20 score and T&T test were taken before the operation, and 4 weeks and 12 weeks after the operation. Results In the T& T test, there were 59.5% and 73.0% of the patients whose olfaction were improved 4 and 12 weeks after the operation. The improvement rates were 77.3% and 86.4% in the VAS score. There were statistical difference between the pre-operation and post-operative 4 and 12 weeks(P<0.0001)in the T& T test and the VAS score, while the difference between the 4 weeks and 12 weeks after the operation were statistical insignificant(P=0.720,0.147). There was statistical difference between the pre-operation and post-operative 4 and 12 weeks(P<0.000 1)in the SNOT-20 test, while the difference between the 4 weeks and 12 weeks after the operation was statistically insignificant(P=0.055). Lund-Mackay CT score, T & T test, and VAS scores were positively correlated(r=0.569,P<0.000 1;r=0.782,P<0.000 1). Conclusion The olfaction and QOL of the patients significantly improve after endoscopic sinus surgery, and the difference between the 4 weeks and 12 weeks after the operation is statistically insignificant. The extent of the disease in the CRS and the degree of olfactory disorder are positively correlated. Reference | Related Articles | Metrics

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Clinical observation of compacept in the treatment of diabetes mellitus with CRVO-ME high reflex point BAO Ying, LIU Zhigao, JANG Pengfei, CUI Wenxuan, ZHENG Xiaoxia, YANG Mengyao, SI Mingwei, WANG Yu, WANG Hong Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (3): 55-60.   DOI: 10.6040/j.issn.1673-3770.0.2023.504 Abstract （80）      PDF（pc） （459KB）（65）       Save Objective To observe the changes in hyperreflective dots(HRD)in the retina of patients with non-ischemic central retinal vein occlusion-macular edema(CRVO-ME)treated with conbercept. Methods Eighty cases and 80 eyes of non-ischemic CRVO-ME patients were selected and divided into 40 cases(40 eyes)in the diabetic group and 40 cases(40 eyes)in the non-diabetic group according to the presence or absence of diabetes mellitus. Best corrected visual acuity(BCVA), central macular thickness(CMT)and the number of HRDs in the inner and outer retinal layers were compared and analysed in the two groups before and 1, 3 and 6 months after intravitreal injection of conbercept(IVC)treatment. Results At 3 and 6 months after IVC, BCVA in the non-diabetic group was significantly higher than that in the diabetic group(F=4.106,P=0.046;F=10.474,P=0.002), and CMT was significantly lower at 6 months after IVC(F=10.688,P=0.002). There was no significant difference in the amount of HRD in the inner retina between the two groups before and after IVC(F=1.608,P=0.209), but there was a significant difference in the amount of HRD in the outer retina(F=4.290,P=0.042). Conclusion IVC is effective in the treatment of non-ischemic CRVO-ME. HRD in the outer layer of the retina can be used as an imaging marker to monitor the inflammatory response and assess prognosis. The long-term therapeutic effect of non-ischemic CRVO-ME in diabetic group is worse than in non-diabetic group. Therefore, more attention should be paid to the long-term follow-up of diabetic patients to avoid serious complications. Reference | Related Articles | Metrics

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Stickler's syndrome in children without retinal detachment:a case report and literature review LU Song, XIA Yifan, LI Ziye, WEI Jing Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (3): 97-101.   DOI: 10.6040/j.issn.1673-3770.0.2023.050 Abstract （88）      PDF（pc） （2887KB）（67）       Save Objective To investigate the clinical presentation, diagnosis, treatment, and prognosis of children with Stickler syndrome to enable early diagnosis. Methods We retrospectively analyzed and summarized the medical records of a child with Stickler syndrome without retinal detachment and reviewed the relevant literature. He presented to our hospital with a complaint of decreased visual acuity in the left eye with visual distortion for 15 days, and was examined by optical coherence tomography and visual field and fundus fluorescein angiography in both eyes. Intraocular fluid examination and gene sequencing detected the COL2A1 variant c.1597C>T/ p.Arg533*(NM_001844.5), and he was diagnosed with Stickler syndrome type I. Retinal laser photocoagulation and intraocular pressure(IOP)lowering treatment were performed. Results After treatment, the child's visual acuity in the left eye returned to 0.5 and his IOP returned to normal. Conclusion Early treatment of Stickler syndrome in children is important. Genetic testing in any child for whom Stickler syndrome is suspected, as well as preventive treatment and regular multisystem follow-up, is recommended for patients who fit the relevant clinical picture, especially if they have high myopia before the age of 6 years. Reference | Related Articles | Metrics

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Pathogenesis and treatment of vasomotor rhinitis CUI Zhe-zhu,HAN Yu,YE Hui,JIANG Xian,CUI Chun-lian,JIN Shun-ji JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （2088）      PDF（pc） （112KB）（1712）       Save Objective To investigate the pathogenesis and therapy of vasomotor rhinitis. Method One hundred and seventysix patients with vasomotor rhinitis were randomly divided into three groups: the autonomic nerve regulation group (n=62 ), the laser therapy for single inferior turbinate group (n=50) and the drug therapy group (n=64). Results The effect of laser therapy for the single inferior turbinate group was better than that of the autonomic nerve regulation group, but there was no significant difference between the two groups statistically. The effect of laser therapy for the single inferior turbinate group and the autonomic nerve regulation group was better than that for the drug therapy group (P=0.004, P= 0.041). Conclusion Laser therapy for the single inferior turbinate and autonomic nerve regulation are all effective for vasomotor rhinitis. Vasomotor rhinitis is probably caused by regional vegetosis of the nasal mucosa. Related Articles | Metrics

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High-resolution CT findings of scutum in cholesteatoma of middle ears GUO Yan-hong, PAN Yan, WANG Ji-sheng JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (2): 17-19.   DOI: 10.6040/j.issn.1673-3770.0.2014.307 Abstract （2763）      PDF（pc） （2262KB）（1199）       Save Objective To evaluate erosion of scutum in the diagnosis of middle ear cholesteatoma by high-resolution CT scan(HRCT). Methods HRCT findings of 38 patients(in 42 ears)with middle ear cholesteatoma in our department were reviewed. The condition of the scutum was observed with CT scanning and surgical findings. Result There are 37 ears with erosion of scutum, 4 ears with marginal/central perforation and 1 ear with intact tympanic membrane. Conclusion Scutum erosion demonstrates an important role in the diagnosis of cholesteatoma of middle ear, however, this sign cannot be found in some patienas with cholesteatoma. Reference | Related Articles | Metrics

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Decompression of recurrent nerve. LÜ Zhenghua JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (2): 17-19.   DOI: 10.6040/j.issn.1673-3770.1.2016.05 Abstract （1410）      PDF（pc） （978KB）（831）       Save Reference | Related Articles | Metrics