Most Download Articles

    Published in last 1 year | In last 2 years| In last 3 years| All| Most Downloaded in Recent Month| Most Downloaded in Recent Year|

    Most Downloaded in Recent Month
    Please wait a minute...
    Establishment and application of model of chronic rhinosinusitis in mice
    WANG Zhiyuan, ZHANG Gehua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 76-78.   DOI: 10.6040/j.issn.1673-3770.0.2015.184
    Abstract2159)      PDF(pc) (954KB)(1748)       Save
    Chronic rhinosinusitis(CRS) is a common chronic inflammatory disease of the upper respiratory tract, which seriously affects the patients' quality of life. Because of its uncertain pathogenesis, the curative effect is not satisfactory. Animal model of CRS is the ideal means for study of the human CRS pathological mechanism and curative effect. Mice are currently common CRS animals. The main content of the review includes research progress of the mice CRS-building methods, the evaluation index and application status of the model.
    Reference | Related Articles | Metrics
    Clinical features and diagnosis of allergic rhinitis.
    YAN Aihui, HAN Jiali
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 7-9.   DOI: 10.6040/j.issn.1673-3770.0.2016.243
    Abstract1575)      PDF(pc) (979KB)(1030)       Save
    Reference | Related Articles | Metrics
    Effects of 01% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome
    ZHANG Ju, WU Xin-yi
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (1): 49-51.   DOI: 10.6040/j.issn.1673-3770.0.2014.342
    Abstract3985)      PDF(pc) (929KB)(1341)       Save
    Objective To evaluate the effects of 0.1% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome. Methods A total of 60 patients (120 eyes) with dry eye syndrome were randomly divided into the experimental group (60 eyes) treated by 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops and the control group (60 eyes) treated by bysodium hyaluronate eye drops. Both groups were measured the Schirmer I test(SIt), tear film break-up time(BUT) and corneal fluorescein staining(FLs) before and after a month. Results There were no significant differences between the experimental group and the control group in SIt, BUT and FLs before treatment (P>0.05). After treatment, all the indicators of SIt, BUT and FLs of the experimental group and the control group were better than before (P<0.05). The experimental group was superior to the control group in the three indicators (SIt, BUT and FLs)(P<0.05). Conclusion 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops is effective in treatment of dry eye, and is superior to bysodium hyaluronate eye drops alone.
    Reference | Related Articles | Metrics
    Research progress of dry eye animal model.
    HU Jindong, LIU Xinquan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 109-113.   DOI: 10.6040/j.issn.1673-3770.0.2016.420
    Abstract1948)      PDF(pc) (899KB)(1298)       Save
    Dry eye is the most common ocular surface disease; however, its pathogenesis has not yet been fully elucidated. Therefore, the establishment of a dry eye model is particularly important for research into the conditions origins and its possible treatments. The current models used to establish tear deficiency either make use of an autoimmune reaction, involve the removal of the lacrimal gland(i.e., extirpation)or blockage of the lacrimal nerve, or use drugs that inhibit parasympathetic activity. Other methods of inducing dry eye involve burning the meibomian gland, decreasing the blink rate, reducing vitamin A intake, using preservatives, changing sex hormone levels, increasing tear osmolality, or carefully controlling the system environment. Meanwhile, some researchers combine the aforementioned models to produce dry eye, including combining parasympathetic inhibitory drugs with a controlled environmental system or using preservatives following removal of the lacrimal gland. In this article, we summarize the commonly used dry eye models.
    Reference | Related Articles | Metrics
    Fufanghuangbai Liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal (40 cases report)
    YANG Mei-yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (2): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2014.254
    Abstract2930)      PDF(pc) (924KB)(1249)       Save
    Objective To investigate the clinical effect of Fufanghuangbai liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal. Methods In the Juye County People's Hospital otolaryngology from January 2012 to April 2014, 80 cases of eczema were randomly divided into control group and observation group, the control group of 40 patients were given triamcinolone acetonide acetate, 40 patients were given Fufanghuangbai liquid combined with triamcinolone acetonide acetate treatment, compared two groups of patients with clinical treatment effect and adverse reaction. Results After 1 weeks of treatment, the observation group efficiency was 45%, although slightly higher than that of the control group was 40%, but the two groups had no statistical difference (P>0.05). In observed group, the total efficiency of 75%, it was slightly higher than 72.5% of the control group, but the two groups had no statistical difference (P>0.05). After 2 weeks treatment, the observed group was 77.5%, significantly higher than the control group of 40%, a significant difference between two groups (P<0.05). Total effective rate of observation group was 92.5%, significantly higher than the control group of 72.5%, with a significant difference between two groups (P<0.05). Patients in the two groups after treatment had no significant adverse reactions. Conclusion Fufanghuangbai liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal has satisfied effect, it can significantly improve the patient's clinical symptoms with less adverse reaction.
    Reference | Related Articles | Metrics
    Research advances on Argonaute2 and its role in human tumors.
    ZHANG Yanhui, DONG Pin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (3): 95-99.   DOI: 10.6040/j.issn.1673-3770.0.2016.485
    Abstract2397)      PDF(pc) (1052KB)(1223)       Save
    With the rapid development of proteomics, proteins related to tumorigenesis and progression have been continuously discovered and applied to clinical diagnosis. By constituting RNA-induced silencing complex(RISC), selfcatalysis and overexpression, Argonaute2 plays an important role in human tumorigenesis and progression, and is becoming a research focus. In this article, we will review the research advances on the structure, function and mechanism of Argonaute2 in tumor development.
    Reference | Related Articles | Metrics
    The groove behind the palatovaginal canal: a landmark for identification of the palatovaginal canal
    MENG Qingguo, LU Yongtian, WU Xiaoliu, LI Jianxing, SUN Huanji, ZHANG Baoying, XIE Chang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 55-61.   DOI: 10.6040/j.issn.1673-3770.0.2015.124
    Abstract2283)      PDF(pc) (4366KB)(1050)       Save
    Objective To explore the groove behind the palatovaginal canal (PVC) is a critical landmark for safe identification of the PVC during endoscopic endonasal transpterygoid approaches and transfer CT scan of the pterygopalatine fossa. Methods Probes were inserted thorough the PVC of 20 dry skulls. The PVC and the groove behind it were proved on MSCT, meanwhile a comparative study was also carried out by the traditional method to identificate the PVC. Dissection of two skulls and cadaveric heads was performed to demonstrate the endoscopic anatomy of the PV canal and tbe groove. Results The grooves can be found in all 20 dry skulls and appeared as groof near the posterior opening of PV canal. 26 sids were deep while 14 sides were dimple. Mainly appeared as tube-shaped (24 sides) or ovoid dimple-shaped (16 sides). In CT scan, the average angle between PVS and the hard palate was 53.14±5.48°, while between the groove and the hard palate was 20.93±6.28°. There was also statistical difference for identification of the PVC in transfer CT between the traditional method and the method assisting with the groove. Anatomic steps and foundations for dissection of the PVC while using the groove as a landmark were described. Conclusion Anatomic investigation, radiologic studies and comparison between the methods for identification of the PVC demonstrate the important anatomic relationship of the PVC with the groove, and reveal the groove as a landmark in endoscopic endonasal transpterygoid approaches and transfer CT scan of the pterygopalatine fossa.
    Reference | Related Articles | Metrics
    Treatment experience of preservation of laryngeal function in surgical management of pyriform sinus carcinoma.
    SONG Xicheng, ZHANG Hua, LIU Zhonglu, WANG Yunqiang, WANG Yan, ZHANG Qiang, WANG Qiang, KANG Shasha, SONG Yipeng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2016.262
    Abstract1883)      PDF(pc) (1040KB)(1500)       Save
    Objective To investigate preservation and reconstruction of larynx function in surgical treatment of pyriform sinus carcinoma. Methods A retrospective analysis of 102 cases of pyriform cancer treated in June 2004 to October 2015 underwent surgeries with laryngeal functions preserved was carried out. There were 9 cases of stage Ⅰ, 11 cases of stage Ⅱ, 47 cases of stage Ⅲ and 35 stage Ⅳ, according to the 2002 UICC staging. Pharyngeal lateral wall approach, hyoid region approach and paraglottic space approach were chosen respectively to remove the tumor as per preoperative evaluation, followed by repairing of surgical defects and reconstruction of laryngeal and pharyngeal functions. 93 cases of postoperative radiotherapy were implemented. Results All patients recovered well after surgery except 1 patient with pharyngeal fistula and infection. All repairing materials of different methods survived and the average time of postoperative oral intake was 12.47 days. All patients retained good laryngeal functions with 95 decannulations and the 3-year and 5-year survival rates were 59.3% and 40.7% respectively. Conclusion Comprehensive preoperative investigations as laryngoscopy and radiological assessment may give good suggestions in selecting appropriate surgical approaches; good surgical approach may help provide good feasibility and visibility, and ensure complete removal of the tumors with safety margins; through the epiglottis flipping and/or thyroid reinforcement repairing methods, the incidence of accidental swallowing and pharyngeal fistula can be reduced; pyriform sinus carcinoma are found mostly in advanced stages, single treatment is often ineffective in controlling the lesion, and radiotherapy is necessary as a comprehensive treatment to improve the local control rate and survival rate. Appropriate surgical approaches and repairing methods can help surgeons to completely remove the tumor, and preserve or rebuild laryngeal and pharyngeal functions in managing chosen patients with pyriform sinus cancer.
    Reference | Related Articles | Metrics
    Application of acellular dermal matrix in otorhinolaryngological reconstructive surgery
    QIN He, SUN Jian-jun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 75-77.  
    Abstract956)      PDF(pc) (903KB)(1868)       Save

    The unique features of acellular dermal matrix make it one of excellent material for repairing tissue defects. This article reviews the histological characteristics of acellular dermal matrix and its application in otolaryngological reconstructive surgery.

    Related Articles | Metrics
    Application and progress of three-dimensional-printing technology in rhinology
    CHENG Xiqiao, QU Shenhong
    Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (2): 128-136.   DOI: 10.6040/j.issn.1673-3770.0.2023.270
    Abstract89)      PDF(pc) (1123KB)(263)       Save
    Three-dimensional(3D)-printing technology is based on a digital model and 3D-printed structures from powdered metal or other materials printed layer by layer. The application of 3D-printing-technology in the medical field, combined with advanced imaging technology and artificial intelligence, facilitates clinical teaching, preoperative planning, and doctor-patient communication, and enhances tissue and organ repair and reconstruction. The nasal anatomy is fine, the adjacent structure is complex, the individual differences are evident, and the operation is difficult. With the improvement of quality of life, the demand for defect repair caused by rhinoplasty and other diseases have increased gradually, and conventional surgery cannot fully satisfy various needs. The combination of 3D-printing and various technologies is consistent with this trend and has become a hot topic in rhinology and other disciplines in recent years. Therefore, this review summarizes the 3D-printing technology methods in this research direction, and presents recent progress in rhinology in nasal reconstruction and plastic surgery, 3D-printing nasal bones, postoperative tissue reconstruction, improvement of nasal ventilation function, assisted surgery, teaching and anatomical training, and drug delivery. Furthermore, future research directions and prospects for practical applications are highlighted.
    Reference | Related Articles | Metrics
    Therapeutic efficacy of Xuesaitong combined with Gastrodin for sudden deafness
    MA Ya-lin1, REN Ping-zhi2, CHAI Mao-wen1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 44-45.  
    Abstract2195)      PDF(pc) (962KB)(2034)       Save

    Objective   To explore the therapeutic efficacy of Xuesaitong combined with Gastrodin for sudden deafness. Methods   150 patients with sudden deafness were randomly divided into the Xuesaitong group, the Gastrodin group and the combined group, with 50 cases in each group. The combined group was synchronously treated with Xuesaitong and Gastrodin. Their hearing therapeutic efficacies were compared. Results   The total effective rate and recovery rate were 72% and 20% in the Xuesaitong group, 68% and 18% in the Gastrodin group,and 88% and 38% in the combined group. They were significantly higher in the combined group than in the other two groups (all P<0.05). Conclusion   The combined therapy for sudden deafness is obviously better than individual therapy.

    Related Articles | Metrics
    Progress in diabetic retinopathy mechanisms and cellular models
    WANG Jiaojiao, LI MiaoOverview,SONG ZongmingGuidance
    Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (5): 93-99.   DOI: 10.6040/j.issn.1673-3770.0.2021.203
    Abstract1453)      PDF(pc) (473KB)(658)       Save
    Diabetic retinopathy is the leading cause of poor vision and blindness in adults. A reasonable model for diabetic retinopathy can not only simulate its pathogenic mechanism, but also reduce economic investment. Therefore, screening and constructing suitable cell models is the core of research. In this paper, the mechanisms of inflammatory response, apoptosis, vascular dysfunction, and neurovascular unit dysfunction in diabetic retinopathy were discussed. Moreover, several models of endothelial cells, pericytes, retinal pigment epithelial cells, and glial cells were summarized to provide a useful reference for further studies on the mechanism of diabetic retinopathy and the development of relevant drugs.
    Reference | Related Articles | Metrics
    Minimally invasive otoendoscopic surgery: a new path for ear surgery
    Dengyuan WANG, Zhibin CHEN, Guangqian XING
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 27-30.   DOI: 10.6040/j.issn.1673-3770.1.2019.020
    Abstract1693)   HTML26)    PDF(pc) (807KB)(803)       Save

    This article reviews the history, advantages and disadvantages, and current applications of otoendoscopic ear surgery. The otoendoscopic approach has unique advantages over the microscopic approach; it allows the surgeon to visualize the surgical site more clearly from multiple angles and at various magnifications, enabling completion of procedures using the transcanal approach, thereby reducing the need for endoauricular or postauricular incisions and avoiding the associated morbidity. Otoendoscopes also reduce the rates of cholesteatoma recidivism in chronic ear surgery. Otoendoscopic ear surgery appears to be a promising new technique and a reliable alternative to traditional microscopic surgery.

    Reference | Related Articles | Metrics
    Lens vault changes and associated factors after implantation of implantable collamer lenses with central flow
    WAN Bo, LI Donghui, LUO Yan, LI Ying
    Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (2): 36-41.   DOI: 10.6040/j.issn.1673-3770.1.2020.008
    Abstract3233)   HTML40)    PDF(pc) (1740KB)(974)       Save
    Objective To investigate the changes to the lens vault(LV)and anterior chamber structures after implantation of implantable collamer lenses(ICL)with central flow in patients with myopia. The relationship between LV and its associated factors, both preoperatively and postoperatively, will also be analyzed. Methods One hundred and forty eyes of 72 patients who underwent ICL implantations were enrolled between January 2015 and January 2017. Visual acuity, intraocular pressure(IOP), corneal endothelial cell count(ECD), refractive outcomes, LV, and other anterior chamber structures were evaluated and compared after 1 week, 1 month, 3 months and 1 year, postoperatively. We analyzed the relationship between LV and other anterior chamber structures. Results After 1 year, 73% of eyes had gained 1 or more lines of corrected distance visual acuity, progressively fewer eyes had gained an uncorrected distance visual acuity above 20/20, more than 63% were within±0.5 D of the prospective mean refractive spherical equivalent(MRSE), and more than 86% were within±0.1 D of the prospective MRSE. There were no significant differences in MRSE, IOP, and ECD, postoperatively(p>0.05). No complications occurred during the postoperative time. There were no significant LV differences at 1 month and 3 months postoperatively. Meanwhile, LV had decreased significantly in the first postoperative year and was negatively correlated with age, keratometric power, 500 μm angle open distance, 500 μm trabecular iris space area, and the anterior chamber angle. LV was positively correlated with the white-to-white distance, angle-to-angle distance, anterior chamber depth, axial length, and ICL length. Axial length and ICL length were independent factors of LV. Conclusion Implantations of phakic ICL with center flow are safe, effective, and predictable in correcting myopia. LV decreased significantly at 1 year postoperatively, which correlated with multiple factors, both preoperatively and postoperatively.
    Reference | Related Articles | Metrics
    Comparison of high order aberrations in pseudophakia with spherical intraocular lens and aspheric intraocular lens implantation.
    TIAN Jing, LIAO Xuan, LAN Changjun, TAN Qingqing, LIN Jia, WEN Baiwei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 13-17.   DOI: 10.6040/j.issn.1673-3770.1.2017.031
    Abstract1876)      PDF(pc) (902KB)(1046)       Save
    Objective To compare the corneal, internal, and ocular high order aberrations(HOAs)in pseudophakia of spherical intraocular lens(IOL)with aspheric IOL implantation, and to provide evidence for individual selection of aspheric IOL. Methods A prospective, non-randomized, controlled clinical study was conducted on 112 age-matched cataract patients(160 eyes). Patients were divided into four groups, and implanted with AMO Sensor AR40 IOL(group AR40, 40 eyes of 26 patients), AMO Tecnis ZA9003 IOL(group ZA9003, 40 eyes of 31 patients), Bausch & Lomb SofPort AO IOL(group AO, 40 eyes of 28 patients), or Alcon SN60WF IQ IOL(group IQ, 40 eyes of 27 patients). The corneal, internal, and ocular HOAs including total HOA(tHOA), spherical aberration(SA), coma, and trefoil were measured at three months postoperatively with a pupil diameter(PD)of 4 mm or 6 mm. Result There were no statistically significant differences in postoperative uncorrected visual acuity and best corrected visual acuity, and in postoperative corneal tHOA, SA, coma, and trefoil at 4 mm or 6 mm PD among the four groups. At 4 mm PD, there were significant differences in internal SA and coma but no differences in tHOA and trefoil; at 6 mm PD, there were significant differences in internal tHOA, SA, and coma but no differences in trefoil. In addition, there were significant differences in ocular tHOA and SA but no differences in coma and trefoil at 4 mm or 6 mm PD among the four groups. Conclusion Phacoemulsification of the cataract and implantation of an aspheric IOL can reduce corneal SA, resulting in enhanced visual quality. For aspheric IOLs with other SAs, the predictability of corneal SA is exact, which provides a clinical basis for personalized implantation of aspheric IOLs.
    Reference | Related Articles | Metrics
    Progress and challenges in the management of asthma in China
    Jiangtao LIN
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (1): 4-8.   DOI: 10.6040/j.issn.1673-3770.1.2018.015
    Abstract1480)   HTML194)    PDF(pc) (1238KB)(935)       Save
    Reference | Related Articles | Metrics
    Detection of serum total IgE and allergen-specific IgE in healthy adults and its significance.
    YUAN Yuan, WU Zhongfei, CHAO Changjiang, LU Meiping, TIAN Huiqin, CHENG Lei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 34-38.   DOI: 10.6040/j.issn.1673-3770.0.2016.259
    Abstract4379)      PDF(pc) (1217KB)(2347)       Save
    Objective To explore the scientific significance and practical application of serum levels of total IgE(tIgE)and allergen-specific IgE(sIgE)in excluding allergen sensitization. Methods A total of 536 volunteers including 347 males and 189 females, aged 19-60 years with median age of 38 years old received the healthy physical examination were recruited in the study. All the subjects had no history and symptoms of allergic diseases as well as systemic diseases. Serum tIgE was detected by the capture enzyme-linked immunosorbent assay. The tIgE level ≤100 kU/L represented negative while >100 kU/L positive. Serum sIgE was assessed by means of the Phadiatop test using the fluoroimmunoassay. The Phadiatop class 0 means negative and class ≥1 positive. Results Serum level of tIgE among healthy adults was 1.14-1 703.70(median 37.18)kU/L, and it was significantly higher in males than in females(P=0.001). The negative and positive rates of serum tIgE were 72.52% and 27.48%, respectively. Serum level of sIgE(Phadiatop)among healthy adults was 0.01-59.50(median 0.05)kU/L, which had no significant significance between the male and the female(P=0.154). The negative and positive rates of Phadiatop were 82.09% and 17.91%, respectively. There were no statistically significant differences in serum tIgE and sIgE levels among different age groups(P=0.119 and P=0.225, respectively). The Spearman rank correlation coefficient between serum tIgE and sIgE levels was 0.683 with statistical significance(positive correlation, P<0.001). There were 368 subjects(94.85%)with negative Phadiatop and 20 subjects(5.15%)with positive Phadiatop in the serum tIgE negative subjects(n=388), while 75 山东大学耳鼻喉眼学报30卷4期 -袁源,等.健康成人血清总IgE和变应原特异性IgE检测及意义 \=-subjects(51.02%)with positive Phadiatop and 72 subjects(48.98 %)with negative Phadiatop in the serum tIgE positive subjects(n=147). Conclusion More than one fourth subjects among healthy adults have a serum tIgE level higher than 100 kU/L, while less than one fifth subjects have a sensitization to inhaled allergens. There is an obvious correlation between the serum levels of tIgE and sIgE. The serum tIgE level below 100 kU/L may have a clinical value to exclude allergen sensitization; however, the sensitized status may not be confirmed when the tIgE level is higher than 100 kU/L, and case history and clinical manifestations also should be considered.
    Reference | Related Articles | Metrics
    Interpretation of the clinical practice guidelines for diagnostic testing for adult obstructive sleep apnea: an update for 2016. An American Academy of Sleep Medicine Clinical Practice Guideline.
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (1): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2017.084
    Abstract1234)      PDF(pc) (919KB)(1213)       Save
    Reference | Related Articles | Metrics
    Effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomiLeusis.
    JIANG Yang, LI Ying, WANG Zhonghai, JIN Yumei, LIU Xiaowei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (2): 80-83.   DOI: 10.6040/j.issn.1673-3770.0.2015.404
    Abstract1465)      PDF(pc) (930KB)(928)       Save
    Objective To evaluate the effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomi leusis(LASIK). Methods Patients with mild to moderate dry eye were included in the study before LASIK. The implantation of VisiPlug was conducted immediately after the surgery. The scores of dryness, foreign body sensation, burning sensation, photophobia, visual fatigue and blurred vision were recorded on preoperative and postoperative 1 week, 1 month and 3 months. Schirmer I test(SIt), break-up time(BUT)and corneal fluorescein staining(FS)were also tested on each time points. Results There were 130 eyes of 65 patients included in the study, including 22 males and 43 females with the average age of 28.32±7.24(18-47)years. The scores of dryness, foreign body sensation, burning sensation, photophobia, visual fatigue and blurred vision were significantly decreased on each time points after the implantation of the lacrimal plug(F value: 125.64, 263.16, 123.22, 9.80, 76.815, 105.19; P value: 0.000, 0.000, 0.000, 0.002, 0.000, 0.000). Schirmer I test(SIt), break up time(BUT)and corneal fluorescein staining(FS)were also significantly improved on each time points(F value: 45.99, 67.87, 49.01; P value: 0.000, 0.000, 0.000). There was no infection, plug in the overflow, local granulation, and the effect of corneal flap healing. Conclusion Lacrimal plug could be effective and safe in the management of dry eyes after refractive surgery.
    Reference | Related Articles | Metrics
    The calculation of intraocular lens refractive power
    WANG Lei, ZHANG Han
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 21-28.   DOI: 10.6040/j.issn.1673-3770.1.2017.028
    Abstract2072)      PDF(pc) (916KB)(1376)       Save
    This review describes the principles and practice involved in the calculation of intraocular lens(IOL)refractive power. The theories behind formulas for calculating IOL power are described, using regression and optical methods. The review emphasizes the importance of establishing a precise estimation of corneal power as well as accurate techniques for the measurement of axial length and for predicting postoperative anterior chamber depth. The review concludes that current improvements in diagnostic and surgical technology, combined with the latest IOL refractive power formulas, make the calculation and selection of appropriate IOL power among the most effective tools in refractive surgery today.
    Reference | Related Articles | Metrics
    Obesity and obstructive sleep apnea.
    LI Yanzhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 1-4.   DOI: 10.6040/j.issn.1673-3770.0.2016.404
    Abstract998)      PDF(pc) (1088KB)(1077)       Save
    The relationship between obesity and obstructive sleep apnea-hypopnea syndrome(OSAHS)has become a new hot spot in the research of sleep-disordered breathing. Whether there is a cause-and-effect or accompanying relationship between them is not yet clear. Compared with craniofacial malformations, obesity is more likely to induce obstructive sleep apnea syndrome(OSA). The frequency and severity of OSA are related to BMI and obesity. This paper discusses the relationship from four aspects: lipid metabolism disorder, fatty liver, metabolic inflammation, and oxidative stress.
    Reference | Related Articles | Metrics
    Diagnosis and treatment of choroidal neovascularization in pathologic myopia
    Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (5): 157-162.   DOI: 10.6040/j.issn.1673-3770.0.2019.545
    Abstract2010)      PDF(pc) (436KB)(575)       Save
    Pathologic myopia(PM)is a major cause of vision loss worldwide, particularly in Asian countries. Choroidal neovascularization(CNV)is a severe complication of PM, which can cause macular disorders, leading to central scotoma, metamorphopsia, visual field loss, and finally blindness if not treated. The advents of optical coherence topography(OCT), OCT angiography, and fundus fluorescein angiography are helpful in diagnosing CNV due to PM, which can show the position and size of CNV, whether active or passive. For the treatment, photodynamic and anti-vascular endothelial growth factor(anti-VEGF)therapies are widely applied. In recent years, administering the intravitreal anti-VEGF injection has become the first-line treatment for CNV secondary to PM. Many clinical studies have indicated that intravitreal anti-VEGF injections affect antagonizing neovascularization and reduce macular edema, thereby contributing to visual improvements and better long-term outcomes. This article provides an overview of the current diagnosis and treatment options for myopic CNV.
    Reference | Related Articles | Metrics
    A review of squamous cell lines originating from the nasopharynx, oropharynx, laryngopharynx and larynx
    FENG Chengmin, JIN Yidan,LIU Hai, WANG Bing
    Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (6): 113-124.   DOI: 10.6040/j.issn.1673-3770.0.2020.478
    Abstract4160)      PDF(pc) (470KB)(685)       Save
    Larynx squamous cell carcinoma is a common malignant tumor of the head and neck region. The head and neck have complicated anatomical structure, and squamous cell carcinomas with different primary sites have different incidences, strategies of diagnosis and therapy, and even molecular pathogeneses. Therefore, selecting the suitable squamous cell carcinoma cell lines is important for researchers to determine appropriate preclinical research models and to have a better understanding of the mechanisms of tumorigenesis and progression. To provide a reference for researchers, this study summarizes the currently available squamous cell carcinoma cell lines originating from the nasopharynx, oropharynx, laryngopharynx and larynx.
    Reference | Related Articles | Metrics
    Endoscopic endonasal approach to the pterygopalatine fossa: an anatomic study
    SHEN Peng, SUN Zhong-wu, LI Jian-rui, YANG Li-jun, MA Liang, ZHANG Ming-sheng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (2): 58-61.   DOI: 10.6040/j.issn.1673-3770.0.2014.328
    Abstract1419)      PDF(pc) (3076KB)(525)       Save
    Objective To investigate the related anatomy in the pterygopalatine fossa under endoscopy so as to provide anatomical data for endoscopic transnasal surgery. Methods Five (10 sides) cadaveric heads were dissected via sphenopalatine foramen approach and via the posterior wall of the maxillary sinus approach to show the pterygopalatine fossa, then the sphenoid sinus was dissected to show the optic nerve, internal carotid artery and other anatomical structures. Results Different approaches allowed for different exposure of the pterygopalatine fossa structures. All the important anatomical structures and their relations in and around the pterygopalatine fossa could be observed under endoscopy. Conclusion The endoscopic transnasal surgery in the pterygopalatine fossa is feasible and safe as if surgeons master the related anatomy and choose right cases.
    Reference | Related Articles | Metrics
    Progress in metabolomics research in sensorineural hearing loss
    YANG Min, ZHU Xiaoyan, WANG Xu
    Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (2): 113-121.   DOI: 10.6040/j.issn.1673-3770.0.2023.263
    Abstract101)      PDF(pc) (1101KB)(93)       Save
    Sensorineural hearing loss is a common clinical disease in otology, which is hearing loss or hearing loss caused by cochlea, auditory nerve or auditory center organic lesions, and its incidence is related to genetics, age, noise exposure, ototoxic drugs and other factors, and the current incidence is increasing year by year and showing a younger trend. Metabolomics is a life science research that uses high-throughput omics technology to identify and quantify all metabolites, and has been applied to the pathophysiological mechanism of the inner ear in recent years, metabolomics provides new ideas for etiological exploration from the perspective of metabolic changes, and its research problems include analyzing the association between metabolites and sensorineural hearing loss, discovering new metabolic markers, and finding new strategies for preventing and treating sensorineural hearing loss. The application of metabolomics in sensorineural hearing loss contributes to the early diagnosis, individualized treatment and prediction of sensorineural hearing loss. In this paper, the research progress of metabolomics of sensorineural hearing loss is reviewed at home and abroad, and the experimental methods and results of clinical trials and animal experiments are integrated and analyzed, in order to provide a basis for the research and clinical application of metabolomics of sensorineural hearing loss, and put forward a prospect.
    Reference | Related Articles | Metrics
    The law of medication for the treatment of endogenous eye disease in chinese medical code based on data mining
    WANG Shushu, FU Yahui, YU Ruoyu, HOU Yi, YANG Jiguo
    Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (4): 81-87.   DOI: 10.6040/j.issn.1673-3770.0.2021.020
    Abstract1722)      PDF(pc) (4397KB)(601)       Save
    Objective To collect the prescription of Chinese Medical Code the treatment of cataract, and to summarize the clinical application of traditional Chinese medicine in the treatment of cataract by using the cloud platform(V2.3.5)database of ancient and modern medical records. Methods To search the prescription of Chinese Medical Code for treating cataract, to select the prescription for treating cataract according to the inclusion and exclusion criteria, to establish a Excel database, and to import the cloud platform of ancient and modern medical records(V2.3.5)in batches. Results A total of 249 prescriptions were selected, Contains 244 herbs, The total frequency was 2 596 times; efficacy 396, Total efficacy frequency 5 486 times; Four, properties 9 times. Total frequency 2 922 times; Five tastes,11 times. The total frequency is 3 697 times; The total frequency was 3 750. The top 3 drugs with high frequency of cataract treatment were Fangfeng, Angelica sinensis and Glycyrrhiza uralensis; The drug with high correlation was the highest in people participating in windbreak. Four properties 9 with cold, warm, slightly cold, flat. Conclusion Using the cloud platform(V1.4.5)of ancient and modern medical records to analyze the data, to show the law of drug use in the treatment of cataract eye disease in Chinese Medical Code, and to provide a reference for the summary of clinical practice of traditional Chinese medicine in the treatment of cataract eye disease.
    Reference | Related Articles | Metrics
    Diagnosis and treatment of parapharyngeal space neoplasms
    HU Juan-juan, HONG Yu-ming
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 85-90.   DOI: 10.6040/j.issn.1673-3770.0.2014.159
    Abstract2228)      PDF(pc) (972KB)(1314)       Save
    Anatomy of parapharyneal space is very complicated. Many types of parapharyngeal space neoplasms can occur, and all of them demonstrate different clinical manifestations. Therefore, it is more difficult to diagnose and treat the parapharyngeal space neoplasms than other head and neck neoplasms. Common diagnostics methods include bimanual examination, imaging studies, cytopathology, transoral and transcervical biopsy. All these methods can help doctor determine the nature and blood supply of tumors and understand the relationship between neoplasms and adjacent structure, which provide a reliable basis for the ensuing treatment. This paper aims to state the diagnosis and treatment of parapharyngeal space neoplasms, especially how to select surgical procedures.
    Reference | Related Articles | Metrics
    Treatment of sudden seafness by heart and spleen
    LIN Yushan, LU Biaoqing
    Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (6): 6-11.   DOI: 10.6040/j.issn.1673-3770.0.2019.584
    Abstract1412)      PDF(pc) (486KB)(235)       Save
    Objective The aim of this study was to examine the clinical effects of Guipi Decoction in the treatment of sudden deafness. Methods From January 2015 to June 2019, 108 patients with sudden deafness of Qi and blood deficiency type, who were hospitalized in the otolaryngology department of Zhongshan Hospital(affiliated with Guangzhou University of Traditional Chinese Medicine), and had complete clinical data were divided into the study group(n=78)and the control group(n=30). The control group was treated with conventional western medicine, while the study group was given Guipi Decoction along with western medicine treatment. Results The total effective rate of the study group was 79.49%, which was higher than that of the control group(60.00%). The difference between the two groups was statistically significant(P<0.05). There was no significant difference in the effective rate of sense(P>0.05). Conclusion The clinical effect of routine western medicine combined with Guipi Decoction in the treatment of sudden deafness of qi deficiency type is better than that of routine western medicine alone, which may have a clinical application.
    Reference | Related Articles | Metrics
    Application of ocular response analyzer in the intraocular pressure measurement
    JIANG Yang1, QIU Jia-ji2, JIN Yu-mei1, LI Ying1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 58-60.  
    Abstract1145)      PDF(pc) (1025KB)(1639)       Save

    Objective   To compare ocular response analyzer(ORA), goldmann applanation tonometer(GAT)and non-contact tonometer (NCT)in the intraocular pressure measurement. Methods   The patients were recruited as the normal group(168 eyes), the glaucoma group(62 eyes) and the post-refractive-surgery group (102 eyes). The intraocular pressure and the central corneal thickness(CCT) of all patients were measured by ORA and A-type ultra-sonography. The intraocular pressure of the normal group and the post-refractive-surgery group was measured by NCT  and GAT in the glaucoma group. Results   In the normal group and the post-refractive-surgery group, NCT value was (17.44±3.53) mmHg and (13.91±4.99) mmHg respectively. In the glaucoma group, GAT value was (18.90±3.74) mmHg. In all three groups, ORA values were(18.33±4.00) mmHg, ( 19.91±4.44) mmHg and (16.69±5.24) mmHg)respectively. ORA values were higher than NCT or GAT value in all groups. There were medium-level correlations between CCT value and NCT value in normal group and post-refractive-surgery group(r=0.466,0.472).There was a medium-level correlation between CCT values and GAT value in the glaucoma group (r=0.434).There was a low-level correlation between CCT value and ORA value in all groups(r=0.258, 0.221,0.249). Conclusion   Compared with the goldmann applanation tonometer and non-contact tonometer, ORA can provide more accurate  IOP value and be less influenced by corneal factors.

    Related Articles | Metrics
    null
    HAN Hao-lun, WU Wei, WANG Hong-nan, LI Bao-wei, DING Rui-ying
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 48-49.  
    Abstract990)      PDF(pc) (979KB)(1497)       Save
    null
    Related Articles | Metrics
    Reinnervation vesus non-reinnervation surgery for vocal fold paralysis
    FENG Yun, YANG Dazhang, LÜ Qiuping, LIU Dandan, WANG Naya
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (3): 54-58.   DOI: 10.6040/j.issn.1673-3770.0.2015.077
    Abstract2093)      PDF(pc) (1531KB)(855)       Save
    Objective To compare the efficacy of reinnervation and non-reinnervation surgery in the treatment of vocal cord paralysis (VCP). Methods ① Of the 21 cases of unilateral vocal cord paralysis (UVCP), 15 were treated with reinnervation (recurrent laryngeal nerve decompression, anastomosis of ansa cervicalis nerve and recurrent laryngeal nerve, anastomosis of end to end of recurrent laryngeal nerve, nerve muscular pedicle technique to lateral cricoarytenoid muscle), and 6 were treated with non-reinnervation (vocal cord autologous fat injection, type Ⅰ thyroplasty using autologous cartilage). ② Of the 16 cases of bilateral vocal cord paralysis (BVCP), 6 were treated with reinnervation (recurrent laryngeal nerve decompression, bilateral nerve muscular pedicle technique to posterior cricoarytenoid muscle), and 10 were treated with non-reinnervation (vocal cord lateralization, endoscopic resection of arytenoid). The therapeutic effects were evaluated with fiber laryngoscope, strobe laryngoscope, and voice assessment. Results ① Of the 15 UVCP cases treated with reinnervation, vocal cord regained different degrees of movement and adduction when pronunciating. Vocal cord vibration and mucosal wave regained symmetry, and glottal closure was good. MPT before and after surgery was 5.51±1.05 and 12.10±1.41 seconds (P<0.01). Of the 6 UVCP cases treated with non-reinnervation treatment, hoarseness symptoms were improved, but there was no movement of the vocal cords. MPT before and after surgery was 5.47±0.45 and 11.83±1.47 seconds (P<0.01). The difference between MPT of reinnervation and non-reinnervation surgery was not statistically significant (P>0.05). ② Of the 6 BVCP cases treated with reinnervation, 4 had partial vocal cord abduction restored and dyspnea was relieved. Of the 10 BVCP cases treatedwith non-innervation surgery, dyspnea was relieved. Decannulated rate of cases treated with reinnervation and non-reinnervation was 66.7% (4/6) and 100% (10/10), respectively. The difference between the two groups was not statistically significant as analyzed with Fisher exact test (P>0.05). Conclusion Reinnervation and non-reinnervation surgery have considerably good therapeutic effects on UVCP, and the former has a better long-term efficacy. In BVCP, non-reinnervation has better therapeutic effect than reinnervation, but the latter can maintain voice quality. Surgical treatment should be chosen based on surgeons’ expertise, and patients’ physical condition and needs.
    Reference | Related Articles | Metrics
    Application of titanium ossicular replacement prosthesis in open mastoidectomy with tympanoplasty for ossicular chain reconstruction.
    LIU Bin, JIANG Yuling, XIAO Xuping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 80-83.   DOI: 10.6040/j.issn.1673-3770.0.2015.398
    Abstract1499)      PDF(pc) (949KB)(1165)       Save
    Objective To explore the effects of using titanium ossicular replacement prosthesis in open mastoidectomy with ympanoplasty. Method From January 2013 to March 2015, 65 cases with chronic suppurative otitis media and middle ear cholesteatoma were treated with open mastoidectomy and tympanoplasty. Ossicular chains were reconstructed by partial ossicular replacement prosthesis(PORP)or total ossicular replacement prosthesis(TORP). The clinical data of these cases were retrospectively analyzed. The hearing threshold of air conduction and air bone gap(ABG)were compared before and 1,3,6 months after surgery. Results After 6 months of operation, the pure tone average(PTA)and averaged ABG of patients with chronic suppurative otitis media or middle ear cholesteatoma were dropped compared with those before surgery, with significant difference(P<0.05). There were 39 ears with an ABG lower than 20 dB after operation. Conclusion The effects of using titanium ossicular replacement prosthesis in open mastoidectomy with tmpanoplasty is satisfied for patients with chronic suppurative otitis media or middle ear cholesteatoma. The surgical indication and technique, as well as perioperative management, should be considered to ensure the success of operation.
    Reference | Related Articles | Metrics
    Perioperative treatment in endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma
    CHEN Guojing, CAI Xiaolan, LI Xuezhong, ZHANG Liqiang, ZHU Huitao
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (3): 35-38.   DOI: 10.6040/j.issn.1673-3770.0.2015.125
    Abstract1460)      PDF(pc) (915KB)(653)       Save
    Objective To explore the perioperative medicine treatment and notes of endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps(CRSwNP) and asthma. Methods From June 2010 to December 2013, 109 patients with CRSwNP accompanying with asthma were treated by endoscopic sinus surgery(ESS). All patients with asthma were evaluated pre-operation and performed ESS 6 months after completely controlled. Medication such as atomization inhalation and systemic corticosteroids were given to control and prevent asthma attack during peri-operation. Results No asthma attack happened during the treatment process. Only 1 patient had wheezing on the 2nd day post-operation by oral analgesics. Endoscopy examination was administrated in a follow-up period of 1 to 3 years after the surgery. Among them, 5 patients(4.59%) were completely controlled, 94(86.24%) were partly controlled and 10(9.17%) were not. Only 1 patient was treated with operation because of avascular necrosis of the femoral head 13 months after ESS. Conclusion It is useful to prevent asthma attack and improve ESS efficacy in CRSwNP that depends on asthma evaluation before ESS and rigorous medicine peri-operative treatment.
    Reference | Related Articles | Metrics
    Interpretation of “The Third Edition of the International Classification of Sleep Disorders(ICSD)”.
    SHANG Wei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2016.386
    Abstract3479)      PDF(pc) (1002KB)(2464)       Save
    The third edition of the International Classification of Sleep Disorders(ICSD-3)is the key reference for the diagnosis of sleep disorders. ICSD-3 is built on the same basic outline as ICSD-2, preserving the major diagnostic classifications. Significant modifications have been made to the nosology of insomnia, narcolepsy, and sleep-related breathing disorders. Major changes of the manual are reviewed in this article.
    Reference | Related Articles | Metrics
    Effect of YAG laser on corneal endothelial cellsin posterior capsule opacification
    WANG Jian-min1, LI Jian-ping2, LI Lin-lin3, LIU Jie-hui2, ZHENG Min2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    DOI: 10.6040/j.issn.1673-3770.0.2013.331
    Assessment ofquality of life in children with adenoid hypertrophy by OSA-18 questionnaire
    LONG Chaoqing, YAN Yongyi, RONG Qingfeng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (3): 13-15.   DOI: 10.6040/j.issn.1673-3770.0.2014.419
    Abstract3728)      PDF(pc) (1197KB)(1033)       Save
    Objective To investigate the value of OSA-18 questionnaire in assessment of quality of life in the children with adenoid hypertrophy. Methods Electronic nasopharyngoscopy and polysomnography (PSG) were underwent in 56 children with adenoid hypertrophy, and their quality of life were evaluated by OSA-18 questionnaire. The correlations between adenoid hypertrophy and OSA-18 scores were analyzed. Results The quality of life in 80.36% children with adenoid hypertrophy were significantly affected.Their OSA-18 total score were moderate and severe. There was significant correlation between OSA-18 total score and apneahypopneaindex(AHI), lowestoxygen saturation(LSaO2), and adenoid size. Conclusion There is an obvious correlation between adenoid size and OSA-18 score. OSA-18 questionnaire can be used asan indicatorin assessment of quality of life in the children with adenoid hypertrophy.
    Reference | Related Articles | Metrics
    Analysis of audiological and imaging characteristics of 149 children with unilateral sensorineural hearing loss
    HU Chunyan, DANG Panhong, ZHANG Rui, FAN Mengyun
    Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (1): 31-36.   DOI: 10.6040/j.issn.1673-3770.0.2021.418
    Abstract785)      PDF(pc) (2241KB)(172)       Save
    Objective To analyze the clinical audiological data and imaging manifestations of unilateral sensorineural hearing loss(USHL)in children, and explore its etiology. Methods A total of 149 patients with USHL, aged from one month to 14 years, were analyzed retrospectively. Results 95.97% of the analyzed patients had severe or extremely severe hearing loss, namely single-sided deafness. 38.26% of the patients with USHL were detected through hearing examinations after their hearing screenings were not passed suffered from unilateral hearing loss as per the findings 20.13% children were found by perceiving unicat eral hearing loss. No obvious imaging abnormalities were found in 47 patients. Among the other 102 patients with imaging abnormalities, one had complete dysplasia(Michel malformation), one had dysplasia of the cochlea, and three had common cavity malformation. Two patients had dysplasia of the cochlea and seven patients had dysplasia of the cochlea. These included four patients with IP-Ⅰ malformation, two with IP-Ⅱ malformation, and one with IP-Ⅲ malformation. Seven patients had vestibular aqueduct enlargement, while 28 patients had bony internal auditory canal stenosis or cochlear foramina stenosis. One patient had internal auditory canal enlargement, while 46 patients had cochlear dysplasia, including 10 patients with cochlear nerve absence and 26 with cochlear nerve tenaciousness. Conclusion Most children with USHL experience severe and extremely severe deafness. The proportion of cochlear neurodysplasia and cochlear dysplasia are high in children with USHL. It is also closely related to congenital dysplasia. Therefore, routine temporal bone imaging examinations should be performed for children with USHL.
    Reference | Related Articles | Metrics
    Complications and treatment of UPPP
    ZHANG Hua, ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 12-14.  
    Abstract2121)      PDF(pc) (983KB)(3483)       Save
    Related Articles | Metrics
    Cited: Baidu(1)
    Effects of budesonide combined with saline nasal irrigation on chronic rhinosinusitis and nasal secretion of
    ZHENG Yani, LIU He, MA Liang, ZHANG Mingsheng, SUN Zhongwu
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2018, 32 (3): 58-62.   DOI: 10.6040/j.issn.1673-3770.0.2017.455
    Abstract2733)      PDF(pc) (459KB)(494)       Save
    Objective To investigate the effects of budesonide combined with saline nasal irrigation on chronic rhinosinusitis(CRS)and nasal secretion of interleukin(IL)-6, IL-8, and tumor necrosis factor-alpha(TNF-α). Methods One hundred and twenty-eight subjects were selected for the study from the patients with CRS treated in our hospital from February 2016 to May 2017. They were divided using a random number table generator into a control group that received saline nasal lavage alone(n=64)and an observation group that received saline nasal lavage to which budesonide suspension was added(n=64). The clinical efficacy and changes in IL-6, IL-8 and TNF-α levels in nasal secretions, the Lund-Kennedy score for the nasal cavity, and the computed tomography score for the paranasal sinuses were compared between the two groups before and after 4 weeks of treatment. Results The efficacy rate was significantly higher in the observation group than in the control group(93.75% [60/64] vs. 71.88% [46/64]; P<0.01). The nasal Lund-Kennedy and paranasal sinus computed tomography scores were significantly lower in both study groups after treatment than before treatment(P<0.01); however, the decreases in these scores were significantly greater in the observation group(P<0.01). The IL-6, IL-8, and TNF-α levels in nasal secretions were also significantly lower in both study groups after treatment than before treatment(P<0.01); however, the decreases in levels of these inflammatory markers were significantly greater in the observation group(P<0.01). No obvious adverse reactions occurred in either study group during treatment. Conclusion Budesonide combined with saline nasal irrigation can significantly relieve nasal inflammation, help to relieve symptoms such as nasal congestion and swelling, and have a curative effect in patients with CRS.
    Reference | Related Articles | Metrics
    Relationship between Friedman OSA staging and ZPPP plus GAHM
    SUN Xiao-qiang1, YI Hong-liang2, CAO Zhen-yu2, ZHANG Yu-jun2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 8-9.  
    Abstract1814)      PDF(pc) (1023KB)(2655)       Save

    Objective To explore the relationship between Friedman OSA staging and genioglossus advancement and hyoid suspension(GAHM) plus Z-palatopharyngoplasty(ZPPP). Methods 26 patients with severe OSAHS (AHI>40)were performed GAHM plus ZPPP. The obstructive sites were identified in both oropharynx and hypopharynx. The follow up lasted at least 6 months postoperatively. The Chi square test was used to compare the preoperative and postoperative results. Results Satistying clinic results for the patients with Friedman OSA stages Ⅱ were 100%, while the overall success rate of Friedman OSA stages Ⅲ was 22.2%. Conclusion ZPPP plus GAHM is an effective method for patients with Friedman OSA stages Ⅱ.

    Related Articles | Metrics
    Detection and clinical application of nasal nitric oxide
    Zhiwen CHEN,Lei CHENG
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 124-128.   DOI: 10.6040/j.issn.1673-3770.1.2019.026
    Abstract4432)   HTML42)    PDF(pc) (437KB)(2087)       Save

    Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO)examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable.

    Reference | Related Articles | Metrics
    lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus
    DI Guohua, LIU Junru, ZHAO Yanxiang, GAO Yingkai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (6): 5-7.   DOI: 10.6040/j.issn.1673-3770.0.2015.253
    Abstract3462)      PDF(pc) (893KB)(1339)       Save
    Objective To explore the clinical efficacy of lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus. Methods A total of 90 cases of idiopathic tinnitus were randomly divided into treatment group and control group. The treatment group was treated by two simultaneous methods. The first method used intravenous drip of drugs to nurture nerves and to improve blood circulation in the inner ear. The other one was to combine 2% lidocaine with retroauricular injection of gastrodine. The control group received the first treatment only. One course of treatment lasted for 14 d. All patients were followed up for 3 months. Results The total efficacy of treatment group and control group was 84.44% and 55.56%, respectively. After 3-month of follow-up, the total efficacy of treatment group and control group was 82.22% and 55.11%, respectively. There was statistical difference between the statistics (P<0.05). No obvious adverse effects were observed. Conclusion Combination of 2% lidocaine and gastrodine injection is simple and effective in the treatment of idiopathic tinnitus.
    Reference | Related Articles | Metrics
    Meta-analysis of clinical intradermal acupuncture efficacy for treatment of allergic rhinitis
    ZHAI Rui, LI Yuan, YU Jinglong, CHEN Xi, ZHENG Youyou, LIU Zhaolan, WANG Junhong
    Journal of Otolaryngology and Ophthalmology of Shandong University    2023, 37 (3): 35-45.   DOI: 10.6040/j.issn.1673-3770.0.2022.364
    Abstract531)      PDF(pc) (1352KB)(278)       Save
    Objective To systematically evaluate the clinical efficacy and safety of intradermal acupuncture in the treatment of allergic rhinitis using Meta-analysis. Methods PubMed, The Cochrane Library, Web of Science, SinoMed, VIP, CNKI, and Wanfang databases were searched for randomized controlled trials which used intradermal acupuncture to treat allergic rhinitis from database inception to October 1, 2022. Two researchers conducted independent screening, data extraction, bias risk assessment, and meta-analysis of the literature. Results This study included 29 clinical trials and 2342 patients. Compared with the positive control group, the intradermal acupuncture combined therapy group showed improvements in clinical total effective rate [RR=1.24, 95%CI(1.16, 1.33), P<0.001], quantitative scores of symptoms and signs [MD=-0.67, 95%CI(-1.12, -0.22), P=0.003], visual analogue score of nasal symptoms [MD=-0.62, 95%CI(-0.97, -0.28), P<0.001], number of recurrences [RR=0.58, 95%CI(0.41, 0.82), P=0.002], nasal resistance [MD=-0.13, 95%CI(-0.21, -0.05), P=0.001], and quality of life score for nasal conjunctivitis[MD=-4.17, 95%CI(-6.06, -2.29), P<0.001]. Compared with antihistamines, there was no significant difference in clinical total effective rate[RR=1.01, 95%CI(0.92, 1.11), P=0.78] and quality of life score for nasal conjunctivitis[MD=0.43, 95%CI(-1.78, 2.65), P=0.70] after treatment. No serious adverse reactions occurred after intradermal acupuncture treatment. Conclusion Using intradermal acupuncture to treat allergic rhinitis shows good curative effects and safety, and can reduce recurrence rates and nasal resistance, as well as improve quality of life. Due to the limits of our experimental design and issues related to the quantity and quality of original literature, the results of our meta-analysis still need to be further verified. In the future, relevant research should utilize other methodologies and strict experimental designs to provide more powerful, high-quality evidence-based data for the development of clinical diagnosis and treatment guidelines.
    Reference | Related Articles | Metrics
    A contrast of the therapeutic effects of Nasonex and Rhinocort in the treatment of allergic rhinitis
    XIE Xiao-shuai,LI Liang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract6569)      PDF(pc) (254KB)(2000)       Save
    To investigate the therapeutic effects of Nasonex Nasal Spray(momestasone furoate) and Rhinocort Nasal Spray(budesonide) on allergic rhinitis(AR). Methods160 patients with AR were randomly divided into two groups: the Nasonex group (n=80) were treated with Nasonex once daily (total 200μg) and the Rhinocort group (n=80) were treated with Rhinocort once daily (total 256μg) for 4 weeks. Clinical effects and adverse drug reactions were observed. ResultsThere were statistical differences between the pre-and post-treatment groups (both P<0.05). The total effective rate was 97.5% in the Nasonex group and 92.5% in the Rhinocort group, however, there was no statistical difference between the two groups (P>0.05). No severe adverse drug reaction was found in either group. ConclusionsBoth medicines have good therapeutic effects on allergic rhinitis. Either one can be used for allergic rhinitis alone and achieve ideal therapeutic efficacies.
    Related Articles | Metrics
    Laryngoscopic characteristics and diagnosis of laryngeal tuberculosis
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 59-63.  
    Abstract1383)      PDF(pc) (1601KB)(1476)       Save

    Objective    To explore the clinical manifestations of the laryngeal tuberculosis(LTB) to improve the diagnosis of LTB. Method    The clinical dates of  13  LTB cases were reviewed. Results    Hoarseness, sore throat and cough were the most common symptoms in LTB. Fever, weight loss, fatigue and other general symptoms were rare. In this cohort, there were 13 hoarseness, 9 sore throat (69%), 6 cough (46%) and 1 fever, weight loss and fatigue (8%). Three types were identified under the laryngoscope, including infiltrative edema type (four cases), proliferative hyperplasia type (six cases), and chronic laryngitis-like type (three cases). Lung CT demonstrated 11 pulmonary tuberculosis infections. Throat biopsy was performed in eleven cases except of two whose lesions were confined to the vocal cords. Among these cases, ten were confirmed as LTB but one. PPD test showed twelve positive cases. Conclusion    LTB, though with non-specific clinical manifestations, shows some kinds of specific characteristics under the laryngoscopy. Early detection relies mainly on laryngoscopy, however, diagnosis should be confirmed with the combination of biopsy, lung CT and the PPD test.

    Related Articles | Metrics
    Effects of mydriasis on anterior chamber parameters measured by a Pentacam before and after cataract surgery.
    YANG Yuhuan, ZHANG Jie, ZHANG Jinpeng, YAN Hong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 5-8.   DOI: 10.6040/j.issn.1673-3770.1.2017.024
    Abstract1429)      PDF(pc) (889KB)(765)       Save
    Objective To observe the effect of mydriasis on center anterior chamber depth, anterior chamber volume, corneal surface keratometry and astigmatism before and after cataract surgery. Methods This study included 25 eyes of 22 patients diagnosed with cataract and indicated for phacoemulsification with intraocular lens(IOL)implantation at Tangdu Hospital, the Fourth Military Medical University.For each patient, anterior segment parameters were measured 1-2 days before and after surgery, respectively, using a Pentacam HR system under conditions of normal pupils and dilated pupils. Results The mean preoperative central anterior chamber depths were(2.71±0.56)mm and(2.79±0.53)mm before and after mydriasis, respectively(t=-4.246; P<0.001). The mean postoperative central anterior chamber depths were(3.60±0.98)mm and(4.45±0.35)mm before and after mydriasis, respectively(t=-4.473;P<0.001). The mean postoperative anterior chamber volumes were(146.9±37.1)mm3 and(163.3±33.9)mm3 before and after mydriasis, respectively(t=-3.633;P= 0.001). Conclusions The central anterior chamber depths before and after cataract surgery and the anterior chamber volumes after cataract surgery increase after mydriasis, which may lead to errors in IOL calculation. In patients with cataracts, the central anterior chamber depths and anterior chamber volumes should be measured before mydriasis.
    Reference | Related Articles | Metrics
    Progress in the research of intraocular lens power calculation formulas
    TAN Yan, LI Can
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (6): 95-98.   DOI: 10.6040/j.issn.1673-3770.0.2019.275
    Abstract2492)      PDF(pc) (311KB)(948)       Save
    With the development of phacoemulsification surgery, the calculation of intraocular lens power has been paid greater attention. Various intraocular lens power formulas have been presented to optimize the visual quality after surgery. This paper comprehensively describes the progress in the research of various intraocular lens power formulas, such as the first-generation intraocular lens formula, the second-generation formula, Hill-RBF, Barrett True-K, and so on.
    Reference | Related Articles | Metrics
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (2): 1-4.   DOI: 10.6040/j.issn.1673-3770.1.2012.016
    Abstract1529)      PDF(pc) (1279KB)(1504)       Save
    Related Articles | Metrics
    Cytoskeleton-associated protein in the inner ear and gene mutations cause hereditary deafness
    YANG Xia, GAO Xia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 80-84.  
    Abstract1170)      PDF(pc) (1006KB)(1493)       Save

    The correlated hereditary deafness-associated genes include cytoskeletal proteins, extracellular matrix proteins, channels and gap junction proteins, transcription factor genes, mitochondrial genes and other unknown function genes. Most of the cloned genes are cytoskeletal molecules.This paper makes a summary about major structural protein associated with hair cells and the pathogenesis of gene mutations lead to hereditary deafness.

    Related Articles | Metrics
    Clinical analysis of 68 cases of multiple primary cancers of head and neck
    HUANG Fang, WEI Guifang, HUANG Sicheng, HUANG Xiangqin
    Journal of Otolaryngology and Ophthalmology of Shandong University    2018, 32 (6): 43-47.   DOI: 10.6040/j.issn.1673-3770.0.2018.329
    Abstract1217)      PDF(pc) (444KB)(334)       Save
    Objective To summarize and analyze the incidence of multiple primary cancers(MPCs)of the head and neck region in patients hospitalized in the otolaryngology department. Methods Retrospective analysis of the clinical data of 68 patients with head and neck MPCs was conducted using SPSS 21.0. Results Overall, 648 cases of malignant tumors were found in 8758 patients treated in the same period. Among them, 68 cases were diagnosed with MPC with an occurrence rate of 0.78%. The annual occurrence rate of MPC during 2014-2017 was 0.72%, 0.72%, 0.77%, and 0.86%, successively, and showed an upward trend. The MPC group included 61 males and 7 females, and the proportion of males was higher than that in a single primary cancer group. There were 62 cases of double cancer, 6 of triple cancer, 35 of synchronous carcinoma, and 33 of metachronous carcinoma. Forty-four patients had a previous history of smoking/drinking, and male smokers/drinkers were significantly higher than females(χ2 = 6.40, P=0.006). Hypopharyngeal cancer accounted for the highest incidence of MPC(23.81%), followed by oral cancer(14.71%)and laryngeal cancer(9.33%). The most common primary cancer associated with oral cancer, hypopharyngeal cancer, and laryngeal cancer was esophageal cancer. There were 45 cases(66.18%)that presented the second cancer in less than 5 years after the first. Twenty-two patients had received radiation/chemotherapy, and these patients had a higher proportion of metachronous MPC(χ2 = 18.64, P<0.001). Conclusion The highest incidence of MPC in the head and neck in consecutive order is hypopharyngeal, oral, and laryngeal cancer. There is a high possibility of head and neck cancer presenting in combination with upper gastrointestinal cancers, such as esophageal cancer. It has been suggested that gastroscopy be listed as a routine examination both pre-operatively and at follow-up. Commonly, the interval between the second and first cancer was less than 5 years; hence, the first 5 years of follow-up and long-term regular follow-up should be fortified after radiotherapy for malignant tumors. MPC should be considered when devising a radiotherapy program, and special attention should be paid to the radiation protection of the surrounding tissues and organs.
    Reference | Related Articles | Metrics