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Complications and treatment of UPPP ZHANG Hua, ZHANG Qing-quan JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 12-14.   Abstract （1872）      PDF（pc） （983KB）（2928）       Save Related Articles | Metrics Cited: Baidu(1)

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HIV/AIDS in throat in 6 cases ZUO Wen-na, WANG Hong-qin, LI Guo-li JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 56-57.   DOI: 10.6040/j.issn.1673-3770.0.2014.134 Abstract （2193）      PDF（pc） （934KB）（2455）       Save Objective To deepen the understandings of ENT doctors on HIV infection in which primary complains were sore throat and/or fever to avoid misdiagnosis. Methods Clinical data of 6 cases of HIV infection, whose initial office visits were ENT department, were reviewed. Results Of 6 patients, there were 3 cases of tonsillitis, 2 cases of oral candida infection, and 1 case of Kaposi sarcoma in throat. Conclusion The diagnosis of AIDS, complained primarily of sore throat, can be established by combining with medical history, clinical manifestation and serological examination. ENT doctors must pay much attention to it. Reference | Related Articles | Metrics

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Balloon catheter dilation technology in combination with fibrolaryngoscope in treating sinus cyst XIAO Jian-xin, CHEN Rui-kai, HE Bi-yi, CHEN Wei-xiong, WANG Yue-jian JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 46-48.   Abstract （1230）      PDF（pc） （1073KB）（2977）       Save Objective   To evaluate the effect of nasal endoscopic sinus surgery and balloon catheter dilation technology in combination with fibrolaryngoscopy in treating sinus cyst. Methods   The clinical data of 14 cases (19 maxillary sinuses, 3 frontal sinuses) using the balloon catheter dilation technology in combination with fibrolaryngoscopy (the balloon group) and 16 cases (23 maxillary sinuses, 8 frontal sinuses) using conventional nasal endoscopic sinus surgery (the conventional group) were retrospectively analyzed. Visual analog scale (VAS) was used to record operative difficulty grade and operation time. Nasal endoscopy, coronal sinus CT scanning, Lund-Kennedy endoscopy and Lund-Mackay CT scan staging scores were used to evaluate the post-operative prognosis. Results   The balloon group was longer in operative time than the conventional group (P<0.001). During follow-up periods of  8 and 24 weeks after the operation, the sinus ostia were patency, and the nasal cavities recovered well. Conclusion   In the sinus cyst operation, the balloon group and the conventional group  equally  achieve good curative effects. In the balloon group, the nasal cavity and sinus structures can be preserved with  minimal invasion, but the operation is more difficult and longer than those in the conventional group, due to the fibrolaryngoscope. Related Articles | Metrics

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Expressions and clinical significances of osteopontin and p53 in laryngeal squamous cell carcinoma tissues CHEN Jian-qiu1,2, ZHU Min-hui1, QIU Xiao-xia1, XIA Si-wen1,YE Ben2, CHEN Shi-cai1, ZHENG Hong-liang1 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2011, 25 (2): 19-22.   Abstract （1029）      PDF（pc） （575KB）（1283）       Save  Objective    To study OPN and p53 expressions and detect their correlation and clinicopathological value in laryngeal squamous cell carcinoma (LSCC) and adjacent tissues. Methods     The SP immunohistochemical method was used to study the OPN and p53 expressions in routinely embedded sections of surgical specimens of 44 laryngeal squamous cell carcinomas and adjacent tissues，and clinicopathological features were analyzed. Results    ①The positive rates of OPN and p53 protein were 75.0 %（33 cases）and 65.9%（29 cases）in LSCC, and 13.6%（6 cases）and 2.3%（1 case）in adjacent tissue respectively; ②The OPN expression level was significantly correlated with tumor stage, grade and the presence of lymph nodes, but was not correlated with age, gender and primary tumor site; ③Expression of OPN was positively correlated with that of p53(r＝0. 360，P＝0.016). Conclusions     OPN expression is higher in LSCC than in adjacent tissue, and may participate in the development and metastasis of LSCC. OPN might be an important biological marker in LSCC prognosis. Related Articles | Metrics

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Detection and clinical application of nasal nitric oxide Zhiwen CHEN,Lei CHENG Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 124-128.   DOI: 10.6040/j.issn.1673-3770.1.2019.026 Abstract （3636）   HTML （31）    PDF（pc） （437KB）（1618）       Save Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO）examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable. Reference | Related Articles | Metrics

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Surgical experience of otitis media in patients with one hearing ear only. DU Lijun, TONG Jun, CHEN Wenwen, DENG Yaxin, CAI Xunhua, SHAN Liang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (6): 8-10.   DOI: 10.6040/j.issn.1673-3770.0.2015.435 Abstract （989）      PDF（pc） （1027KB）（449）       Save Objective To summarize the surgical experience of otitis media, as well as cholesteatoma of the middle ear, in patients with one hearing ear only. Methods A total of 13 patients with otitis media underwent operation between May 2000 and Jan 2013. The surgical and follow-up data were retrospectively collected and compared with those of 15 patients(as pre-group )who received surgical treatment before 2000. Results All patients achieved dry ear after follow-up(ranged from 6 months to 156 months, averaged follow-up was 84.55±56.84 months). The A-B GAP and air conduction(AC)were dropped after treatment compared with those before operation(P<0.01). The overall effective rate of operation was 92.31 %( 12/13). In those with successful operation, 4 case with GAP<10 dB HL, 7 cases with GAP between 11 and 20 dB HL, there was no significant difference in bone conduction(BC)before and after treatment(P>0.05). The proportion of patients with GAP difference over 20 dB HL and 30 dB HL were 76.92%(10/13)and 30.77%(4/13), which was significant higher than those of 40.00%(6/15)and 13.33%(2/15)in pre-group. Conclusion This study shows a more safe and effective outcome in surgical treatment otitis media in patients with one hearing ear only. Reference | Related Articles | Metrics

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Treatment experience of preservation of laryngeal function in surgical management of pyriform sinus carcinoma. SONG Xicheng, ZHANG Hua, LIU Zhonglu, WANG Yunqiang, WANG Yan, ZHANG Qiang, WANG Qiang, KANG Shasha, SONG Yipeng JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2016.262 Abstract （1521）      PDF（pc） （1040KB）（1025）       Save Objective To investigate preservation and reconstruction of larynx function in surgical treatment of pyriform sinus carcinoma. Methods A retrospective analysis of 102 cases of pyriform cancer treated in June 2004 to October 2015 underwent surgeries with laryngeal functions preserved was carried out. There were 9 cases of stage Ⅰ, 11 cases of stage Ⅱ, 47 cases of stage Ⅲ and 35 stage Ⅳ, according to the 2002 UICC staging. Pharyngeal lateral wall approach, hyoid region approach and paraglottic space approach were chosen respectively to remove the tumor as per preoperative evaluation, followed by repairing of surgical defects and reconstruction of laryngeal and pharyngeal functions. 93 cases of postoperative radiotherapy were implemented. Results All patients recovered well after surgery except 1 patient with pharyngeal fistula and infection. All repairing materials of different methods survived and the average time of postoperative oral intake was 12.47 days. All patients retained good laryngeal functions with 95 decannulations and the 3-year and 5-year survival rates were 59.3% and 40.7% respectively. Conclusion Comprehensive preoperative investigations as laryngoscopy and radiological assessment may give good suggestions in selecting appropriate surgical approaches; good surgical approach may help provide good feasibility and visibility, and ensure complete removal of the tumors with safety margins; through the epiglottis flipping and/or thyroid reinforcement repairing methods, the incidence of accidental swallowing and pharyngeal fistula can be reduced; pyriform sinus carcinoma are found mostly in advanced stages, single treatment is often ineffective in controlling the lesion, and radiotherapy is necessary as a comprehensive treatment to improve the local control rate and survival rate. Appropriate surgical approaches and repairing methods can help surgeons to completely remove the tumor, and preserve or rebuild laryngeal and pharyngeal functions in managing chosen patients with pyriform sinus cancer. Reference | Related Articles | Metrics

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Treatment experience of different sphenoid sinus endoscopic surgical approaches under CT scan. CHU Shidong, CI Jun, WANG Haiying, WANG Changyang, ZHOU Huai'en, BAO Qingfu JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 47-50.   DOI: 10.6040/j.issn.1673-3770.0.2017.048 Abstract （1411）      PDF（pc） （2662KB）（641）       Save Objective To investigate the morphology of the sphenoid sinus using images from a computed tomography(CT)scan. Methods Image data acquired between July 2008 and July 2015 from 98 inpatients with sphenoid sinus diseases were retrospectively analyzed. The sphenoid sinus diseases were treated using one of three endoscopic surgical approaches. Sixty-four, 24, and 10 patients underwent the nasal cavity-olfactory cleft, Messerklinger, and Wigand approaches, respectively. Results The patients received over 6 months of follow-up and the windows of the sphenoid sinuses remained unobstructed and the symptoms were controlled. There were no serious operative or postoperative complications. Conclusion A CT scan can guide endoscopic sphenoid sinus surgery, which is minimally invasive, safe, and effective. Reference | Related Articles | Metrics

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Interpretation of “The Third Edition of the International Classification of Sleep Disorders(ICSD)”. SHANG Wei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2016.386 Abstract （2889）      PDF（pc） （1002KB）（1647）       Save The third edition of the International Classification of Sleep Disorders(ICSD-3)is the key reference for the diagnosis of sleep disorders. ICSD-3 is built on the same basic outline as ICSD-2, preserving the major diagnostic classifications. Significant modifications have been made to the nosology of insomnia, narcolepsy, and sleep-related breathing disorders. Major changes of the manual are reviewed in this article. Reference | Related Articles | Metrics

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lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus DI Guohua, LIU Junru, ZHAO Yanxiang, GAO Yingkai JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (6): 5-7.   DOI: 10.6040/j.issn.1673-3770.0.2015.253 Abstract （2884）      PDF（pc） （893KB）（735）       Save Objective To explore the clinical efficacy of lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus. Methods A total of 90 cases of idiopathic tinnitus were randomly divided into treatment group and control group. The treatment group was treated by two simultaneous methods. The first method used intravenous drip of drugs to nurture nerves and to improve blood circulation in the inner ear. The other one was to combine 2% lidocaine with retroauricular injection of gastrodine. The control group received the first treatment only. One course of treatment lasted for 14 d. All patients were followed up for 3 months. Results The total efficacy of treatment group and control group was 84.44% and 55.56%, respectively. After 3-month of follow-up, the total efficacy of treatment group and control group was 82.22% and 55.11%, respectively. There was statistical difference between the statistics (P<0.05). No obvious adverse effects were observed. Conclusion Combination of 2% lidocaine and gastrodine injection is simple and effective in the treatment of idiopathic tinnitus. Reference | Related Articles | Metrics

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null JIN Min1, WANG Chun-ling1, CAI Xiao-lan2, ZHANG Li1 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 54-57.   Abstract （1031）      PDF（pc） （1006KB）（1373）       Save null Related Articles | Metrics

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Clinical comparison of polysomnography with portable sleep monitoring device. ZHANG Rong, WANG Honghong, YU Leilei, LIU Liang, SUN Jianjun, LI Jinrang, ZHAN Muxia JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 65-67.   DOI: 10.6040/j.issn.1673-3770.0.2016.247 Abstract （1791）      PDF（pc） （938KB）（773）       Save Objective To evaluate the sensitivity and specificity of portable sleep monitoring device in measuring apnea hypopnea syndrome events. Methods A total of 120 patients were inspected by polysomnography and portable sleep monitor with synchronous monitoring, and the data were recorded and analyzed to evaluate its diagnostic efficiency. Results The polysomnography results was in agreement with portable sleep monitoring results. Apnea hypoventilation index, lowest oxygen saturation, oxygen index reduction had correlate statistical significance. Conclusion The portable sleep monitoring as a simple and convenient detection method, can be widely applied to clinic. Reference | Related Articles | Metrics

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Fufanghuangbai Liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal (40 cases report) YANG Mei-yan JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (2): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2014.254 Abstract （2346）      PDF（pc） （924KB）（619）       Save Objective To investigate the clinical effect of Fufanghuangbai liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal. Methods In the Juye County People's Hospital otolaryngology from January 2012 to April 2014, 80 cases of eczema were randomly divided into control group and observation group, the control group of 40 patients were given triamcinolone acetonide acetate, 40 patients were given Fufanghuangbai liquid combined with triamcinolone acetonide acetate treatment, compared two groups of patients with clinical treatment effect and adverse reaction. Results After 1 weeks of treatment, the observation group efficiency was 45%, although slightly higher than that of the control group was 40%, but the two groups had no statistical difference (P>0.05). In observed group, the total efficiency of 75%, it was slightly higher than 72.5% of the control group, but the two groups had no statistical difference (P>0.05). After 2 weeks treatment, the observed group was 77.5%, significantly higher than the control group of 40%, a significant difference between two groups (P<0.05). Total effective rate of observation group was 92.5%, significantly higher than the control group of 72.5%, with a significant difference between two groups (P<0.05). Patients in the two groups after treatment had no significant adverse reactions. Conclusion Fufanghuangbai liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal has satisfied effect, it can significantly improve the patient's clinical symptoms with less adverse reaction. Reference | Related Articles | Metrics

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Surgical management of pyriform sinus carcinoma via the glottis adjacent space approach. PAN Xinliang Journal of Otolaryngology and Ophthalmology of Shandong University    2016, 30 (3): 1-3.   DOI: 10.6040/j.issn.1673-3770.0.2016.232 Abstract （1589）      PDF（pc） （1144KB）（863）       Save Reference | Related Articles | Metrics

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J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (1): 47-47.   DOI: 10.6040/j.issn.1673-3770.0.2012.367 Abstract （1488）      PDF（pc） （902KB）（1065）       Save Related Articles | Metrics

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Analysis of clinical manifestations and misdiagnosis of jugular phelebectasia in children SUN Chang-zhi, LUO Ren-zhong, LIU Wen-long, LI Yan, HOU Chao JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 53-55.   DOI: 10.6040/j.issn.1673-3770.0.2014.018 Abstract （1491）      PDF（pc） （950KB）（544）       Save Objective To analyze the clinical manifestations and the cause of misdiagnosis of jugular phelebectasia in children. Methods From January 2006 to June 2013, 21 cases of jugular phelebectasia in children were collected and reviewed. Their clinical manifestation, diagnostic methods and the cause of misdiagnosis were analyzed. 21 children without jugular phelebectasia were selected as control group. Results Their clinical manifestations showed a soft cystic cervical mass during Valsalva manoeuvre or loud speaking. All the cases visited other hospital 2.4 times averagely and received imaging exams 1.9 times averagely before final diagnosis. There was no significant difference in the diameter of jugular vein between jugular phelebectasia patients and the control group during the resting state(P>0.05), however, the diameter of jugular vein were larger in jugular phelebectasia patients during Valsalva manoeuvre or load speaking(P<0.05). All the jugular phelebectasia were diagnosed by color Doppler ultrasonography. Conclusion The manifestation of jugular phelebectasia is typical. The effective method to diagnose jugular phelebectasia is color Doppler ultrasonography. Deepening the understanding of jugular phelebectasia could decrease the misdiagnosis. Reference | Related Articles | Metrics

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Cervical vertebral osteomyelitis secondary to necrotizing otitis externa:a case report and review of literature TIAN Jun, LIU Liangfa, BAI Jiaqi Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (4): 1-5.   DOI: 10.6040/j.issn.1673-3770.0.2022.174 Abstract （480）      PDF（pc） （5816KB）（193）       Save Objective To outline and analyze the clinical features and treatment option of cervical osteomyelitis secondary to necrotizing otitis externa. Methods We performed a retrospective review, along with literature review, of a case of C2-C6 osteomyelitis secondary to a necrotizing otitis externa in a diabetic patient, in order to outline its clinical manifestation, diagnosis, treatment option and prognosis. Results A total of five relevant studies published in Chinese and English from 2005 to 2022 were reviewed, and four cases(including the case presented in this study)were analyzed. The four cases involved three men and one woman(age range: 54-72 years). Only one patient had a history of head and neck radiotherapy, the remaining three were known diabetic patients. The lesions were extensive, involving two to five vertebral bodies. The causative pathogens isolated were all bacteria; however, the strains varied among the cases. After a systematic treatment, three patients(75%)succumbed to the disease as a result of bacterial resistance, poor compliance to medications, and severe comorbidity. Conclusion The lesions of necrotizing otitis externa can extend from the skull base to the cervical vertebrae, causing cervical osteomyelitis: a life-threatening condition that requires an aggressive treatment. Reference | Related Articles | Metrics

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Preliminary clinical analysis of neo-adjuvant chemotherapy with nimotuzumab plus nedaplatin and fluorouracil in hypopharyngeal squamous cell carcinoma. DONG Pin, YING Xinjiang, CHEN Xinwei, DENG Zhihong, ZHANG Shaoqiang, YU Ziwei, JIN Bin, SUN Zhenfeng, XIE Jin, ZHU Jiangcai JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 10-14.   DOI: 10.6040/j.issn.1673-3770.0.2016.222 Abstract （1594）      PDF（pc） （1051KB）（525）       Save Objective To investigate the safety and efficacy of nimotuzumab combined with nedaplatinand and fluorouracil(5-FU)as neo-adjuvant chemotherapy in the treatment of hypopharyngeal squamous cell carcinoma. Methods Between July 2012 and December 2014, we performed initial treatment on 91 cases of hypopharyngeal squamous cell carcinoma with the nimotuzumab(300 mg/m2 day 1)combined with nedaplatin(90 mg/m2 day 1)and 5-FU(750 mg/m2 day1-5)as neo-adjuvant chemotherapy, with one cycle for 3 weeks. Two cycles were followed by surgery and radiation therapy. The primary endpoint was tumor response rate, pathological complete response rate, the rate of laryngeal preservation and chemotherapy related toxicity. Results The response rate of tumor was 86.8%(79/91)after two cycles of neo-adjuvant chemotherapy. Fifty-two patients(57.1%)got downstage, with T downstage in 47(51.6%)cases and N downstage in 20(22.0%)cases. Eighty-eight patients got surgery after the neo-adjuvant chemotherapy, of which 68 patients(77.3%)preserved laryngeal function. The pathological complete response was 8.8%(8/91)of the total. The toxicity was mild and manageable. There were 29 cases of neutropenia(31.9%), 26 cases of nausea/vomiting(28.6%). Conclusion Nimotuzumab plus nedaplatin and 5-FU regimen as neo-adjuvant chemotherapy was highly effective for improving the hypopharyngeal carcinoma patients’ tumor response rate and preserving their organ function, while the toxicities were well tolerable. Reference | Related Articles | Metrics

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Treatment of palatal myoclonus objective tinnitus guided by palatal electromyogram WANG Tan, AN Feng-wei, CHEN Jian-qiu, LIN Jia-feng, HOU Xiao-zhi, XIE Cui-li, WANG Ying, LIN Juan JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (1): 12-14.   DOI: 10.6040/j.issn.1673-3770.0.2014.242 Abstract （1439）      PDF（pc） （917KB）（500）       Save Objective To observe the clinical efficacy of botulinum toxin typeA(BTX-A) in the treatment of palatal myoclonus objective tinnitus(PMOT)under the guidance of palatal electromyography(P-EMG). Method The clinical data of 3 bilateral PMOT patients were reviewed. With endoscopic assistance, the disposable hypodermic needle electrode was inserted at the initiation site of tensor veli palatine(TVP), levator veli palatine(LVP), and termination site of LVP through nasal cavity. The direction and depth of the electrodes were adjusted according to the denseness of electric potential outbreak in the EMG diagram d. The superficial site, with the most dense electric potential outbreak was chosen as the point for injection. At each point, 5U BTXA was injected every time and the total amount was 30U . The therapeutic effects and adverse reaction were observed for 6 months afterthe injection. Result ① Therapeutic effectiveness: The PMOT was disappeared 26 h, 25 h and 28 h after the injection in 3 patients, respectively. None of positive expressions was observed in monthly endoscopic examination, P-EMG, and acoustic immittance examination 5 months after the injection. Recurrence of unilateral tinnitus was noted in only one patient.② Adverse reaction :The side effects, such as open rhinolalia, mild nasal regurgitation and mild ear stuffiness with tinnitus, were identified, but disappeared 2 weeks later afterthe treatment. Conclusion Using P-EMG during BTXA injection can accurately determine the site for injection, extend the action time of BTXA, reduce the adverse reaction, and achieve a good clinical results. Reference | Related Articles | Metrics

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Transoral endoscopic dissection of parapharyngeal space. ZHANG Baoying, LU Yongtian, LI Jianxing JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (4): 38-41.   DOI: 10.6040/j.issn.1673-3770.0.2015.094 Abstract （1830）      PDF（pc） （1960KB）（681）       Save Objective To investigate the transoral anatomic characteristics of parapharyngeal space. Methods A total of 5 fresh cadaver heads (including 1 injected cadaver head) were dissected to illustrate the transoral approach of parapharyngeal space anatomy. Results The superior constrictor muscle was the landmark to enter the prestyloid space. The stylopharyngeus and styloglossus muscles were critical marks which divided the parapharyngeal space into 2 parts. Posterior to these muscles and laterally to the superior constrictor muscle, the internal carotid artery, internal jugular vein, and lower cranial nerves were identifiable. Conclusion Our dissection emphasizes the role of the stylopharyngeus and styloglossus muscles. The lateral surface of the superior constrictor muscle is essential to protect the internal carotid artery. Reference | Related Articles | Metrics

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Glaucoma valve implantation for various refractory glaucomas XU Hong1, LI Ming2, WEN Shu-ling1 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 83-84.   Abstract （1372）      PDF（pc） （938KB）（1063）       Save Objective    To investigate the clinical effect of glaucoma valve implantation on various refractory glaucomas. Methods    23 patients (23 eyes) with refractory glaucoma who underwent glaucoma valve implantation were divided into two groups according to glaucoma types and treatment methods: group A included 14 patients (14 eyes) who had neovascular glaucoma and underwent glaucoma valve implantation and retinal photocoagulation; group B included 9 patients (9 eyes) who had other refractory glaucomas and underwent glaucoma valve implantation and mitomycin C treatment. The visual acuity，intraocular pressure and complications were recorded, and the operation success rate was calculated. Results    The average intraocular pressure of two groups was obviously lower after operation than before operation(P<0.05). The visual acuity was improved in 8 eyes(57.14%) of group A and 6 eyes(66.67%) of group B 6 months after operation. There was no serious complication in all patients. The operation success rate was 85.71%（12/23) in group A and 88.89%（8/9） in group B. Conclusion    Glaucoma valve implantation is ideal treatment for refractory glaucoma，which can decrease intraocular pressure and increase operation success rate. Related Articles | Metrics

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Establishment of sensorineural deafness model in C57 mice by cisplatin HE Jing-chun1, RUAN Qing-wei2, HAN Miao-miao1, JIN Bin1, LI Ke-yong1, DONG Pin1 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (1): 1-5.   DOI: 10.6040/j.issn.1673-3770.0.2013.237 Abstract （1285）      PDF（pc） （2145KB）（1171）       Save Objective   To establish a cisplatin-induced sensorineural deafness model in C57 mice. Methods   C57BL/6J mice were divided randomly into four groups：group A (5μL normal saline injected into the round window niche), group B (5μLcisplatin (1mg/mL) injected into the round window niche), group C (10μL cisplatin (1mg/mL) injected daily into middle ear cavity for 5 days), and group D ( cisplatin (6mg/kg) injected daily into the abdominal cavity for 5 days). 10 dB increase or above in the reaction threshold of  whole octave band auditory brainstem response (ABR) was to define the decline of the hearing capacity. The stereocilia and cuticular plate of hair cells stained with fluorescent phalloidin were observed. Results   In group A,C and D, the whole octave band ABR reaction thresholds showed no difference before and after the administration (P>0.05). However, the reaction threshold were all elevated 48h after the administration in B group (P<0.05). Meanwhile, in group B, outer hair cell (OHC) lesions were more severe than those of inner hair cell (IHC), and the hair cells lesions aggravated gradually from the base to apex of chochlea. Conclusion   The administration of cisplatin through the window niche is the effective method to establish sensorineural deafness model in C57 mice. Related Articles | Metrics

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Efficacy of pingyangmycin local injection and CO2 laser in the treatment of pharyngeal and laryngeal hemangioma WANG Hong-ming1, XUE Wei-shuang2, HE Rui-yan3, JIANG Xue-jun1 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 26-27.   Abstract （1049）      PDF（pc） （1138KB）（1351）       Save Objective To investigate the efficacy of Pingyangmycin local injection and CO2 laser in the treatment of pharyngeal and laryngeal hemangiomas. Methods 25 cases of pharyngeal and laryngeal hemangioma were divided into two groups: Pingyangmycin treatment group (Group A, 16 cases) and CO2 laser treatment group (Group B, 9 cases). Results The cure rate was 81.3% (10/13) in group A and 88.9%(1/9) in group B without serious complication. Conclusion Both Pingyangmycin local injection and CO2 laser surgery are effective therapeutic methods for pharyngeal and laryngeal hemangioma, and individualized treatment could improve the effect. Related Articles | Metrics

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Transnasal endoscopic repair of cerebrospinal fluid rhinorrhea: a clinical analysis of 16 cases. WANG Junmin, CHEN Haibing, CHEN Xi, LU Meiping, CHEN Zhibin, CHENG Lei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (6): 37-41.   DOI: 10.6040/j.issn.1673-3770.0.2016.377 Abstract （1091）      PDF（pc） （2017KB）（555）       Save Objective To evaluate the surgical technique and clinical effects of transnasal endoscopic repair of cerebrospinal fluid(CSF)rhinorrhea. Methods From 2010 to 2015, sixteen patients with CSF rhinorrhea were treated with transnasal endoscopic surgery, including 5 patients with traumatic CSF rhinorrhea, 6 patients with spontaneous CSF rhinorrhea, and 5 patients with iatrogenic CSF rhinorrhea. The temporalis muscle, temporalis fascial, middle turbinate mucosa and bone, nasal septum mucosa, inferior turbinate mucosa, fascia lata, abdominal fat, and uncinate process mucosa were used for repairing the CSF fistulae. Results Fifteen patients were successfully repaired after the first operation, and 1 after the second attempt. No serious complications were observed during and after the operation. Conclusion Transnasal endoscopic repair of CSF rhinorrhea is a safe, effective, minimally invasive, and high successful surgical procedure. Accurate leakage site identification before the operation, suitable surgical approach and repairing materials are critical to achieving successful result. Reference | Related Articles | Metrics

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （1290）      PDF（pc） （116KB）（700）       Save Related Articles | Metrics

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Effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomiLeusis. JIANG Yang, LI Ying, WANG Zhonghai, JIN Yumei, LIU Xiaowei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (2): 80-83.   DOI: 10.6040/j.issn.1673-3770.0.2015.404 Abstract （1188）      PDF（pc） （930KB）（505）       Save Objective To evaluate the effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomi leusis(LASIK). Methods Patients with mild to moderate dry eye were included in the study before LASIK. The implantation of VisiPlug was conducted immediately after the surgery. The scores of dryness, foreign body sensation, burning sensation, photophobia, visual fatigue and blurred vision were recorded on preoperative and postoperative 1 week, 1 month and 3 months. Schirmer I test(SIt), break-up time(BUT)and corneal fluorescein staining(FS)were also tested on each time points. Results There were 130 eyes of 65 patients included in the study, including 22 males and 43 females with the average age of 28.32±7.24(18-47)years. The scores of dryness, foreign body sensation, burning sensation, photophobia, visual fatigue and blurred vision were significantly decreased on each time points after the implantation of the lacrimal plug(F value: 125.64, 263.16, 123.22, 9.80, 76.815, 105.19; P value: 0.000, 0.000, 0.000, 0.002, 0.000, 0.000). Schirmer I test(SIt), break up time(BUT)and corneal fluorescein staining(FS)were also significantly improved on each time points(F value: 45.99, 67.87, 49.01; P value: 0.000, 0.000, 0.000). There was no infection, plug in the overflow, local granulation, and the effect of corneal flap healing. Conclusion Lacrimal plug could be effective and safe in the management of dry eyes after refractive surgery. Reference | Related Articles | Metrics

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Treatment of residual tinnitus after threshold recovery of low frequency sudden deafness: a report of 129 cases. ZHU Jiangbin, NAN Bingwei, CHEN Tao, HAO Zongsheng JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (6): 5-7.   DOI: 10.6040/j.issn.1673-3770.0.2016.082 Abstract （1045）      PDF（pc） （982KB）（435）       Save Objective To investigate the treatment and efficacy of residual tinnitus after the recovery of threshold of low frequency sudden sensorineural hearing loss. Methods Shuxuening injection, prednisone acetate tablets, Gastrodia elata injection, lidocaine injection, hydroch-lorothiazide tablets and mecobalamin injection were used in combination for 10 days. The curative effect was observed. Results The treatment yielded good curative effect: the total effective rate was 93.13%, and the cure rate was 66.41%. After 1-year follow-up, the total effective rate was 93.33%, and the cure rate was 63.81%. Conclusion The combined use of drugs is effective. All drugs are cheap, and there is few side-effect. Reference | Related Articles | Metrics

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Drug therapy for myopia LIU Ling,ZHANG Meixia Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (4): 123-128.   DOI: 10.6040/j.issn.1673-3770.0.2020.313 Abstract （1289）      PDF（pc） （986KB）（267）       Save Myopia is the most common refractive error.Uncorrected refractive error, causing visual impairment, has become an important question of commonality sanitation, owing to affecting the quality of life of individuals and the weightily economy burden.With the prevalence of myopia increasing, controlling myopia progression and protecting eye health have gradually become the hot issue of global concern. And its current treatments include drugs, glasses, and surgery. In recent years, progress has been made in the treatment of myopia. This article focuses on the progress of research on drugs for controlling myopia, including muscarinic receptor antagonists, nicotinic receptor antagonists, and vasoactive intestinal peptides, and their mechanisms of action. Reference | Related Articles | Metrics

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Clinical analysis of endoscopic ligation of the sphenopalatine artery in elderly patients with intractable epistaxis Qiang LI,Zhiyuan LIU,Han ZHOU Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (5): 92-95.   DOI: 10.6040/j.issn.1673-3770.0.2018.366 Abstract （897）   HTML （9）    PDF（pc） （658KB）（292）       Save To investigate the efficacy of endoscopic ligation of the sphenopalatine artery in elderly patients with intractable epistaxis. The study included 41 elderly patients with intractable epistaxis. All patients were randomly assigned to two groups, namely, the treatment group (21 patients undergoing an endoscopic ligation of the sphenopalatine artery) and the control group (20 patients undergoing an endoscopic nasal packing). During the hospitalization and the 6-month follow-up, the epistaxis relapse rate, the postoperative pain, a satisfaction survey, the length of the hospital stay, and complications were evaluated. A significantly higher cure rate was obtained in the treatment group compared with the control group (81.0% vs. 50%, P<0.05). The average hospitalization duration of the treatment group was significantly shorter than that of the control group (6.5 days vs. 10.7 days, P<0.05). The treatment group was remarkably superior to the control group in both the degree of postoperative pain and satisfaction (both P<0.001). No severe complications were observed in any patient. For elderly patients with intractable epistaxis, endoscopic ligation of the sphenopalatine artery should be considered as a first-line treatment due to its advantages such as fast and effective action, short hospital stay, little postoperative pain, and few complications. Table and Figures | Reference | Related Articles | Metrics

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Application of radiofrequency ablation with plasma spot excitation in early glottic carcinoma(Tis-T1b) XIAO Xuping, ZHOU En, XIAO Yu Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (2): 60-66.   DOI: 10.6040/j.issn.1673-3770.1.2020.102 Abstract （1057）      PDF（pc） （4025KB）（110）       Save Objective This study aimed to evaluate the efficacy of radiofrequency coblation(RFC)in the treatment of early glottic carcinoma(Tis-T1b). Methods A total of 58 patients with early glottic carcinoma(Tis-T1b)at People's Hospital were enrolled from October 2018 to April 2020. All patients were men. According to the surgical method, 31 and 27 patients were included in the RFC and CO2 laser groups, respectively. The average patient age was 52.1±8.7 and 55.6±10.3 years in the RFC and CO2 laser groups, respectively. In the RFC group, the tumor-node-metastasis(TNM)stage was Tis, T1a, and T1b in 6, 23, and 2 patients, respectively, while in the CO2 laser surgery group, the TNM stage was Tis, T1a, and T1b in 3, 22, and 2 patients, respectively. All patients were followed up for 6-18 months, and the operation time, postoperative pain score, and cough score were recorded. All patients underwent reassessment at 1, 3, and 6 months after surgery using an electronic laryngoscope. Results The operation time was shorter in the RFC group than in CO2 laser group(11.81 vs. 16.77 min, P<0.001). There were no significant differences in the length of hospital stay, blood loss, pain score, cough score, anterior conglutination rate, and granulomatous hyperplasia between the groups(P=0.676,0.390,0.483,0.483,0.094,0.788). All patients were followed up in the outpatient department. No deaths occurred during the follow-up period. Four patients developed local recurrence, including 2 patients(1 patient with T1b involving anterior commissure and 1 patient with T1a)in the RFC group and 2 patients(2 patients with T1b involving anterior commissure)in the CO2 laser group. Both patients in the RFC group underwent repeat plasma surgery and 1 patient in the CO2 laser group underwent CO2 laser extended resection. In one patient with unilateral cervical lymph node metastasis, the surgery was converted to open surgery. There was no significant difference in the local recurrence rate between the groups(P=0.276). The acoustic parameters of Jitter, Shimer, and NHR recovered gradually in all patients at different time points postoperatively(P<0.05), and the acoustic parameters of the RFC group were better than those of the CO2 laser group(P=0.000,0.001,0.000). Conclusion Radiofrequency ablation with the plasma spot excitation technique is safe and effective for the treatment of early glottic carcinoma(Tis-T1b). It has the advantages of short operation time, small mucosal injury, and good preservation of voice function. However, the long-term tumor control rate and survival rate need to be further observed. Reference | Related Articles | Metrics

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Application of 5-fluorouracil and mitomycin C in improved external dacryocystorhinostomy FAN Wei, WANG Tian-yi, DENG Ai-jun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 99-100.   DOI: 10.6040/j.issn.1673-3770.0.2014.278 Abstract （1174）      PDF（pc） （1853KB）（335）       Save Reference | Related Articles | Metrics

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Outcome of artificial divergence surgery in patients with infantile nystagmus syndrome (6 cases report) LUAN Yanan, GUO Jingli, WANG Lihua JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 69-71.   DOI: 10.6040/j.issn.1673-3770.0.2015.146 Abstract （1379）      PDF（pc） （953KB）（305）       Save Objective To investigate the outcome of artificial divergence surgery in patients with infantile nystagmus syndrome. Methods Six infantile nystagmus syndrome patients with blocking convergence enrolled in out department from March 2012 to September 2014 were retrospectively evaluated. Corrected visual acuity was measured respectively. The head turn (HT) was measured when patients staring at distance fixation using a goniometer. Binocular vision function of patients was evaluated by the Titmus Stereo Test and the Worth Four Light Test in appropriate refractive correction. Prism adaptation test was used in all patients pre-operatively. The amounts of bilateral medial rectus recession was 3-4 mm. Results The average post-operative follow-up period was 9.8 months (range, 3-12 months). After surgery, the HT was eliminated in 4 patients, improved in 1 patient and ineffective in 1 patient. Monocular and binocular corrected visual acuity was improved in 3 patients and unchanged in 3 patients. Stereopsis acuity was improved in 2 patients and unchanged in 4 patients. 1 patient was consecutive exotropia. Conclusion The results of this study preliminarily showed artificial divergence surgery was effective to INS patients with blocking convergence. Reference | Related Articles | Metrics

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The application of Sinus Jel in adult patients of nasal polyps with sleep-disordered breathing. WANG Haipeng, XU Huijuan, ZHANG Xiufang, WANG Huizhong, LI Yanzhong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 58-60.   DOI: 10.6040/j.issn.1673-3770.0.2016.153 Abstract （1504）      PDF（pc） （974KB）（550）       Save Objective To explore whether PureRegen Gel Sinus is a suitable nasal packing material for patients with sleep-disordered breathing(SDB)caused by chronic rhinosinusitis plus nasal polys(CRSwNP). Methods A total of 216 CRSwNP cases including 156 SDB and 60 non-SDB cases were divided into 4 groups. Group A(60 non-SDB cases)and group B(56 SDB cases)were treated with PureRegen Gel Sinus after nasal sinus surgery. Group C included 47 SDB cases treated with Nasopore. Group D included 53 SDB cases treated with Medical Sponge. The nasal reactions of the 4 groups were compared with Visual Analogue Scale(VAS). Results There were significant differences in headache, rhinalgia and postoperative bleeding between group A and B(P<0.05). Patients with SDB were more intolerant to these complications. There were statistical differences in headache, rhinalgia, rhinobyon and lacrimation between group B and C(P<0.05). PureRegen Gel Sinus was was superior to Nasopore. There were statistical differences in headache, rhinalgia, rhinobyon, lacrimation, dysphagia and postoperative bleeding between group B and D(P<0.05). PureRegen Gel Sinus was no better than medical sponge in dealing with postoperative bleeding, but it was still acceptable. PureRegen Gel Sinus was superior to medical sponge in other aspects. Conclusion PureRegen Gel Sinus is more suitable for clinical practice as a packing material. In addition, SDB can worsen headache, rhinalgia and postoperative bleeding, which may be associated with inflammation resulted from long-term oxygen depletion. Reference | Related Articles | Metrics

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Physiological characteristics of voice and care of vocal health in the elderly Jiejie XU Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 14-18.   DOI: 10.6040/j.issn.1673-3770.1.2019.022 Abstract （1297）   HTML （20）    PDF（pc） （665KB）（882）       Save Degenerative age-related changes in the body organs can affect the structure and physiological function of the vocal cords and cause senescence of voice in the elderly. This paper summarizes the changes in laryngeal structure, glottis appearance, and physiological vocal characteristics of aged subjects, and states the steps that need to be taken to care for vocal health of patients at an advanced age. This will be helpful to distinguish between the physiological and pathological changes of the larynx in the elderly and carry out appropriate and reasonable voice protection measures, thereby improving the quality of life in the aged population.Degenerative age-related changes in the body organs can affect the structure and physiological function of the vocal cords and cause senescence of voice in the elderly. This paper summarizes the changes in laryngeal structure, glottis appearance, and physiological vocal characteristics of aged subjects, and states the steps that need to be taken to care for vocal health of patients at an advanced age. This will be helpful to distinguish between the physiological and pathological changes of the larynx in the elderly and carry out appropriate and reasonable voice protection measures, thereby improving the quality of life in the aged population. Reference | Related Articles | Metrics

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Effect of mitomycin C in treatment of epithelial ingrowth after LASIK SUN Li-wang, CHE Cheng-kai, SU Gang, LIU Guang-yuan J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (4): 79-80.   DOI: 10.6040/j.issn.1673-3770.0.2013.099 Abstract （1413）      PDF（pc） （859KB）（1256）       Save Objective    To observe the clinical effect of mitomycin C(MMC)during treatment of epithelial ingrowth(EI) after laser in situ keratomileusis(LASlK). Methods    10 patients (12 eyes) with epithelial ingrowth after LASlK were treated with surgery. MMC 0.02% was applied in treatment of epithelial ingrowth. Results    The uncorrected visual acuity increased to 0.86±0.15 after surgery. The corneal flaps recovered well． Conclusion    MMC treatment of corneal epithelial ingrowth after LASIK can effectively prevent recurrence and achieve good clinical effect. Related Articles | Metrics

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Time pattern of audiological recoverey with intratympanic steroid injection as primary treatment for sudden sensorineural hearing loss ZHANG Cai-xia, LIU Yang-yun, CHEN Zhi-xi, JIANG Wen, LI Zheng-xian, CHEN Qiong, CHANG En-ge JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (1): 15-18.   DOI: 10.6040/j.issn.1673-3770.0.2014.284 Abstract （2422）      PDF（pc） （935KB）（382）       Save Objective To explore the time pattern of audiological recovery with intratympanic steroid injection as primary treatment for sudden sensorineural hearing loss (SSNHL) to define best strategy. Methods All 135 patients underwent a two-week systemic steroid therapy, while 72 of them received extra intratympanic injection in the mean time. All cases were followed up 2 months. Results No difference in total effective rates between the two treatments on 3rd day, 7th day,14th day and 1 month was noted. There was no difference between the 7th day and 14th day in combined treatment was noted (P=0.065) but not in systemic steroid therapy alone(P=0.029). Conclusion As a primary treatment, the curative effects between the intratympanic steroid administration and systemic steroid therapy shows no difference. The peaked time of hearing improvement of the former is earlier than that of the latter. Reference | Related Articles | Metrics

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Changes of serum myocardial enzymes and uric acid in patients with severe obstructive sleep apnea hypopnea syndrome complicated with hypertension ZOU Juanjuan, WANG Yan, LI Yanzhong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 1-5.   DOI: 10.6040/j.issn.1673-3770.0.2015.221 Abstract （1000）      PDF（pc） （1348KB）（324）       Save Objective To explore the levels of creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and uric acid (UA) in patients with severe obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with hypertension. Methods A total of 140 OSAHS cases were divided into simple OSAHS group (n=67) and OSAHS complicated with hypertension group (n=23, OSAHS+HT group), 30 patients with simple hypertension were included into the hypertension group, and 20 healthy people served as controls. The levels of CK, CK-MB, LDH and UA of the 4 groups were measured. The rates of abnormal cardiac structure and function in OSAHS group and OSAHS+HT group were analyzed. Results Compared with the control group, the levels of CK, CK-MB, LDH and UA in the other 3 groups were higher (P<0.05, or P<0.01). Compared with simple OSAHS group, the levels of CK, LDH and UA in OSAHS+HT group were higher (P<0.05), but the level of CK-MB had no significant difference (P>0.05). The incidence of left ventricular hypertrophy, ventricular septal thickening, left atrial enlargement, aortic valve regurgitation and E/A<1 was higher in OSAHS+HT group than in OSAHS group (P<0.05, or P<0.01). The levels of serum CK, LDH and UA in OSAHS patients were positively correlated with AHI, but negatively correlated with SpO2. There was no significant correlation between CK-MB and AHI, and SpO2. Conclusion Severe OSAHS patients have increased serum myocardial enzymes and uric acid level. For OSAHS patients complicatedwith hypertension, uric acid and myocardial enzymes will increase more significantly. Patients with severe OSAHS may have abnormal cardiac structure and function, and hypertension may increase this probability. UA, CK and LDH are associated with the severity of OSAHS and degree of hypoxia. Reference | Related Articles | Metrics

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Comparison of high order aberrations in pseudophakia with spherical intraocular lens and aspheric intraocular lens implantation. TIAN Jing, LIAO Xuan, LAN Changjun, TAN Qingqing, LIN Jia, WEN Baiwei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 13-17.   DOI: 10.6040/j.issn.1673-3770.1.2017.031 Abstract （1536）      PDF（pc） （902KB）（669）       Save Objective To compare the corneal, internal, and ocular high order aberrations(HOAs)in pseudophakia of spherical intraocular lens(IOL)with aspheric IOL implantation, and to provide evidence for individual selection of aspheric IOL. Methods A prospective, non-randomized, controlled clinical study was conducted on 112 age-matched cataract patients(160 eyes). Patients were divided into four groups, and implanted with AMO Sensor AR40 IOL(group AR40, 40 eyes of 26 patients), AMO Tecnis ZA9003 IOL(group ZA9003, 40 eyes of 31 patients), Bausch & Lomb SofPort AO IOL(group AO, 40 eyes of 28 patients), or Alcon SN60WF IQ IOL(group IQ, 40 eyes of 27 patients). The corneal, internal, and ocular HOAs including total HOA(tHOA), spherical aberration(SA), coma, and trefoil were measured at three months postoperatively with a pupil diameter(PD)of 4 mm or 6 mm. Result There were no statistically significant differences in postoperative uncorrected visual acuity and best corrected visual acuity, and in postoperative corneal tHOA, SA, coma, and trefoil at 4 mm or 6 mm PD among the four groups. At 4 mm PD, there were significant differences in internal SA and coma but no differences in tHOA and trefoil; at 6 mm PD, there were significant differences in internal tHOA, SA, and coma but no differences in trefoil. In addition, there were significant differences in ocular tHOA and SA but no differences in coma and trefoil at 4 mm or 6 mm PD among the four groups. Conclusion Phacoemulsification of the cataract and implantation of an aspheric IOL can reduce corneal SA, resulting in enhanced visual quality. For aspheric IOLs with other SAs, the predictability of corneal SA is exact, which provides a clinical basis for personalized implantation of aspheric IOLs. Reference | Related Articles | Metrics

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null GONG Xiang-rong, WANG Gui-sheng, YANG Guo-jian, SUN Yan-qing, CUI Hong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 55-57.   Abstract （805）      PDF（pc） （904KB）（1283）       Save null Related Articles | Metrics

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Comparison of the efficacy of three different techniques in tonsillectomy. GONG Mingjie, LIU Kan, ZHANG Lei, YAN Biao, ZOU Jiaping, LI Weizhong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (1): 70-73.   DOI: 10.6040/j.issn.1673-3770.0.2015.345 Abstract （1629）      PDF（pc） （870KB）（654）       Save Objective To compare the clinical efficacy of cold dissection, monopolar diathermy dissection and radiofrequency ablation in tonsillectomy. Methods Patients undergone tonsillectomy were divided into 3 groups: cold dissection + suture group(group A, n=65), unipolar electric coagulation resection group(group B, n=40), plasma radiofrequency resection group(group C, n=38). The operation time, intraoperative blood loss, pain score, and postoperative albuginea of all groups were recorded and compared. Results The average operation time and intraoperative blood loss of group A, B and C were(58.8, 27.0 and 23.7)min,(34.2, 16.1 and 12.5)mL, respectively. There was significant difference in postoperative pain score 3 hour and 1 day after surgery. Conclusion Compared with cold dissection and monopolar diathermy dissection, radiofrequency ablation is more expansive, but it needs shorter operation time and causes less intraoperative bleeding and pain. Reference | Related Articles | Metrics

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SUN Ziwen1, CUI Hongwei2, SUN XilingEtiology, pathogenesis, and management of dry eye SUN Ziwen, CUI Hongwei, SUN Xiling, CHEN Chen, ZHANG Lu, HU Zhulin Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (2): 159-166.   DOI: 10.6040/j.issn.1673-3770.0.2018.411 Abstract （1435）      PDF（pc） （533KB）（327）       Save Due to multiple influences of internal factors(tear film destruction, sex hormone disorders)and external factors(environment, surgery, and drugs), patients with dry eye disease have been encountered much more frequently and are presenting at a younger age. Dry eye disease has become one of the most common diseases of the ocular surface, with a multifactorial etiology. This paper reviews the newer reports on etiology, pathogenesis, and management of dry eye. Reference | Related Articles | Metrics

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Intratympanic dexamethasone injections through pharyngotympanic tube for sudden sensorineural hearing loss WU Yun-gang， LI Xiao-yu， PANG Tai-zhong， GAO Fu-ping， LI Shan， WANG Cai-hua， ZHANG Hui， HUANG Meng-meng JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 29-30.   Abstract （1334）      PDF（pc） （1930KB）（1266）       Save Objective   To investigate the efficacy of intratympanic dexamethasone injection through the  pharyngotympanic tube (PTIDI)for 20 patients with sudden sensorineural hearing loss(SSNHL). Methods   Deamethasone(5mg) was injected into the middle ear through the pharyngotympanic tube for 20 patients of SSNHL sensorneural hearing loss. The medication was repeated every day until a total of 7-10 doses(3550mg) was reached. Results   The 20 patients were followed up for two weeks. One (5%) recovered completely, Three (15%) demonstrated a 32dBHL improvement in PTA, and 11 (55%) showed no response. Conclusions   PTIDI is a simple and effective treatment for SSNHL. It can be applied to the patients who failed to respond to conventional treatment and can avoided the side effects followed  by highdosage systemic corticostemid treatment. Related Articles | Metrics

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Allergic conjunctivitis: diagnosis and treatment. JIE Ying, LU Hongshuang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (3): 31-36.   DOI: 10.6040/j.issn.1673-3770.0.2017.174 Abstract （946）      PDF（pc） （1918KB）（490）       Save Allergic conjunctivitis is a common ocular disease, including seasonal allergic conjunctivitis(SAC), perennial allergic conjunctivitis(PAC), vernal keratoconjunctivitis(VKC), atopic keratoconjunctivitis(AKC), and giant papillary conjunctivitis(GPC). Allergic conjunctivitis can affect patients’ qualify of life and might even lead to blindness in severe conditions. Recently, many studies have reported new strategies for the diagnosis of allergic conjunctivitis, which include tear cytology and detection of allergen-specific IgE in tears, as well as other molecular tests. New types of immunomodulators are of great help in treating severe cases, and allergen-specific immunotherapy is gaining momentum for the management of SAC and PAC. Reference | Related Articles | Metrics

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Analysis of the clinical efficacy of endoscopy-assisted intraoral removal of an elongated styloid process without tonsillectomy WANG Xuechang, WANG Tao, REN Xin, ZHAO Mingjun Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (4): 17-21.   DOI: 10.6040/j.issn.1673-3770.0.2020.413 Abstract （700）      PDF（pc） （3365KB）（124）       Save Objective To investigate the surgical methods and clinical effects of tonsil-sparing styloid process truncation assisted by endoscopy via an oral approach. Methods We retrospectively analyzed the clinical data of 36 patients with styloid process syndrome(65 sides), the data included the main complaints, course of disease, misdiagnosis, length of the styloid process, and the degree of tonsil enlargement. Results Among the 36 patients, 7 had a unilateral styloid process, 29 had bilateral styloid processes, and 65 had styloid processes. The main complaints were pharyngeal foreign body sensation in 27, neck and shoulder pain or discomfort in 12, sore throat and pain associated with swallowing in 11, dry throat and cough in 7, facial pain in 1, and ear pain in 3 patients. The duration of illness ranged from 20 days to 3 years, with an average of 10 months. Of the misdiagnoses, twenty were pharyngitis, four were gastroesophageal reflux, two were thyroid disease, one was cervical spondylosis, and one was upper respiratory tract infection. The misdiagnosis ratio was 77.8%. Among the 36 patients, 14 had no tonsil hypertrophy, 20 had first-degree enlargement, and 2 had second-degree enlargement. None of the patients had a history of chronic tonsillitis or a tonsil mass. The average length of the preoperative styloid process is(4.38±0.78)cm; the longest is 7.89cm. The average length of the truncated styloid process is(2.09±0.93)cm. The duration of surgery was(67.08±28.4)min, and the blood loss during surgery was(8.42±5.58)mL. In six patients, seven side styloid processes were fractured externally due to the deep position or difficulty of separation. After postoperative follow-up for more than 3 months, 27 cases had resolved symptoms, 4 cases had symptom relief, 4 cases had no change in symptoms. One case was lost to follow-up. Conclusion Tonsil-sparing styloidectomy assisted by the endoscopic transoral approach preserves normal tonsils, with less surgical trauma, less pain, faster recovery, less bleeding, and good surgical results. It is effective for treating styloid process syndrome, which is a safe and minimally invasive surgical method. Reference | Related Articles | Metrics

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Observation of collagen in PHEMA Keratoprothesis implanted into alkali burned rabbit corneas by picric sirius red staining. BAI Hua, GUO Huiling, WANG Liqiang, HUANG Yifei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (4): 69-73.   DOI: 10.6040/j.issn.1673-3770.0.2014.128 Abstract （977）      PDF（pc） （4914KB）（336）       Save Objective To observe the dynamic changes of type and distribution of collagen fiber in the porous skirt of new type one-piece keratoprosthesis (KPros) made of PHEMA implanted into the alkali burned rabbit corneas. Methods A total of 10 pieces KPros were implanted into the alkali burned rabbit corneas. The skirt of kpro was obtained after 2, 8, 16 and 22 weeks. The samples were treated with picric-sirius red staining and observed by polarizing microscopy. Results This material PHEMA allowed the cornea and surrounding tissue growing and forming a multi-site stable fiber-connections under polarized light after staining. The new organization within the pores was mainly type I collagen and its growth performance was that yellow-green type Ⅲ collagen become mature red type Ⅰ collagen in process and cells were active especially in limbus. Conclusion The dynamic changes of collagen observation, can be concluded that the PHEMA pores and the cornea shown the similar performance and consistent with normal rabbit corneal implant healing. Reference | Related Articles | Metrics

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Clinical analysis of 216 cases of congenital pyriform sinus fistula treated by radiofrequency ablation DOU Qianwen, TIAN Xiufen Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (2): 39-45.   DOI: 10.6040/j.issn.1673-3770.1.2020.092 Abstract （1116）      PDF（pc） （2702KB）（221）       Save Objective Congenital pyriform sinus fistula(CPSF)is a rare parotid source disease. It is easily misdiagnosed as a simple abscess in the neck in clinical practice. In the past, neck fistulectomy was usually the treatment of choice; however, it was traumatic, and the fistula could not be eliminated completely, thus leading to recurrence. Our study aimed to investigate congenital pyriform sinus fistula and evaluate the therapeutic effect of radiofrequency ablation in the treatment of congenital pyriform sinus fistula. Methods The data of 216 patients with congenital pyriform sinus fistula treated by radiofrequency ablation between March 2013 and May 2019 were collected and analyzed retrospectively. Results Among the 216 patients, the ratio of males to females was approximately 1.18∶1, and 90.7% of the cases were left-sided, 8.3% were right-sided, and only 1.0% were bilateral. The age range of the patients was 23-66 years. Eight patients were lost to follow-up, with an average follow-up of 15 months. Among 208 patients after coblation, 17 cases(8.2%)had postoperative hoarseness, 12 cases(5.8%)had recurrence, and there was no infection, irritating cough, or esophageal injury. Conclusion Radiofrequency ablation is the first choice for the treatment of congenital pyriform sinus fistula. Reference | Related Articles | Metrics

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Clinical observation of corneal stronmal layer injection in the treatment of fungal keratitis SHUAI Shao-shuai, HE Xia-yi, NING Hong- zhu, LUO You-qiong, LIANG Si-min JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 76-78.   DOI: 10.6040/j.issn.1673-3770.0.2014.142 Abstract （1394）      PDF（pc） （950KB）（468）       Save Objective To observe clinical effect of the stromal layer of fluconazole injection of fungal keratitis. Methods 70 eyes diagnosed as fungal keratitis were randomly divided to two groups with 35 eyes in each. The treatment group was firstly treated helcoma with stomal layer of fluconazole injection, then treated with fluconazole eye ointment and recombinant bovine basic fibroblast growth factor gel enveloping eyes. The control group was firstly treated helcoma with iodine cautery and then used fluconazole eye ointment and recombinant bovine basic fibroblast growth factor gel enveloping eyes. The clinical feasibility of iodine cautery and the stromal layer of fluconazole injection in the treatment of fungal keratitis were observed and compared. Results Thirty-five eyes in the treatment group used the stromal layer of fluconazole injection, all helcoma healed up. The course was shorten and the effect was better than the control group(P<0.05).The average visual acuity of two groups before and after treatment was statistical different(P<0.05). Conclusion Corneal stromal layer injection in the treatment of fungal keratitis can enhance the curative rate obviously. It is an effective and safe therapeutic method. Reference | Related Articles | Metrics

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Intravitreal injection of conbercept for macular edema secondary to retinal vein occlusion. YAN Xiaoteng, FENG Jun, KANG Xinle JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 105-108.   DOI: 10.6040/j.issn.1673-3770.0.2016.002 Abstract （890）      PDF（pc） （1401KB）（496）       Save Objective To explore the effects of intravitreal injection of conbercept for macular edema(ME)secondary to retinal vein occlusion(RVO). Methods A prospective, continuity and uncontrolled clinical case analysis was used. Thirty cases(30 eyes)with ME secondary to RVO in our hospital from September 2014 to February 2015 were selected, in which 9 cases(9 eyes)were central retinal vein occlusion(CRVO)and 21 cases(21 eyes)were branch retinal vein occlusion(BRVO). All cases were treated with intravitreal injection of conbercept for 3 times and followed up for 6 months. Best corrected visual acuity(BCVA)and central macular thickness(CMT)were observed. Results In patients with BRVO, mean BCVA before treatment and 6 months after treatment were(0.77±0.24)logMAR,(0.27±0.19)logMAR, and CMT were(596.8±139.6)μm,(272.6±29.2)μm, respectively, the difference has statistical significance(t=4.483, P<0.05; t=7.189, P<0.05). In patients with CRVO, mean BCVA before treatment and 6 months after treatment were(0.87±0.55)logMAR,(0.43±0.2)logMAR, and CMT were(647.3±163.6)μm,(393.1±121.5)μm, respectively, the difference has statistical significance(t=2.288, P<0.05; t=7.189, P<0.05). Conclusion Intravitreal injections of conbercept is effective for ME secondary to RVO. Reference | Related Articles | Metrics

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Experiences of surgical treatment of complicated congenital preauricular fistula. YI Xing, WU Xuewen, MEI Lingyun, HE Chufeng, JIANG Lu, CAI Xinzhang, TIAN Xiange, FENG Yong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (3): 64-67.   DOI: 10.6040/j.issn.1673-3770.0.2016.382 Abstract （1329）      PDF（pc） （1975KB）（700）       Save Objective To explore the surgical methods for complicated congenital preauricular fistula, so as to provide references for clinical treatment. Methods The clinical data of 71(80 ears)patients with complicated congenital preauricular fistula who were hospitalized in our hospital from May 2011 to May 2016 were retrospectively analyzed. Results All patients received surgery by secreting the whole tissue 1 week after the affected ear infection was controlled. The patients were postoperatively followed up for 3 monts-5 years, and 78 ears(97.5%)showed no recurrence, while only 2 ears(2.5%)recurred postoperatively and were cured by secondary surgery. Another 1 ear(1.25%)had incision suture infection on d4 after operation, which was cured after wound dressing change and anti-infection treatment. Conclusion Selection of proper surgical time, precise determination of surgical boundary and resection of the whole lesion tissues are beneficial to the radical resection of complicated congenital preauricular fistula and the reduction of recurrence rate. Reference | Related Articles | Metrics

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Research progress of inflammatory factors in Keratoconus LI Mengting, HE Shuxi, WANG Hua Journal of Otolaryngology and Ophthalmology of Shandong University    2023, 37 (2): 151-158.   DOI: 10.6040/j.issn.1673-3770.0.2021.536 Abstract （139）      PDF（pc） （500KB）（46）       Save Keratoconus(KC)is a progressive corneal dilation disease, which aggravates myopia and astigmatism. The pathophysiological mechanism of KC remains vague. The role of genetic and inflammatory factors on KC has been investigated by previous studies. Detectable levels of inflammatory factors and proteases were found in the tears of patients with KC. Interleukin-6, tumor necrosis factor-α, and matrix metalloproteinase-9 were found in the tears of patients with KC. A higher level was positively correlated with the clinical course of KC. In addition, some external factors can indirectly lead to the aggravation of inflammation through certain behaviors, thus accelerating the occurrence and development of KC, such as eye rubbing, allergic reaction, etc. Pathological eye rubbing will change the corneal morphology, change the corneal environment, and cause indirect corneal injury. Immunoglobulin E in allergic reaction is the potential inflammatory molecule of KC. This paper aimed to review previous studies on inflammatory factors and the pathways leading to KC. Reference | Related Articles | Metrics