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Effects of 01% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome ZHANG Ju, WU Xin-yi JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (1): 49-51.   DOI: 10.6040/j.issn.1673-3770.0.2014.342 Abstract （3886）      PDF（pc） （929KB）（1146）       Save Objective To evaluate the effects of 0.1% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome. Methods A total of 60 patients (120 eyes) with dry eye syndrome were randomly divided into the experimental group (60 eyes) treated by 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops and the control group (60 eyes) treated by bysodium hyaluronate eye drops. Both groups were measured the Schirmer I test(SIt), tear film break-up time(BUT) and corneal fluorescein staining(FLs) before and after a month. Results There were no significant differences between the experimental group and the control group in SIt, BUT and FLs before treatment (P>0.05). After treatment, all the indicators of SIt, BUT and FLs of the experimental group and the control group were better than before (P<0.05). The experimental group was superior to the control group in the three indicators (SIt, BUT and FLs)(P<0.05). Conclusion 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops is effective in treatment of dry eye, and is superior to bysodium hyaluronate eye drops alone. Reference | Related Articles | Metrics

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Progress in diabetic retinopathy mechanisms and cellular models WANG Jiaojiao, LI MiaoOverview,SONG ZongmingGuidance Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (5): 93-99.   DOI: 10.6040/j.issn.1673-3770.0.2021.203 Abstract （1270）      PDF（pc） （473KB）（521）       Save Diabetic retinopathy is the leading cause of poor vision and blindness in adults. A reasonable model for diabetic retinopathy can not only simulate its pathogenic mechanism, but also reduce economic investment. Therefore, screening and constructing suitable cell models is the core of research. In this paper, the mechanisms of inflammatory response, apoptosis, vascular dysfunction, and neurovascular unit dysfunction in diabetic retinopathy were discussed. Moreover, several models of endothelial cells, pericytes, retinal pigment epithelial cells, and glial cells were summarized to provide a useful reference for further studies on the mechanism of diabetic retinopathy and the development of relevant drugs. Reference | Related Articles | Metrics

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null XIAO Jian-xin, YU Qing-qing, TANG Jun, ZHANG Chao, SHI Si-si, CHEN Wei-xiong, WANG Yue-jian JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 38-42.   Abstract （1399）      PDF（pc） （2489KB）（2171）       Save null Related Articles | Metrics

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One-stage nasal surgery and uvulopalatopharyngoplasty for obstructive sleep apnea-hyponea syndrome PANG Tai-zhong， WU Yun-gang， LI Xiao-yu， MA Lin-xiang， DING De-tao， HUANG Meng-meng, WANG Cai-hua， ZHANG Yong-hong, ZHANG Hui JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (3): 7-9.   Abstract （952）      PDF（pc） （943KB）（2698）       Save Objective   To investigate the clinical efficacy of uvulopalatopharyngoplasty(UPPP) with nasal surgery for patients with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods   40 OSAHS patients were divided into the A or B group, in which group A underwent UPPP with nasal surgery, which group B underwent only UPPP. The clinical results and the average apnea-hypopnea index (AHI) before and after the operation were compared. Results   The average AHI were all decreased, however, the result of group A was better than the group B 6 months after the operation. Conclusion   UPPP with nasal  surgery is an available and relatively safe surgical approach for the OSAHS patients with nasal obstruction. Related Articles | Metrics

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The groove behind the palatovaginal canal: a landmark for identification of the palatovaginal canal MENG Qingguo, LU Yongtian, WU Xiaoliu, LI Jianxing, SUN Huanji, ZHANG Baoying, XIE Chang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 55-61.   DOI: 10.6040/j.issn.1673-3770.0.2015.124 Abstract （2234）      PDF（pc） （4366KB）（882）       Save Objective To explore the groove behind the palatovaginal canal (PVC) is a critical landmark for safe identification of the PVC during endoscopic endonasal transpterygoid approaches and transfer CT scan of the pterygopalatine fossa. Methods Probes were inserted thorough the PVC of 20 dry skulls. The PVC and the groove behind it were proved on MSCT, meanwhile a comparative study was also carried out by the traditional method to identificate the PVC. Dissection of two skulls and cadaveric heads was performed to demonstrate the endoscopic anatomy of the PV canal and tbe groove. Results The grooves can be found in all 20 dry skulls and appeared as groof near the posterior opening of PV canal. 26 sids were deep while 14 sides were dimple. Mainly appeared as tube-shaped (24 sides) or ovoid dimple-shaped (16 sides). In CT scan, the average angle between PVS and the hard palate was 53.14±5.48°, while between the groove and the hard palate was 20.93±6.28°. There was also statistical difference for identification of the PVC in transfer CT between the traditional method and the method assisting with the groove. Anatomic steps and foundations for dissection of the PVC while using the groove as a landmark were described. Conclusion Anatomic investigation, radiologic studies and comparison between the methods for identification of the PVC demonstrate the important anatomic relationship of the PVC with the groove, and reveal the groove as a landmark in endoscopic endonasal transpterygoid approaches and transfer CT scan of the pterygopalatine fossa. Reference | Related Articles | Metrics

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SUN Ziwen1, CUI Hongwei2, SUN XilingEtiology, pathogenesis, and management of dry eye SUN Ziwen, CUI Hongwei, SUN Xiling, CHEN Chen, ZHANG Lu, HU Zhulin Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (2): 159-166.   DOI: 10.6040/j.issn.1673-3770.0.2018.411 Abstract （2066）      PDF（pc） （533KB）（773）       Save Due to multiple influences of internal factors(tear film destruction, sex hormone disorders)and external factors(environment, surgery, and drugs), patients with dry eye disease have been encountered much more frequently and are presenting at a younger age. Dry eye disease has become one of the most common diseases of the ocular surface, with a multifactorial etiology. This paper reviews the newer reports on etiology, pathogenesis, and management of dry eye. Reference | Related Articles | Metrics

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Diagnosis and treatment of parapharyngeal space neoplasms HU Juan-juan, HONG Yu-ming JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 85-90.   DOI: 10.6040/j.issn.1673-3770.0.2014.159 Abstract （2159）      PDF（pc） （972KB）（1222）       Save Anatomy of parapharyneal space is very complicated. Many types of parapharyngeal space neoplasms can occur, and all of them demonstrate different clinical manifestations. Therefore, it is more difficult to diagnose and treat the parapharyngeal space neoplasms than other head and neck neoplasms. Common diagnostics methods include bimanual examination, imaging studies, cytopathology, transoral and transcervical biopsy. All these methods can help doctor determine the nature and blood supply of tumors and understand the relationship between neoplasms and adjacent structure, which provide a reliable basis for the ensuing treatment. This paper aims to state the diagnosis and treatment of parapharyngeal space neoplasms, especially how to select surgical procedures. Reference | Related Articles | Metrics

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Establishment and application of model of chronic rhinosinusitis in mice WANG Zhiyuan, ZHANG Gehua JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 76-78.   DOI: 10.6040/j.issn.1673-3770.0.2015.184 Abstract （2067）      PDF（pc） （954KB）（1463）       Save Chronic rhinosinusitis(CRS) is a common chronic inflammatory disease of the upper respiratory tract, which seriously affects the patients' quality of life. Because of its uncertain pathogenesis, the curative effect is not satisfactory. Animal model of CRS is the ideal means for study of the human CRS pathological mechanism and curative effect. Mice are currently common CRS animals. The main content of the review includes research progress of the mice CRS-building methods, the evaluation index and application status of the model. Reference | Related Articles | Metrics

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Treatment experience of preservation of laryngeal function in surgical management of pyriform sinus carcinoma. SONG Xicheng, ZHANG Hua, LIU Zhonglu, WANG Yunqiang, WANG Yan, ZHANG Qiang, WANG Qiang, KANG Shasha, SONG Yipeng JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2016.262 Abstract （1841）      PDF（pc） （1040KB）（1355）       Save Objective To investigate preservation and reconstruction of larynx function in surgical treatment of pyriform sinus carcinoma. Methods A retrospective analysis of 102 cases of pyriform cancer treated in June 2004 to October 2015 underwent surgeries with laryngeal functions preserved was carried out. There were 9 cases of stage Ⅰ, 11 cases of stage Ⅱ, 47 cases of stage Ⅲ and 35 stage Ⅳ, according to the 2002 UICC staging. Pharyngeal lateral wall approach, hyoid region approach and paraglottic space approach were chosen respectively to remove the tumor as per preoperative evaluation, followed by repairing of surgical defects and reconstruction of laryngeal and pharyngeal functions. 93 cases of postoperative radiotherapy were implemented. Results All patients recovered well after surgery except 1 patient with pharyngeal fistula and infection. All repairing materials of different methods survived and the average time of postoperative oral intake was 12.47 days. All patients retained good laryngeal functions with 95 decannulations and the 3-year and 5-year survival rates were 59.3% and 40.7% respectively. Conclusion Comprehensive preoperative investigations as laryngoscopy and radiological assessment may give good suggestions in selecting appropriate surgical approaches; good surgical approach may help provide good feasibility and visibility, and ensure complete removal of the tumors with safety margins; through the epiglottis flipping and/or thyroid reinforcement repairing methods, the incidence of accidental swallowing and pharyngeal fistula can be reduced; pyriform sinus carcinoma are found mostly in advanced stages, single treatment is often ineffective in controlling the lesion, and radiotherapy is necessary as a comprehensive treatment to improve the local control rate and survival rate. Appropriate surgical approaches and repairing methods can help surgeons to completely remove the tumor, and preserve or rebuild laryngeal and pharyngeal functions in managing chosen patients with pyriform sinus cancer. Reference | Related Articles | Metrics

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Diagnosis and treatment of thyroid-associated ophthalmopathy ZHU Mingjuan, XING Kai, KANG Zefeng, LIU Jian J Otolaryngol Ophthalmol Shandong Univ    2018, 32 (5): 110-113.   DOI: 10.6040/j.issn.1673-3770.0.2018.034 Abstract （1843）      PDF（pc） （436KB）（650）       Save Thyroid-related ophthalmopathy is an organ-specific autoimmune disease associated with abnormal thyroid function. The extra-glandular ocular involvement affects the appearance of the patient; severe cases can present with diplopia, decreased vision, or even blindness. The pathogenesis is not yet fully understood, and the current clinical therapeutic approaches cannot cure or provide relief to all patients. Moreover, there are many clinical treatment methods. Histopathological examination of the ocular soft tissue and extra-ocular muscles shows some immune inflammatory response, but the exact pathogenesis of this disease is not clear. This article reviews the latest research on the clinical diagnosis and treatment of thyroid-related ophthalmopathy. Reference | Related Articles | Metrics

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Advances in research on related signaling pathways in allergic rhinitisHUANG Jiali1 Review YANG Shurong2〓Guidance 1.Department of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine,Nanchang 330000, Jiangxi, China 2.Department of Otolaryngology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, Jiangxi, ChinaAbstract: The occurrence and development of allergic rhinitis involves a variety of signal transduction pathways. Studying signal transduction pathways can promote the progress of pathogenesis research, suggesting that we can block the conduction of pathways in a pathway to achieve therapeutic effects. Open up new prospects for designing and developing more effective new drug treatments.The common signaling pathways in allergic rhinitis are reviewed in this article to provide a reference for the treatment of allergic rhinitis. Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (4): 125-129.   DOI: 10.6040/j.issn.1673-3770.0.2019.355 Abstract （1243）      PDF（pc） （379KB）（319）       Save The occurrence and development of allergic rhinitis involves a variety of signal transduction pathways. Studying signal transduction pathways can promote the progress of pathogenesis research, suggesting that we can block the conduction of pathways in a pathway to achieve therapeutic effects. Open up new prospects for designing and developing more effective new drug treatments.The common signaling pathways in allergic rhinitis are reviewed in this article to provide a reference for the treatment of allergic rhinitis. Reference | Related Articles | Metrics

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Interpretation of “The Third Edition of the International Classification of Sleep Disorders(ICSD)”. SHANG Wei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2016.386 Abstract （3420）      PDF（pc） （1002KB）（2372）       Save The third edition of the International Classification of Sleep Disorders(ICSD-3)is the key reference for the diagnosis of sleep disorders. ICSD-3 is built on the same basic outline as ICSD-2, preserving the major diagnostic classifications. Significant modifications have been made to the nosology of insomnia, narcolepsy, and sleep-related breathing disorders. Major changes of the manual are reviewed in this article. Reference | Related Articles | Metrics

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Advances in the application of hyaluronic acid in chronic sinusitis CAO Xuan,XIAO Xuping, LI Yunqiu Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (3): 104-109.   DOI: 10.6040/j.issn.1673-3770.0.2021.226 Abstract （797）      PDF（pc） （452KB）（344）       Save In otolaryngology-head and neck surgery, chronic sinusitis is a common disease that affects 5%-12% of the population with a complex etiology and pathophysiological mechanism. Drug and surgical treatment for this disease are constantly being improved. Hyaluronic acid(HA), through various pathways, is widely used in clinical practice in patients with chronic rhinosinusitis(CRS). This paper aims to explain the possible mechanism of action of hyaluronic acid in CRS and its current application in achieving the treatment mode, as well as explore the possible future treatment mode of HA to improve the clinical treatment of CRS. Reference | Related Articles | Metrics

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Acute sinusitis combined with orbital cellulitis and intracranial infection in a child: a case report and literature review LU Huan, HE Benchao, LIAO Hongming Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 46-50.   DOI: 10.6040/j.issn.1673-3770.0.2022.549 Abstract （127）      PDF（pc） （2380KB）（164）       Save Acute sinusitis is a common inflammatory reaction disease of the nasal cavity and sinus mucosa, which can extend to adjacent tissues or organs, such as the orbit and intracranial regions. Children often experience sinusitis, which is affected by anatomical and functional dysplasia of the sinuses and is prone to complications. The main complication is orbital cellulitis; however, additional intracranial complications can occur if treatment is not administered in a timely manner. When conservative treatment is ineffective, surgical treatment should be pursued. The present study retrospectively analyzed clinical data from a patient with orbital cellulitis complicated by intracranial infection caused by acute sinusitis, followed by a review of the relevant literature aimed at deepening understanding of this disease. Reference | Related Articles | Metrics

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Idiopathic macular hole surgery prognosis based on macular hole size LI Hao, ZHOU Fang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    DOI: 10.6040/j.issn.1673-3770.0.2014.012

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Obesity and obstructive sleep apnea. LI Yanzhong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 1-4.   DOI: 10.6040/j.issn.1673-3770.0.2016.404 Abstract （956）      PDF（pc） （1088KB）（947）       Save The relationship between obesity and obstructive sleep apnea-hypopnea syndrome(OSAHS)has become a new hot spot in the research of sleep-disordered breathing. Whether there is a cause-and-effect or accompanying relationship between them is not yet clear. Compared with craniofacial malformations, obesity is more likely to induce obstructive sleep apnea syndrome(OSA). The frequency and severity of OSA are related to BMI and obesity. This paper discusses the relationship from four aspects: lipid metabolism disorder, fatty liver, metabolic inflammation, and oxidative stress. Reference | Related Articles | Metrics

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To analyze the mortality trend of nasopharyngeal carcinoma based on Joinpoint regression and an age-period-cohort model DAI Honglei, WANG Qiuyang, MA Wenxue, GUAN Bin, QI Jingjing Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 27-31.   DOI: 10.6040/j.issn.1673-3770.0.2022.440 Abstract （102）      PDF（pc） （1535KB）（86）       Save Objective To explore the long-term development trend of nasopharyngeal carcinoma mortality in China from 1990 to 2019. Methods Data obtained from the GHDx database established by the Global Burden of Disease Project was analyzed in this study. The Joinpoint regression model was used to analyze the trend of NPC mortality in China, and the age-period-cohort model was used to estimate the age effect, period effect, and cohort effect on nasopharyngeal carcinoma mortality risk in China. Results Overall, from 1990 to 2019, the nasopharyngeal carcinoma mortality rate in China showed a downward trend year by year. The Joinpoint regression model showed that the overall trend was divided into five segments, and the AAPC value was -2.454%. The trend of nasopharyngeal carcinoma mortality in males could be divided into five segments, with an AAPC value of -1.958%. The change trend of female nasopharyngeal carcinoma mortality can be divided into six segments, and the AAPC value was -3.498%. Additionally, increasing age significantly increases nasopharyngeal carcinoma mortality, and the cycle effect of mortality generally shows an upward trend. Conclusion The cohort reduction effect may lead to a decrease in nasopharyngeal carcinoma mortality, while an increase in age and the cycle effect may lead to an increase in cancer mortality. Reference | Related Articles | Metrics

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Multicentric plasma cell type Castleman disease involving multiple sites in children: a case report and literature review CHEN Kun, LU Hui, LI Lei, ZHANG Fan, YANG Jun, HUANG Qi Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 54-58.   DOI: 10.6040/j.issn.1673-3770.0.2022.329 Abstract （98）      PDF（pc） （5428KB）（152）       Save Objective To explore the pathogenesis, clinical presentation, diagnostic basis, differential diagnosis, and treatment options for multicentric Castleman disease. Methods Clinical data of a child diagnosed with multicentric Castleman disease of the plasma cell type were retrospectively analyzed, and the relevant literature was summarized. Results Multicentric Castleman disease is characterized by unclear pathogenesis and often lacks typical clinical manifestations and pathological features, making its diagnosis extremely challenging. In this case, the child received treatment with rituximab static drops, supplemented with dexamethasone, antibiotics, and gamma globulin to control the nasal infection and exudation. Following 28 days of treatment, the systemic disease subsided significantly and the blood biochemical index gradually recovered. After 13 months, the child had recovered well with no adverse effects or sequelae. Conclusion Multicentric Castleman disease is a rare lymphoproliferative disease, with rare occurrence in the nasal region. The current treatment plans mainly focus on adults, with limited reporting on children. Personalized treatment measures still need to be developed for children. Rituximab is a safe and effective treatment option for children with challenging surgical resection and unfavorable treatment outcomes. Reference | Related Articles | Metrics

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Progress in the research of intraocular lens power calculation formulas TAN Yan, LI Can Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (6): 95-98.   DOI: 10.6040/j.issn.1673-3770.0.2019.275 Abstract （2439）      PDF（pc） （311KB）（875）       Save With the development of phacoemulsification surgery, the calculation of intraocular lens power has been paid greater attention. Various intraocular lens power formulas have been presented to optimize the visual quality after surgery. This paper comprehensively describes the progress in the research of various intraocular lens power formulas, such as the first-generation intraocular lens formula, the second-generation formula, Hill-RBF, Barrett True-K, and so on. Reference | Related Articles | Metrics

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Application of acellular dermal matrix in otorhinolaryngological reconstructive surgery QIN He, SUN Jian-jun JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 75-77.   Abstract （925）      PDF（pc） （903KB）（1721）       Save The unique features of acellular dermal matrix make it one of excellent material for repairing tissue defects. This article reviews the histological characteristics of acellular dermal matrix and its application in otolaryngological reconstructive surgery. Related Articles | Metrics

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Clinical observation on the effects of three surgical methods for pterygium. WANG Dan, WANG Rui, ZHANG Qiming, WANG Liwen JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (2): 94-97.   DOI: 10.6040/j.issn.1673-3770.0.2015.372 Abstract （1222）      PDF（pc） （922KB）（670）       Save Objective To compare the therapeutic effects of simple pterygium excision, pterygium excision combined with free conjunctival flap transplantation and pterygium excision combined with autologous corneal limbus stem cell transplantation in the treatment of pterygium. Methods Totally 162 patients(186 eyes)were randomly divided into Group A, B and C. Group A were treated with simple pterygium excision, Group B with pterygium excision combined with free conjunctival flap transplantation, and Group C with pterygium excision combined with autologous corneal limbus stem cell transplantation. The recurrence rate, incidence of complications and change of tear function after surgeries were compared among the three groups. Result Group A was significantly lower than Group B and C in the cure rate, was higher than Group B and C in the incidence of complications and recurrence rate, and was longer than Group B and C in repair time(P<0.05). The incidence of complications, recurrence rate were lower and cure rate and repair time were better in Group C than those in Group B(P<0.05). The early postoperative tear films stability of Group B and C were better than that of Group A, with statistically significant difference(P<0.05). Conclusion Compared with single pterygium excision and pterygium excision combined with free conjunctival flap transplantation, pterygium excision combined with autologous corneal limbus stem cell transplantation is an effective method to treat pterygium,which can reduce the rate of complications, the recurrence,and improve tear function for patients with pterygium. Reference | Related Articles | Metrics

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Perioperative treatment in endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma CHEN Guojing, CAI Xiaolan, LI Xuezhong, ZHANG Liqiang, ZHU Huitao JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (3): 35-38.   DOI: 10.6040/j.issn.1673-3770.0.2015.125 Abstract （1417）      PDF（pc） （915KB）（564）       Save Objective To explore the perioperative medicine treatment and notes of endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps(CRSwNP) and asthma. Methods From June 2010 to December 2013, 109 patients with CRSwNP accompanying with asthma were treated by endoscopic sinus surgery(ESS). All patients with asthma were evaluated pre-operation and performed ESS 6 months after completely controlled. Medication such as atomization inhalation and systemic corticosteroids were given to control and prevent asthma attack during peri-operation. Results No asthma attack happened during the treatment process. Only 1 patient had wheezing on the 2nd day post-operation by oral analgesics. Endoscopy examination was administrated in a follow-up period of 1 to 3 years after the surgery. Among them, 5 patients(4.59%) were completely controlled, 94(86.24%) were partly controlled and 10(9.17%) were not. Only 1 patient was treated with operation because of avascular necrosis of the femoral head 13 months after ESS. Conclusion It is useful to prevent asthma attack and improve ESS efficacy in CRSwNP that depends on asthma evaluation before ESS and rigorous medicine peri-operative treatment. Reference | Related Articles | Metrics

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Meta-analysis of the curative effect of traditional Chinese medicine decoction combined with conventional western medicine on allergic rhinitis ZHU Zhengru, ZHANG Xiaobing Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (3): 281-289.   DOI: 10.6040/j.issn.1673-3770.0.2020.519 Abstract （647）      PDF（pc） （5868KB）（146）       Save Objective Meta-analysis was conducted to explore the influence of combined Chines decoctione and conventional western medicine on the short-term and long-term efficacy of allergic rhinitis. Methods Computer retrieval Chinese National Knowledge Infrastructure(CNKI), Wan Fang Data, VIP, CBM, Pubmed, Embase, The Cochrane Library databases of combining traditional Chinese and western medicine treatment of allergic rhinitis in clinical research of randomized controlled trials, from building Library retrieval timeuntil October 2020. After quality evaluation and relevant data extraction by two professional researchers, RevMan5.3 software and Stata 15.0 software were used for Meta analysis. Results In the end into the 20 research, a total of 2056 patients, using fixed effect model to the total effect value to merge, Meta analysis results show that the recent effective rate of combining traditional Chinese decoctione and conventional western medicine treatment of allergic rhinitis was superior to that of control group ［RR=1.18, 95%CI(1.13,1.22), P<0.001］, long-term effectiveness significantly better than control group ［RR=1.79, 95%CI(1.50,2.13), P<0.001］, After classification, the short-term effective rates of tonifying fei-qi method, fortifying the Spleen and boosting qi method and Qingxuan-fei-qi method combined with conventional western medicine were all better than those of the control group. Meta-analysis results were ［RR=1.17, 95%CI(1.11,1.23), P<0.001］,［RR=1.18, 95%CI(1.09,1.29), P<0.001］,［RR=1.18, 95%CI(1.10,1.26), P<0.001］, respectively. the difference is statistically significant. In this study, funnel plot showed the basic symmetry between the left and the right, and the begg bias test was used to obtain P=0.069>0.05 means that the publication bias of the 19 literatures selected in this study is small. Conclusion This study shows that the combined treatment of Chinese medicine decoction and conventional western medicine for AR is superior to the treatment of western medicine alone in both short-term and long-term efficacy. Reference | Related Articles | Metrics

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Meta-analysis of clinical intradermal acupuncture efficacy for treatment of allergic rhinitis ZHAI Rui, LI Yuan, YU Jinglong, CHEN Xi, ZHENG Youyou, LIU Zhaolan, WANG Junhong Journal of Otolaryngology and Ophthalmology of Shandong University    2023, 37 (3): 35-45.   DOI: 10.6040/j.issn.1673-3770.0.2022.364 Abstract （470）      PDF（pc） （1352KB）（190）       Save Objective To systematically evaluate the clinical efficacy and safety of intradermal acupuncture in the treatment of allergic rhinitis using Meta-analysis. Methods PubMed, The Cochrane Library, Web of Science, SinoMed, VIP, CNKI, and Wanfang databases were searched for randomized controlled trials which used intradermal acupuncture to treat allergic rhinitis from database inception to October 1, 2022. Two researchers conducted independent screening, data extraction, bias risk assessment, and meta-analysis of the literature. Results This study included 29 clinical trials and 2342 patients. Compared with the positive control group, the intradermal acupuncture combined therapy group showed improvements in clinical total effective rate ［RR=1.24, 95%CI(1.16, 1.33), P<0.001］, quantitative scores of symptoms and signs ［MD=-0.67, 95%CI(-1.12, -0.22), P=0.003］, visual analogue score of nasal symptoms ［MD=-0.62, 95%CI(-0.97, -0.28), P<0.001］, number of recurrences ［RR=0.58, 95%CI(0.41, 0.82), P=0.002］, nasal resistance ［MD=-0.13, 95%CI(-0.21, -0.05), P=0.001］, and quality of life score for nasal conjunctivitis［MD=-4.17, 95%CI(-6.06, -2.29), P<0.001］. Compared with antihistamines, there was no significant difference in clinical total effective rate［RR=1.01, 95%CI(0.92, 1.11), P=0.78］ and quality of life score for nasal conjunctivitis［MD=0.43, 95%CI(-1.78, 2.65), P=0.70］ after treatment. No serious adverse reactions occurred after intradermal acupuncture treatment. Conclusion Using intradermal acupuncture to treat allergic rhinitis shows good curative effects and safety, and can reduce recurrence rates and nasal resistance, as well as improve quality of life. Due to the limits of our experimental design and issues related to the quantity and quality of original literature, the results of our meta-analysis still need to be further verified. In the future, relevant research should utilize other methodologies and strict experimental designs to provide more powerful, high-quality evidence-based data for the development of clinical diagnosis and treatment guidelines. Reference | Related Articles | Metrics

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Efficacy of Omalizumab in children with moderate and severe allergic asthma and chronic sinusitis CHONG Weikun, WANG Juan Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 21-26.   DOI: 10.6040/j.issn.1673-3770.0.2022.544 Abstract （198）      PDF（pc） （2565KB）（160）       Save Objective To investigate the efficacy of Omalizumab in the treatment of children with moderate to severe allergic asthma and chronic sinusitis. Methods The clinical data of children with moderate and severe allergic asthma and chronic sinusitis treated with Omalizumab from September 2020 to April 2022 were retrospectively analyzed. A comparison was performed on the changes of childhood asthma control test(C-ACT), fractional concentration of exhaled nitric oxide(FeNO), forced expiratory volume in the first second percentage to predicted value(FEV1% pred)and small airway function, the improvement of chronic sinusitis symptoms,before and after treatment with Omalizumab. Results A total of 26 children completed treatment and follow-up. After 16 weeks of Omalizumab treatment, asthma symptoms and lung function were improved. Compared to pre-treatment, the C-ACT score increased from(15.57±3.25)score to(24.98±5.21)score(F=15.711 2, P<0.001)and FeNO decreased from(31.55±15.57)ppb to(19.86±9.80)ppb(F=4.426 5, P=0.002 2). Lung function indicators showed that FEV1%pred and FEV1/forced vital capacity(FEV1/FVC)increased post-treatment, but the differences were not statistically significant(P=0.995 4, P=0.938 2). The maximal expiratory flow percentage of the predicted value, forced expiratory flow at 75% to predicted value, forced expiratory flow at 50% to predicted value all increased significantly(P=0.047 7, P=0.000 5, P<0.001). The symptoms of sinusitis were also significantly improved, and the visual analogue scale score increased from 6.40±2.98 pre-treatment to 0.85±0.40 post-treatment(t=27.241 9, P<0.001). Conclusion Omalizumab can significantly improve the clinical symptoms, lung function indicators and quality of life of children with moderate and severe allergic asthma and chronic sinusitis. Reference | Related Articles | Metrics

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Animal model of obstructive sleep apnea syndrome in rats LIU Zhonglu, WANG Yan， LI Yanzhong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    Abstract （2088）      PDF（pc） （365KB）（1980）       Save To build up a steady and credible animal model of obstructive sleep apnea syndrome(OSAS)． MethodsSodium Hyaluronate was injected into the palatoglossal arch， palatopharyngeal arch and root of the tongue of eight Wistar rats. An electroencephalogram, electromyogram and oronasal airflow were recorded by PSG before and 4 weeks after injection when rats were under light anesthesia, which was expected to be similar to the sleep state. ResultsWhen the animals were under light anesthesia, the electroencephalogram and electromyogram were similar to the sleep state. All animals showed apnea with unusual movements of the thorax and the abdomen before and 4 weeks after injections. Differences between apnea index(AI) and the longest apnea before and after injection of Sodium Hyaluronate was obvious(P＜0.05). ConclusionAn animal model of OSAS in rats established by injection of Sodium Hyaluronate was steady, credible and similar to OSAS of human beings. It can be used to study the pathogenesis, pathological and physiological changes, and complication of OSAS. Related Articles | Metrics

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Detection of serum total IgE and allergen-specific IgE in healthy adults and its significance. YUAN Yuan, WU Zhongfei, CHAO Changjiang, LU Meiping, TIAN Huiqin, CHENG Lei JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 34-38.   DOI: 10.6040/j.issn.1673-3770.0.2016.259 Abstract （4282）      PDF（pc） （1217KB）（2230）       Save Objective To explore the scientific significance and practical application of serum levels of total IgE(tIgE)and allergen-specific IgE(sIgE)in excluding allergen sensitization. Methods A total of 536 volunteers including 347 males and 189 females, aged 19-60 years with median age of 38 years old received the healthy physical examination were recruited in the study. All the subjects had no history and symptoms of allergic diseases as well as systemic diseases. Serum tIgE was detected by the capture enzyme-linked immunosorbent assay. The tIgE level ≤100 kU/L represented negative while >100 kU/L positive. Serum sIgE was assessed by means of the Phadiatop test using the fluoroimmunoassay. The Phadiatop class 0 means negative and class ≥1 positive. Results Serum level of tIgE among healthy adults was 1.14-1 703.70(median 37.18)kU/L, and it was significantly higher in males than in females(P=0.001). The negative and positive rates of serum tIgE were 72.52% and 27.48%, respectively. Serum level of sIgE(Phadiatop)among healthy adults was 0.01-59.50(median 0.05)kU/L, which had no significant significance between the male and the female(P=0.154). The negative and positive rates of Phadiatop were 82.09% and 17.91%, respectively. There were no statistically significant differences in serum tIgE and sIgE levels among different age groups(P=0.119 and P=0.225, respectively). The Spearman rank correlation coefficient between serum tIgE and sIgE levels was 0.683 with statistical significance(positive correlation, P<0.001). There were 368 subjects(94.85%)with negative Phadiatop and 20 subjects(5.15%)with positive Phadiatop in the serum tIgE negative subjects(n=388), while 75 山东大学耳鼻喉眼学报30卷4期 -袁源,等.健康成人血清总IgE和变应原特异性IgE检测及意义 \=-subjects(51.02%)with positive Phadiatop and 72 subjects(48.98 %)with negative Phadiatop in the serum tIgE positive subjects(n=147). Conclusion More than one fourth subjects among healthy adults have a serum tIgE level higher than 100 kU/L, while less than one fifth subjects have a sensitization to inhaled allergens. There is an obvious correlation between the serum levels of tIgE and sIgE. The serum tIgE level below 100 kU/L may have a clinical value to exclude allergen sensitization; however, the sensitized status may not be confirmed when the tIgE level is higher than 100 kU/L, and case history and clinical manifestations also should be considered. Reference | Related Articles | Metrics

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Amyloidosis of the head and neck: a clinicopathological study of 23 cases LIU Yaqin, ZHANG Liqing, ZHANG Jiacheng, DONG Weida, ZHOU Han Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (1): 72-77.   DOI: 10.6040/j.issn.1673-3770.0.2019.464 Abstract （1307）      PDF（pc） （4404KB）（367）       Save Objective The objective of this study was to investigate the clinical features,diagnosis, treatment, and prognosisofamyloidosis of the head and neck region. Methods The clinical data of 23 patients who were pathologically diagnosed with amyloidosis and admitted to our hospital from the April of 2007 to October 2018 were collected and analyzed. Results The study included 16 patients with primary localized amyloidosis and 7 patients with secondary localized amyloidosis. All the patients received surgical treatment. Postoperative follow-up ranged from 5 months to 11 years. Recurrence was observed in 2 patients who presented with multiple-localized amyloidosis, hoarseness, and foreign body sensation. Conclusion Clinical manifestations of amyloidosis of the head and neck region are variable. This disease develops slowly and tends to recur. The laryngoscopic characteristics are diverse and necessitate distinction from other tumors.However, it can be diagnosed by staining with Congo red in pathological sections. Treatment of amyloidosis is mostly surgical and based on long-term follow-up. Reference | Related Articles | Metrics

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null GONG Xiang-rong, WANG Gui-sheng, YANG Guo-jian, SUN Yan-qing, CUI Hong JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 55-57.   Abstract （905）      PDF（pc） （904KB）（1480）       Save null Related Articles | Metrics

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Relationship between Friedman OSA staging and ZPPP plus GAHM SUN Xiao-qiang1, YI Hong-liang2, CAO Zhen-yu2, ZHANG Yu-jun2 JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 8-9.   Abstract （1772）      PDF（pc） （1023KB）（2533）       Save Objective To explore the relationship between Friedman OSA staging and genioglossus advancement and hyoid suspension(GAHM) plus Z-palatopharyngoplasty(ZPPP). Methods 26 patients with severe OSAHS (AHI>40)were performed GAHM plus ZPPP. The obstructive sites were identified in both oropharynx and hypopharynx. The follow up lasted at least 6 months postoperatively. The Chi square test was used to compare the preoperative and postoperative results. Results Satistying clinic results for the patients with Friedman OSA stages Ⅱ were 100%, while the overall success rate of Friedman OSA stages Ⅲ was 22.2%. Conclusion ZPPP plus GAHM is an effective method for patients with Friedman OSA stages Ⅱ. Related Articles | Metrics

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lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus DI Guohua, LIU Junru, ZHAO Yanxiang, GAO Yingkai JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (6): 5-7.   DOI: 10.6040/j.issn.1673-3770.0.2015.253 Abstract （3373）      PDF（pc） （893KB）（1246）       Save Objective To explore the clinical efficacy of lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus. Methods A total of 90 cases of idiopathic tinnitus were randomly divided into treatment group and control group. The treatment group was treated by two simultaneous methods. The first method used intravenous drip of drugs to nurture nerves and to improve blood circulation in the inner ear. The other one was to combine 2% lidocaine with retroauricular injection of gastrodine. The control group received the first treatment only. One course of treatment lasted for 14 d. All patients were followed up for 3 months. Results The total efficacy of treatment group and control group was 84.44% and 55.56%, respectively. After 3-month of follow-up, the total efficacy of treatment group and control group was 82.22% and 55.11%, respectively. There was statistical difference between the statistics (P<0.05). No obvious adverse effects were observed. Conclusion Combination of 2% lidocaine and gastrodine injection is simple and effective in the treatment of idiopathic tinnitus. Reference | Related Articles | Metrics

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Clinical significance of grading low middle fossa tegmen plate with high-resolution computed tomography SUN Xiaowei, LI Dongmei, DOU Fenfen, ZHANG Zihe, ZHANG Jianji, DING Yuanping, SHI Li JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (6): 22-25.   DOI: 10.6040/j.issn.1673-3770.0.2015.209 Abstract （2159）      PDF（pc） （1810KB）（1787）       Save Objective To observe the effect of high-resolution computed tomography (HRCT) grading of low middle fossa tegmen plate on the elimination of diseased tissue in epitympanum and to investigate the grading standard of low middle fossa tegmen plate. Methods The CT images obtained from 87 chronic otitis media (COM) cases were subjected to coronal reconstruction. A horizontal tangent L1 at the highest point along the upper wall of external auditory canal, a horizontal tangent L2 at the highest point of the semicircular canal structure, and a horizontal tangent L3 at the lowest point along the middle fossa tegmen plate were created to measure the distance between L1 and L2, L1 and L3, and to calculate the r value (b/a). The r value was used to divide the low middle fossa tegmen plate into five grades: non-low, mild, moderate, severe, and absolute low. Pre-operative evaluation and postoperative results were compared. Results Surgeons had different opinions on the r value: (1) If r < 1/4, the low middle cranial fossa cover identified by the Radiation Department could not be accepted. (2) If 1/4 ≤ r < 1/3, the low middle cranial fossa cover identified by the Radiation Department could be accepted, but it was not mentioned in the operation record. (2) If 1/3 < r ≤ 1/2, wearing was found at the bottom wall of the middle fossa tegmen plate upon clearing the diseased tissue, and the operation would be affected because of bleeding. (4) If 1/2 < r ≤3/4, the surgeons were able to identify the low middle fossa tegmen plate before operation; but some cases' back wall of the external auditory canals could be preserved after the diseased tissue in the epitympanum was cleared. (5) If r > 3/4, the surgeons experienced difficulty in finding the trum tympanicum and pathway behind the ear because the low middle fossa tegmen plate wore down the back wall of external auditory canal. Conclusion The r value can be used to divide the low middle fossa tegmen plate into five grades: non, mild, moderate, severe, and absolute low. Mild grade has no effect on the removal of lesions,moderate grade makes the removal of lesions difficult, severe grade requires destruction of the back wall of external auditory canal, and absolute low grade means wearing down of the back wall of external auditory canal is inevitable. Reference | Related Articles | Metrics

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Association of glycosylated hemoglobin variation index with diabetic retinopathy severity HE Jing, LEI Chunyan, ZHANG Meixia Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (2): 34-40.   DOI: 10.6040/j.issn.1673-3770.0.2023.376 Abstract （39）      PDF（pc） （1067KB）（52）       Save Objective This study investigated the correlation between hemoglobin variation index(HGI)and the severity of retinopathy and macular edema in patients with type 2 diabetes mellitus(T2DM). Methods A total of 294 T2DM patients were enrolled. Based on the 2022 International Academy of Ophthalmology diagnostic criteria for diabetic retinopathy(DR), patients were classified into: proliferative DR(PDR), non-PDR(NPDR), and no microangiopathy(NC). DR severity was further categorized as mild NPDR, moderate NPDR, severe NPDR, and PDR. According to the international grading standards for diabetic macular edema(DME), patients were categorized as: central involved DME(CI-DME), non-central involved DME(NCI-DME), and no central involved DME(NDME). DME severity: NCI-DME <CI-DME. General clinical data were collected, and HGI differences between groups were analyzed. Results Patients with NPDR and PDR group had significantly higher HGI than those with NC. PDR patients had higher HGI than NPDR patients. Similarly, NCI-DME and CI-DME patients had significantly higher HGI than NDME patients, with CI-DME having the highest HGI. Univariate Logistic regression analysis revealed significant correlations between the presence of DR and T2DM, course of diabetes(P<0.01), body mass index(P=0.01), diastolic blood pressure(P=0.04), HGI(P=0.01), fasting plasma glucose(P=0.04), and HbA1c(P=0.01). Additionally, a significant correlation(P<0.001)was found between HGI and DR severity. Conclusion HGI is closely associated with the severity of both DR And DME in T2DM patients. Reference | Related Articles | Metrics

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Relationship between allergic diseases and mental-psychological factors FAN Chang'e, ZHANG Junjing, WANG Hongtian, MA Tingting, WANG Xueyan Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 101-105.   DOI: 10.6040/j.issn.1673-3770.0.2022.391 Abstract （105）      PDF（pc） （414KB）（148）       Save Allergic diseases are a major class of diseases mediated by immunoglobulin E, affecting about 20% of the global population. Parallel to the increase in the prevalence of allergic diseases is the increase in various social and psychological pressures. The placebo and nocebo effects of allergic diseases suggest that psychosocial factors are closely related to allergic diseases. Psychological intervention and treatment cannot be ignored. Clinicians must follow the new medical model of biology psychology society, break the vicious cycle of mental psychology and allergic diseases in a timely manner, and improve the treatment efficiency of allergic diseases.The paper reviews the interrelationships between allergic diseases and psychological problems. This article reviews the relationship between allergic diseases and psychosocial problems in order to provide guidance for clinical practice. Reference | Related Articles | Metrics

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Clinical features and diagnosis of allergic rhinitis. YAN Aihui, HAN Jiali JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 7-9.   DOI: 10.6040/j.issn.1673-3770.0.2016.243 Abstract （1533）      PDF（pc） （979KB）（849）       Save Reference | Related Articles | Metrics

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Evaluation of voice and mental state in patients with functional dysphonia ZHANG Kaiting, LIU Jie, XU Zhenju, ZHANG Xiaoxue, CAO Songli, HAN Min Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (3): 37-41.   DOI: 10.6040/j.issn.1673-3770.1.2020.114 Abstract （1927）      PDF（pc） （656KB）（281）       Save Objective We aimed to explore the clinical importance of voice and mental state assessment in the diagnosis and treatment of functional speech disorders. Methods We selected 72 patients with functional dysphonia(experimental group)and 40 individuals without dysphonia(control group)from the Department of Otolaryngology, Affiliated Hospital of Qingdao University, from August 2017 to October 2020. In the functional dysphonia group, 50 individuals had enhanced dysphonia and 22 had diminished dysphonia. All patients underwent voice assessment, evaluation using the Grade, Roughness, Breathiness, Asthenia, Strain(GRBAS)scale and voice handicap index(VHI)scale, dynamic laryngoscopy, and evaluation of anxiety(Self-Rating Anxiety Scale, SAS)and depression(Self-Rating Depression Scale, SDS). We compared evaluation results of the various indicators between the two groups. Results In the experimental group, the GRBAS score was 1.92±1.03 and the VHI score was 58.43±23.17. Vocal cord closure, mucosal wave, symmetry, and periodicity scores in the experimental group were significantly different from those of the control group, in stroboscopic examination. In computer voice evaluation, the frequency perturbation, amplitude perturbation, and maximum sound time in the experimental group were significantly different from these values of the control group. We found significant differences in SAS and SDS scores between the experimental and control groups. Conclusion Voice and mental state assessment are important for guiding the diagnosis and treatment of patients with functional phonation disorder. Reference | Related Articles | Metrics

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Advancements in surgical repair after maxillectomy LI Yanan，,HUANGFU Hui Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (5): 113-117.   DOI: 10.6040/j.issn.1673-3770.0.2020.326 Abstract （1057）      PDF（pc） （380KB）（272）       Save Maxillary defects can result from trauma, congenital malformation and other causes, but are mostly caused after malignant tumor resection. Postoperative defects of key anatomical structures severely damage the patient's esthetic appearance and cause the loss of swallowing, pronunciation, chewing and others functions, leading to physical and mental trauma. Therefore, the anatomical complexity of the maxilla makes reconstruction surgery one of the most difficult challenge for surgeons. However, there is no unified classification system or corresponding method for maxillary defect repair. This review is aimed at summarizing the classification system for maxillary defects, repair types, advantages and disadvantages, repair methods and future prospects of maxillary defect classification. Reference | Related Articles | Metrics

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The correlation between arterial blood gas analysis and hearing screening results in neonates PAN Linlin, FANG Xuhua, ZHAI Feng, GUI Yiding, BIAN Zhouliang, CHEN Jie Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (1): 20-24.   DOI: 10.6040/j.issn.1673-3770.0.2021.350 Abstract （714）      PDF（pc） （543KB）（152）       Save Objective This study aimed to examine the relationship between arterial blood gas and hearing screening test in neonates. Methods The results of hearing screening test and arterial blood gas analysis of 496 newborns in the Neonatal Department of Shanghai Children's Medical Center were retrospectively analyzed. Results The pass rate of automated auditory brainstem response(AABR), distortion product otoacoustic emissions(DPOAE)and acoustic immittance is 61.9%(307/496), 61.3%(304/496), 90.1%(447/496)and 56.7%(281/496)respectively. There were significant differences in the pass rates of the three hearing screening methods(χ2=131.00, P<0.001). The pass rate of AABR was in extremely strong consistency with that of DPOAE(Kappa=0.817, P<0.001), while the pass rate of both AABR and DPOAE were in very weak consistency with that of acoustic immittance(Kappa=0.262 and 0.256, respectively. all P<0.001). Univariate Logistic regression analysis showed that the failure of hearing screening was correlated with increased lactic acid(OR=0.544, P=0.001), increased partial pressure of carbon dioxide(OR=1.917, P=0.009)and decreased pH value(OR=1.692, P=0.021). Multivariate Logistic regression analysis showed that failed hearing screening results were correlated with increased lactic acid(OR=0.627, P=0.018)and decreased partial oxygen pressure(OR=1.493, P=0.047). No significant correlations were found between hearing screening and the results of partial pressure of carbon dioxide, pH and blood oxygen saturation(P>0.05). Conclusion Neonatal hypoxia and the accompanying change of blood gas might have an impact on hearing screening results. Reference | Related Articles | Metrics

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Research progress on the pathogenesis and control of ocular toxoplasmosis ZHANG YuOverview,QU YiGuidance Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (5): 70-76.   DOI: 10.6040/j.issn.1673-3770.0.2022.076 Abstract （466）      PDF（pc） （498KB）（294）       Save Ocular toxoplasmosis is a unilateral necrotizing retinochoroiditis caused by intraocular infection with Toxoplasma gondii. When people are infected with T.gondii, tachyzoites can cross the blood-retinal barrier and infect most nucleated cells to directly cause tissue damage. At the same time, they can also cause a series of excessive cellular immune responses to further aggravate tissue damage and cause visual impairment. Finally, tachyzoites can create an equilibrium between parasite invasion and host resistance, thus forming tissue cysts in the host. Aside from the traditional drug treatment of pyrimethamine and sulfadiazine in clinical practice, new combined treatment programs and anti-T.gondii compounds have also been studied and applied to achieve precise treatment and reduce the toxic and side effects of systemic drugs. This article focuses on reviewing the pathogenesis and control of ocular toxoplasmosis, together with the current clinical predicaments, so as to provide a theoretical basis for the diagnosis and treatment of this disease in the future. Reference | Related Articles | Metrics

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Pedicled superficial temporal fascia flap and local skin graft combined with cartilage transplantation effectively repair cartilage scaffold exposure in auricular reconstruction LIU Yuhong, BO Lin, LIU Xingang, SU Faren, MA Qifa Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 9-12.   DOI: 10.6040/j.issn.1673-3770.0.2023.316 Abstract （98）      PDF（pc） （7164KB）（81）       Save Objective The study aimed to investigate the therapeutic efficacy of transplantation and concealment by pedicled superficial temporal fascia flap and local skin grafting in conjunction with cartilage transplantation for the repair of exposed cartilage scaffolds following auricular reconstruction. Methods Six patients with cartilage scaffold exposure post-auricular reconstruction surgery underwent treatment. Granulation tissue and necrotic cartilage were thoroughly removed from the wound. In cases of cartilage defects, the repair involved utilizing either residual ear cartilage or autogenous costal cartilage. Subsequently, we flipped over the superficial temporal fascia flap to concealment by the exposed cartilage and employed a medium-thickness free skin graft for skin grafting. Results All surgical wounds healed through primary intention and grafts exhibited complete survival. Postoperative follow-ups ranging from 3 months to 3 years revealed a reconstructed ear with a realistic shape, distinct contour, and no recurrence of cartilage exposure or other issues. The patients expressed satisfaction with the surgical outcome. Conclusion The application of transplantation and concealment by pedicled superficial temporal fascia flap and local skin grafting for repairing cartilage scaffold exposure after auricular reconstruction yielded good results worthy of clinical recognition and application. Reference | Related Articles | Metrics

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Helicobacter pylori in throat swabs of patients with chronic pharyngitis under a multifunction microscopy LI Li-Na, ZHANG Yan-Ping, LIU Jin-Wei, MA Lei, ZHANG Zong-Lin, DENG Hui-Yan, LUO Xiao-Pei, WANG Ya-Ying, ZHOU Feng-Shu JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2009, 23 (3): 60-62.   Abstract （2193）      PDF（pc） （265KB）（1727）       Save Objective   To explore the helicobacter pylori（HP） distributions by  multifunction microscopy in pharyngeal secretion of patients with chronic pharyngitis. Methods   From September 2005 to December 2007, 295 patients with chronic pharyngitis and 30 controls were subjected to throat swab tests by multifunctional microscopy with 20000 magnification. Assessment was conducted by one professional worker. A Chi-square test was used to explore the statistical significance in terms of the outcome in the two groups. Results   In the chronic pharyngitis group, HP was positive in 229 patients（77.63%，229/295）and negative in 66 ones（22.37%，66/295）. In the control group, HP was found in only 2 individuals（6.67%，2/30）and the rest were negative（93.33%，28/30）. The infective rate of HP was statistically significant between the chronic pharyntitis group and the control group (χ2=6.670，P＜0.05). Conclusions   Helicobacter pylori might be a pathogen of chronic pharyngitis that has been neglected by physicians for a long time. Multifunction microscopy may provide a new method to screen HP in patients with chronic pharyngitis. Related Articles | Metrics

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Radiofrequency ablation combined with endoscopy for nasal inverted papillomo LIU Ji-yuan, SHE Zhi-qiang, LONG Zeng-yong, LU Ling-juan JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 42-43.   Abstract （2093）      PDF（pc） （895KB）（1664）       Save Objective   To anaylze the clinical effect of radiofrequency ablation combined with endoscopy for nasal inverted papillomo(NIP). Methods   The clinical data of 23 cases of NIP treated by radiofrequency ablation combined with endoscopy from 2007 to 2010 were retrospectively analyzed. Results   Followed up for 6 months,  nasal obstruction disappeared and nasal ventilation was obviously improved. No patient had septal perforation and nasal deformity after the operation, and no complications occurred. Conclusion   Radiofrequency ablation combined with endoscopic is a safe and reliable method for NIP. Related Articles | Metrics

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null ZHANG Xiu-ping, HU Hai-peng, LIU Yun-xia JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 69-71.   Abstract （955）      PDF（pc） （1392KB）（1856）       Save null Related Articles | Metrics

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Advances in T-bet and TGF-β in allergic rhinitis CHEN Fang, LI Xiao-yan. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 83-86.   Abstract （1070）      PDF（pc） （982KB）（1594）       Save The differentiation balance of Th1/Th2 is affected by T-box expression in T cells (T-bet), which is responsible for Th1 cell development, inhibits the T lymphocyte immune and plays an important role in the regulation of the immune response. Transforming growth factor-β(TGF-β) as a multifunctional cytokine, mainly  realize Th1 differentiation blockade through the inhibition of T-bet. The review aims to summarize current knowledge about T-bet and TGF-β involvement in the biological characteristics， the role in Th1/Th2 cell differentiation and in allergic rhinitis pathogenesis. Related Articles | Metrics

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Detection and clinical application of nasal nitric oxide Zhiwen CHEN,Lei CHENG Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 124-128.   DOI: 10.6040/j.issn.1673-3770.1.2019.026 Abstract （4326）   HTML （41）    PDF（pc） （437KB）（2015）       Save Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO）examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable. Reference | Related Articles | Metrics

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Unilateral vocal cord paralysis as the initial manifestation of parathyroid adenoma: a case report and literature review WANG Tingyu, LÜ Zhenghua, HAN Qianqian, SUN Zhen, ZHANG Haiyan, XU Wei Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 59-65.   DOI: 10.6040/j.issn.1673-3770.0.2022.476 Abstract （97）      PDF（pc） （6489KB）（152）       Save Objective To investigate the clinical diagnosis, treatment, and prognosis of parathyroid adenoma(PA)with unilateral vocal cord paralysis as the first symptom and to facilitate accurate diagnosis and proper treatment. Methods The clinical data of one patient with unilateral vocal cord paralysis as the initial manifestation of PA were retrospectively analyzed, along with a review and discussion of the relevant literature. Results Recurrent laryngeal nerve injury can be caused by benign parathyroid adenoma compression. However, unilateral vocal cord paralysis as the initial and only manifestation of parathyroid adenoma is rare and difficult to detect. Parathyroid adenoma located in the middle-lower region of the dorsal thyroid lobe and the inferior thyroid artery may sandwich and pinch the recurrent laryngeal nerve, causing nerve swelling and, subsequently, vocal cord paralysis. Subjective and objective voice evaluation, in combination with laryngeal electromyography before and after the operation, revealed that accurate diagnosis, timely PA resection, and decompression of the recurrent laryngeal nerve can rescue nerve function and vocal cord movement. Additionally, these interventions can revert patient parathyroid hormone and blood calcium levels to normal. Conclusion PA rarely damage the recurrent laryngeal nerve. When unilateral vocal cord paralysis is its first and only symptom, PA can be easily misdiagnosed or remain undiagnosed. In patients with unilateral vocal cord paralysis, if a benign parathyroid tumor is found, the possibility of benign tumor compression and recurrent laryngeal nerve dysfunction should be considered, especially if the tumor is located in the middle-lower region of the dorsal thyroid lobe, where the inferior thyroid artery branches into the gland. Timely surgical resection and nerve decompression are the best choices of treatment. Reference | Related Articles | Metrics

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Central retinal artery occlusion caused by facial filling with hyaluronic acid: a case report and literature review LI Shuting, ZHAO Hui, SI Mingwei, CUI Wenxuan, YANG Mengyao, WANG Hong Journal of Otolaryngology and Ophthalmology of Shandong University    2024, 38 (1): 66-71.   DOI: 10.6040/j.issn.1673-3770.0.2023.021 Abstract （112）      PDF（pc） （3380KB）（95）       Save Objective Through the case data of a patient with central retinal artery occlusion(CRAO)caused by hyaluronic acid filling in the nose, the study discusses the pathogenesis and treatment methods. Methods A female patient experienced a sudden loss of visual acuity with superior temporal visual obscuration in the right eye after receiving a nasal hyaluronic acid injection. After treatment at a local hospital, the patient came to our hospital for initial examination, and was treated with medication and external counterpulsation therapy. Results After 3 days of treatment, corrected visual acuity was 0.15 in the right eye; fundus examination showed enhanced optic disc edema and a decrease in the area of peripapillary white spots. Conclusion CRAO is a disease caused by central retinal artery occlusion and corresponding retinal nutrient supply deficiency. External counterpulsation has the distinction of being a non-invasive treatment(therefore avoiding the side effects of invasive treatment)and it is easy to administer and promote, and is an effective adjunctive treatment for CRAO. Reference | Related Articles | Metrics

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Localization of vocal cord paralysis by electronic fibrolaryngoscopic swallowing study LI Jin-rang， GUO Hong-guang JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 55-58.   Abstract （979）      PDF（pc） （1213KB）（1369）       Save Objective    To evaluate the application of electronic fibrolaryngoscopic swallowing study in the localization of vocal cord paralysis. Methods    The electronic fibrolaryngoscopic swallowing study was conducted in 15 patients with unilateral vocal cord paralysis. The duration of the disease varied from 5 days to 10 months. There were 5 cases of right side vocal cord paralysis and 10 cases of left side vocal cord paralysis. The lesions of vagus nerve were in the high level (at or above the ganglion of the vagus nerve) in 4 cases, low level (below the ganglion of the vagus nerve) in 4 cases, and unknown level in 7 cases. Results    There was residual food in the pyriform sinus on the paralysed side of the vocal cord in all the 4 cases with highlevel vagus nerve damage, but only one case with lowlevel vagus nerve damage. Among the patients with unknown lesions of vagus nerve, residual food in the pyriform sinus on the impaired side of the vocal cord was found in 2 cases but not in another 5 cases.  Conclusion    The impaired site of the vagus nerve can be possibly determined according to whether or not there was residual food in the pyriform sinus on the impaired side of the unilateral vocal cord paralysis. Related Articles | Metrics

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Prospect and progress of allergic rhinitis. ZHANG Ruxin JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 3-6.   DOI: 10.6040/j.issn.1673-3770.0.2016.241 Abstract （1438）      PDF（pc） （1102KB）（1139）       Save Reference | Related Articles | Metrics

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Minimally invasive otoendoscopic surgery: a new path for ear surgery Dengyuan WANG, Zhibin CHEN, Guangqian XING Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 27-30.   DOI: 10.6040/j.issn.1673-3770.1.2019.020 Abstract （1632）   HTML （26）    PDF（pc） （807KB）（641）       Save This article reviews the history, advantages and disadvantages, and current applications of otoendoscopic ear surgery. The otoendoscopic approach has unique advantages over the microscopic approach; it allows the surgeon to visualize the surgical site more clearly from multiple angles and at various magnifications, enabling completion of procedures using the transcanal approach, thereby reducing the need for endoauricular or postauricular incisions and avoiding the associated morbidity. Otoendoscopes also reduce the rates of cholesteatoma recidivism in chronic ear surgery. Otoendoscopic ear surgery appears to be a promising new technique and a reliable alternative to traditional microscopic surgery. Reference | Related Articles | Metrics