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    Balloon catheter dilation technology in combination with fibrolaryngoscope in treating sinus cyst
    XIAO Jian-xin, CHEN Rui-kai, HE Bi-yi, CHEN Wei-xiong, WANG Yue-jian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 46-48.  
    Abstract1230)      PDF(pc) (1073KB)(2981)       Save

    Objective   To evaluate the effect of nasal endoscopic sinus surgery and balloon catheter dilation technology in combination with fibrolaryngoscopy in treating sinus cyst. Methods   The clinical data of 14 cases (19 maxillary sinuses, 3 frontal sinuses) using the balloon catheter dilation technology in combination with fibrolaryngoscopy (the balloon group) and 16 cases (23 maxillary sinuses, 8 frontal sinuses) using conventional nasal endoscopic sinus surgery (the conventional group) were retrospectively analyzed. Visual analog scale (VAS) was used to record operative difficulty grade and operation time. Nasal endoscopy, coronal sinus CT scanning, Lund-Kennedy endoscopy and Lund-Mackay CT scan staging scores were used to evaluate the post-operative prognosis. Results   The balloon group was longer in operative time than the conventional group (P<0.001). During follow-up periods of  8 and 24 weeks after the operation, the sinus ostia were patency, and the nasal cavities recovered well. Conclusion   In the sinus cyst operation, the balloon group and the conventional group  equally  achieve good curative effects. In the balloon group, the nasal cavity and sinus structures can be preserved with  minimal invasion, but the operation is more difficult and longer than those in the conventional group, due to the fibrolaryngoscope.

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    HIV/AIDS in throat in 6 cases
    ZUO Wen-na, WANG Hong-qin, LI Guo-li
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 56-57.   DOI: 10.6040/j.issn.1673-3770.0.2014.134
    Abstract2198)      PDF(pc) (934KB)(2466)       Save
    Objective To deepen the understandings of ENT doctors on HIV infection in which primary complains were sore throat and/or fever to avoid misdiagnosis. Methods Clinical data of 6 cases of HIV infection, whose initial office visits were ENT department, were reviewed. Results Of 6 patients, there were 3 cases of tonsillitis, 2 cases of oral candida infection, and 1 case of Kaposi sarcoma in throat. Conclusion The diagnosis of AIDS, complained primarily of sore throat, can be established by combining with medical history, clinical manifestation and serological examination. ENT doctors must pay much attention to it.
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    Complications and treatment of UPPP
    ZHANG Hua, ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 12-14.  
    Abstract1878)      PDF(pc) (983KB)(2948)       Save
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    Clinical trial of postaurical drug injection to treat sudden hearing loss
    JIANG Chao-yong, CAI Yong-ming, YIN Ya-lei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (6): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2014.070
    Abstract3510)      PDF(pc) (912KB)(966)       Save
    Objective To evaluate the postaurical injection of corticosteroids to treat sudden hearing loss. Methods 65 patients with sudden hearing loss were divided into postaurical injection group (n=32) and intratympanic administration group (n=33). In addition to conventional medication, two groups were injected dexamethasone 0.5 mg through postaurical or intratympanic approaches on every three days in a 14-day course. Results The hearing improvement in postaurical injection group and intratympanic administration group were 13.2±8.6 dB and 14.6±11.1 dB. Compared to the pre-treatment, the differences were significant in both groups (P<0.05), however, no significant difference were noted between the groups (P>0.05). Adverse reactions occurred less in experimental group than the control (P<0.05). Conclusion Postaurical injection is effective, simple and safe to treat sudden hearing loss, which can serve as an alternative for intratympanic administration.
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    Endoscopic medial maxillectomy in combination with lacrimal passage implantation of tube for sinonasal inverted papilloma invading maxillary sinus
    MAN Rong-jun, ZHU Yong-kang, ZHANG Xiu-fang, WANG Hai-peng, WANG Xiao, WANG Hui-zhong, HU Yan-sheng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 42-44.   DOI: 10.6040/j.issn.1673-3770.0.2014.041
    Abstract1336)      PDF(pc) (1859KB)(751)       Save
    Objective To evaluate the efficacy of endoscopic medial maxillectomy in combination with lacrimal passage implantation of tube for sinonasal inverted papilloma invading maxillary sinus. Methods From January 2006 to October 2010, 32 patients with sinonasal inverted papilloma invading maxillary sinus received endoscopic medial maxillectomy in combination with lacrimal passage implantation of tube in our hospital. The clinical data of the patients were analyzed retrospectively. Results All the tumors were in T3 Krouse stage and were thoroughly excided. 2 cases had recurrence and were cured after local debridement. The overall recurrence rate was 6.3%(2 of 32). Followed up from 12 to 72 months, all of the patients had no epiphora and other complications. Conclusion Endoscopic medial maxillectomy is a good technique for maxillary sinus inverted papilloma of T3 Krouse stage, and lacrimal passage implantation of tube can be used to prevent stenosis of nasolacrymal duct.
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    Detection and clinical application of nasal nitric oxide
    Zhiwen CHEN,Lei CHENG
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 124-128.   DOI: 10.6040/j.issn.1673-3770.1.2019.026
    Abstract3652)   HTML33)    PDF(pc) (437KB)(1636)       Save

    Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO)examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable.

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    Interpretation of “The Third Edition of the International Classification of Sleep Disorders(ICSD)”.
    SHANG Wei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2016.386
    Abstract2892)      PDF(pc) (1002KB)(1648)       Save
    The third edition of the International Classification of Sleep Disorders(ICSD-3)is the key reference for the diagnosis of sleep disorders. ICSD-3 is built on the same basic outline as ICSD-2, preserving the major diagnostic classifications. Significant modifications have been made to the nosology of insomnia, narcolepsy, and sleep-related breathing disorders. Major changes of the manual are reviewed in this article.
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    Comparison of coblation, ultrasonic knife and conventional approach in tonsillectomy.
    ZHANG Liqing, YANG Cuifang, ZHOU Huaqun, LU Meiping, DONG Weida
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 56-60.   DOI: 10.6040/j.issn.1673-3770.0.2016.123
    Abstract4025)      PDF(pc) (971KB)(1181)       Save
    Objective To evaluate the advantages and disadvantages of coblation, ultrasonic knife and conventional approach in tonsillectomy. Methods A total of 117 cases in need of tonsillectomy were collected and divided into 3 groups: coblation tonsillectomy group(group A, n=39), ultrasound knife tonsillectomy group(group B, n=39)and the traditional tonsillectomy group(group C, n=39). The operation time, blood loss, postoperative sore throat situation, postoperative primary and secondary bleeding and so on were recorded and compared. Results The operation time was shorter, and intraoperative blood loss was less in group A and B than in group C(P<0.05). The operation time in group A [(9.92±4.04)min] was shorter than that [(15.86±1.36)min] in group B,(P<0.05). There was no difference in intraoperative blood loss between group A and B(P>0.05). The degree of the pain in the first three days after surgery in group A and in group B was significantly lower than that in group C(P<0.05), but no statistically significant differences were observed after three days(P>0.05). Postoperative throat pain in group A was lighter than that in group B, but there was no significant difference(P>0.05). Postoperative primary hemorrhage occurred in 1 case in group A and C, while secondary hemorrhage occurred in 1, 1 and 2 cases in group A, B and C, respectively. There was no significant difference in the time of pseudo-membrane defulvium among the three groups(P>0.05). Pharyngeal edema score 24 hours after operation in group A and group B was significantly lower than in group C(P<0.05), but there was no statistically significant difference between group A and group B(P>0.05). Conclusion Coblation tonsillectomy is the more safe and effective method, but its cost is relatively high. It is suitable for patients with good economic conditions and high quality of life. Ultrasonic knife tonsillectomy is suggested to be appropriate for patients with adhesive tonsillitis of long duration.
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    lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus
    DI Guohua, LIU Junru, ZHAO Yanxiang, GAO Yingkai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (6): 5-7.   DOI: 10.6040/j.issn.1673-3770.0.2015.253
    Abstract2896)      PDF(pc) (893KB)(737)       Save
    Objective To explore the clinical efficacy of lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus. Methods A total of 90 cases of idiopathic tinnitus were randomly divided into treatment group and control group. The treatment group was treated by two simultaneous methods. The first method used intravenous drip of drugs to nurture nerves and to improve blood circulation in the inner ear. The other one was to combine 2% lidocaine with retroauricular injection of gastrodine. The control group received the first treatment only. One course of treatment lasted for 14 d. All patients were followed up for 3 months. Results The total efficacy of treatment group and control group was 84.44% and 55.56%, respectively. After 3-month of follow-up, the total efficacy of treatment group and control group was 82.22% and 55.11%, respectively. There was statistical difference between the statistics (P<0.05). No obvious adverse effects were observed. Conclusion Combination of 2% lidocaine and gastrodine injection is simple and effective in the treatment of idiopathic tinnitus.
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    A case of ceruminoma in right external auditory canal
    YU Hai-yang, ZHANG Zeng, DIAO Xiu-li, WANG Wei-guo
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 101-102.   DOI: 10.6040/j.issn.1673-3770.0.2014.009
    Abstract1413)      PDF(pc) (1254KB)(891)       Save
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    Treatment experience of preservation of laryngeal function in surgical management of pyriform sinus carcinoma.
    SONG Xicheng, ZHANG Hua, LIU Zhonglu, WANG Yunqiang, WANG Yan, ZHANG Qiang, WANG Qiang, KANG Shasha, SONG Yipeng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2016.262
    Abstract1526)      PDF(pc) (1040KB)(1025)       Save
    Objective To investigate preservation and reconstruction of larynx function in surgical treatment of pyriform sinus carcinoma. Methods A retrospective analysis of 102 cases of pyriform cancer treated in June 2004 to October 2015 underwent surgeries with laryngeal functions preserved was carried out. There were 9 cases of stage Ⅰ, 11 cases of stage Ⅱ, 47 cases of stage Ⅲ and 35 stage Ⅳ, according to the 2002 UICC staging. Pharyngeal lateral wall approach, hyoid region approach and paraglottic space approach were chosen respectively to remove the tumor as per preoperative evaluation, followed by repairing of surgical defects and reconstruction of laryngeal and pharyngeal functions. 93 cases of postoperative radiotherapy were implemented. Results All patients recovered well after surgery except 1 patient with pharyngeal fistula and infection. All repairing materials of different methods survived and the average time of postoperative oral intake was 12.47 days. All patients retained good laryngeal functions with 95 decannulations and the 3-year and 5-year survival rates were 59.3% and 40.7% respectively. Conclusion Comprehensive preoperative investigations as laryngoscopy and radiological assessment may give good suggestions in selecting appropriate surgical approaches; good surgical approach may help provide good feasibility and visibility, and ensure complete removal of the tumors with safety margins; through the epiglottis flipping and/or thyroid reinforcement repairing methods, the incidence of accidental swallowing and pharyngeal fistula can be reduced; pyriform sinus carcinoma are found mostly in advanced stages, single treatment is often ineffective in controlling the lesion, and radiotherapy is necessary as a comprehensive treatment to improve the local control rate and survival rate. Appropriate surgical approaches and repairing methods can help surgeons to completely remove the tumor, and preserve or rebuild laryngeal and pharyngeal functions in managing chosen patients with pyriform sinus cancer.
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    Treatment of sudden hearing loss by monosialotetrahexosylganlioside
    SHEN Feng
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (1): 24-25.   DOI: 10.6040/j.issn.1673-3770.0.2012.163
    Abstract2407)      PDF(pc) (967KB)(1324)       Save

    Objective   To investigate the efficacy of monosialotetrahexosylganlioside in the treatment of sudden hearing lossl. Methods   80 cases suffered from sudden hearing loss were randomly divided into 2 groups. Except for glucocorticoid plus vasodilators and hyperbaric oxygen therapy, 40 cases in the treatment group were administrated with monosialotetrahexosylganlioside, while the other 40 cases in the control group were given mecobalamin injection. One course lasted for 10 days. Results   The total effective rates of hearing improvement between the treatment group and control group were 85% and 62.5%, while the cure rates of both groups were 52.5% and 27.5%(P<0.05).  Meanwhile, the total effective rate of tinnitus in the treatment and control group were 80% and 51.7%(P<0.05). Conclusion   Monosialotetrahexosylganlioside plays a positive role in the treatment of sudden hearing loss.

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    Detection of serum total IgE and allergen-specific IgE in healthy adults and its significance.
    YUAN Yuan, WU Zhongfei, CHAO Changjiang, LU Meiping, TIAN Huiqin, CHENG Lei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 34-38.   DOI: 10.6040/j.issn.1673-3770.0.2016.259
    Abstract3649)      PDF(pc) (1217KB)(1545)       Save
    Objective To explore the scientific significance and practical application of serum levels of total IgE(tIgE)and allergen-specific IgE(sIgE)in excluding allergen sensitization. Methods A total of 536 volunteers including 347 males and 189 females, aged 19-60 years with median age of 38 years old received the healthy physical examination were recruited in the study. All the subjects had no history and symptoms of allergic diseases as well as systemic diseases. Serum tIgE was detected by the capture enzyme-linked immunosorbent assay. The tIgE level ≤100 kU/L represented negative while >100 kU/L positive. Serum sIgE was assessed by means of the Phadiatop test using the fluoroimmunoassay. The Phadiatop class 0 means negative and class ≥1 positive. Results Serum level of tIgE among healthy adults was 1.14-1 703.70(median 37.18)kU/L, and it was significantly higher in males than in females(P=0.001). The negative and positive rates of serum tIgE were 72.52% and 27.48%, respectively. Serum level of sIgE(Phadiatop)among healthy adults was 0.01-59.50(median 0.05)kU/L, which had no significant significance between the male and the female(P=0.154). The negative and positive rates of Phadiatop were 82.09% and 17.91%, respectively. There were no statistically significant differences in serum tIgE and sIgE levels among different age groups(P=0.119 and P=0.225, respectively). The Spearman rank correlation coefficient between serum tIgE and sIgE levels was 0.683 with statistical significance(positive correlation, P<0.001). There were 368 subjects(94.85%)with negative Phadiatop and 20 subjects(5.15%)with positive Phadiatop in the serum tIgE negative subjects(n=388), while 75 山东大学耳鼻喉眼学报30卷4期 -袁源,等.健康成人血清总IgE和变应原特异性IgE检测及意义 \=-subjects(51.02%)with positive Phadiatop and 72 subjects(48.98 %)with negative Phadiatop in the serum tIgE positive subjects(n=147). Conclusion More than one fourth subjects among healthy adults have a serum tIgE level higher than 100 kU/L, while less than one fifth subjects have a sensitization to inhaled allergens. There is an obvious correlation between the serum levels of tIgE and sIgE. The serum tIgE level below 100 kU/L may have a clinical value to exclude allergen sensitization; however, the sensitized status may not be confirmed when the tIgE level is higher than 100 kU/L, and case history and clinical manifestations also should be considered.
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    Physiology and pathology review of the middle ear muscles
    Zhao HAN, Juan DING
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (5): 6-10.   DOI: 10.6040/j.issn.1673-3770.1.2019.038
    Abstract2380)   HTML1199)    PDF(pc) (1036KB)(711)       Save

    With the complex anatomy of the human ear, we need to better understand the physiological and pathological characteristics of the “noise reduction system” of the ear, the most critical part being the middle ear muscle (MEM). MEMs play an important protective role by constantly monitoring acoustic input and dynamically adjusting hearing sensitivity, to enhance external sounds and to reduce transmission of loud sound through the middle ear. If the MEMs lose the ability to regulate cramps, spasms, or dystonia in the ear, the resulting abnormal pressure can have a significant impact on internal cellular pressure, which can cause some otologic disorders including tinnitus, Meniere’s disease, and sensorineural hearing loss. This literature review aims to explain the physiological structure and function of MEMs and discuss several otological disorders associated with MEM dysfunction.

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    Establishment of sensorineural deafness model in C57 mice by cisplatin
    HE Jing-chun1, RUAN Qing-wei2, HAN Miao-miao1, JIN Bin1, LI Ke-yong1, DONG Pin1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (1): 1-5.   DOI: 10.6040/j.issn.1673-3770.0.2013.237
    Abstract1285)      PDF(pc) (2145KB)(1175)       Save

    Objective   To establish a cisplatin-induced sensorineural deafness model in C57 mice. Methods   C57BL/6J mice were divided randomly into four groups:group A (5μL normal saline injected into the round window niche), group B (5μLcisplatin (1mg/mL) injected into the round window niche), group C (10μL cisplatin (1mg/mL) injected daily into middle ear cavity for 5 days), and group D ( cisplatin (6mg/kg) injected daily into the abdominal cavity for 5 days). 10 dB increase or above in the reaction threshold of  whole octave band auditory brainstem response (ABR) was to define the decline of the hearing capacity. The stereocilia and cuticular plate of hair cells stained with fluorescent phalloidin were observed. Results   In group A,C and D, the whole octave band ABR reaction thresholds showed no difference before and after the administration (P>0.05). However, the reaction threshold were all elevated 48h after the administration in B group (P<0.05). Meanwhile, in group B, outer hair cell (OHC) lesions were more severe than those of inner hair cell (IHC), and the hair cells lesions aggravated gradually from the base to apex of chochlea. Conclusion   The administration of cisplatin through the window niche is the effective method to establish sensorineural deafness model in C57 mice.

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    Glaucoma valve implantation for various refractory glaucomas
    XU Hong1, LI Ming2, WEN Shu-ling1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 83-84.  
    Abstract1372)      PDF(pc) (938KB)(1063)       Save

    Objective    To investigate the clinical effect of glaucoma valve implantation on various refractory glaucomas. Methods    23 patients (23 eyes) with refractory glaucoma who underwent glaucoma valve implantation were divided into two groups according to glaucoma types and treatment methods: group A included 14 patients (14 eyes) who had neovascular glaucoma and underwent glaucoma valve implantation and retinal photocoagulation; group B included 9 patients (9 eyes) who had other refractory glaucomas and underwent glaucoma valve implantation and mitomycin C treatment. The visual acuity,intraocular pressure and complications were recorded, and the operation success rate was calculated. Results    The average intraocular pressure of two groups was obviously lower after operation than before operation(P<0.05). The visual acuity was improved in 8 eyes(57.14%) of group A and 6 eyes(66.67%) of group B 6 months after operation. There was no serious complication in all patients. The operation success rate was 85.71%(12/23) in group A and 88.89%(8/9) in group B. Conclusion    Glaucoma valve implantation is ideal treatment for refractory glaucoma,which can decrease intraocular pressure and increase operation success rate.

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    A study of laser-assisted tympanostomy in the treatment of 20 cases of secretory otitis media.
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (1): 85-87.   DOI: 10.6040/j.issn.1673-3770.0.2016.113
    Abstract1727)      PDF(pc) (1587KB)(655)       Save
    Objective To evaluate the efficacy of laser-assisted tympanostomy in the treatment of secretory otitis media. Methods A total of 20 cases(25 ears)of secretory otitis media were treated with laser perforation, combined with oral antibiotics, hormone and other drugs. Results Of all 25 ears, 17 were healed after one perforation, 4 after two perforations, and 4 ears received tube insertion after perforation failed. The effective rate of perforation was 84%(21/25). Conclusion Laser-assisted tympanostomy is effective, simple and repeatable for secretory otitis media.
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    Application of titanium ossicular replacement prosthesis in open mastoidectomy with tympanoplasty for ossicular chain reconstruction.
    LIU Bin, JIANG Yuling, XIAO Xuping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 80-83.   DOI: 10.6040/j.issn.1673-3770.0.2015.398
    Abstract1210)      PDF(pc) (949KB)(858)       Save
    Objective To explore the effects of using titanium ossicular replacement prosthesis in open mastoidectomy with ympanoplasty. Method From January 2013 to March 2015, 65 cases with chronic suppurative otitis media and middle ear cholesteatoma were treated with open mastoidectomy and tympanoplasty. Ossicular chains were reconstructed by partial ossicular replacement prosthesis(PORP)or total ossicular replacement prosthesis(TORP). The clinical data of these cases were retrospectively analyzed. The hearing threshold of air conduction and air bone gap(ABG)were compared before and 1,3,6 months after surgery. Results After 6 months of operation, the pure tone average(PTA)and averaged ABG of patients with chronic suppurative otitis media or middle ear cholesteatoma were dropped compared with those before surgery, with significant difference(P<0.05). There were 39 ears with an ABG lower than 20 dB after operation. Conclusion The effects of using titanium ossicular replacement prosthesis in open mastoidectomy with tmpanoplasty is satisfied for patients with chronic suppurative otitis media or middle ear cholesteatoma. The surgical indication and technique, as well as perioperative management, should be considered to ensure the success of operation.
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    Clinical significance of grading low middle fossa tegmen plate with high-resolution computed tomography
    SUN Xiaowei, LI Dongmei, DOU Fenfen, ZHANG Zihe, ZHANG Jianji, DING Yuanping, SHI Li
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (6): 22-25.   DOI: 10.6040/j.issn.1673-3770.0.2015.209
    Abstract1887)      PDF(pc) (1810KB)(1525)       Save
    Objective To observe the effect of high-resolution computed tomography (HRCT) grading of low middle fossa tegmen plate on the elimination of diseased tissue in epitympanum and to investigate the grading standard of low middle fossa tegmen plate. Methods The CT images obtained from 87 chronic otitis media (COM) cases were subjected to coronal reconstruction. A horizontal tangent L1 at the highest point along the upper wall of external auditory canal, a horizontal tangent L2 at the highest point of the semicircular canal structure, and a horizontal tangent L3 at the lowest point along the middle fossa tegmen plate were created to measure the distance between L1 and L2, L1 and L3, and to calculate the r value (b/a). The r value was used to divide the low middle fossa tegmen plate into five grades: non-low, mild, moderate, severe, and absolute low. Pre-operative evaluation and postoperative results were compared. Results Surgeons had different opinions on the r value: (1) If r < 1/4, the low middle cranial fossa cover identified by the Radiation Department could not be accepted. (2) If 1/4 ≤ r < 1/3, the low middle cranial fossa cover identified by the Radiation Department could be accepted, but it was not mentioned in the operation record. (2) If 1/3 < r ≤ 1/2, wearing was found at the bottom wall of the middle fossa tegmen plate upon clearing the diseased tissue, and the operation would be affected because of bleeding. (4) If 1/2 < r ≤3/4, the surgeons were able to identify the low middle fossa tegmen plate before operation; but some cases' back wall of the external auditory canals could be preserved after the diseased tissue in the epitympanum was cleared. (5) If r > 3/4, the surgeons experienced difficulty in finding the trum tympanicum and pathway behind the ear because the low middle fossa tegmen plate wore down the back wall of external auditory canal. Conclusion The r value can be used to divide the low middle fossa tegmen plate into five grades: non, mild, moderate, severe, and absolute low. Mild grade has no effect on the removal of lesions,moderate grade makes the removal of lesions difficult, severe grade requires destruction of the back wall of external auditory canal, and absolute low grade means wearing down of the back wall of external auditory canal is inevitable.
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    Cervical vertebral osteomyelitis secondary to necrotizing otitis externa:a case report and review of literature
    TIAN Jun, LIU Liangfa, BAI Jiaqi
    Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (4): 1-5.   DOI: 10.6040/j.issn.1673-3770.0.2022.174
    Abstract484)      PDF(pc) (5816KB)(194)       Save
    Objective To outline and analyze the clinical features and treatment option of cervical osteomyelitis secondary to necrotizing otitis externa. Methods We performed a retrospective review, along with literature review, of a case of C2-C6 osteomyelitis secondary to a necrotizing otitis externa in a diabetic patient, in order to outline its clinical manifestation, diagnosis, treatment option and prognosis. Results A total of five relevant studies published in Chinese and English from 2005 to 2022 were reviewed, and four cases(including the case presented in this study)were analyzed. The four cases involved three men and one woman(age range: 54-72 years). Only one patient had a history of head and neck radiotherapy, the remaining three were known diabetic patients. The lesions were extensive, involving two to five vertebral bodies. The causative pathogens isolated were all bacteria; however, the strains varied among the cases. After a systematic treatment, three patients(75%)succumbed to the disease as a result of bacterial resistance, poor compliance to medications, and severe comorbidity. Conclusion The lesions of necrotizing otitis externa can extend from the skull base to the cervical vertebrae, causing cervical osteomyelitis: a life-threatening condition that requires an aggressive treatment.
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    Lateralization of the Webb polarization test in five patients.
    LIU Ping, PAN Xiaochun, BU Chuan, XU Yangbin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (3): 115-116.   DOI: 10.6040/j.issn.1673-3770.0.2016.530
    Abstract997)      PDF(pc) (1057KB)(628)       Save
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    Physiological characteristics of voice and care of vocal health in the elderly
    Jiejie XU
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 14-18.   DOI: 10.6040/j.issn.1673-3770.1.2019.022
    Abstract1298)   HTML20)    PDF(pc) (665KB)(882)       Save

    Degenerative age-related changes in the body organs can affect the structure and physiological function of the vocal cords and cause senescence of voice in the elderly. This paper summarizes the changes in laryngeal structure, glottis appearance, and physiological vocal characteristics of aged subjects, and states the steps that need to be taken to care for vocal health of patients at an advanced age. This will be helpful to distinguish between the physiological and pathological changes of the larynx in the elderly and carry out appropriate and reasonable voice protection measures, thereby improving the quality of life in the aged population.Degenerative age-related changes in the body organs can affect the structure and physiological function of the vocal cords and cause senescence of voice in the elderly. This paper summarizes the changes in laryngeal structure, glottis appearance, and physiological vocal characteristics of aged subjects, and states the steps that need to be taken to care for vocal health of patients at an advanced age. This will be helpful to distinguish between the physiological and pathological changes of the larynx in the elderly and carry out appropriate and reasonable voice protection measures, thereby improving the quality of life in the aged population.

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    Wideband tympanometry test in infants
    ZHOU Jialei, SUN Shibing, LI Xiaoyan
    J Otolaryngol Ophthalmol Shandong Univ    2018, 32 (4): 91-94.   DOI: 10.6040/j.issn.1673-3770.0.2018.150
    Abstract2087)      PDF(pc) (350KB)(1119)       Save
    The special anatomical and functional characteristics of the middle and outer ear of infants limit the usability of traditional single-frequency tympanometry testing in assessing middle ear function. The wideband tympanometry test can evaluate the reception and transmission of sound energy in a wide frequency range(0.2-8 kHz). Compared with the conventional single-frequency tympanometry, it does not require external pressure to the ear-canal and has the advantages of short test time and dynamic assessment of peripheral auditory development characteristics and middle ear function in infants. The wideband tympanometry test can improve the accuracy of hearing screening and middle ear function assessment in infants.
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    Treatment of allergic rhinitis with traditional Chinese medicine.
    XIE Hui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 22-25.   DOI: 10.6040/j.issn.1673-3770.0.2016.244
    Abstract1217)      PDF(pc) (1061KB)(842)       Save
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    The calculation of intraocular lens refractive power
    WANG Lei, ZHANG Han
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 21-28.   DOI: 10.6040/j.issn.1673-3770.1.2017.028
    Abstract1857)      PDF(pc) (916KB)(1074)       Save
    This review describes the principles and practice involved in the calculation of intraocular lens(IOL)refractive power. The theories behind formulas for calculating IOL power are described, using regression and optical methods. The review emphasizes the importance of establishing a precise estimation of corneal power as well as accurate techniques for the measurement of axial length and for predicting postoperative anterior chamber depth. The review concludes that current improvements in diagnostic and surgical technology, combined with the latest IOL refractive power formulas, make the calculation and selection of appropriate IOL power among the most effective tools in refractive surgery today.
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    CHEN Xiu-li, YING Liang, YUAN Gong-qiang, DONG Xiao-guang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 80-82.  
    Abstract1312)      PDF(pc) (1500KB)(899)       Save

    null

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    Clinical comparison of polysomnography with portable sleep monitoring device.
    ZHANG Rong, WANG Honghong, YU Leilei, LIU Liang, SUN Jianjun, LI Jinrang, ZHAN Muxia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 65-67.   DOI: 10.6040/j.issn.1673-3770.0.2016.247
    Abstract1795)      PDF(pc) (938KB)(774)       Save
    Objective To evaluate the sensitivity and specificity of portable sleep monitoring device in measuring apnea hypopnea syndrome events. Methods A total of 120 patients were inspected by polysomnography and portable sleep monitor with synchronous monitoring, and the data were recorded and analyzed to evaluate its diagnostic efficiency. Results The polysomnography results was in agreement with portable sleep monitoring results. Apnea hypoventilation index, lowest oxygen saturation, oxygen index reduction had correlate statistical significance. Conclusion The portable sleep monitoring as a simple and convenient detection method, can be widely applied to clinic.
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    Correlation between chronic cough and postnasal drip syndrome in children
    LI Shu-jie,ZHANG Feng,GAO Zhen-feng,LU¨ Ling-yan,WU Yu-mei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract2075)      PDF(pc) (251KB)(1864)       Save
    Objective: To explore the correlation between chronic cough and postnasal drip syndrome(PNDS) in children. Method: A retrospective study was carried out among 75 cases of postnasal drip syndrome. Results: Chronic cough was the main complaint but no obvious lesions were found in the throat, trachea and branches, however, definite lesions were determined in the nasal cavity and/or paranasal sinuses including chronic rhinitis, nasosinusitis, allergic rhinitis and adenoiditis. 30 cases were misdiagnosed as repetitive respiratory infection, bronchitis, variant asthma, foreign bodies in the respiratory tract, or pneumonia, and in 13 cases a diagnosis was missed. Conclusion: Postnasal drip syndrome can be cured following effective treatment.
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    Treatment experience of different sphenoid sinus endoscopic surgical approaches under CT scan.
    CHU Shidong, CI Jun, WANG Haiying, WANG Changyang, ZHOU Huai'en, BAO Qingfu
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 47-50.   DOI: 10.6040/j.issn.1673-3770.0.2017.048
    Abstract1414)      PDF(pc) (2662KB)(651)       Save
    Objective To investigate the morphology of the sphenoid sinus using images from a computed tomography(CT)scan. Methods Image data acquired between July 2008 and July 2015 from 98 inpatients with sphenoid sinus diseases were retrospectively analyzed. The sphenoid sinus diseases were treated using one of three endoscopic surgical approaches. Sixty-four, 24, and 10 patients underwent the nasal cavity-olfactory cleft, Messerklinger, and Wigand approaches, respectively. Results The patients received over 6 months of follow-up and the windows of the sphenoid sinuses remained unobstructed and the symptoms were controlled. There were no serious operative or postoperative complications. Conclusion A CT scan can guide endoscopic sphenoid sinus surgery, which is minimally invasive, safe, and effective.
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    Diagnostic value of detection of pepsin in the saliva for laryngopharyngeal reflux
    TAO Yanli, YUAN Tiejun
    Journal of Otolaryngology and Ophthalmology of Shandong University    2018, 32 (6): 52-55.   DOI: 10.6040/j.issn.1673-3770.0.2018.219
    Abstract1534)      PDF(pc) (391KB)(444)       Save
    Objective To determine whether detection of pepsin in the saliva could be useful for diagnosing laryngopharyngeal reflux(LPR). Methods Twenty-five patients having LPR with reflux symptoms index scale(RSI)>13 and a reflux symptoms index scale(RFS)>7 were selected. Pepsin levels were measured by protease-labeling prior to treatment. Patients were treated with esomeprazole along with 2.5% sodium bicarbonate atomization inhalation therapy. Two months after completion of treatment, the RSI, RFS, and pepsin in the saliva were measured again. Results Out of 25, 12 salivary samples were positive and 13 were negative before treatment. PPI test results were positive in 10 cases and negative in 15 cases after treatment. The results of saliva pepsin test and PPI test were both positive in 9 cases and negative in 12 cases. One case had a positive result in the PPI test, and 3 cases had positive results in the salivary pepsin test. The diagnostic criteria for this study included a positive result on PPI test, and a sensitivity and specificity of 90.00% and 80.00%, respectively, in the detection results of pepsin. All 25 patients were able to complete the entire investigation and treatment course. The symptoms improved in 19 cases, while they did not significantly improve in 6 cases. The scores of the RSI scale before and after treatment were 19.84±3.96 and 7.00±2.84 respectively, with the difference being statistically significant(P<0.001). Signs obviously improved in all 25 cases. The RFS scale score before and after treatment was 14.08±3.51 and 5.44±3.07 respectively, with the difference being statistically significant(P<0.001). Conclusion The detection of pepsin in the saliva can be used for the diagnosis of LPR.
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    The application of Sinus Jel in adult patients of nasal polyps with sleep-disordered breathing.
    WANG Haipeng, XU Huijuan, ZHANG Xiufang, WANG Huizhong, LI Yanzhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 58-60.   DOI: 10.6040/j.issn.1673-3770.0.2016.153
    Abstract1508)      PDF(pc) (974KB)(555)       Save
    Objective To explore whether PureRegen Gel Sinus is a suitable nasal packing material for patients with sleep-disordered breathing(SDB)caused by chronic rhinosinusitis plus nasal polys(CRSwNP). Methods A total of 216 CRSwNP cases including 156 SDB and 60 non-SDB cases were divided into 4 groups. Group A(60 non-SDB cases)and group B(56 SDB cases)were treated with PureRegen Gel Sinus after nasal sinus surgery. Group C included 47 SDB cases treated with Nasopore. Group D included 53 SDB cases treated with Medical Sponge. The nasal reactions of the 4 groups were compared with Visual Analogue Scale(VAS). Results There were significant differences in headache, rhinalgia and postoperative bleeding between group A and B(P<0.05). Patients with SDB were more intolerant to these complications. There were statistical differences in headache, rhinalgia, rhinobyon and lacrimation between group B and C(P<0.05). PureRegen Gel Sinus was was superior to Nasopore. There were statistical differences in headache, rhinalgia, rhinobyon, lacrimation, dysphagia and postoperative bleeding between group B and D(P<0.05). PureRegen Gel Sinus was no better than medical sponge in dealing with postoperative bleeding, but it was still acceptable. PureRegen Gel Sinus was superior to medical sponge in other aspects. Conclusion PureRegen Gel Sinus is more suitable for clinical practice as a packing material. In addition, SDB can worsen headache, rhinalgia and postoperative bleeding, which may be associated with inflammation resulted from long-term oxygen depletion.
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    Behcets disease misdiagnosed as acute epiglottitis: a report of two cases.
    SUN Shasha, QIU Jie, ZANG Chuanshan, SUN Yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (5): 107-109.   DOI: 10.6040/j.issn.1673-3770.1.2017.255
    Abstract1048)      PDF(pc) (2028KB)(677)       Save
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    Treatment of palatal myoclonus objective tinnitus guided by palatal electromyogram
    WANG Tan, AN Feng-wei, CHEN Jian-qiu, LIN Jia-feng, HOU Xiao-zhi, XIE Cui-li, WANG Ying, LIN Juan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (1): 12-14.   DOI: 10.6040/j.issn.1673-3770.0.2014.242
    Abstract1440)      PDF(pc) (917KB)(505)       Save
    Objective To observe the clinical efficacy of botulinum toxin typeA(BTX-A) in the treatment of palatal myoclonus objective tinnitus(PMOT)under the guidance of palatal electromyography(P-EMG). Method The clinical data of 3 bilateral PMOT patients were reviewed. With endoscopic assistance, the disposable hypodermic needle electrode was inserted at the initiation site of tensor veli palatine(TVP), levator veli palatine(LVP), and termination site of LVP through nasal cavity. The direction and depth of the electrodes were adjusted according to the denseness of electric potential outbreak in the EMG diagram d. The superficial site, with the most dense electric potential outbreak was chosen as the point for injection. At each point, 5U BTXA was injected every time and the total amount was 30U . The therapeutic effects and adverse reaction were observed for 6 months afterthe injection. Result ① Therapeutic effectiveness: The PMOT was disappeared 26 h, 25 h and 28 h after the injection in 3 patients, respectively. None of positive expressions was observed in monthly endoscopic examination, P-EMG, and acoustic immittance examination 5 months after the injection. Recurrence of unilateral tinnitus was noted in only one patient.② Adverse reaction :The side effects, such as open rhinolalia, mild nasal regurgitation and mild ear stuffiness with tinnitus, were identified, but disappeared 2 weeks later afterthe treatment. Conclusion Using P-EMG during BTXA injection can accurately determine the site for injection, extend the action time of BTXA, reduce the adverse reaction, and achieve a good clinical results.
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    Surgical treatment of parapharyngeal space tumors via endoscopic transoral approach:a retrospective analyses of 5 cases
    LUO Xing-gu, LU Yong-tian, WANG Xiao-bin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (4): 56-58.   DOI: 10.6040/j.issn.1673-3770.0.2013.291
    Abstract1496)      PDF(pc) (1922KB)(623)       Save
    Objective To investigate the surgical indications, technique, and advantages of resection of parapharyngeal space(PPS) tumors through endoscopic transoral approach. Method Retrospective analysis were carried out in 5 parapharyngeal space tumors patients who received endoscopic transoral approach surgery. Results All the tumors were completely removed and the intraoperative blood loss was 20~60 mL. No serious complications occured and all the patiens were discharged in 5 days after the operation. No recurrence was found in a 1-2 years follow-up. Conclusion Preoperative CT and MRI provide useful clinical informations for surgical planning, such as tumor's location, size, state of invasion, the relationship with adjacent structures, and the likely origin. The endoscopic transoral approach is a good procedure to remove the tumors located anteromedially to the carotid sheath, with minimal invasiveness, no scar in the neck and few complication. However, it is not applicable for PPS tumors encasing the internal carotid arteries or located posterior or posterolateral to the carotid sheath, operative
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    Diagnosis and treatment of stylohyoid ligament ossification
    JIANG Shao-hong, ZHANG Qing-quan, SONG Xi-cheng, WANG Qiang, ZHU Yu-hong, ZHANG Qiang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (6): 7-8.   DOI: 10.6040/j.issn.1673-3770.0.2014.192
    Abstract1961)      PDF(pc) (894KB)(604)       Save
    Objective To explore the clinical features and operation method of styloid process abnormal and stylohyoid ligament ossification. Methods CT scanning and styloid 3D reconstruction were pre-operatively performed on 9 patients with stylohyoid ligament ossification, and cervical approach-styloidectomy was performed to amputate ossificated stylohyoid ligament, ceratohyal and part of styloid process. Results The clinical symptoms of 8 patients disappeared and the symptoms of 1 patient significantly relieved after the operation, no obvious complications occurred. Conclusion Patients with styloid process of stylohyoid ligament ossification of the styloid process can be definitely diagnosed by CT scan and should undergo cervical approach styloidectomy which produces exactly curative effect and no significant adverse reactions.
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    Comparison of 4 surgical methods of adenoidectomy
    CHEN Xiu-mei, ZHANG Qing-quan, LUAN Jian-gang, SONG Xi-cheng, ZHANG Tian-zhen, WANG Li, LIU Zhong-lu
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (3): 73-76.   DOI: 10.6040/j.issn.1673-3770.0.2012.352
    Abstract3584)      PDF(pc) (927KB)(1374)       Save

    Objective   To evaluate four surgical methods of adenoidectomy. Method   Clinical data 138 cases of adenoid hypertrophy were reviewed. Four different surgical methods were applied, including conventional transoral adenoidectomy with a currete(group A, 20 cases),  conventional transoral adenoidectomy with a currete plus punch forceps (group B, 63 cases),  endoscopic adenoidectomy (group C, 25 cases), and plasma ablation(group D, 30 cases). The effects, residue, complication, operation time and blood loss were evaluated  among the methods. Result   The effective rate was 90% for group A, but 100% for the other three groups. The residual rates in descending order were 60% in group A,  6.67% in group D, and zero in both group B and C. Post-op hemorrhage occurred in 4 cases (1 in group A, 2 in group B,  and 1 in group C). 6 cases presented  nasal synechia (4 in group B, 2 in group C) . Operation time of group A and group D were longer than the other two groups. There was no significant difference in  blood loss between the group A and B. The maximal loss was noted in group C, however the minimal loss was in group D. Conclusion   The conventional transoral adenoidectomy with a currete should be abandoned because of the high rate of residue. Though plasma ablation shows the advantages, including short operation time and little blood loss,  cost of this method is one big concern. It can only be applied in the patients who can afford it and give much attention to the blood loss. For the majority of patients, conventional transoral adenoidectomy plus punch forceps or endoscopic adenoidectomy are desirable , which are relatively simple and affordable.

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    Transoral endoscopic dissection of parapharyngeal space.
    ZHANG Baoying, LU Yongtian, LI Jianxing
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (4): 38-41.   DOI: 10.6040/j.issn.1673-3770.0.2015.094
    Abstract1832)      PDF(pc) (1960KB)(682)       Save
    Objective To investigate the transoral anatomic characteristics of parapharyngeal space. Methods A total of 5 fresh cadaver heads (including 1 injected cadaver head) were dissected to illustrate the transoral approach of parapharyngeal space anatomy. Results The superior constrictor muscle was the landmark to enter the prestyloid space. The stylopharyngeus and styloglossus muscles were critical marks which divided the parapharyngeal space into 2 parts. Posterior to these muscles and laterally to the superior constrictor muscle, the internal carotid artery, internal jugular vein, and lower cranial nerves were identifiable. Conclusion Our dissection emphasizes the role of the stylopharyngeus and styloglossus muscles. The lateral surface of the superior constrictor muscle is essential to protect the internal carotid artery.
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    Surgical procedures and application of uvulopalatopharyngoplasty and its modified methods in patients with obstructive sleep apnea.
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (1): 64-69.   DOI: 10.6040/j.issn.1673-3770.0.2017.036
    Abstract1375)      PDF(pc) (956KB)(817)       Save
    The stenosis soft palate level is common in patients with obstructive sleep apnea syndrome(OSA)and uvulopalatopharyngoplasty(UPPP)is the classic method to relieve the obstructive sites. This review mainly describes surgical procedures of UPPP and its modified methods and theirs efficacy in the treatment of OSA.
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    Clinical analysis of endoscopic ligation of the sphenopalatine artery in elderly patients with intractable epistaxis
    Qiang LI,Zhiyuan LIU,Han ZHOU
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (5): 92-95.   DOI: 10.6040/j.issn.1673-3770.0.2018.366
    Abstract901)   HTML9)    PDF(pc) (658KB)(293)       Save
    Objective

    To investigate the efficacy of endoscopic ligation of the sphenopalatine artery in elderly patients with intractable epistaxis.

    Methods

    The study included 41 elderly patients with intractable epistaxis. All patients were randomly assigned to two groups, namely, the treatment group (21 patients undergoing an endoscopic ligation of the sphenopalatine artery) and the control group (20 patients undergoing an endoscopic nasal packing). During the hospitalization and the 6-month follow-up, the epistaxis relapse rate, the postoperative pain, a satisfaction survey, the length of the hospital stay, and complications were evaluated.

    Results

    A significantly higher cure rate was obtained in the treatment group compared with the control group (81.0% vs. 50%, P<0.05). The average hospitalization duration of the treatment group was significantly shorter than that of the control group (6.5 days vs. 10.7 days, P<0.05). The treatment group was remarkably superior to the control group in both the degree of postoperative pain and satisfaction (both P<0.001). No severe complications were observed in any patient.

    Conclusion

    For elderly patients with intractable epistaxis, endoscopic ligation of the sphenopalatine artery should be considered as a first-line treatment due to its advantages such as fast and effective action, short hospital stay, little postoperative pain, and few complications.

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    Auditory brainstem implantation
    CHEN Yan-li, Huang Fang
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (3): 83-86.   DOI: 10.6040/j.issn.1673-3770.0.2012.316
    Abstract3058)      PDF(pc) (958KB)(2059)       Save

    Auditory brainstem implant (ABI) is one of the developments in the cochlear implant technology. Its operating principle is similar to artificial cochlear implant. However, rather than stimulating the neural elements in cochlea as artificial cochlear implant, the auditory complex residing in brainstem is stimulated directly. The indications, contraindications, surgical approaches,  methods, complications and hearing improvement of ABI are summarized in this paper.

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    High-resolution CT findings of scutum in cholesteatoma of middle ears
    GUO Yan-hong, PAN Yan, WANG Ji-sheng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (2): 17-19.   DOI: 10.6040/j.issn.1673-3770.0.2014.307
    Abstract2348)      PDF(pc) (2262KB)(898)       Save
    Objective To evaluate erosion of scutum in the diagnosis of middle ear cholesteatoma by high-resolution CT scan(HRCT). Methods HRCT findings of 38 patients(in 42 ears)with middle ear cholesteatoma in our department were reviewed. The condition of the scutum was observed with CT scanning and surgical findings. Result There are 37 ears with erosion of scutum, 4 ears with marginal/central perforation and 1 ear with intact tympanic membrane. Conclusion Scutum erosion demonstrates an important role in the diagnosis of cholesteatoma of middle ear, however, this sign cannot be found in some patienas with cholesteatoma.
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    WANG Hong-zeng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 47-48.  
    Abstract917)      PDF(pc) (934KB)(756)       Save
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    Comparison of the efficacy of three different techniques in tonsillectomy.
    GONG Mingjie, LIU Kan, ZHANG Lei, YAN Biao, ZOU Jiaping, LI Weizhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (1): 70-73.   DOI: 10.6040/j.issn.1673-3770.0.2015.345
    Abstract1633)      PDF(pc) (870KB)(661)       Save
    Objective To compare the clinical efficacy of cold dissection, monopolar diathermy dissection and radiofrequency ablation in tonsillectomy. Methods Patients undergone tonsillectomy were divided into 3 groups: cold dissection + suture group(group A, n=65), unipolar electric coagulation resection group(group B, n=40), plasma radiofrequency resection group(group C, n=38). The operation time, intraoperative blood loss, pain score, and postoperative albuginea of all groups were recorded and compared. Results The average operation time and intraoperative blood loss of group A, B and C were(58.8, 27.0 and 23.7)min,(34.2, 16.1 and 12.5)mL, respectively. There was significant difference in postoperative pain score 3 hour and 1 day after surgery. Conclusion Compared with cold dissection and monopolar diathermy dissection, radiofrequency ablation is more expansive, but it needs shorter operation time and causes less intraoperative bleeding and pain.
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    A review of squamous cell lines originating from the nasopharynx, oropharynx, laryngopharynx and larynx
    FENG Chengmin, JIN Yidan,LIU Hai, WANG Bing
    Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (6): 113-124.   DOI: 10.6040/j.issn.1673-3770.0.2020.478
    Abstract3377)      PDF(pc) (470KB)(190)       Save
    Larynx squamous cell carcinoma is a common malignant tumor of the head and neck region. The head and neck have complicated anatomical structure, and squamous cell carcinomas with different primary sites have different incidences, strategies of diagnosis and therapy, and even molecular pathogeneses. Therefore, selecting the suitable squamous cell carcinoma cell lines is important for researchers to determine appropriate preclinical research models and to have a better understanding of the mechanisms of tumorigenesis and progression. To provide a reference for researchers, this study summarizes the currently available squamous cell carcinoma cell lines originating from the nasopharynx, oropharynx, laryngopharynx and larynx.
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    Clinical individual case analysis of poor cases after cataract surgery
    LI Jian-ping,ZHU Wei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 1-1.  
    Abstract832)      PDF(pc) (1036KB)(1570)       Save
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    Hearing screenings  in 11894 infants
    LIU Zhi-qi1,2, LIU Li-si1, YANG Kun3
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (2): 8-12.   DOI: 10.6040/j.issn.1673-3770.0.2012.297
    Abstract1726)      PDF(pc) (967KB)(1344)       Save

    Objective    To obtain the pass rate of hearing screening, the incidence and cause of hearing loss in the newborns. Methods   11894 cases were screened by a two-stage program of transient evoked oto-acoustic emissions test(TEOAE). The failed were re-examined with DPOAE,1000Hz probe tone tympanometry, auditory brainstem response(ABR) 3 months later. The results were analyzed. Results  The primary screening pass rate was  82.64%, while the secondary pass rate was 78.71%. The pass rates were 84.63% and 78.00% in the obstetric ward and NICU ward,respectively (ANOVA, P<0.05). 68 cases (including 106 ears) were diagnosed as hearing loss with the incidence rate at 0.57%. Among them, there were 31 conductive hearing loss, 16 sensorineural hearing loss, and 21 mixed hearing loss. In the groups with the tests failed bilaterally or unilaterally , the corresponding prevalence rate was 12.92% (38/294) or 5.00% (30/600). The proportions of moderate and severe hearing were 3.33% (1/30) and 18.42% (14/76) (ANOVA, P<0.05). The possible causes of hearing loss consisted of jaundice (24.56%, 14/57), infection (24.56%, 14/57), asphyxia (19.30%, 11/57), low birth weight (17.54%, 10/57), and other factors (14.04%, 8/57). Conclusion   Hearing screening is a basic project for early detection of neonatal hearing loss. Binaurally failed cases are more likely to develop into hearing loss than the unilateral, and the degree of hearing loss might also be more severe. Jaundice, infection, asphyxia, and low birth weight are major causes for neonatal hearing loss.

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    ELP enteric soft capsule and grommet insertion for chronic secretory otitis media
    WANG Gang, WU Chang-song, LIU Cheng, CHEN Shi-qin, HU Jin-wang
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (2): 16-17.   DOI: 10.6040/j.issn.1673-3770.0.2012.309
    Abstract2295)      PDF(pc) (924KB)(1109)       Save

    Objective   To assess the efficacy of ELP enteric soft capsule and grommet insertion for chronic secretory otitis media with simple grommet insertion. Methods   60 cases(72 ears) chronic secretory otitis media were randomly divided into experimental group 30 cases(38 ears) and control group 30 cases(34 ears). Control group patients for simple grommet insertion by ear endoscopy, Experimental group patients for grommet insertion and ELP enteric soft capsule, assess the efficacy of tow groups after 6-month follow-up. Results   Experimental group 21cases(26 ears) cure, 6 cases(8 ears) improve, 3 cases(4 ears) invalid, Total efficiency 34/38. Control group 16 cases(16ears) cure, 7 cases(8 ears) improve, 7 cases(10 ears) invalid, Total efficiency 24/38. Efficacy of experimental group is better than control group(P=0.043). Conclusion   The efficacy of ELP enteric soft capsule and grommet insertion for chronic secretory otitis media is better than simple grommet insertion, can improve cure rate.

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    Research progress of dry eye animal model.
    HU Jindong, LIU Xinquan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 109-113.   DOI: 10.6040/j.issn.1673-3770.0.2016.420
    Abstract1482)      PDF(pc) (899KB)(605)       Save
    Dry eye is the most common ocular surface disease; however, its pathogenesis has not yet been fully elucidated. Therefore, the establishment of a dry eye model is particularly important for research into the conditions origins and its possible treatments. The current models used to establish tear deficiency either make use of an autoimmune reaction, involve the removal of the lacrimal gland(i.e., extirpation)or blockage of the lacrimal nerve, or use drugs that inhibit parasympathetic activity. Other methods of inducing dry eye involve burning the meibomian gland, decreasing the blink rate, reducing vitamin A intake, using preservatives, changing sex hormone levels, increasing tear osmolality, or carefully controlling the system environment. Meanwhile, some researchers combine the aforementioned models to produce dry eye, including combining parasympathetic inhibitory drugs with a controlled environmental system or using preservatives following removal of the lacrimal gland. In this article, we summarize the commonly used dry eye models.
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    ZHANG Xiu-ping, HU Hai-peng, LIU Yun-xia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 69-71.  
    Abstract872)      PDF(pc) (1392KB)(1342)       Save
    null
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    Effect of upper airway pressure measurements for obstructive sites in uvulopalatopharyngoplasty failures
    SHEN Ping,LI Wu-yi,LIU Wen,GAO Zhi-Qiang,HUO Hong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1489)      PDF(pc) (268KB)(1521)       Save
    Objective To determine the sites of upper airway collapse by upper airway pressure measurements in subjects demonstrated to have obstructive sleep apnea (OSA) after uvulopalatopharyngoplasty (UPPP). Methods Nocturnal polysomnography and continuous upper airway pressure measurements with ApneaGraph were performed on 10 subjects with subjective snoring or excessive daytime sleepiness after UPPP. The ApneaGraph transducer catheter contained two pressure sensors and two temperature sensors used for determination of the obstruction sites and the apnoeic events during sleep. The obstructive sites were in the upper (retropalatal oropharynx) or lower levels( the retroglossal region). The lower limit of the upper airway obstruction was determined by the pressure patterns. The constituent ratio was used to reflect the obstructive proportion of different levels. The effects of posture on apnea hypopnea index(AHI) were also analyzed. Results 3 patients had moderate OSA and 7 patients had severe OSA. 6(60%) cases had predominant sites of obstructions in the upper level(the constituent ratio of the retropalatal obstruction >50%), and 4 patients(40%) in the lower level(the constituent ratio of the retroglossal obstruction>50%). The supine AHI(66.52±22.51) was higher than the lateral AHI(47.82±21.82) and the difference between them was significant(P=0.017). Conclusion Upper airway pressure measurements can accurately identify the level of upper airway obstruction. Most patients with OSA following UPPP have the predominant obstructive sites at the retropalatal oropharynx and they tend to have more AHI in the supine position than in the lateral position.
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