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    One-stage nasal surgery and uvulopalatopharyngoplasty for obstructive sleep apnea-hyponea syndrome
    PANG Tai-zhong, WU Yun-gang, LI Xiao-yu, MA Lin-xiang, DING De-tao, HUANG Meng-meng, WANG Cai-hua, ZHANG Yong-hong, ZHANG Hui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (3): 7-9.  
    Abstract971)      PDF(pc) (943KB)(2725)       Save

    Objective   To investigate the clinical efficacy of uvulopalatopharyngoplasty(UPPP) with nasal surgery for patients with obstructive sleep apnea-hypopnea syndrome(OSAHS). Methods   40 OSAHS patients were divided into the A or B group, in which group A underwent UPPP with nasal surgery, which group B underwent only UPPP. The clinical results and the average apnea-hypopnea index (AHI) before and after the operation were compared. Results   The average AHI were all decreased, however, the result of group A was better than the group B 6 months after the operation. Conclusion   UPPP with nasal  surgery is an available and relatively safe surgical approach for the OSAHS patients with nasal obstruction.

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    XIAO Jian-xin, YU Qing-qing, TANG Jun, ZHANG Chao, SHI Si-si, CHEN Wei-xiong, WANG Yue-jian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (5): 38-42.  
    Abstract1423)      PDF(pc) (2489KB)(2183)       Save
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    Establishment and application of model of chronic rhinosinusitis in mice
    WANG Zhiyuan, ZHANG Gehua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 76-78.   DOI: 10.6040/j.issn.1673-3770.0.2015.184
    Abstract2135)      PDF(pc) (954KB)(1729)       Save
    Chronic rhinosinusitis(CRS) is a common chronic inflammatory disease of the upper respiratory tract, which seriously affects the patients' quality of life. Because of its uncertain pathogenesis, the curative effect is not satisfactory. Animal model of CRS is the ideal means for study of the human CRS pathological mechanism and curative effect. Mice are currently common CRS animals. The main content of the review includes research progress of the mice CRS-building methods, the evaluation index and application status of the model.
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    Interpretation of “The Third Edition of the International Classification of Sleep Disorders(ICSD)”.
    SHANG Wei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 18-20.   DOI: 10.6040/j.issn.1673-3770.0.2016.386
    Abstract3466)      PDF(pc) (1002KB)(2445)       Save
    The third edition of the International Classification of Sleep Disorders(ICSD-3)is the key reference for the diagnosis of sleep disorders. ICSD-3 is built on the same basic outline as ICSD-2, preserving the major diagnostic classifications. Significant modifications have been made to the nosology of insomnia, narcolepsy, and sleep-related breathing disorders. Major changes of the manual are reviewed in this article.
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    Detection of serum total IgE and allergen-specific IgE in healthy adults and its significance.
    YUAN Yuan, WU Zhongfei, CHAO Changjiang, LU Meiping, TIAN Huiqin, CHENG Lei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 34-38.   DOI: 10.6040/j.issn.1673-3770.0.2016.259
    Abstract4359)      PDF(pc) (1217KB)(2319)       Save
    Objective To explore the scientific significance and practical application of serum levels of total IgE(tIgE)and allergen-specific IgE(sIgE)in excluding allergen sensitization. Methods A total of 536 volunteers including 347 males and 189 females, aged 19-60 years with median age of 38 years old received the healthy physical examination were recruited in the study. All the subjects had no history and symptoms of allergic diseases as well as systemic diseases. Serum tIgE was detected by the capture enzyme-linked immunosorbent assay. The tIgE level ≤100 kU/L represented negative while >100 kU/L positive. Serum sIgE was assessed by means of the Phadiatop test using the fluoroimmunoassay. The Phadiatop class 0 means negative and class ≥1 positive. Results Serum level of tIgE among healthy adults was 1.14-1 703.70(median 37.18)kU/L, and it was significantly higher in males than in females(P=0.001). The negative and positive rates of serum tIgE were 72.52% and 27.48%, respectively. Serum level of sIgE(Phadiatop)among healthy adults was 0.01-59.50(median 0.05)kU/L, which had no significant significance between the male and the female(P=0.154). The negative and positive rates of Phadiatop were 82.09% and 17.91%, respectively. There were no statistically significant differences in serum tIgE and sIgE levels among different age groups(P=0.119 and P=0.225, respectively). The Spearman rank correlation coefficient between serum tIgE and sIgE levels was 0.683 with statistical significance(positive correlation, P<0.001). There were 368 subjects(94.85%)with negative Phadiatop and 20 subjects(5.15%)with positive Phadiatop in the serum tIgE negative subjects(n=388), while 75 山东大学耳鼻喉眼学报30卷4期 -袁源,等.健康成人血清总IgE和变应原特异性IgE检测及意义 \=-subjects(51.02%)with positive Phadiatop and 72 subjects(48.98 %)with negative Phadiatop in the serum tIgE positive subjects(n=147). Conclusion More than one fourth subjects among healthy adults have a serum tIgE level higher than 100 kU/L, while less than one fifth subjects have a sensitization to inhaled allergens. There is an obvious correlation between the serum levels of tIgE and sIgE. The serum tIgE level below 100 kU/L may have a clinical value to exclude allergen sensitization; however, the sensitized status may not be confirmed when the tIgE level is higher than 100 kU/L, and case history and clinical manifestations also should be considered.
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    Diagnosis and treatment of parapharyngeal space neoplasms
    HU Juan-juan, HONG Yu-ming
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 85-90.   DOI: 10.6040/j.issn.1673-3770.0.2014.159
    Abstract2210)      PDF(pc) (972KB)(1294)       Save
    Anatomy of parapharyneal space is very complicated. Many types of parapharyngeal space neoplasms can occur, and all of them demonstrate different clinical manifestations. Therefore, it is more difficult to diagnose and treat the parapharyngeal space neoplasms than other head and neck neoplasms. Common diagnostics methods include bimanual examination, imaging studies, cytopathology, transoral and transcervical biopsy. All these methods can help doctor determine the nature and blood supply of tumors and understand the relationship between neoplasms and adjacent structure, which provide a reliable basis for the ensuing treatment. This paper aims to state the diagnosis and treatment of parapharyngeal space neoplasms, especially how to select surgical procedures.
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    Treatment of allergic rhinitis with traditional Chinese medicine.
    XIE Hui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 22-25.   DOI: 10.6040/j.issn.1673-3770.0.2016.244
    Abstract1472)      PDF(pc) (1061KB)(1542)       Save
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    Relationship between Friedman OSA staging and ZPPP plus GAHM
    SUN Xiao-qiang1, YI Hong-liang2, CAO Zhen-yu2, ZHANG Yu-jun2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (6): 8-9.  
    Abstract1803)      PDF(pc) (1023KB)(2631)       Save

    Objective To explore the relationship between Friedman OSA staging and genioglossus advancement and hyoid suspension(GAHM) plus Z-palatopharyngoplasty(ZPPP). Methods 26 patients with severe OSAHS (AHI>40)were performed GAHM plus ZPPP. The obstructive sites were identified in both oropharynx and hypopharynx. The follow up lasted at least 6 months postoperatively. The Chi square test was used to compare the preoperative and postoperative results. Results Satistying clinic results for the patients with Friedman OSA stages Ⅱ were 100%, while the overall success rate of Friedman OSA stages Ⅲ was 22.2%. Conclusion ZPPP plus GAHM is an effective method for patients with Friedman OSA stages Ⅱ.

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    Effects of 01% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome
    ZHANG Ju, WU Xin-yi
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (1): 49-51.   DOI: 10.6040/j.issn.1673-3770.0.2014.342
    Abstract3961)      PDF(pc) (929KB)(1270)       Save
    Objective To evaluate the effects of 0.1% cyclosporin eye drops in combination with sodium hyaluronate eye drops in the treatment of dry eye syndrome. Methods A total of 60 patients (120 eyes) with dry eye syndrome were randomly divided into the experimental group (60 eyes) treated by 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops and the control group (60 eyes) treated by bysodium hyaluronate eye drops. Both groups were measured the Schirmer I test(SIt), tear film break-up time(BUT) and corneal fluorescein staining(FLs) before and after a month. Results There were no significant differences between the experimental group and the control group in SIt, BUT and FLs before treatment (P>0.05). After treatment, all the indicators of SIt, BUT and FLs of the experimental group and the control group were better than before (P<0.05). The experimental group was superior to the control group in the three indicators (SIt, BUT and FLs)(P<0.05). Conclusion 0.1%cyclosporin eye drops in combination with sodium hyaluronate eye drops is effective in treatment of dry eye, and is superior to bysodium hyaluronate eye drops alone.
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    Research progress of dry eye animal model.
    HU Jindong, LIU Xinquan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 109-113.   DOI: 10.6040/j.issn.1673-3770.0.2016.420
    Abstract1929)      PDF(pc) (899KB)(1277)       Save
    Dry eye is the most common ocular surface disease; however, its pathogenesis has not yet been fully elucidated. Therefore, the establishment of a dry eye model is particularly important for research into the conditions origins and its possible treatments. The current models used to establish tear deficiency either make use of an autoimmune reaction, involve the removal of the lacrimal gland(i.e., extirpation)or blockage of the lacrimal nerve, or use drugs that inhibit parasympathetic activity. Other methods of inducing dry eye involve burning the meibomian gland, decreasing the blink rate, reducing vitamin A intake, using preservatives, changing sex hormone levels, increasing tear osmolality, or carefully controlling the system environment. Meanwhile, some researchers combine the aforementioned models to produce dry eye, including combining parasympathetic inhibitory drugs with a controlled environmental system or using preservatives following removal of the lacrimal gland. In this article, we summarize the commonly used dry eye models.
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    Blink reflex and electrical neurography in the clinical evaluation of Bell′s facial palsy
    LIANG Zhen-yuan,HONG Yu-ming,LIN Po-shui
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)   
    Abstract1581)      PDF(pc) (68KB)(2503)       Save
    Objective To explore the effects of the blink reflex(BR) and electrical neurography(ENG) in the evaluation of Bell′s facial palsy. Method Haishen nerve examination instruments were used to stimulate the super-orbital nerve to record wave R1and R2 of the ocular orbicular muscle in the same sides and wave R2 of the ocular orbicular muscle in the opposite sides. A concentric needle electrode was used to stimulate the facial nerve to record the latent phase of movement and the scope of wave M. Also the BR and ENG were determined and compared with the controls. Result BR was abnormal in 35 cases of Bell′s facialpalsy in different degrees, and ENG was abnormal in some of the cases. Conclusions Both BR and ENG can reflex the degree, location and prognosis of the facial nerves.BR is more important in early diagnosis and prognosis than ENG,but their combination is more valuable than when only one is used.
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    Fufanghuangbai Liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal (40 cases report)
    YANG Mei-yan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (2): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2014.254
    Abstract2919)      PDF(pc) (924KB)(1236)       Save
    Objective To investigate the clinical effect of Fufanghuangbai liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal. Methods In the Juye County People's Hospital otolaryngology from January 2012 to April 2014, 80 cases of eczema were randomly divided into control group and observation group, the control group of 40 patients were given triamcinolone acetonide acetate, 40 patients were given Fufanghuangbai liquid combined with triamcinolone acetonide acetate treatment, compared two groups of patients with clinical treatment effect and adverse reaction. Results After 1 weeks of treatment, the observation group efficiency was 45%, although slightly higher than that of the control group was 40%, but the two groups had no statistical difference (P>0.05). In observed group, the total efficiency of 75%, it was slightly higher than 72.5% of the control group, but the two groups had no statistical difference (P>0.05). After 2 weeks treatment, the observed group was 77.5%, significantly higher than the control group of 40%, a significant difference between two groups (P<0.05). Total effective rate of observation group was 92.5%, significantly higher than the control group of 72.5%, with a significant difference between two groups (P<0.05). Patients in the two groups after treatment had no significant adverse reactions. Conclusion Fufanghuangbai liquid combined with triamcinolone acetonide acetate treating eczema of external auditory canal has satisfied effect, it can significantly improve the patient's clinical symptoms with less adverse reaction.
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    Research advances on Argonaute2 and its role in human tumors.
    ZHANG Yanhui, DONG Pin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (3): 95-99.   DOI: 10.6040/j.issn.1673-3770.0.2016.485
    Abstract2385)      PDF(pc) (1052KB)(1199)       Save
    With the rapid development of proteomics, proteins related to tumorigenesis and progression have been continuously discovered and applied to clinical diagnosis. By constituting RNA-induced silencing complex(RISC), selfcatalysis and overexpression, Argonaute2 plays an important role in human tumorigenesis and progression, and is becoming a research focus. In this article, we will review the research advances on the structure, function and mechanism of Argonaute2 in tumor development.
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    lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus
    DI Guohua, LIU Junru, ZHAO Yanxiang, GAO Yingkai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (6): 5-7.   DOI: 10.6040/j.issn.1673-3770.0.2015.253
    Abstract3441)      PDF(pc) (893KB)(1325)       Save
    Objective To explore the clinical efficacy of lidocaine combined with retroauricular injection of gastrodine in the treatment of idiopathic tinnitus. Methods A total of 90 cases of idiopathic tinnitus were randomly divided into treatment group and control group. The treatment group was treated by two simultaneous methods. The first method used intravenous drip of drugs to nurture nerves and to improve blood circulation in the inner ear. The other one was to combine 2% lidocaine with retroauricular injection of gastrodine. The control group received the first treatment only. One course of treatment lasted for 14 d. All patients were followed up for 3 months. Results The total efficacy of treatment group and control group was 84.44% and 55.56%, respectively. After 3-month of follow-up, the total efficacy of treatment group and control group was 82.22% and 55.11%, respectively. There was statistical difference between the statistics (P<0.05). No obvious adverse effects were observed. Conclusion Combination of 2% lidocaine and gastrodine injection is simple and effective in the treatment of idiopathic tinnitus.
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    Establishment of sensorineural deafness model in C57 mice by cisplatin
    HE Jing-chun1, RUAN Qing-wei2, HAN Miao-miao1, JIN Bin1, LI Ke-yong1, DONG Pin1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (1): 1-5.   DOI: 10.6040/j.issn.1673-3770.0.2013.237
    Abstract1545)      PDF(pc) (2145KB)(1769)       Save

    Objective   To establish a cisplatin-induced sensorineural deafness model in C57 mice. Methods   C57BL/6J mice were divided randomly into four groups:group A (5μL normal saline injected into the round window niche), group B (5μLcisplatin (1mg/mL) injected into the round window niche), group C (10μL cisplatin (1mg/mL) injected daily into middle ear cavity for 5 days), and group D ( cisplatin (6mg/kg) injected daily into the abdominal cavity for 5 days). 10 dB increase or above in the reaction threshold of  whole octave band auditory brainstem response (ABR) was to define the decline of the hearing capacity. The stereocilia and cuticular plate of hair cells stained with fluorescent phalloidin were observed. Results   In group A,C and D, the whole octave band ABR reaction thresholds showed no difference before and after the administration (P>0.05). However, the reaction threshold were all elevated 48h after the administration in B group (P<0.05). Meanwhile, in group B, outer hair cell (OHC) lesions were more severe than those of inner hair cell (IHC), and the hair cells lesions aggravated gradually from the base to apex of chochlea. Conclusion   The administration of cisplatin through the window niche is the effective method to establish sensorineural deafness model in C57 mice.

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    Surgical procedures and application of uvulopalatopharyngoplasty and its modified methods in patients with obstructive sleep apnea.
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (1): 64-69.   DOI: 10.6040/j.issn.1673-3770.0.2017.036
    Abstract1808)      PDF(pc) (956KB)(1387)       Save
    The stenosis soft palate level is common in patients with obstructive sleep apnea syndrome(OSA)and uvulopalatopharyngoplasty(UPPP)is the classic method to relieve the obstructive sites. This review mainly describes surgical procedures of UPPP and its modified methods and theirs efficacy in the treatment of OSA.
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    Progress and challenges in the management of asthma in China
    Jiangtao LIN
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (1): 4-8.   DOI: 10.6040/j.issn.1673-3770.1.2018.015
    Abstract1470)   HTML194)    PDF(pc) (1238KB)(910)       Save
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    ZHANG Xiu-ping, HU Hai-peng, LIU Yun-xia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 69-71.  
    Abstract968)      PDF(pc) (1392KB)(1907)       Save
    null
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    Therapeutic efficacy of Xuesaitong combined with Gastrodin for sudden deafness
    MA Ya-lin1, REN Ping-zhi2, CHAI Mao-wen1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (2): 44-45.  
    Abstract2189)      PDF(pc) (962KB)(2020)       Save

    Objective   To explore the therapeutic efficacy of Xuesaitong combined with Gastrodin for sudden deafness. Methods   150 patients with sudden deafness were randomly divided into the Xuesaitong group, the Gastrodin group and the combined group, with 50 cases in each group. The combined group was synchronously treated with Xuesaitong and Gastrodin. Their hearing therapeutic efficacies were compared. Results   The total effective rate and recovery rate were 72% and 20% in the Xuesaitong group, 68% and 18% in the Gastrodin group,and 88% and 38% in the combined group. They were significantly higher in the combined group than in the other two groups (all P<0.05). Conclusion   The combined therapy for sudden deafness is obviously better than individual therapy.

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    The groove behind the palatovaginal canal: a landmark for identification of the palatovaginal canal
    MENG Qingguo, LU Yongtian, WU Xiaoliu, LI Jianxing, SUN Huanji, ZHANG Baoying, XIE Chang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2015, 29 (5): 55-61.   DOI: 10.6040/j.issn.1673-3770.0.2015.124
    Abstract2272)      PDF(pc) (4366KB)(998)       Save
    Objective To explore the groove behind the palatovaginal canal (PVC) is a critical landmark for safe identification of the PVC during endoscopic endonasal transpterygoid approaches and transfer CT scan of the pterygopalatine fossa. Methods Probes were inserted thorough the PVC of 20 dry skulls. The PVC and the groove behind it were proved on MSCT, meanwhile a comparative study was also carried out by the traditional method to identificate the PVC. Dissection of two skulls and cadaveric heads was performed to demonstrate the endoscopic anatomy of the PV canal and tbe groove. Results The grooves can be found in all 20 dry skulls and appeared as groof near the posterior opening of PV canal. 26 sids were deep while 14 sides were dimple. Mainly appeared as tube-shaped (24 sides) or ovoid dimple-shaped (16 sides). In CT scan, the average angle between PVS and the hard palate was 53.14±5.48°, while between the groove and the hard palate was 20.93±6.28°. There was also statistical difference for identification of the PVC in transfer CT between the traditional method and the method assisting with the groove. Anatomic steps and foundations for dissection of the PVC while using the groove as a landmark were described. Conclusion Anatomic investigation, radiologic studies and comparison between the methods for identification of the PVC demonstrate the important anatomic relationship of the PVC with the groove, and reveal the groove as a landmark in endoscopic endonasal transpterygoid approaches and transfer CT scan of the pterygopalatine fossa.
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    Characteristics of computed tomography of fungal rhino-sinusitis
    ZHENG Jiong, LI Jing
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 45-48.   DOI: 10.6040/j.issn.1673-3770.0.2014.042
    Abstract5271)      PDF(pc) (1896KB)(1144)       Save
    Objective To study the CT features of fungal rhino-sinusitis and to assess its diagnostic value. Methods CT features of 47 cases of fungal rhino-sinusitis proved by surgery and pathology from January 2007 to December 2013 were retrospectively analyzed. Results There are 43 cases of unilateral fungal infection and 4 cases of double sides. On CT scanning, soft tissues were presented in all the infected sinuses of all cases, heterogeneous density with spot,strip or lump calcification was presented in 37 cases(78.7%) and homogeneous density was presented in 10 cases(22.2%). There were bones thickening in 39 lesions(83.0%), dwindling of sinus in 20 patients(42.6%), and air bubble in 11 cases(23.4%).In 41 cases that lesions implicated in the maxilla, 33 cases(80.5%) showed obstruction and dilation of maxillary sinus ostium and 15 cases(36.6%)showed damage or resorption of medial wall. Conclusion Fungal rhino-sinusitis has characteristic findings on CT. The major CT findings are heterogeneous density of sinusal cavity with small calcification appeared as spots,floccose,sand-like or patchy shadows and local bone destruction. CT is a valuable method for diagnosis and treatment of fungal rhino-sinusitis.
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    Lens vault changes and associated factors after implantation of implantable collamer lenses with central flow
    WAN Bo, LI Donghui, LUO Yan, LI Ying
    Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (2): 36-41.   DOI: 10.6040/j.issn.1673-3770.1.2020.008
    Abstract3219)   HTML40)    PDF(pc) (1740KB)(955)       Save
    Objective To investigate the changes to the lens vault(LV)and anterior chamber structures after implantation of implantable collamer lenses(ICL)with central flow in patients with myopia. The relationship between LV and its associated factors, both preoperatively and postoperatively, will also be analyzed. Methods One hundred and forty eyes of 72 patients who underwent ICL implantations were enrolled between January 2015 and January 2017. Visual acuity, intraocular pressure(IOP), corneal endothelial cell count(ECD), refractive outcomes, LV, and other anterior chamber structures were evaluated and compared after 1 week, 1 month, 3 months and 1 year, postoperatively. We analyzed the relationship between LV and other anterior chamber structures. Results After 1 year, 73% of eyes had gained 1 or more lines of corrected distance visual acuity, progressively fewer eyes had gained an uncorrected distance visual acuity above 20/20, more than 63% were within±0.5 D of the prospective mean refractive spherical equivalent(MRSE), and more than 86% were within±0.1 D of the prospective MRSE. There were no significant differences in MRSE, IOP, and ECD, postoperatively(p>0.05). No complications occurred during the postoperative time. There were no significant LV differences at 1 month and 3 months postoperatively. Meanwhile, LV had decreased significantly in the first postoperative year and was negatively correlated with age, keratometric power, 500 μm angle open distance, 500 μm trabecular iris space area, and the anterior chamber angle. LV was positively correlated with the white-to-white distance, angle-to-angle distance, anterior chamber depth, axial length, and ICL length. Axial length and ICL length were independent factors of LV. Conclusion Implantations of phakic ICL with center flow are safe, effective, and predictable in correcting myopia. LV decreased significantly at 1 year postoperatively, which correlated with multiple factors, both preoperatively and postoperatively.
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    Minimally invasive otoendoscopic surgery: a new path for ear surgery
    Dengyuan WANG, Zhibin CHEN, Guangqian XING
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 27-30.   DOI: 10.6040/j.issn.1673-3770.1.2019.020
    Abstract1678)   HTML26)    PDF(pc) (807KB)(791)       Save

    This article reviews the history, advantages and disadvantages, and current applications of otoendoscopic ear surgery. The otoendoscopic approach has unique advantages over the microscopic approach; it allows the surgeon to visualize the surgical site more clearly from multiple angles and at various magnifications, enabling completion of procedures using the transcanal approach, thereby reducing the need for endoauricular or postauricular incisions and avoiding the associated morbidity. Otoendoscopes also reduce the rates of cholesteatoma recidivism in chronic ear surgery. Otoendoscopic ear surgery appears to be a promising new technique and a reliable alternative to traditional microscopic surgery.

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    Progress in diabetic retinopathy mechanisms and cellular models
    WANG Jiaojiao, LI MiaoOverview,SONG ZongmingGuidance
    Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (5): 93-99.   DOI: 10.6040/j.issn.1673-3770.0.2021.203
    Abstract1420)      PDF(pc) (473KB)(625)       Save
    Diabetic retinopathy is the leading cause of poor vision and blindness in adults. A reasonable model for diabetic retinopathy can not only simulate its pathogenic mechanism, but also reduce economic investment. Therefore, screening and constructing suitable cell models is the core of research. In this paper, the mechanisms of inflammatory response, apoptosis, vascular dysfunction, and neurovascular unit dysfunction in diabetic retinopathy were discussed. Moreover, several models of endothelial cells, pericytes, retinal pigment epithelial cells, and glial cells were summarized to provide a useful reference for further studies on the mechanism of diabetic retinopathy and the development of relevant drugs.
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    Complications and treatment of UPPP
    ZHANG Hua, ZHANG Qing-quan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (1): 12-14.  
    Abstract2118)      PDF(pc) (983KB)(3469)       Save
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    Cited: Baidu(1)
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (2): 1-4.   DOI: 10.6040/j.issn.1673-3770.1.2012.016
    Abstract1518)      PDF(pc) (1279KB)(1481)       Save
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    Comparison of 4 surgical methods of adenoidectomy
    CHEN Xiu-mei, ZHANG Qing-quan, LUAN Jian-gang, SONG Xi-cheng, ZHANG Tian-zhen, WANG Li, LIU Zhong-lu
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (3): 73-76.   DOI: 10.6040/j.issn.1673-3770.0.2012.352
    Abstract3918)      PDF(pc) (927KB)(1870)       Save

    Objective   To evaluate four surgical methods of adenoidectomy. Method   Clinical data 138 cases of adenoid hypertrophy were reviewed. Four different surgical methods were applied, including conventional transoral adenoidectomy with a currete(group A, 20 cases),  conventional transoral adenoidectomy with a currete plus punch forceps (group B, 63 cases),  endoscopic adenoidectomy (group C, 25 cases), and plasma ablation(group D, 30 cases). The effects, residue, complication, operation time and blood loss were evaluated  among the methods. Result   The effective rate was 90% for group A, but 100% for the other three groups. The residual rates in descending order were 60% in group A,  6.67% in group D, and zero in both group B and C. Post-op hemorrhage occurred in 4 cases (1 in group A, 2 in group B,  and 1 in group C). 6 cases presented  nasal synechia (4 in group B, 2 in group C) . Operation time of group A and group D were longer than the other two groups. There was no significant difference in  blood loss between the group A and B. The maximal loss was noted in group C, however the minimal loss was in group D. Conclusion   The conventional transoral adenoidectomy with a currete should be abandoned because of the high rate of residue. Though plasma ablation shows the advantages, including short operation time and little blood loss,  cost of this method is one big concern. It can only be applied in the patients who can afford it and give much attention to the blood loss. For the majority of patients, conventional transoral adenoidectomy plus punch forceps or endoscopic adenoidectomy are desirable , which are relatively simple and affordable.

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    SUN Ziwen1, CUI Hongwei2, SUN XilingEtiology, pathogenesis, and management of dry eye
    SUN Ziwen, CUI Hongwei, SUN Xiling, CHEN Chen, ZHANG Lu, HU Zhulin
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (2): 159-166.   DOI: 10.6040/j.issn.1673-3770.0.2018.411
    Abstract2176)      PDF(pc) (533KB)(811)       Save
    Due to multiple influences of internal factors(tear film destruction, sex hormone disorders)and external factors(environment, surgery, and drugs), patients with dry eye disease have been encountered much more frequently and are presenting at a younger age. Dry eye disease has become one of the most common diseases of the ocular surface, with a multifactorial etiology. This paper reviews the newer reports on etiology, pathogenesis, and management of dry eye.
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    A review of squamous cell lines originating from the nasopharynx, oropharynx, laryngopharynx and larynx
    FENG Chengmin, JIN Yidan,LIU Hai, WANG Bing
    Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (6): 113-124.   DOI: 10.6040/j.issn.1673-3770.0.2020.478
    Abstract4131)      PDF(pc) (470KB)(658)       Save
    Larynx squamous cell carcinoma is a common malignant tumor of the head and neck region. The head and neck have complicated anatomical structure, and squamous cell carcinomas with different primary sites have different incidences, strategies of diagnosis and therapy, and even molecular pathogeneses. Therefore, selecting the suitable squamous cell carcinoma cell lines is important for researchers to determine appropriate preclinical research models and to have a better understanding of the mechanisms of tumorigenesis and progression. To provide a reference for researchers, this study summarizes the currently available squamous cell carcinoma cell lines originating from the nasopharynx, oropharynx, laryngopharynx and larynx.
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    Application of acellular dermal matrix in otorhinolaryngological reconstructive surgery
    QIN He, SUN Jian-jun
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 75-77.  
    Abstract953)      PDF(pc) (903KB)(1819)       Save

    The unique features of acellular dermal matrix make it one of excellent material for repairing tissue defects. This article reviews the histological characteristics of acellular dermal matrix and its application in otolaryngological reconstructive surgery.

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    Obesity and obstructive sleep apnea.
    LI Yanzhong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (5): 1-4.   DOI: 10.6040/j.issn.1673-3770.0.2016.404
    Abstract987)      PDF(pc) (1088KB)(1060)       Save
    The relationship between obesity and obstructive sleep apnea-hypopnea syndrome(OSAHS)has become a new hot spot in the research of sleep-disordered breathing. Whether there is a cause-and-effect or accompanying relationship between them is not yet clear. Compared with craniofacial malformations, obesity is more likely to induce obstructive sleep apnea syndrome(OSA). The frequency and severity of OSA are related to BMI and obesity. This paper discusses the relationship from four aspects: lipid metabolism disorder, fatty liver, metabolic inflammation, and oxidative stress.
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    Detection and clinical application of nasal nitric oxide
    Zhiwen CHEN,Lei CHENG
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 124-128.   DOI: 10.6040/j.issn.1673-3770.1.2019.026
    Abstract4411)   HTML42)    PDF(pc) (437KB)(2068)       Save

    Nitric oxide (NO) is synthesized from arginine by the enzyme family NO synthases. NO is an endogenous modulator of airway function. NO from the nose can constitute a nasal defensive barrier, and keep the sinuses relatively sterile. The most commonly clinical detection of nasal nitricc oxide (nNO) is to directly collect NO with a nasal plug probe placed in the anterior nostril. nNO has been used for the screening diagnosis of cystic fibrosis and primary ciliary dyskinesia. However, nNO is related to many influences such as the plugged extent of the sinus. Dynamic monitoring nNO before and after treatment, and combination with frictional exhaled nitric oxide (FeNO)examination to early detect eosinophilic inflmmation in the upper and lower airways are more clinically valuable.

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    Treatment experience of preservation of laryngeal function in surgical management of pyriform sinus carcinoma.
    SONG Xicheng, ZHANG Hua, LIU Zhonglu, WANG Yunqiang, WANG Yan, ZHANG Qiang, WANG Qiang, KANG Shasha, SONG Yipeng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 20-23.   DOI: 10.6040/j.issn.1673-3770.0.2016.262
    Abstract1874)      PDF(pc) (1040KB)(1457)       Save
    Objective To investigate preservation and reconstruction of larynx function in surgical treatment of pyriform sinus carcinoma. Methods A retrospective analysis of 102 cases of pyriform cancer treated in June 2004 to October 2015 underwent surgeries with laryngeal functions preserved was carried out. There were 9 cases of stage Ⅰ, 11 cases of stage Ⅱ, 47 cases of stage Ⅲ and 35 stage Ⅳ, according to the 2002 UICC staging. Pharyngeal lateral wall approach, hyoid region approach and paraglottic space approach were chosen respectively to remove the tumor as per preoperative evaluation, followed by repairing of surgical defects and reconstruction of laryngeal and pharyngeal functions. 93 cases of postoperative radiotherapy were implemented. Results All patients recovered well after surgery except 1 patient with pharyngeal fistula and infection. All repairing materials of different methods survived and the average time of postoperative oral intake was 12.47 days. All patients retained good laryngeal functions with 95 decannulations and the 3-year and 5-year survival rates were 59.3% and 40.7% respectively. Conclusion Comprehensive preoperative investigations as laryngoscopy and radiological assessment may give good suggestions in selecting appropriate surgical approaches; good surgical approach may help provide good feasibility and visibility, and ensure complete removal of the tumors with safety margins; through the epiglottis flipping and/or thyroid reinforcement repairing methods, the incidence of accidental swallowing and pharyngeal fistula can be reduced; pyriform sinus carcinoma are found mostly in advanced stages, single treatment is often ineffective in controlling the lesion, and radiotherapy is necessary as a comprehensive treatment to improve the local control rate and survival rate. Appropriate surgical approaches and repairing methods can help surgeons to completely remove the tumor, and preserve or rebuild laryngeal and pharyngeal functions in managing chosen patients with pyriform sinus cancer.
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    Endotypes and precision medicine in chronic sinusitis treatment
    Huabin LI,Yuting LAI,Wenxiu JIANG
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (3): 9-13.   DOI: 10.6040/j.issn.1673-3770.1.2018.043
    Abstract1276)   HTML20)    PDF(pc) (697KB)(700)       Save

    Chronic rhinosinusitis (CRS) is a common otolaryngologic disease, with a complex intrinsic pathological mechanism. Traditional medicine and surgery do not fully treat CRS. In recent years, precision medicine has been used to develop new biological agents to treat CRS based on its phenotype. This article reviews the current endotypes of CRS that have therapeutic significance, including type II inflammatory, eosinophilic, epithelial barrier function, and epithelium-derived cytokine endotypes, and those that are still in the theoretical stage of research, including the non-type II inflammatory phenotype and tissue remodeling.

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    Comparison of coblation, ultrasonic knife and conventional approach in tonsillectomy.
    ZHANG Liqing, YANG Cuifang, ZHOU Huaqun, LU Meiping, DONG Weida
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (3): 56-60.   DOI: 10.6040/j.issn.1673-3770.0.2016.123
    Abstract4621)      PDF(pc) (971KB)(1596)       Save
    Objective To evaluate the advantages and disadvantages of coblation, ultrasonic knife and conventional approach in tonsillectomy. Methods A total of 117 cases in need of tonsillectomy were collected and divided into 3 groups: coblation tonsillectomy group(group A, n=39), ultrasound knife tonsillectomy group(group B, n=39)and the traditional tonsillectomy group(group C, n=39). The operation time, blood loss, postoperative sore throat situation, postoperative primary and secondary bleeding and so on were recorded and compared. Results The operation time was shorter, and intraoperative blood loss was less in group A and B than in group C(P<0.05). The operation time in group A [(9.92±4.04)min] was shorter than that [(15.86±1.36)min] in group B,(P<0.05). There was no difference in intraoperative blood loss between group A and B(P>0.05). The degree of the pain in the first three days after surgery in group A and in group B was significantly lower than that in group C(P<0.05), but no statistically significant differences were observed after three days(P>0.05). Postoperative throat pain in group A was lighter than that in group B, but there was no significant difference(P>0.05). Postoperative primary hemorrhage occurred in 1 case in group A and C, while secondary hemorrhage occurred in 1, 1 and 2 cases in group A, B and C, respectively. There was no significant difference in the time of pseudo-membrane defulvium among the three groups(P>0.05). Pharyngeal edema score 24 hours after operation in group A and group B was significantly lower than in group C(P<0.05), but there was no statistically significant difference between group A and group B(P>0.05). Conclusion Coblation tonsillectomy is the more safe and effective method, but its cost is relatively high. It is suitable for patients with good economic conditions and high quality of life. Ultrasonic knife tonsillectomy is suggested to be appropriate for patients with adhesive tonsillitis of long duration.
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    Hearing screenings  in 11894 infants
    LIU Zhi-qi1,2, LIU Li-si1, YANG Kun3
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (2): 8-12.   DOI: 10.6040/j.issn.1673-3770.0.2012.297
    Abstract1943)      PDF(pc) (967KB)(1745)       Save

    Objective    To obtain the pass rate of hearing screening, the incidence and cause of hearing loss in the newborns. Methods   11894 cases were screened by a two-stage program of transient evoked oto-acoustic emissions test(TEOAE). The failed were re-examined with DPOAE,1000Hz probe tone tympanometry, auditory brainstem response(ABR) 3 months later. The results were analyzed. Results  The primary screening pass rate was  82.64%, while the secondary pass rate was 78.71%. The pass rates were 84.63% and 78.00% in the obstetric ward and NICU ward,respectively (ANOVA, P<0.05). 68 cases (including 106 ears) were diagnosed as hearing loss with the incidence rate at 0.57%. Among them, there were 31 conductive hearing loss, 16 sensorineural hearing loss, and 21 mixed hearing loss. In the groups with the tests failed bilaterally or unilaterally , the corresponding prevalence rate was 12.92% (38/294) or 5.00% (30/600). The proportions of moderate and severe hearing were 3.33% (1/30) and 18.42% (14/76) (ANOVA, P<0.05). The possible causes of hearing loss consisted of jaundice (24.56%, 14/57), infection (24.56%, 14/57), asphyxia (19.30%, 11/57), low birth weight (17.54%, 10/57), and other factors (14.04%, 8/57). Conclusion   Hearing screening is a basic project for early detection of neonatal hearing loss. Binaurally failed cases are more likely to develop into hearing loss than the unilateral, and the degree of hearing loss might also be more severe. Jaundice, infection, asphyxia, and low birth weight are major causes for neonatal hearing loss.

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    Progress in the research of intraocular lens power calculation formulas
    TAN Yan, LI Can
    Journal of Otolaryngology and Ophthalmology of Shandong University    2019, 33 (6): 95-98.   DOI: 10.6040/j.issn.1673-3770.0.2019.275
    Abstract2485)      PDF(pc) (311KB)(937)       Save
    With the development of phacoemulsification surgery, the calculation of intraocular lens power has been paid greater attention. Various intraocular lens power formulas have been presented to optimize the visual quality after surgery. This paper comprehensively describes the progress in the research of various intraocular lens power formulas, such as the first-generation intraocular lens formula, the second-generation formula, Hill-RBF, Barrett True-K, and so on.
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    Effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomiLeusis.
    JIANG Yang, LI Ying, WANG Zhonghai, JIN Yumei, LIU Xiaowei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (2): 80-83.   DOI: 10.6040/j.issn.1673-3770.0.2015.404
    Abstract1457)      PDF(pc) (930KB)(910)       Save
    Objective To evaluate the effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomi leusis(LASIK). Methods Patients with mild to moderate dry eye were included in the study before LASIK. The implantation of VisiPlug was conducted immediately after the surgery. The scores of dryness, foreign body sensation, burning sensation, photophobia, visual fatigue and blurred vision were recorded on preoperative and postoperative 1 week, 1 month and 3 months. Schirmer I test(SIt), break-up time(BUT)and corneal fluorescein staining(FS)were also tested on each time points. Results There were 130 eyes of 65 patients included in the study, including 22 males and 43 females with the average age of 28.32±7.24(18-47)years. The scores of dryness, foreign body sensation, burning sensation, photophobia, visual fatigue and blurred vision were significantly decreased on each time points after the implantation of the lacrimal plug(F value: 125.64, 263.16, 123.22, 9.80, 76.815, 105.19; P value: 0.000, 0.000, 0.000, 0.002, 0.000, 0.000). Schirmer I test(SIt), break up time(BUT)and corneal fluorescein staining(FS)were also significantly improved on each time points(F value: 45.99, 67.87, 49.01; P value: 0.000, 0.000, 0.000). There was no infection, plug in the overflow, local granulation, and the effect of corneal flap healing. Conclusion Lacrimal plug could be effective and safe in the management of dry eyes after refractive surgery.
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    Progress of immunotherapy for allergic rhinitis.
    LI Yong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 15-21.   DOI: 10.6040/j.issn.1673-3770.0.2016.278
    Abstract1207)      PDF(pc) (1091KB)(1028)       Save
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    The law of medication for the treatment of endogenous eye disease in chinese medical code based on data mining
    WANG Shushu, FU Yahui, YU Ruoyu, HOU Yi, YANG Jiguo
    Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (4): 81-87.   DOI: 10.6040/j.issn.1673-3770.0.2021.020
    Abstract1711)      PDF(pc) (4397KB)(583)       Save
    Objective To collect the prescription of Chinese Medical Code the treatment of cataract, and to summarize the clinical application of traditional Chinese medicine in the treatment of cataract by using the cloud platform(V2.3.5)database of ancient and modern medical records. Methods To search the prescription of Chinese Medical Code for treating cataract, to select the prescription for treating cataract according to the inclusion and exclusion criteria, to establish a Excel database, and to import the cloud platform of ancient and modern medical records(V2.3.5)in batches. Results A total of 249 prescriptions were selected, Contains 244 herbs, The total frequency was 2 596 times; efficacy 396, Total efficacy frequency 5 486 times; Four, properties 9 times. Total frequency 2 922 times; Five tastes,11 times. The total frequency is 3 697 times; The total frequency was 3 750. The top 3 drugs with high frequency of cataract treatment were Fangfeng, Angelica sinensis and Glycyrrhiza uralensis; The drug with high correlation was the highest in people participating in windbreak. Four properties 9 with cold, warm, slightly cold, flat. Conclusion Using the cloud platform(V1.4.5)of ancient and modern medical records to analyze the data, to show the law of drug use in the treatment of cataract eye disease in Chinese Medical Code, and to provide a reference for the summary of clinical practice of traditional Chinese medicine in the treatment of cataract eye disease.
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    Diagnosis and treatment of choroidal neovascularization in pathologic myopia
    Journal of Otolaryngology and Ophthalmology of Shandong University    2020, 34 (5): 157-162.   DOI: 10.6040/j.issn.1673-3770.0.2019.545
    Abstract1983)      PDF(pc) (436KB)(552)       Save
    Pathologic myopia(PM)is a major cause of vision loss worldwide, particularly in Asian countries. Choroidal neovascularization(CNV)is a severe complication of PM, which can cause macular disorders, leading to central scotoma, metamorphopsia, visual field loss, and finally blindness if not treated. The advents of optical coherence topography(OCT), OCT angiography, and fundus fluorescein angiography are helpful in diagnosing CNV due to PM, which can show the position and size of CNV, whether active or passive. For the treatment, photodynamic and anti-vascular endothelial growth factor(anti-VEGF)therapies are widely applied. In recent years, administering the intravitreal anti-VEGF injection has become the first-line treatment for CNV secondary to PM. Many clinical studies have indicated that intravitreal anti-VEGF injections affect antagonizing neovascularization and reduce macular edema, thereby contributing to visual improvements and better long-term outcomes. This article provides an overview of the current diagnosis and treatment options for myopic CNV.
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    Clinical features and diagnosis of allergic rhinitis.
    YAN Aihui, HAN Jiali
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (4): 7-9.   DOI: 10.6040/j.issn.1673-3770.0.2016.243
    Abstract1563)      PDF(pc) (979KB)(994)       Save
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    ELP enteric soft capsule and grommet insertion for chronic secretory otitis media
    WANG Gang, WU Chang-song, LIU Cheng, CHEN Shi-qin, HU Jin-wang
    J Otolaryngol Ophthalmol Shandong Univ    2013, 27 (2): 16-17.   DOI: 10.6040/j.issn.1673-3770.0.2012.309
    Abstract2787)      PDF(pc) (924KB)(1479)       Save

    Objective   To assess the efficacy of ELP enteric soft capsule and grommet insertion for chronic secretory otitis media with simple grommet insertion. Methods   60 cases(72 ears) chronic secretory otitis media were randomly divided into experimental group 30 cases(38 ears) and control group 30 cases(34 ears). Control group patients for simple grommet insertion by ear endoscopy, Experimental group patients for grommet insertion and ELP enteric soft capsule, assess the efficacy of tow groups after 6-month follow-up. Results   Experimental group 21cases(26 ears) cure, 6 cases(8 ears) improve, 3 cases(4 ears) invalid, Total efficiency 34/38. Control group 16 cases(16ears) cure, 7 cases(8 ears) improve, 7 cases(10 ears) invalid, Total efficiency 24/38. Efficacy of experimental group is better than control group(P=0.043). Conclusion   The efficacy of ELP enteric soft capsule and grommet insertion for chronic secretory otitis media is better than simple grommet insertion, can improve cure rate.

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    Balloon catheter dilation technology in combination with fibrolaryngoscope in treating sinus cyst
    XIAO Jian-xin, CHEN Rui-kai, HE Bi-yi, CHEN Wei-xiong, WANG Yue-jian
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2012, 26 (4): 46-48.  
    Abstract1379)      PDF(pc) (1073KB)(3348)       Save

    Objective   To evaluate the effect of nasal endoscopic sinus surgery and balloon catheter dilation technology in combination with fibrolaryngoscopy in treating sinus cyst. Methods   The clinical data of 14 cases (19 maxillary sinuses, 3 frontal sinuses) using the balloon catheter dilation technology in combination with fibrolaryngoscopy (the balloon group) and 16 cases (23 maxillary sinuses, 8 frontal sinuses) using conventional nasal endoscopic sinus surgery (the conventional group) were retrospectively analyzed. Visual analog scale (VAS) was used to record operative difficulty grade and operation time. Nasal endoscopy, coronal sinus CT scanning, Lund-Kennedy endoscopy and Lund-Mackay CT scan staging scores were used to evaluate the post-operative prognosis. Results   The balloon group was longer in operative time than the conventional group (P<0.001). During follow-up periods of  8 and 24 weeks after the operation, the sinus ostia were patency, and the nasal cavities recovered well. Conclusion   In the sinus cyst operation, the balloon group and the conventional group  equally  achieve good curative effects. In the balloon group, the nasal cavity and sinus structures can be preserved with  minimal invasion, but the operation is more difficult and longer than those in the conventional group, due to the fibrolaryngoscope.

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    Model preparation of infectious keratitis
    YAN Yu, ZENG Ao,,HE Yuxi
    Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (5): 125-131.   DOI: 10.6040/j.issn.1673-3770.0.2020.449
    Abstract955)      PDF(pc) (505KB)(462)       Save
    Infectious keratitis is an inflammation caused by the invasion of pathogenic microorganisms on corneal tissue. It is a common cause of blindness in the world. The main pathogenic microorganisms are bacteria, fungi, viruses, and Acanthamoeba. Bacteria is the main cause of infectious keratitis, but fungal keratitis has been increasing year by year in recent years. At present, the effective treatment is local use or subconjunctival injection of anti-bacterial and fungal agents, and systemic use of antiviral drugs, based on the different pathogenic microorganisms. We systematically describe models preparation of infectious keratitis caused by bacteria, fungi, viruses, and Acanthamoeba, including the preparation of the bacterial solution, operation methods and scoring detection methods. This paper elaborates how to prepare a targeted animal model to provide theoretical basis for evaluating and exploring the treatment effect and adverse reactions of infectious keratitis.
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    HIV/AIDS in throat in 6 cases
    ZUO Wen-na, WANG Hong-qin, LI Guo-li
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2014, 28 (5): 56-57.   DOI: 10.6040/j.issn.1673-3770.0.2014.134
    Abstract2598)      PDF(pc) (934KB)(2834)       Save
    Objective To deepen the understandings of ENT doctors on HIV infection in which primary complains were sore throat and/or fever to avoid misdiagnosis. Methods Clinical data of 6 cases of HIV infection, whose initial office visits were ENT department, were reviewed. Results Of 6 patients, there were 3 cases of tonsillitis, 2 cases of oral candida infection, and 1 case of Kaposi sarcoma in throat. Conclusion The diagnosis of AIDS, complained primarily of sore throat, can be established by combining with medical history, clinical manifestation and serological examination. ENT doctors must pay much attention to it.
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    Laryngopharyngeal reflux and otorhinolaryngology diseases
    SUN Na, CHEN Xiaoping
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2016, 30 (6): 85-89.   DOI: 10.6040/j.issn.16733770.0.2016.213
    Abstract1472)      PDF(pc) (1000KB)(845)       Save
    Laryngopharyngeal reflux is one of the major causes of respiratory symptoms related to pharyngeal foreign body sensation, hoarseness and other symptoms of the upper respiratory tract. It is becoming a hotspot of otolaryngologists. At present, there are still a lot of controversies about the diagnosis and treatment of laryngopharyngeal diseases, such as sinusitis, otitis media, sleep apnea hypopnea syndrome, and so on. Now experts on throat diseases are working on a standardized diagnosis, treatment and efficacy evaluation system and carrying out multicenter clinical researches, in order to normalize the diagnosis and treatment of laryngopharyngeal reflux.
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    Comparison of high order aberrations in pseudophakia with spherical intraocular lens and aspheric intraocular lens implantation.
    TIAN Jing, LIAO Xuan, LAN Changjun, TAN Qingqing, LIN Jia, WEN Baiwei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)    2017, 31 (4): 13-17.   DOI: 10.6040/j.issn.1673-3770.1.2017.031
    Abstract1857)      PDF(pc) (902KB)(1030)       Save
    Objective To compare the corneal, internal, and ocular high order aberrations(HOAs)in pseudophakia of spherical intraocular lens(IOL)with aspheric IOL implantation, and to provide evidence for individual selection of aspheric IOL. Methods A prospective, non-randomized, controlled clinical study was conducted on 112 age-matched cataract patients(160 eyes). Patients were divided into four groups, and implanted with AMO Sensor AR40 IOL(group AR40, 40 eyes of 26 patients), AMO Tecnis ZA9003 IOL(group ZA9003, 40 eyes of 31 patients), Bausch & Lomb SofPort AO IOL(group AO, 40 eyes of 28 patients), or Alcon SN60WF IQ IOL(group IQ, 40 eyes of 27 patients). The corneal, internal, and ocular HOAs including total HOA(tHOA), spherical aberration(SA), coma, and trefoil were measured at three months postoperatively with a pupil diameter(PD)of 4 mm or 6 mm. Result There were no statistically significant differences in postoperative uncorrected visual acuity and best corrected visual acuity, and in postoperative corneal tHOA, SA, coma, and trefoil at 4 mm or 6 mm PD among the four groups. At 4 mm PD, there were significant differences in internal SA and coma but no differences in tHOA and trefoil; at 6 mm PD, there were significant differences in internal tHOA, SA, and coma but no differences in trefoil. In addition, there were significant differences in ocular tHOA and SA but no differences in coma and trefoil at 4 mm or 6 mm PD among the four groups. Conclusion Phacoemulsification of the cataract and implantation of an aspheric IOL can reduce corneal SA, resulting in enhanced visual quality. For aspheric IOLs with other SAs, the predictability of corneal SA is exact, which provides a clinical basis for personalized implantation of aspheric IOLs.
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    Drug therapy for myopia
    LIU Ling,ZHANG Meixia
    Journal of Otolaryngology and Ophthalmology of Shandong University    2021, 35 (4): 123-128.   DOI: 10.6040/j.issn.1673-3770.0.2020.313
    Abstract1724)      PDF(pc) (986KB)(624)       Save
    Myopia is the most common refractive error.Uncorrected refractive error, causing visual impairment, has become an important question of commonality sanitation, owing to affecting the quality of life of individuals and the weightily economy burden.With the prevalence of myopia increasing, controlling myopia progression and protecting eye health have gradually become the hot issue of global concern. And its current treatments include drugs, glasses, and surgery. In recent years, progress has been made in the treatment of myopia. This article focuses on the progress of research on drugs for controlling myopia, including muscarinic receptor antagonists, nicotinic receptor antagonists, and vasoactive intestinal peptides, and their mechanisms of action.
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    Research progress in the inflammatory reaction and anti-inflammatory treatments in dry eye
    DI Yu,LI Ying
    Journal of Otolaryngology and Ophthalmology of Shandong University    2022, 36 (2): 144-150.   DOI: 10.6040/j.issn.1673-3770.0.2020.484
    Abstract963)      PDF(pc) (446KB)(436)       Save
    Dry eye is a multifactorial disease of the tear film and ocular surface. In recent years, it has become one of the most common ocular surface diseases, with its prevalence increasing every year. Inflammation plays a key role in the pathogenesis of dry eye. It can stimulate ocular surface cells, activate the local immune response, lead to unstable tear films, increase the osmolality of tears, and then cause local ocular surface damage. Multiple inflammatory mediators and immune cells participate in the development of dry eye. There is increasing research on the inflammatory reaction involved in dry eye, and this paper reviews the inflammatory mediators, immune cells, immune response, and anti-inflammatory treatments to systematically understand the inflammatory reaction mechanism of dry eye and its clinical significance.
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