ISSN 1673-3770 CN 37-1437/R
山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (5): 76-78.doi: 10.6040/j.issn.1673-3770.0.2015.184
王志远, 张革化
WANG Zhiyuan, ZHANG Gehua
摘要： 慢性鼻-鼻窦炎(CRS)是上呼吸道常见的慢性炎症性疾病,严重影响了患者生活质量,目前其发病机制尚不明确。CRS的动物模型是研究人类CRS病理机制和疗效的理想手段。小鼠是目前CRS常用的造模动物。就小鼠CRS的造模方法、模型评价指标及模型的应用现状等做研究综述。
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| [1] Blackwell D L, Collins J G, Coles R. Summary health statistics for U.S. adults: National Health Interview Survey, 1997[J]. Vital Health Stat, 2002(205):1-109. [2] Bachert C, Zhang N, van Z T, et al. Chronic rhinosinusitis: From one disease to different phenotypes[J]. Pediatr Allergy Immunol, 2012, 23 Suppl 22:2-4. [3] Shi J B, Fu Q L, Zhang H, et al. Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities[J]. Allergy, 2015, 70(5):533-539. [4] Xie D Y, Ju J B, Yu H L, et al. Rabbit is suitable for establishing an animal model of rhino-sinusitis[J]. Zhongguo Zuzhi Gongcheng Yanjiu, 2014, 18(18):2830-2835. [5] Casteleyn C, Cornillie P, Hermens A, et al. Topography of the rabbit paranasal sinuses as a prerequisite to model human sinusitis[J]. Rhinology, 2010, 48(3):300-304. [6] Wang H, Long X B, Cao P P, et al. Clara cell 10-kD protein suppresses chitinase 3-like 1 expression associated witheosinophilic chronic rhinosinusitis[J]. Am J Respir Crit Care Med, 2010, 181(9):908-916. [7] Ahn B H, Park Y H, Song D W. A mouse model of acute and chronic rhinosinusitis[J]. Otolaryngol Head Neck Surg, 2005, 133(3):258-259. [8] 王恒,刘争,陆翔, 等.Clara细胞10-KDa蛋白在小鼠细菌性慢性鼻-鼻窦炎模型中的表达[J]. 临床耳鼻咽喉头颈外科杂志, 2008, 22(20):937-940. WANG Heng, LIU Zheng, LU Xiang, et al. Expression of Clara cell 10-KDa protein in murine bacterial chronic rhinosinusitis model[J]. J Clin Otorhinolaryngol Head Neck Surgery, 2008, 22(20):937-940. [9] Jacob A, Faddis B T, Chole R A. Chronic bacterial rhinosinusitis: description of a mouse model[J]. Arch Otolaryngol Head Neck Surg, 2001,127(6):657-664. [10] 俞晨杰,陆玲,顾亚军, 等. 大鼠慢性鼻-鼻窦炎模型的建立及其生物学特性观察[J]. 中国耳鼻咽喉颅底外科杂志,2011,17(6):419-424. YU Chenjie, LU Ling, GU Yajun, et al. Development of a rat model of chronic rhinosinusitis and observation of biological characteristics[J]. Chin J Otorhinolaryngol Skull Base Surgery, 2011, 17(6):419-424. [11] Wang E T, Zheng Y, Liu P F, et al. Eosinophilic chronic rhinosinusitis in East Asians[J]. World J Clin Cases, 2014, 2:873-882. [12] Fokkens W, Lund V, Mullol J, et al. European position paper on rhino-sinusitis and nasal polyps 2012[J]. Rhinol Suppl, 2012, 23:1-298. [13] Newman L J, Platts-Mills T A, Phillips C D, et al. Chronic sinusitis: relationship of computed tomographic findings to allergy, asthma, and eosinophilia[J]. JAMA, 1994, 271(5):363-367. [14] Szucs E, Ravandi S, Goossens A, et al. Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis[J]. Am J Rhinol, 2002, 16(3):131-134. [15] Lindsay R, Slaughter T, Britton-Webb J, et al. Development of a murine model of chronic rhinosinusitis[J]. Otolaryngol Head Neck Surg, 2006, 134(5):724-730. [16] Ahn B H, Park Y H, Shin S H. Mouse model of Aspergillus and Alternaria induced rhinosinusitis[J]. Auris Nasus Larynx, 2009, 36(4):422-426. [17] Kim S W, Kim D W, Khalmuratova R, et al. Resveratrol prevents development of eosinophilic rhinosinusitis with nasal polypsin a mouse model[J]. Allergy, 2013, 68(7):862-869. [18] Khalid A N, Hunt J, Perloff J R, et al. The role of bone in chronic rhinosinusitis[J]. Laryngoscope, 2002, 112(11):1951-1957. [19] Sautter N B, Delaney K L, Hausman F A, et al. Tissue remodeling gene expression in a murine model of chronic rhinosinusitis[J]. Laryngoscope, 2012, 122(4):711-717. [20] Lane A P, Turner J, May L, et al. A genetic model of chronic rhinosinusitis-associated olfactory inflammationreveals reversible functional impairment and dramatic neuroepithelial reorganization[J]. J Neurosci, 2010, 30(6):2324-2329. [21] Turner J H, Liang K L, May L, et al. Tumor necrosis factor alpha inhibits olfactory regeneration in a transgenic modelof chronic rhinosinusitis-associated olfactory loss[J]. Am J Rhinol Allergy, 2010, 24(3):336-340. [22] Ostrowski L E, Yin W, Rogers T D, et al. Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesiacauses chronic rhinosinusitis[J]. Am J Respir Cell Mol Biol, 2010, 43(1):55-63. [23] Lee K I, Kim D W, Kim E H, et al. Cigarette smoke promotes eosinophilic inflammation, airway remodeling, and nasal polyps in a murine polyp model[J]. Am J Rhinol Allergy, 2014, 28(3):208-214. |
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