鼻用激素治疗儿童阻塞性睡眠呼吸暂停低通气综合征疗效的Meta分析

doi:10.6040/j.issn.1673-3770.0.2014.347

摘要/Abstract

摘要： 目的通过Meta分析探讨鼻用激素治疗儿童阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的疗效。方法依照既定的纳入和排除标准, 通过计算机对Pubmed数据库、中国生物医学文献光盘数据库(CBMdisc)、中国知网全文数据库(CNKI)中英文数据库的相关文献进行检索, 并结合文献追溯、网上查询(www.metstr.com;www.cnki.net)的方法获取全文。结果共纳入3篇英文文献, 涉及88例患者, Meta分析结果显示, 鼻用激素可明显减轻患者加权平均呼吸暂停低通气指数(AHI)[WMD=4.07, 95% CI(0.00,8.14), P<0.000 01]。结论应用鼻用激素可能有助于减轻儿童OSAHS患者病情程度。

关键词: 儿童, 睡眠呼吸暂停, 阻塞性, Meta分析, 鼻用激素

Abstract: Objective To investigate the effectiveness of nasal corticosteroids to treat the children with obstructive sleep apnea hypopnea syndrome (OSAHS) using meta-analysis. Methods The published articles were searched from PubMed, Chinese Biomedical Literature CD-ROM databases, and China Academic Journals Full-text database bases on the inclusion and exclusion criteria. The results of the found studies were analyzed. Results 3 English articles and 88 cases were finally included. The results of Meta analysis showed that application of nasal corticosteroids significantly reduced the weighted mean AHI[weighted mean difference (WMD)=4.07, 95% CI(0.00, 8.14), P<0.000 01]. Conclusion Nasal corticosteroids may be helpful in ameliorating children with OSAHS.

Key words: Sleep apnea hypopnea syndrome, obstructive, Meta analysis, Nasal corticosteroids, Child

中图分类号:

R766.7

陈曦, 李进让. 鼻用激素治疗儿童阻塞性睡眠呼吸暂停低通气综合征疗效的Meta分析[J]. 山东大学耳鼻喉眼学报, 2015, 29(2): 9-11.

CHEN Xi, LI Jin-rang. Meta analysis of nasal corticosteroid treatment in the children with obstructive sleep apnea hypopnea syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(2): 9-11.

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