山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (3): 43-45.doi: 10.6040/j.issn.1673-3770.0.2014.215

• 论著 • 上一篇    下一篇

S-100蛋白和HLA-DR在鼻息肉组织中的表达

姜海华   

  1. 滨州医学院烟台附属医院耳鼻喉科, 山东 烟台 264100
  • 收稿日期:2014-06-24 修回日期:2015-05-08 发布日期:2015-06-16
  • 作者简介:姜海华。E-mail:mpjhh@sina.com

Expressions of S-100 protein and HLA-DR in nasal polyps

JIANG Haihua   

  1. Department of Otolaryngology, Yantai Hospital Affiliated to Binzhou Medical University, Yantai 264100, Shandong, China
  • Received:2014-06-24 Revised:2015-05-08 Published:2015-06-16

PDF (PC)

367

被引次数

1

摘要： 目的 研究糖皮质激素治疗前后S-100蛋白和HLA-DR在鼻息肉组织中的表达, 探讨二者介导的免疫反应在糖皮质激素治疗鼻息肉的作用机制。方法 收集2010年11月至2012年6月在滨州医学院烟台附属医院耳鼻喉科行鼻内镜手术治疗的鼻息肉标本74例, 其中激素治疗组37例, 未用激素治疗组37例;另取同期收治的单纯鼻中隔偏曲患者行鼻内镜下鼻中隔偏曲矫正术中切除的下鼻甲组织21例为正常对照组。采用免疫组织化学染色法检测S-100蛋白、HLA-DR在三组的表达水平。结果 S-100蛋白、HLA-DR在有鼻息肉组织中的表达明显高于正常对照组, 差异有统计学意义(P<0.05)。S-100蛋白、HLA-DR在未经治疗的鼻息肉组中的表达明显高于经激素治疗5 d的鼻息肉组, 差异亦有统计学意义(P<0.05)。结论 S-100蛋白、HLA-DR在鼻息肉组织中的高表达提示, 由二者介导的免疫反应在鼻息肉的发病中起重要作用。激素治疗5 d后鼻息肉组织中S-100蛋白、HLA-DR的表达降低, 表明激素的抗免疫机制发挥了作用。

关键词: 鼻息肉, S-100蛋白, HLA-DR, 糖皮质激素

Abstract: Objective To explore the expressions of S-100 protein and HLA-DR in nasal polyps, so as to investigate the immune reaction mediated by the two mechanism of action in the pathogenesis of nasal polyps before and after glucocorticoid treatment. Methods From November 2010 to June 2012, 74 cases of nasal polyp were treated by endoscopy in our department, of them, 37 cases were treated with hormone and 37 cases were treated without. 21 cases of inferior turbinate mucosa taken from patients treated by Deviation of nasal septum served as the control group. Results Expressions of S-100 protein and HLA-DR in the nasal polyp tissues were significantly higher than those in the control group, and they were significantly higher in the treatment group than in the hormone 5 days treatment group (P<0.05). Conclusion In the nasal polyp tissues, high expressions of S 100 protein and HLA-DR suggest that the immune response mediated by the two play an important role in the pathogenesis of nasal polyps. After 5 days hormone treatment, the expressions of S 100 protein and HLA-DR decreased, which suggest that hormones play some role in anti-immune action.

Key words: Glucocorticoid, Nasal polyps, S-100 protein, HLA-DR

中图分类号: 

  • R765.25
[1] Frisman D M, Taylor C R. Immunohistology of the skin: Melanoma, intermediate filament[M]// In: Taylor C R, Cote R J. Immunomicroscopy: adiagnostic tool for the surgical pathologist. 2th ed. Philadelphia: Saunders, 1994: 321.
[2] Reinherz E L, Kung P C, Pesando J M, et al. Is determinants on human T-cell subsets defined by monoclonal antibody: activation stimuli required for expression[J]. J Exp Med, 1979, 150(6):1472-1482.
[3] Coste A, Wang Q P, Roudot-Thoraval F, et al. Epithelial cell proliferation in nasal polyps could be up-regulated by platelet-derived growth factor[J]. Laryngoscope, 1996, 106(5):578-583.
[4] Li H B, Cai K M, Liu Z, et al. Foxp3+T regulatory cells(Tregs)are increased in nasal polyps(NP)after treatment with intranasal steroid[J]. Clin Immunol, 2008, 129(3):394-400.
[5] Karagiannidis C, Akdis M, Holopainen P, et al. lucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma[J]. J Allergy Clin Immunol, 2004, 114(6):1425-1433.
[1] 李梦欣,徐慧,张晓玲,薛晴,纪霜钰,李莹莹,崔丽梅,郭兆剑,宋西成,孙岩,陈良. 糖皮质激素通过下调水通道蛋白2缓解精氨酸加压素诱导的膜迷路积水[J]. 山东大学耳鼻喉眼学报, 2026, 40(3): 1-6.
[2] 冯思聪,于晓岚,娄丹. 基于囊泡组织Ki67、GM-CSF表达评估Messerklinger中鼻甲成形术对慢性鼻-鼻窦炎合并鼻息肉的效果[J]. 山东大学耳鼻喉眼学报, 2026, 40(3): 31-39.
[3] 段思妤,薛金梅. 组蛋白去乙酰化酶2在慢性气道炎症性疾病糖皮质激素抵抗中的研究进展[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 120-126.
[4] 熊琴, 张砚, 乌日娜, 李锋, 唐力行. 鼻用糖皮质激素在儿童中的应用[J]. 山东大学耳鼻喉眼学报, 2025, 39(6): 160-167.
[5] 张家齐,袁野,洪陈,顾敏,程雷,陆美萍. 基于孟德尔随机化的肠道菌群与慢性鼻窦炎鼻息肉的因果关系及代谢物中介研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 49-60.
[6] 张广玲,陈兴雪,武天义,孙占伟,王卫卫,李世超,王广科. Tespa1在慢性鼻窦炎伴鼻息肉中的表达及作用研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 35-42.
[7] 曹正勇,李小波. 慢性鼻-鼻窦炎合并哮喘术后短程局部使用糖皮质激素辅助治疗的安全性和有效性[J]. 山东大学耳鼻喉眼学报, 2025, 39(2): 43-50.
[8] 王文晴,张丹,朱梦迪,王路阳,杨培培,孙思思,张秋敏,周慧. 慢性鼻窦炎伴鼻息肉复发手术时临床及组织病理学特征变化[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 46-53.
[9] 王奥维,时文杰. CRSwNP中医证型与TFH细胞相关因子的相关性研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 54-60.
[10] 张婕,尼玛吉宗,徐小东,周菁,刘建敏,罗依蕤,杜进涛,巴罗. 藏红花素在嗜酸性慢性鼻窦炎伴鼻息肉中调控2型炎症反应的研究[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 61-67.
[11] 石忠刚,蔡晓岚,李学忠,张立强,冯昕. 上颌骨囊肿并内翻性乳头状瘤1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 123-129.
[12] 张韵秋,任秀敏,徐鸥,董金辉,王建星. 奥马珠单抗靶向治疗慢性鼻窦炎伴鼻息肉的研究进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(1): 136-140.
[13] 王振晓,时光刚,何明强,时蕾. 哮吼患者的治疗选择和管理策略[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 136-144.
[14] 陈兴雪,张广玲,武天义,王卫卫,孙占伟,李世超,王广科. 抗IL-4Rα单克隆抗体与鼻内镜手术治疗嗜酸性粒细胞型慢性鼻窦炎伴鼻息肉的疗效分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 43-54.
[15] 张诗涵,刘红兵. 基质金属蛋白酶对慢性鼻窦炎组织重塑的影响[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 116-123.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发