眼缺血综合征研究进展

doi:10.6040/j.issn.1673-3770.1.2020.059

山东大学耳鼻喉眼学报 ›› 2020, Vol. 34 ›› Issue (4): 23-27.doi: 10.6040/j.issn.1673-3770.1.2020.059

• 眼缺血综合征多学科精准诊疗专家笔谈 • 上一篇下一篇

眼缺血综合征研究进展

王露萍黄映湘,王艳玲

王露萍综述黄映湘, 王艳玲审校首都医科大附属北京友谊医院眼科, 北京 100050

收稿日期:2020-06-21 出版日期:2020-07-20 发布日期:2020-08-28
基金资助:
国家自然科学基金资助(81870686);首都卫生发展科研专项资助(首发2018-1-2021)doi:106040/jissn1673-377012020059·专家笔谈·眼缺血综合征研究进展王露萍综述

Recent ocular ischemic syndrome advancesWANG Luping Overview HUANG Yingxiang, WANG Yanling Guidance Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract:

Key words:Ocular ischemic syndrome;
Fluorescein angiography;
Optical coherence tomography angiography;
Cell therapy眼缺血综合征(ocular ischemic syndrome, OIS)是由同侧颈总动脉或颈内动脉狭窄或阻塞导致眼动脉(视网膜中央动脉及睫状前/后动脉)低灌注, 而产生一系列脑部和眼部症状的慢性进行性眼病。1963年Hedges^［1］首次报道颈内动脉闭塞患者不仅存在对侧肢体运动及感觉障碍, 并且合并一系列眼部症状, 如一过性黑矇、视物模糊等。除此之外, Hedges观察到此类患者视网膜存在静脉扩张和周边点片状出血, 由此提出颈动脉供血不足引起视网膜缺血缺氧的理论基础。OIS起病隐匿, 眼部表现复杂多样, 且容易被其他眼血管疾病掩盖, 如糖尿病性视网膜病变和视网膜静脉阻塞等, 因此临床上容易漏诊或误诊, 导致患者不可逆的视力丧失, 5年死亡率高达40%, 患者大多死于心肌梗死和脑梗死等心脑血管事件^［2-3］。因此, OIS需要眼科、神经科和心脏病科等多学科综合诊疗, 通过大规模临床研究, 建立OIS医学数据库, 进一步规范多学科诊疗流程, 对于降低患者的患盲率和死亡率是至关重要的。

Received:2020-06-21 Online:2020-07-20 Published:2020-08-28

摘要/Abstract

摘要： 眼缺血综合征起病隐匿,眼部表现多样,临床上易被漏诊或误诊从而导致患者不可逆的视力丧失,且合并眼缺血综合征患者远期心脑血管疾病死亡风险较高。提高各学科临床医生对眼缺血综合征的认知和诊疗水平有助于发挥多学科交叉协同作用,预防和早期发现血管性疾病的危险因素和全身性并发症,降低致盲率和致死率。本文就眼缺血综合征的流行病学、临床表现以及诊疗措施的最新研究进展进行综述。

关键词: 眼缺血综合征, 荧光血管造影, 光学相干断层扫描血管成像, 干细胞治疗

Abstract: Ocular ischemic syndrome(OIS)is usually undiagnosed or misdiagnosed due to its asymptomatic onset, complicated ocular manifestations, and the lack of awareness, and patients with OIS have a higher mortality. Improving the understanding, diagnosis, and treatment of OIS through multidisciplinary collaboration is key to investigating and preventing systemic vascular events as well as decreasing blindness and mortality. This review summarizes the recent advances in the epidemiology, clinical diagnosis, and management of OIS.

Key words: Ocular ischemic syndrome, Fluorescein angiography, Optical coherence tomography angiography, Cell therapy

中图分类号:

R771.3

王露萍黄映湘, 王艳玲. 眼缺血综合征研究进展[J]. 山东大学耳鼻喉眼学报, 2020, 34(4): 23-27.

Ocular ischemic syndrome(OIS)is usually undiagnosed or misdiagnosed due to its asymptomatic onset, complicated ocular manifestations, and the lack of awareness, and patients with OIS have a higher mortality. Improving the understanding, diagnosis, and treatment of OIS through multidisciplinary collaboration is key to investigating and preventing systemic vascular events as well as decreasing blindness and mortality. This review summarizes the recent advances in the epidemiology, clinical diagnosis, and management of OIS.. Recent ocular ischemic syndrome advancesWANG Luping Overview HUANG Yingxiang, WANG Yanling Guidance Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract:[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 23-27.

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眼缺血综合征研究进展

Recent ocular ischemic syndrome advancesWANG Luping Overview HUANG Yingxiang, WANG Yanling Guidance Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaAbstract:

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