山东大学耳鼻喉眼学报 ›› 2022, Vol. 36 ›› Issue (3): 202-208.doi: 10.6040/j.issn.1673-3770.0.2021.420

• 临床研究 • 上一篇    下一篇

基于数据挖掘探究阮岩治疗慢性鼻窦炎的用药规律

刘铮1,2, 方彩珊1, 毛淑娴3, 蓝婉宁1, 金燕1,2, 廖柏霖4, 黄丹琳1, 钟方鉴1, 阮岩5   

  1. 1. 广州中医药大学第一临床医学院, 广东 广州 510405;
    2. 广州中医药大学第一附属医院 治未病科, 广东 广州 510405;
    3. 广州中医药大学第二临床医学院, 广东 广州 510405;
    4. 广州中医药大学第三临床医学院, 广东 广州 510405;
    5. 广州中医药大学第一附属医院 耳鼻喉科, 广东 广州 510405
  • 发布日期:2022-06-15
  • 通讯作者: 阮岩. E-mail:ruanyan63@163.com
  • 基金资助:
    国家自然科学基金面上项目(8197151814);2020年阮岩省名中医传承工作室项目(2100600145);广州中医药大学第一附属医院创新强院耳鼻喉科项目(211010010715)

Exploring the medication pattern of professor Ruan Yan in the treatment of chronic sinusitis based on data mining

LIU Zheng1,2, FANG Caishan1, MAO Shuxian3, LAN Wanning1, JIN Yan1,2, LIAO Bolin4, HUANG Danlin1, ZHONG Fangjian1, RUAN Yan2   

  1. 1. The First Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    2. Department of Pre-treatment, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    3. The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    4. The Third Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China;
    5. Department of Otolaryngology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China
  • Published:2022-06-15

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摘要： 目的 基于中医传承辅助平台系统分析广州中医药大学第一附属医院阮岩教授治疗慢性鼻窦炎的用药规律。 方法 通过收集和整理阮岩教授门诊治疗慢性鼻窦炎患者的有效病历,严格按照纳入与排除标准,遴选符合标准的医案,建立医案数据库,运用频数统计、关联规则分析、聚类分析对医案中的证型分布、药物频数、中药组合等进行统计分析,探讨阮岩教授治疗慢性鼻窦炎的用药特点及组方规律。 结果 共收集阮岩教授治疗慢性鼻窦炎医案159则,包含245个处方,共109味中药(除去甜叶菊)。其中159个医案中脾胃湿热证型占比最大;使用频次≥20的中药有24味;对高频中药进行关联规则分析得到关联药对13个,三味关联中药药组15个,四味关联中药药组4个,并通过聚类分析和因子分析得出7个治疗慢性鼻窦炎的潜在核心基础方及7个核心新处方。 结论 岭南大部分慢性鼻窦炎患者的证型与气候特点相一致,以脾胃湿热证型的患者居多。阮岩教授治疗慢性鼻窦炎有其独特的治法,认为虚实夹杂是其主要病机,擅于运用补脾益气、宣通鼻窍、清热化湿等主要治法,因地制宜,达到标本兼治。其中,苍耳子散是阮岩教授治疗慢性鼻窦炎最常用的基础方。

关键词: 慢性鼻窦炎, 数据挖掘, 用药规律, 组方规律, 苍耳子散

Abstract: Objective To analyze the medication patterns of Professor Ruan Yan of the First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, for the treatment of chronic sinusitis, based on the Traditional Chinese Medicine(TCM)inheritance aid platform system. Methods Valid medical records of patients with chronic rhinosinusitis from Professor Ruan Yan's outpatient clinic were collected and collated. The medical cases that met the criteria were selected strictly according to the inclusion and exclusion criteria, and a medical case database was established. Subsequently, frequency statistics, association rule analysis, and cluster analysis were used to statistically analyze the distribution of evidence types, frequency of drugs, and combinations of Chinese medicines in the medical case repertoire. This was done to explore the characteristics of Professor Ruan Yan's treatment of chronic rhinosinusitis and the rules of prescription grouping. Results We collected 159 medical records of patients treated for chronic sinusitis by Professor Ruan Yan, containing 245 prescriptions with 109 Chinese herbs(except Stevia rebaudiana). The statistical analysis showed that the largest proportion of all cases was the spleen and stomach damp-heat evidence type; 24 herbs were used ≥20 times. The association rule analysis of high-frequency herbs yielded 13 associated pairs, 15 groups of three associated herbs, and four groups of four associated herbs. Additionally, seven potential core basic prescriptions and seven core new prescriptions for the treatment of chronic sinusitis were derived using cluster and factor analyses. Conclusion Most patients with chronic rhinosinusitis in Lingnan have evidence patterns consistent with climatic characteristics, with the majority of patients having the damp-heat evidence pattern of the spleen and stomach. Professor Ruan Yan considers deficiency and reality as the main pathogenesis based on his unique treatment method for chronic sinusitus. Additionally, Professor Ruan Yan is good at using the main treatment methods such as benefiting qi and strengthening the spleen, promoting nasal circulation, and clearing heat and dampness to achieve both the symptoms and the root cause of the disease according to local conditions. What'more, Xanthium Powder is the basic prescription of Professor Ruan Yan for treating chronic sinusitis.

Key words: Chronic sinusitis, Data mining, Medication pattern, Prescription pattern, Xanthium Powder

中图分类号: 

  • R276.1
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