细胞焦亡在慢性气道炎症性疾病中的研究进展

doi:10.6040/j.issn.1673-3770.0.2022.197

摘要/Abstract

摘要： 细胞焦亡是由半胱氨酸蛋白酶介导的促炎性的细胞程序性死亡,包括caspase-1介导的经典途径和caspase-4/5/11介导的非经典途径。细胞焦亡在慢性气道炎症性疾病的发生发展过程中发挥重要作用,已成为慢性气道炎症性疾病发病机制的研究热点。论文介绍细胞焦亡的概念,及其在变应性鼻炎、慢性鼻窦炎、哮喘和慢性阻塞性肺疾病中的研究进展,可能为治疗该类疾病提供新思路。

关键词: 细胞焦亡, 变应性鼻炎, 慢性鼻窦炎, 哮喘, 慢性阻塞性肺疾病

Abstract: Pyroptosis is a form of programmed cell death that involves the activation of canonical(caspase-1-dependent)and noncanonical(caspase-4/5/11-dependent)pathways, which are normally triggered by inflammatory factors. Pyroptosis has become a trending discussion topic due to its role in promoting chronic inflammatory airway diseases, as revealed by previous studies. This paper reviews the latest research advances in pyroptosis, with respect to allergic rhinitis, chronic sinusitis, asthma, and chronic obstructive pulmonary diseases, with the aim of catalyzing new ideas for improved treatments.

Key words: Pyroptosis, Allergic rhinitis, Chronic sinusitis, Asthma, Chronic obstructive pulmonary disease

中图分类号:

袁玥,付圣尧,姜彦,陈敏. 细胞焦亡在慢性气道炎症性疾病中的研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(4): 166-171.

YUAN Yue, FU Shengyao, JIANG Yan, CHEN Min. Research progress of pyroptosis in chronic airway inflammatory disease[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 166-171.

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