山东大学耳鼻喉眼学报 ›› 2021, Vol. 35 ›› Issue (4): 35-39.doi: 10.6040/j.issn.1673-3770.0.2021.140

• • 上一篇    下一篇

累及喉部的进行性结节性组织细胞增生症1例并文献复习

廖静雯1,陈敏1,李娜1,黄沂传1,赵涵2   

  1. 青岛大学附属医院 1. 耳鼻咽喉头颈外科;
    2.病理科, 山东 青岛 266071
  • 发布日期:2021-08-05
  • 通讯作者: 李娜. E-mail:dr.lina@163.com

Laryngeal involvement in progressive nodular histiocytosis: a case report with literature review

LIAO Jingwen1, CHEN Min1, LI Na1, HUANG Yichuan1, ZHAO Han2   

  1. Affiliated Hospital of Qingdao University 1.Department of Otorhinolaryngology & Head and Neck Surgery;
    2. Department of Pathology Qingdao 266071, Shandong, China;
  • Published:2021-08-05

摘要: 目的 探讨1例罕见的累及喉部的进行性结节性组织细胞增生症的诊疗过程、临床及病理特点。 方法 提取患者的病例资料、病理切片,对切片进行免疫组化染色观察,总结本病历的特点并查询PNH相关文献。 结果 本病历中患者的病理提示梭形细胞弥漫浸润,免疫组化显示CD68和CD163阳性。患者出现声门上狭窄、气管壁增厚、气管内多发结节,曾因呼吸困难行气管切开,累及皮肤形成多发结节,面部结节形成“狮面”外观,确诊后予以安罗替尼药物治疗可减缓病情发展。 结论 该病通过病理检查确诊,可累及喉部引起呼吸困难,面部结节除非严重影响功能,不主张手术切除皮损。

关键词: 组织细胞增生症, 非肿瘤性增生性皮肤病, 非朗格汉斯细胞组织细胞增生症,

Abstract: Objective To explore the diagnosis and treatment, the clinical characteristic, as well as the pathological features, of a rare case of progressive nodular histiocytosis involving the larynx. Methods Patient case data, pathological sections were extracted and observed by immunohistochemical staining to summarize the characteristics of this case and to consult the literature related to PNH. Results The pathology of the patient in this case suggested a diffuse infiltration of spindle cells, and immunohistochemistry was positive for CD68 and CD163. The patient presented with supraglottic stenosis, thickening of the tracheal wall, and multiple nodules in the trachea. The patient had undergone a tracheotomy due to dyspnea. This disease involves the skin, and it manifests in multiple nodules and facial nodules that give rise to a “lion face” appearance. After diagnosis, treatment with anlotinib can delay the development of this disease. Conclusion The disease is diagnosed based on pathological examination. It can involve the larynx and cause breathing difficulties. Surgical removal of the facial nodules is not recommended unless body function is seriously affected.

Key words: Histiocytosis, Non-neoplastic proliferative skin disease, Non-Langerhans cell histiocytosis, Laryngeal

中图分类号: 

  • R758.6
[1] Taunton OD, Yeshurun D, Jarratt M. Progressive nodular histiocytoma[J]. Arch Dermatol, 1978, 114(10): 1505-1508.
[2] 渠涛, 方凯. 进行性结节性组织细胞增生症[J]. 临床皮肤科杂志, 2015,44(9): 555-558. doi:10.16761/j.cnki.1000-4963.2015.09.022. QU Tao, FANG Kai. Progressive nodular Histiocytosis: a case report and literature review[J]. J Clin Dermatol, 2015,44(9): 555-558. doi:10.16761/j.cnki.1000-4963.2015.09.022.
[3] Chu AC. The confusing state of the histiocytoses[J]. Br J Dermatol, 2000, 143(3): 475-476. doi:10.1111/j.1365-2133.2000.03821.x.
[4] Glavin FL, Chhatwall H, Karimi K. Progressive nodular Histiocytosis: a case report with literature review, and discussion of differential diagnosis and classification[J]. J Cutan Pathol, 2009, 36(12): 1286-1292. doi:10.1111/j.1600-0560.2009.01454.x.
[5] Amin SM, Riddle C, Fraga GR, et al. Progressive nodular Histiocytosis with normal karyotypic analysis[J]. Dermatol Online J, 2013, 19(6): 18577.
[6] Nofal A, Assaf M, Tawfik A, et al. Progressive nodular Histiocytosis: a case report and literature review[J]. Int J Dermatol, 2011, 50(12): 1546-1551. doi:10.1111/j.1365-4632.2011.04904.x.
[7] Hilker O, Kovneristy A, Varga R, et al. Progressive nodular Histiocytosis[J]. J Ger Soc Dermatol: JDDG, 2013, 11(4): 301-307. doi:10.1111/j.1610-0387.2012.08069.x.
[8] Bratschi MW, Steinmann P, Wickenden A, et al. Current knowledge on Mycobacterium leprae transmission: a systematic literature review[J]. Lepr Rev, 2015, 86(2): 142-155.
[9] 程海星, 葛兰, 翟志芳, 等. 肉芽肿性蕈样肉芽肿[J]. 临床皮肤科杂志, 2019,48(12): 749-751. doi:10.16761/j.cnki.1000-4963.2019.12.013. CHENG Haixing, GE Lan, ZHAI Zhifang, et al. A case of granulomatous mycosis fungoides[J]. J Clin Dermatol, 2019,48(12): 749-751. doi:10.16761/j.cnki.1000-4963.2019.12.013.
[10] Spagnolo P, Renzoni EA, Wells AU, et al. C-C chemokine receptor 2 and sarcoidosis: association with Lofgren's syndrome[J]. Am J Respir Crit Care Med, 2003, 168(10): 1162-1166. doi:10.1164/rccm.200303-456OC.
[11] 王晓琴, 程岩峰, 韩秀萍. 皮肤结节病12例诊断与误诊分析[J]. 中国误诊学杂志, 2011, 11(3): 638.
[12] Gonzalez Ruíz A, Bernal Ruíz AI, Aragoneses Fraile H, et al. Progressive nodular Histiocytosis accompanied by systemic disorders[J]. Br J Dermatol, 2000, 143(3): 628-631. doi:10.1111/j.1365-2133.2000.03723.x.
[13] Watanabe T, Watanabe D, Tamada Y, et al. Progressive nodular Histiocytosis-A five-year follow up[J]. Eur J Dermatol, 2008, 18(2): 200-202. doi:10.1684/ejd.2008.0370.
[14] Huet F, Brenaut E, Costa S, et al. Progressive nodular Histiocytosis improved by methotrexate[J]. Eur J Dermatol, 2017, 27(6): 661-663. doi:10.1684/ejd.2017.3115.
[15] Williams A, Thomas AG, Kwatra KS, et al. Progressive nodular Histiocytosis associated with eale's disease[J]. Indian J Dermatol, 2015, 60(4): 388-390. doi:10.4103/0019-5154.160492.
[16] 王俊, 冉凤鸣, 金兵. 安罗替尼治疗恶性肿瘤的临床研究进展[J]. 中国肿瘤, 2019, 28(5): 359-366. doi:10.11735/j.issn.1004-0242.2019.05.A008. WANG Jun, RAN Fengming, JIN Bing. Progress on clinical research of anlotinib in cancer treatment[J]. China Cancer, 2019, 28(5): 359-366. doi:10.11735/j.issn.1004-0242.2019.05.A008.
[17] Wang LL, He Z, Yang S, et al. The impact of previous therapy strategy on the efficiency of anlotinib hydrochloride as a third-line treatment on patients with advanced non-small cell lung cancer(NSCLC): a subgroup analysis of ALTER0303 trial[J]. Transl Lung Cancer Res, 2019, 8(5): 575-583. doi:10.21037/tlcr.2019.09.21.
[18] Chi Y, Fang ZW, Hong XN, et al. Safety and efficacy of anlotinib, a multikinase angiogenesis inhibitor, in patients with refractory metastatic soft-tissue sarcoma[J]. Clin Cancer Res, 2018, 24(21): 5233-5238. doi:10.1158/1078-0432.CCR-17-3766.
[1] 李利杰,田秀芬. CO2激光联合低温等离子治疗早期声门型喉癌40例[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 79-85.
[2] 毛泽凡陈曦,程雷. 喉神经内分泌癌的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 114-119.
[3] 王媚 李志海. 喉癌干细胞:克服多药耐药性的潜在治疗靶点[J]. 山东大学耳鼻喉眼学报, 2022, 36(4): 120-128.
[4] 秦铭,孙占伟,王卫卫,李世超,武天义,王广科. 咽喉反流症状或体征评分阳性的慢性鼻窦炎患者鼻内镜术后碱性等渗盐水冲洗的疗效观察[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 147-153.
[5] 曾宪廷,王广科,孙占伟,武天义,李世超,王卫卫. 伴咽喉反流的难治性鼻窦炎术后应用质子泵抑制剂的疗效观察[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 189-194.
[6] 侯波,梁程程,魏东敏,雍蓉,雷大鹏,李梅. 耳鼻咽喉门诊咽喉良性病变老年患者喉镜观察与嗓音声学分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 20-25.
[7] 王晓亭,陈正侬,易红良. 利用RNA-seq探讨谷氨酰胺剥夺对喉癌细胞转录组的影响[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 26-31.
[8] 刘勇,袁存立,曹慧,郑成彩,晁方, 许风雷. CHD1L通过EMT促进喉鳞状细胞癌细胞的增殖、侵袭和转移[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 32-39.
[9] 曾斌, 吕丹, 任佳, 胡娟娟, 于凌昱, 卢欢, 杨慧. 喉显微外科技术在严重新生儿上气道梗阻中的应用[J]. 山东大学耳鼻喉眼学报, 2022, 36(1): 95-99.
[10] 黄桂亮,孙昌志,罗仁忠,陈彦球,刘少锋,许家健. 内镜在婴幼儿舌根囊肿手术中的临床应用分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(1): 100-105.
[11] 赵海涛, 王亚芳, 赫莉, 陈文静, 邢民者, 郑文娟,阎玉彦,刘晓峰. 可视喉镜在先天性舌根囊肿患儿手术麻醉中的应用[J]. 山东大学耳鼻喉眼学报, 2022, 36(1): 106-110.
[12] 龙婷,刘雨薇,王生才,张杰,李艳珍,张雪溪,刘悄吟,刘志勇,孙念,倪鑫. 内镜CO2激光烧灼术治疗273例儿童先天性梨状窝瘘的临床分析[J]. 山东大学耳鼻喉眼学报, 2022, 36(1): 125-130.
[13] 冯成敏,敬一丹,刘海,王冰. 咽喉部鳞状细胞癌细胞系[J]. 山东大学耳鼻喉眼学报, 2021, 35(6): 113-124.
[14] 王迪,程金章,于丹. 基于机器学习的人工智能技术在耳鼻喉科临床诊疗中的应用进展[J]. 山东大学耳鼻喉眼学报, 2021, 35(6): 125-131.
[15] 冯世强,姜宪. 可调式支撑喉镜辅助治疗难治性扁桃体术后出血[J]. 山东大学耳鼻喉眼学报, 2021, 35(5): 67-69.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] 杨长亮,黄治物,姚行齐,诸勇,孙艺 . 正常气骨导听性脑干反应及其应用[J]. 山东大学耳鼻喉眼学报, 2006, 20(1): 9 -13 .
[2] 曹忠良 . 颌面复合伤155例临床分析[J]. 山东大学耳鼻喉眼学报, 2006, 20(1): 89 -89 .
[3] 毕景云 . 鼻中隔矫正术后血肿的处理[J]. 山东大学耳鼻喉眼学报, 2006, 20(1): 90 -91 .
[4] 刘大昱,潘新良,雷大鹏,许风雷,张立强,栾信庸 . 梨状窝内侧壁癌的手术治疗[J]. 山东大学耳鼻喉眼学报, 2007, 21(1): 8 -11 .
[5] 楼正才 . 掌拳击伤鼓膜损伤机制及临床特点分析[J]. 山东大学耳鼻喉眼学报, 2008, 22(2): 188 -188 .
[6] 刘 艳,刘新义,王金平,李大健 . 后鼓室解剖结构测量观察及临床意义[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 218 -221 .
[7] 赵 敏,王守森,甄泽年,陈贤明,王茂鑫 . 鼻内镜联合显微镜行蝶窦及经蝶鞍区微创手术[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 244 -245 .
[8] 伦 杰,吕心红 . 鼻部脂溢性角化病1例[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 252 -252 .
[9] 王红霞,王鹏程 . NSE、S100及GFAP在视网膜母细胞瘤中的表达及意义[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 263 -264 .
[10] 黄 方,黄海琼,黄建强,何荷蕃 . 支气管内镜视频监视系统在小儿气管-支气管异物诊治中的应用[J]. 山东大学耳鼻喉眼学报, 2008, 22(3): 276 -277 .