Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 109-113.doi: 10.6040/j.issn.1673-3770.0.2020.037

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Progress in aryl hydrocarbon receptor-induced inhibition of Th17 immune response in allergic rhinitis

YANG Yanyan, YANG YujuanOverview,SONG XichengGuidance   

  1. Department of Otorhinolaryngology & Head and Neck surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, Shandong, China
  • Published:2021-02-01

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Abstract: Allergic rhinitis(AR)is an immunoglobulin E(IgE)-mediated inflammatory response on the nasal mucous membranes that usually ensues contact with allergens. Studies on a Th1/Th2 cell model alone are not sufficient for discussing the pathogenesis of AR; hence, the Th1/Th2; Thl7/Treg cell model has recently been a topic of concern. The aryl hydrocarbon receptor(AhR)is a member of the basic helix-loop-helix/PER-ARNT-SIM family, which is activated by its ligand and expresses strong immunomodulation potential by regulating the differentiation of T lymphocytes and dendritic cells. This effect may play a protective role in autoimmune and allergic diseases. This report summarizes our study on the correlation between AhR activation and Th17 immune responses in AR patients, and provides new insights for further diagnosis and treatment of AR.

Key words: Allergic rhinitis, Th17, Treg, Aryl hydrocarbon receptor

CLC Number: 

  • R765.21
[1] Seidman MD, Gurgel RK, Lin SY, et al. Clinical practice guideline: allergic rhinitis[J]. Otolaryngol Head Neck Surg, 2015, 152(2): 197-206. doi: 10.1177/0194599814562166.
[2] 王玮豪, 黄雪琨, 陈壮桂, 等. 广州地区变应性鼻炎与非变应性鼻炎临床特征的研究[J]. 中国耳鼻咽喉头颈外科, 2016, 23(9): 533-536. doi:10.16066/j.1672-7002.2016.09.011. WANG Weihao, HUANG Xuekun, CHEN Zhuanggui, et al. Clinical characteristics in patients with allergic rhinitis and nonallergic rhinitis in Guangzhou[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2016, 23(9): 533-536. doi:10.16066/j.1672-7002.2016.09.011.
[3] Maio S, Baldacci S, Carrozzi L, et al. Respiratory symptoms/diseases prevalence is still increasing: a 25-yr population study[J]. Respir Med, 2016, 110: 58-65. doi:10.1016/j.rmed.2015.11.006.
[4] 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组.变应性鼻炎诊断和治疗指南(2015年,天津)[J].中华耳鼻咽喉头颈外科杂志, 2016, 51(1): 6-24. doi:10.3760/cma.j.issn.1673-0860.2016.01.004.
[5] Meng YF, Wang CS, Zhang L. Recent developments and highlights in allergic rhinitis[J]. Allergy, 2019, 74(12): 2320-2328. doi:10.1111/all.14067.
[6] Gu ZW, Wang YX, Cao ZW. Neutralization of interleukin-17 suppresses allergic rhinitis symptoms by downregulating Th2 and Th17 responses and upregulating the Treg response[J]. Oncotarget, 2017, 8(14): 22361-22369. doi:10.18632/oncotarget.15652.
[7] Kuwabara T, Ishikawa F, Kondo M, et al. The Role of IL-17 and Related Cytokines in Inflammatory Autoimmune Diseases[J]. Mediators Inflamm, 2017, 2017(12): 1-11. doi:10.1155/2017/3908061.
[8] Esser C, Rannug A. The aryl hydrocarbon receptor in barrier organ physiology, immunology, and toxicology[J]. Pharmacol Rev, 2015, 67(2): 259-279. doi:10.1124/pr.114.009001.
[9] Wei P, Hu GH, Kang HY, et al. Increased aryl hydrocarbon receptor expression in patients with allergic rhinitis[J]. QJM, 2014, 107(2): 107-113. doi:10.1093/qjmed/hct188.
[10] 卢汉桂, 林歆胜, 姚丹勉, 等. 变应性鼻炎大鼠IL-35的表达及对辅助性T细胞免疫调节的影响[J]. 山东大学耳鼻喉眼学报, 2018, 32(5): 66-70. doi:10.6040/j.issn.1673-3770.0.2018.105. LU Hangui, LIN Xinsheng, YAO Danmian, et al. Expression of IL-35 in allergic rhinitis and its effect on the immunoregulation of T cells[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 66-70. doi:10.6040/j.issn.1673-3770.0.2018.105.
[11] Quintana FJ, Basso AS, Iglesias AH, et al. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor[J]. Nature, 2008, 453(7191): 65-71. doi:10.1038/nature06880.
[12] Naufel AO, Aguiar MCF, Madeira FM, et al. Treg and Th17 cells in inflammatory periapical disease: a systematic review[J]. Braz Oral Res, 2017, 31: e103. doi:10.1590/1807-3107bor-2017.vol31.0103.
[13] Ren J, Li B. The functional stability of FOXP3 and RORγt in treg and Th17 and their therapeutic applications[J]. Adv Protein Chem Struct Biol, 2017, 107: 155-189. doi:10.1016/bs.apcsb.2016.10.002.
[14] Wei P, Hu GH, Kang HY, et al. An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Th17 response in allergic rhinitis patients[J]. Lab Invest, 2014, 94(5): 528-535. doi:10.1038/labinvest.2014.8.
[15] Ye J, Qiu J, Bostick JW, et al. The aryl hydrocarbon receptor preferentially marks and promotes gut regulatory T cells[J]. Cell Rep, 2017, 21(8): 2277-2290. doi:10.1016/j.celrep.2017.10.114.
[16] 赵竞一,盖建青,闫新宇,等.鼻敏煎治疗变应性鼻炎及对Treg/Th17免疫平衡的影响[J]. 中国耳鼻咽喉头颈外科, 2018, 25(9): 44-49. doi: CNKI:SUN:EBYT.0.2018-09-012. ZHAO Jingyi, GAI Jianqing, YAN Xinyu, et al. Effect of Bimin Decoction on allergic rhinitis and immune balance of Th1/Th2 in lung qi weak and cold pattern patients[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2018, 25(9): 497-502. doi: CNKI:SUN:EBYT.0.2018-09-012.
[17] 马娓, 黄文娟, 余静, 等. 芳香烃受体调控调节性T细胞的研究进展[J]. 中国细胞生物学学报, 2017, 39(1): 114-120. doi: 10.11844/cjcb.2017.01.0209. MA Wei, HUANG Wenjuan, YU Jing, et al. Progress of the role-aryl hydrocarbon receptor on regulatory T cell[J]. Chinese Journal of Cell Biology, 2017, 39(1): 114-120. doi: 10.11844/cjcb.2017.01.0209.
[18] Abron JD, Singh NP, Mishra MK, et al. An endogenous aryl hydrocarbon receptor ligand, ITE, induces regulatory T cells and ameliorates experimental colitis[J]. Am J Physiol Gastrointest Liver Physiol, 2018, 315(2): G220-G230. doi:10.1152/ajpgi.00413.2017.
[19] Goettel JA, Gandhi R, Kenison JE, et al. AHR activation is protective against colitis driven by T cells in humanized mice[J]. Cell Rep, 2016, 17(5): 1318-1329. doi:10.1016/j.celrep.2016.09.082.
[20] de Lima KA, Donate PB, Talbot J, et al. TGFβ1 signaling sustains aryl hydrocarbon receptor(AHR)expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism[J]. Cell Death Dis, 2018, 9(11): 1130. doi:10.1038/s41419-018-1107-7.
[21] Ehrlich AK, Pennington JM, Bisson WH, et al. TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation[J]. Toxicol Sci, 2018, 161(2): 310-320. doi:10.1093/toxsci/kfx215.
[22] Schiering C, Wincent E, Metidji A, et al. Feedback control of AHR signalling regulates intestinal immunity[J]. Nature, 2017, 542(7640): 242-245. doi:10.1038/nature21080.
[23] 霍娟, 杨晋, 胡文霞, 等. 类风湿关节炎患者外周血芳香烃受体表达与Th17细胞相关性研究[J]. 国际免疫学杂志, 2016, 39(5): 437-441. doi: 10.3760/cma.j.issn.1673-4394.2016.05.004. HUO Juan, YANG Jin, HU Wenxia, et al. Association of the expression of AhR in peripheral blood mononuclear cells and Th17 cell in the patients with rheumatoid arthritis[J]. International Journal of Immunology, 2016, 39(5): 437-441. doi: 10.3760/cma.j.issn.1673-4394.2016.05.004.
[24] Lanis JM, Alexeev EE, Curtis VF, et al. Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia[J]. Mucosal Immunol, 2017, 10(5): 1133-1144. doi:10.1038/mi.2016.133.
[25] Cheng L, Qian L, Tan Y, et al. Unbalanced expression of aryl hydrocarbon receptor in peripheral blood CCR6+CD4+ and CD4+CD25+T cells of rheumatoid arthritis[J]. Rev Bras Reumatol Engl Ed, 2017, 57(3): 190-196. doi:10.1016/j.rbre.2016.07.002.
[26] Li XM, Peng J, Gu W, et al. TCDD-induced activation of aryl hydrocarbon receptor inhibits Th17 polarization and regulates non-eosinophilic airway inflammation in asthma[J]. PLoS One, 2016, 11(3): e0150551. doi:10.1371/journal.pone.0150551.
[27] Yu HT, Jiang LL, Liu RQ, et al. Association between the ratio of aryl hydrocarbon receptor(AhR)in Th17 cells to AhR in Treg cells and SLE skin lesions[J]. Int Immunopharmacol, 2019, 69: 257-262. doi:10.1016/j.intimp.2019.01.039.
[28] Al-Ghezi ZZ, Singh N, Mehrpouya-Bahrami P, et al. AhR activation by TCDD(2, 3, 7, 8-tetrachlorodibenzo-p-dioxin)attenuates pertussis toxin-induced inflammatory responses by differential regulation of tregs and Th17 cells through specific targeting by microRNA[J]. Front Microbiol, 2019, 10: 2349. doi:10.3389/fmicb.2019.02349.
[29] Li XL, Cannon AR, Hammer AM, et al. IL-23 restoration of Th17 effector function is independent of IL-6 and TGF-β in a mouse model of alcohol and burn injury[J]. J Leukoc Biol, 2017, 102(3): 915-923. doi:10.1189/jlb.3A1216-527R.
[30] Angelos MG, Ruh PN, Webber BR, et al. Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent stem cells[J]. Blood, 2017, 129(26): 3428-3439. doi:10.1182/blood-2016-07-730440.
[31] 朱俊宇, 范霞, 梁华平. AhR调控炎性细胞因子的研究进展[J]. 免疫学杂志, 2017, 33(1): 73-77. doi: 10.1343/j.cnki.immunoi.j.20170014. ZHU Junyu, FAN Xia, LIANG Huaping. Research progress in regulation of aryl hydrocarbon receptor on inflammatory cytokines[J]. Immunological Journal, 2017, 33(1): 73-77. doi: 10.1343/j.cnki.immunoi.j.20170014.
[32] Shi Q, Lei Z, Cheng G, et al. Mitochondrial ROS activate interleukin-1β expression in allergic rhinitis[J]. Oncol Lett, 2018, 16(3): 3193-3200. doi:10.3892/ol.2018.8984.
[33] Li JP, Phadnis-Moghe AS, Crawford RB, et al. Aryl hydrocarbon receptor activation by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin impairs human B lymphopoiesis[J]. Toxicology, 2017, 378: 17-24. doi:10.1016/j.tox.2016.12.010.
[34] Dolciami D, Gargaro M, Cerra B, et al. Binding mode and structure-activity relationships of ITE as an aryl hydrocarbon receptor(AhR)agonist[J]. Chem Med Chem, 2018, 13(3): 270-279. doi:10.1002/cmdc.201700669.
[35] Zhu JY, Luo L, Tian LX, et al. Aryl hydrocarbon receptor promotes IL-10 expression in inflammatory macrophages through src-STAT3 signaling pathway[J]. Front Immunol, 2018, 9: 2033. doi:10.3389/fimmu.2018.02033.
[36] Yu SQ, Jin L, Che N, et al. Dendritic cells modified with Der p1 antigen as a therapeutic potential for allergic rhinitis in a murine model via regulatory effects on IL-4, IL-10 and IL-13[J]. Int Immunopharmacol, 2019, 70: 216-224. doi:10.1016/j.intimp.2019.02.045.
[37] Tsuji G, Hashimoto-Hachiya A, Kiyomatsu-Oda M, et al. Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis[J]. Cell Death Dis, 2017, 8(7): e2931. doi:10.1038/cddis.2017.322.
[38] Mohinta S, Kannan AK, Gowda K, et al. Differential regulation of Th17 and T regulatory cell differentiation by aryl hydrocarbon receptor dependent xenobiotic response element dependent and independent pathways[J]. Toxicol Sci, 2015, 145(2): 233-243. doi:10.1093/toxsci/kfv046.
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