Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (1): 109-113.doi: 10.6040/j.issn.1673-3770.0.2020.037

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Progress in aryl hydrocarbon receptor-induced inhibition of Th17 immune response in allergic rhinitis

YANG Yanyan, YANG YujuanOverview,SONG XichengGuidance   

  1. Department of Otorhinolaryngology & Head and Neck surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, Shandong, China
  • Published:2021-02-01

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Abstract: Allergic rhinitis(AR)is an immunoglobulin E(IgE)-mediated inflammatory response on the nasal mucous membranes that usually ensues contact with allergens. Studies on a Th1/Th2 cell model alone are not sufficient for discussing the pathogenesis of AR; hence, the Th1/Th2; Thl7/Treg cell model has recently been a topic of concern. The aryl hydrocarbon receptor(AhR)is a member of the basic helix-loop-helix/PER-ARNT-SIM family, which is activated by its ligand and expresses strong immunomodulation potential by regulating the differentiation of T lymphocytes and dendritic cells. This effect may play a protective role in autoimmune and allergic diseases. This report summarizes our study on the correlation between AhR activation and Th17 immune responses in AR patients, and provides new insights for further diagnosis and treatment of AR.

Key words: Allergic rhinitis, Th17, Treg, Aryl hydrocarbon receptor

CLC Number: 

  • R765.21
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