补体在喉鳞状细胞癌发生发展中作用机制的研究进展

doi:10.6040/j.issn.1673-3770.0.2023.334

Abstract

Abstract: The complement system is an important part of the immune system and is involved in the occurrence and development of a variety of diseases such as autoimmune diseases, infectious diseases, rheumatic diseases, blood diseases, and cancer. Laryngeal cancer the common malignancy of the head and neck Studying the mechanism whereby complement affects laryngeal squamous cell carcinoma and identifying effective biomarkers will help improve the diagnosis and treatment of laryngeal squamous cell carcinoma. This article briefly reviews the activation of the complement system, and explains how complement proteins affect the development and metastasis of laryngeal squamous cell carcinoma from the levels of the tumor microenvironment and the tumor cells themselves and their secretions, to provide a reference for further research on the clinical application of targeted therapy for laryngeal squamous cell carcinoma.

Key words: Complement system, Laryngeal squamous cell carcinoma, Tumor microenvironment, Epithelial- mesenchymal transition

CLC Number:

R739.65

HU Yi, KONG Xuhui. Research progress on the mechanism of complement in the development of laryngeal squamous cell carcinoma[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 148-155.

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Research progress on the mechanism of complement in the development of laryngeal squamous cell carcinoma

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