Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (2): 122-127.doi: 10.6040/j.issn.1673-3770.0.2022.516

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Expression and clinical significance of IL-29 and TLR4 in eosinophil infiltrated nasal polyps

YAN Huijuan, XIAO Xuping, ZHONG Yu   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, The First Affiliated Hospital of Hunan Normal University / Hunan provincial People's Hospital, Changsha 410005, Hunan, China
  • Online:2024-03-20 Published:2024-03-29

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Abstract: Nasal polyp is a chronic inflammatory disease of the nasal cavity and the nasal sinus mucosal epithelium. It is a common condition in otorhinolaryngology. Nasal polyp result from inflammation and fibrin deposition and are related to epithelial barrier dysfunction. Although endoscopic sinus surgery is relatively mature, some nasal polyps are difficult to treat and the condition has a high recurrence rate. Previous studies reported a 50% recurrence in patients with. Interleukin-29(IL-29), a newly discovered member of type Ⅲ interferon, mediates signal transduction by binding to its receptor complex, activates downstream signalling pathways, and induces the generation of inflammatory components. Toll-like receptor 4(TLR4), a member of the Toll-like receptor family, is involved in innate immunity and mediates inflammatory responses by recognizing lipopolysaccharide or bacterial endotoxins. Studies have shown that the expression of TLR4 in patients with nasal polyps is significantly increased. Although IL-29 and TLR4 are important in regulating inflammatory responses, their relationship and their correlation with eosinophil infiltration in patients with nasal polyps are unclear. An exploration of the clinical indicators related to eosinophil infiltration in nasal polyps may provide new ideas for the diagnosis and treatment of nasal polyps.

Key words: Eosinophil, Nasal polyp, Interleukin-29, Toll-like receptor 4

CLC Number: 

  • R765.25
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