长期使用前列腺素药物对青光眼患者睑板腺功能及角膜结构的影响

doi:10.6040/j.issn.1673-3770.0.2015.530

摘要/Abstract

摘要： 目的探讨长期使用前列腺素类药物(PGs)对青光眼患者睑板腺功能及角膜结构的影响。方法选取 31例(62眼)原发性开角型青光眼(POAG)患者为研究对象,其中15例(30眼)初诊患者未使用前列腺素类药物,设为对照组;16例(32眼)长期使用前列腺素类药物患者设为观察组。比较两组睑板腺功能、角膜各层细胞形态及数量、角膜上皮下神经纤维状况。结果观察组角膜基底层细胞密度、基质细胞激活态分级及神经扭曲度均高于对照组,而结膜杯状细胞密度、角膜上皮下神经分支数均低于对照组,差异有统计学意义(P<0.05);2组角膜层炎症细胞、朗格汉斯细胞、内皮细胞密度及神经密度、神经反光度比较差异无统计学意义(P>0.05);两组睑板腺功能障碍(MGD)发生率分别为46.7%(14/30)和71.9%(23/32),差异有统计学意义(P<0.05)。结论青光眼患者长期使用前列腺素药物治疗后其睑板腺功能及角膜结构会出现一定程度的损害,不仅MGD发生率提高,且角膜基质层细胞的形态改变,角膜下各层细胞及角膜上皮下神经纤维的变化明显,角膜下各层细胞密度下降。

关键词: 前列腺素, 青光眼, 角膜, 睑板腺

Abstract: Objective To investigate the influence of prostaglandins(PGs)long-term use on meibomian gland function and corneal structure in patients with primary open angle glaucoma(POAG). Methods A total of 31 POAG patients(62 eyes)were include in this study, in which 15 cases without administration of prostaglandin drug were set as the control group; and 16 cases with long-term use of prostaglandin drugs were set as the observation group. Meibomian gland function, shape and cell density of corneal cells, status of subbasal nerve fiber bundles were compared between two groups. Results The density of basal cells, stromal cells and degree of neural distortion were significantly higher in observation group than those in the control group, and density of conjunctival goblet cell, number of branches to cornea subcutaneous nerve were significantly lower in observation group than those than the control group, with significant differences(P<0.05); there was no significnat difference in density of inflammatory cells, Langerhans cells and endothelial cell. neuronal density, and nerve luminosity variations between two groups(P>0.05). the incidence of MGD was 46.7% in the control group and was 71.9% in the observation group(P<0.05). Conclusion Long-term use of PGs may lead a meibomian gland dysfunction and damage to structure of the cornea in patients with glaucoma, including increased risk of MGD, changes in density of subcorneal cells and function of subbasal nerve fiber bundles.

Key words: Meibomian gland, Prostaglandins, Glaucoma, Corneal

中图分类号:

R775

李冬梅. 长期使用前列腺素药物对青光眼患者睑板腺功能及角膜结构的影响[J]. 山东大学耳鼻喉眼学报, 2016, 30(3): 89-92.

LI Dongmei. Influence of long-term use of prostaglandin drugs on meibomian gland function and corneal structure in patients with primary open angle glaucoma.[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 89-92.

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