ISSN 1673-3770 CN 37-1437/R
山东大学耳鼻喉眼学报 ›› 2016, Vol. 30 ›› Issue (5): 75-80.doi: 10.6040/j.issn.1673-3770.0.2015.511
关乐静, 张亚梅
GUAN Lejing, ZHANG Yamei
摘要： 阻塞性睡眠呼吸暂停低通气综合征(OSAHS)在儿童中发病率较高,呼吸暂停引起的低氧血症可导致多系统器官功能损害。研究发现,OSAHS可对儿童的肺功能造成不同程度的影响,手术治疗后肺功能有一定的改善。本文就OSAHS对儿童肺功能的影响及治疗OSAHS后肺功能的改善情况做了综述。
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| [1] Xu Z, Jiaqing A, Yuchuan L, et al. A case-control study of obstructive sleep apnea-hypopnea syndrome in obese and nonobese chinese children[J]. Chest, 2008, 133(3):684-689. [2] Capdevila O S, Kheirandish-Gozal L, Dayyat E, et al. Pediatric obstructive sleep apnea:complications, management, and long-term outcomes[J]. Proc Am Thorac Soc, 2008, 5(2):274-282. [3] Marcus C L, Brooks L J, Draper K A, et al. Diagnosis and management of childhood obstructive sleep apnea syndrome[J]. Pediatrics, 2012, 130(3):576-584. [4] Li A M, So H K, Au C T, et al. Epidemiology of obstructive sleep apnoea syndrome in Chinese children: a two-phase community study[J]. Thorax, 2010, 65(11):991-997. [5] Stauffer J L, White D P, Zwillich C W. Pulmonary function in obstructive sleep apnea. Relationships to pharyngeal resistance and cross-sectional area[J]. Chest, 1990, 97(2):302-307. [6] 谭海,张锦. 中重度阻塞性睡眠呼吸暂停低通气综合征患者肺功能的研究[J]. 宁夏医学院学报, 2004, 26(3):167-169. TAN Hai, ZHANG Jin. Pulmonary function in patients with moderate to severe obstructive sleep apnea hypopnea syndrome[J]. Journal of Ningxia Medical College, 2004, 26(3):167-169. [7] Yadav S P, Dodeja O P, Gupta K B, et al. Pulmonary function tests in children with adenotonsillar hypertrophy[J]. Int J Pediatr Otorhinolaryngol, 2003, 67(2):121-125. [8] Ray R M, Bower C M. Pediatric obstructive sleep apnea: the year in review[J]. Curr Opin Otolaryngol Head Neck Surg, 2005, 13(6):360-365. [9] Chang S J, Chae K Y. Obstructive sleep apnea syndrome in children: epidemiology, pathophysiology, diagnosis and sequelae[J]. Korean J Pediatr, 2010, 53(10):863-871. [10] Standards and indications for cardiopulmonary sleep studies in children. American Thoracic Society[J]. Am J Respir Crit Care Med, 1996, 153(2):866-878. [11] Sun Y, Ning Y, Huang L, et al. Polysomnographic characteristics of daytime sleepiness in obstructive sleep apnea syndrome[J]. Sleep Breath, 2012, 16(2):375-381. [12] Lee S J, Kang H W, Lee L H. The relationship between the Epworth Sleepiness Scale and polysomnographic parameters in obstructive sleep apnea patients[J]. Eur Arch Otorhinolaryngol, 2012, 269(4):1143-1147. [13] Farber J M. Clinical practice guideline:diagnosis and management of childhood obstructive sleep apnea syndrome[J]. Pediatrics, 2002, 110(6):1255-1257. [14] Maurizi M, Paludetti G, Todisco T, et al. Pulmonary function studies in adenoid hypertrophy[J]. Int J Pediatr Otorhinolaryngol, 1980, 2(3):243-250. [15] Vogt B, Falkenberg C, Weiler N, et al. Pulmonary function testing in children and infants[J]. Physiol Meas, 2014, 35(3):R59-R90. [16] Stocks J, Sonnappa S, Lum S. Lung function testing in children: importance of race and ethnic-specific reference equations[J]. Expert Rev Respir Med, 2014, 8(5):527-531. [17] Smith L J. Pulmonary function testing in children[J]. J Asthma, 1990, 27(3):135-136. [18] 吴艺虹,王实,毕英,等. 阻塞性睡眠呼吸暂停低通气综合征患者运动心肺功能变化[J]. 中国呼吸与危重监护杂志, 2006, 5(2):129-131. WU Yihong, WANG Shi, BI Ying, et al. Changes of exercise cardiopulmonary function in patients with obstructive sleep apnea hypopnea syndrome[J]. Chin J Resp Crit Care Med, 2006, 5(2):129-131. [19] Meurice J C, Marc I, Carrier G, et al. Effects of mouth opening on upper airway collapsibility in normal sleeping subjects[J]. Am J Respir Crit Care Med, 1996, 153(1):255-259. [20] Kim E J, Choi J H, Kim K W, et al. The impacts of open-mouth breathing on upper airway space in obstructive sleep apnea:3-D MDCT analysis[J]. Eur Arch Otorhinolaryngol, 2011, 268(4):533-539. [21] Settergren G, Angdin M, Astudillo R, et al. Decreased pulmonary vascular resistance during nasal breathing:modulation by endogenous nitric oxide from the paranasal sinuses[J]. Acta Physiol Scand, 1998, 163(3):235-239. [22] 刘强和,伍伟景. 鼻源性一氧化氮的生理和病理作用[J]. 国外医学(耳鼻咽喉科学分册), 2004, 28(2):72-74. LIU Qianghe, WU Weijing. The physiological and pathological role of Nasal nitric oxide[J]. Otolaryngol Foreign Med Sci, 2004, 28(2):72-74. [23] Pires M G, Di Francesco R C, Grumach A S, et al. Evaluation of inspiratory pressure in children with enlarged tonsils and adenoids[J]. Braz J Otorhinolaryngol, 2005, 71(5):598-601. [24] 陈宝元. 睡眠呼吸障碍临床及研究的进展[J]. 中华结核和呼吸杂志, 2004, 27(1):20-22. CHEN Baoyuan. Advances in the clinical and basic research of sleep breathing disorders[J]. Chin J Tuberc Resp Dis, 2004, 27(1):20-22. [25] Zerah-Lancner F, Lofaso F, Coste A, et al. Pulmonary function in obese snorers with or without sleep apnea syndrome[J]. Am J Respir Crit Care Med, 1997, 156(2 Pt 1):522-527. [26] Chaouat A, Weitzenblum E, Krieger J, et al. Association of chronic obstructive pulmonary disease and sleep apnea syndrome[J]. Am J Respir Crit Care Med, 1995, 151(1):82-86. [27] Weitzenblum E, Krieger J, Oswald M, et al. Chronic obstructive pulmonary disease and sleep apnea syndrome[J]. Sleep, 1992, 15(6 Suppl):S33-S35. [28] Niedzielska G, Kotowski M, Niedzielski A. Assessment of pulmonary function and nasal flow in children with adenoid hypertrophy[J]. Int J Pediatr Otorhinolaryngol, 2008, 72(3):333-335. [29] 陈晓颖,黄敬孚. 睡眠呼吸暂停低通气综合征患儿的肺功能变化及其预测价值[J]. 中国实用儿科杂志, 2006, 21(8):602-604. CHEN Xiaoying, HUANG Jingfu. The change and predictive value of pulmonary function of sleep apnea hyperpnoea syndrome in children[J]. Chin J Pract Pedia, 2006, 21(8):602-604. [30] 支聪聪,石艳玺,邱菊,等. 儿童肺功能检测及临床应用[J]. 临床荟萃, 2011, 26(18):1652-1656. ZHI Chongchong, SHI Yanxi, QIU Ju, et al. Detection and clinical application of pulmonary function in children[J].Clin Focus, 2011, 26(18):1652-1656. [31] Arens R, Muzumdar H. Childhood obesity and obstructive sleep apnea syndrome[J]. J Appl Physiol(1985), 2010, 108(2):436-444. [32] Marcus C L, Curtis S, Koerner C B, et al. Evaluation of pulmonary function and polysomnography in obese children and adolescents[J]. Pediatr Pulmonol, 1996, 21(3):176-183. [33] Silvestri J M, Weese-Mayer D E, Bass M T, et al. Polysomnography in obese children with a history of sleep-associated breathing disorders[J]. Pediatr Pulmonol, 1993, 16(2):124-129. [34] Verhulst S L, Van Gaal L, De Backer W, et al. The prevalence, anatomical correlates and treatment of sleep-disordered breathing in obese children and adolescents[J]. Sleep Med Rev, 2008, 12(5):339-346. [35] Bhattacharjee R, Kim J, Kheirandish-Gozal L, et al. Obesity and obstructive sleep apnea syndrome in children:a tale of inflammatory cascades[J]. Pediatr Pulmonol, 2011, 46(4):313-323. [36] Arens R, Sin S, Nandalike K, et al. Upper airway structure and body fat composition in obese children with obstructive sleep apnea syndrome[J]. Am J Respir Crit Care Med, 2011, 183(6):782-787. [37] Ip M S, Lam B, Ng M M, et al. Obstructive sleep apnea is independently associated with insulin resistance[J]. Am J Respir Crit Care Med, 2002, 165(5):670-676. [38] Van Eyck A, Van Hoorenbeeck K, De Winter B Y, et al. Sleep-disordered breathing and pulmonary function in obese children and adolescents[J]. Sleep Med, 2014, 15(8):929-933. [39] Abreu R R, Rocha R L, Lamounier J A, et al. Etiology, clinical manifestations and concurrent findings in mouth-breathing children[J]. J Pediatr(Rio J), 2008, 84(6):529-535. [40] 黄锟,陶芳标. 肥胖与儿童肺功能损伤[J]. 中国学校卫生, 2005, 26(6):518-520. HUANG Kun,TAO Fangbiao. Obesity and pulmonary function damage in children [J]. Chin J School Health, 2005, 26(6):518-520. [41] Zerah-Lancner F, Lofaso F, DOrtho M P, et al. Predictive value of pulmonary function parameters for sleep apnea syndrome[J]. Am J Respir Crit Care Med, 2000, 162(6):2208-2212. [42] Kavukcu S, Coskun S, Cevik N, et al. The importance of pulmonary function tests in adenotonsillectomy indications[J]. Indian J Pediatr, 1993, 60(2):249-255. [43] Marcus C L. Pathophysiology of childhood obstructive sleep apnea:current concepts[J]. Respir Physiol, 2000, 119(2-3):143-154. [44] 庞冲,刘传合,谷庆隆,等. 腺样体、扁桃体肥大患儿肺功能的改变及手术对其影响[J]. 中国中西医结合耳鼻咽喉科杂志, 2012, 20(3):179-181, 188. PANG Chong, LIU Chuanhe, GU Qinglong, et al. Pulmonary function in children with adenoid and tonsil hypertrophy[J]. Chin J Otorhinolaryngol Integ Med, 2012, 20(3):179-181, 188. [45] Hudgel D W, Shucard D W. Coexistence of sleep apnea and asthma resulting in severe sleep hypoxemia[J]. JAMA, 1979, 242(25):2789-2790. [46] Catterall J R, Douglas N J, Calverley P M, et al. Irregular breathing and hypoxaemia during sleep in chronic stable asthma[J]. Lancet, 1982, 1(8267):301-304. [47] Janson C, De Backer W, Gislason T, et al. Increased prevalence of sleep disturbances and daytime sleepiness in subjects with bronchial asthma:a population study of young adults in three European countries[J]. Eur Respir J, 1996, 9(10):2132-2138. [48] Kheirandish-Gozal L, Dayyat E A, Eid N S, et al. Obstructive sleep apnea in poorly controlled asthmatic children:effect of adenotonsillectomy[J]. Pediatr Pulmonol, 2011, 46(9):913-918. [49] 黄素红,李清明,江远仕. 阻塞性睡眠呼吸暂停低通气综合征患者肺功能的临床研究[J]. 齐齐哈尔医学院学报, 2013, 34(10):1425-1426. HUANG Suhong, LI Qingming, JIANG Yuanshi. Changes in pulmonary function in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)[J]. J Qiqihar Univ Med, 2013, 34(10):1425-1426. |
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