山东大学耳鼻喉眼学报 ›› 2015, Vol. 29 ›› Issue (4): 80-85.doi: 10.6040/j.issn.1673-3770.0.2015.007

• 综述 • 上一篇    下一篇

早期喉癌及喉癌前病变诊断的研究进展

严羽, 朱江   

  1. 重庆医科大学附属第一医院耳鼻咽喉科, 重庆 400016
  • 收稿日期:2015-01-04 修回日期:2015-04-10 出版日期:2015-08-16 发布日期:2015-08-16
  • 通讯作者: 朱江。E-mail:zhujiang163mail@163.com E-mail:zhujiang163mail@163.com
  • 作者简介:严羽。E-mail:13896550317@163.com
  • 基金资助:
    国家临床重点专科建设项目经费资助[卫办医政函(2012)649号]; 重庆市医学科研重点项目经费资助(项目编号 2013-1-004)

Advances in the diagnosis of early laryngeal carcinoma and precancerous laryngeal lesions.

YAN Yu, ZHU Jiang   

  1. Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • Received:2015-01-04 Revised:2015-04-10 Online:2015-08-16 Published:2015-08-16

摘要: 近年来早期喉癌及喉癌前病变的诊断方法, 呈现出多样化和多元化, 主要包括分子、影像、内镜检查等方面, 各种诊断方法又相互提携促进、渗透发展。现对这些诊断方法及其研究进展进行综述, 以期对临床工作有一定指导意义。

关键词: 诊断, 喉癌前状态, 喉肿瘤

Abstract: In recent years, the approaches to diagnose early laryngeal carcinoma and precancerous lesions emerge in a diversified and multielement way, including molecular, imaging, endoscopic methods and so on. All the approaches mutually promote and influence on each other. This paper reviews these diagnostic methods and progress so as to guide the clinical work.

Key words: Diagnosis, Laryngeal neoplasms, Precancerous laryngeal conditions

中图分类号: 

  • R762
[1] Marioni G, Marchese-Ragona R, Cartei G, et al. Current opinion in diagnosis and treatment of laryngeal carcinoma[J]. Cancer Treat Rev, 2006, 32(7):504-515.
[2] Hinerman R W, Mendenhall W M, Amdur R J, et al. Early laryngeal cancer[J]. Curr Treat Options Oncol, 2002, 3(1):3-9.
[3] Ferlito A. The natural history of early vocal cord cancer[J]. Acta Otolaryngol, 1995, 115(2):345-347.
[4] 覃扬达.喉的癌前病变[J].中国医学文摘·老年医学,2004,13(2):121-123. QIN Yangda. Laryngeal precancerous lesions[J]. Chin Med Abs·Ger Med, 2004, 13(2):121-123.
[5] Hojslet P E, Nielsen V M, Palvio D. Premalignant lesions of the larynx a follow-up study[J]. Acta Otolaryngol, 1989, 107(12):180-185.
[6] Ballantyne J, Groves J. Scott-Brown' s diseases of the ear, nose and throat[M]. Sevenoaks: Butterworths, 1980: 109-122.
[7] 黄选兆,汪吉宝.实用耳鼻咽喉科学[M].北京:人民卫生出版社,1998:501-502.
[8] 李惠萍,崔秀娟,关超,等.喉癌前病变100例分析[J].中华耳鼻咽喉科杂志,1995,30(5):302-304. LI Huiping, CUI Xiujuan, GUAN Chao, et al. Analysis of 100 cases of precancerous laryngeal lesions[J]. Chin J Otorhinolarynol, 1995, 30(5):302-304.
[9] Maran A G. Head and neck surgery: an encyclopaedia of ignorance[J]. J Laryngol Otol, 1990, 104(7):529-533.
[10] 蔡冰国,王雪峰.喉癌前病变的诊断和治疗[J].社区医学杂志,2008,6(9):38-40. CAI Bingguo, WANG Xuefeng. Diagnosis and treatment of laryngeal cancer before lesions[J]. J Community Med, 2008, 6(9):38-40.
[11] 凌玲,罗敏捷,来茂德,等.表皮生长因子受体在喉癌及喉癌前病变中的表达[J].中国肿瘤临床,1999,26(1):36-38. LING Ling, LUO Minjie, LAI Maode, et al. Expression of epidermal growth factor receptor in laryngeal carcinoma and precancerous laryngeal lesions[J]. Chin Clinical Tumor, 1999, 26(1):36-38.
[12] 周光耀,林代诚,梁传余,等.p53蛋白在喉上皮癌前病变及癌组织中的表达及其意义[J].华西医大学报,1999,30(3):265-267. ZHOU Guangyao, LIN Daicheng, LIANG Chuanyu, et al. Expression of p53 protein in premalignant lesion and carcinoma of larynx[J]. J West Chin Univ Med Sci, 1999, 30(3):265-267.
[13] Yoo W J, Cho S H, Lee Y S, et al. Loss of heterozygosity on chromosomes 3p,8p,9p and 17p in the progression of squamous cell carcinoma of the larynx[J]. J Korean Med Sci, 2004, 19(3):345-351.
[14] 罗文军,郭伟,罗甜,等.磁共振成像在喉癌诊断中的应用价值[J].实用临床医学, 2014,15(6):103-104. LUO Wenjun, GUO Wei, LUO Tian, et al. Application value of magnetic resonance imaging in the diagnosis of laryngeal carcinoma[J]. Pra Clinical Med, 2014, 15(6):103-104.
[15] 杨璇,周建荣.抗survivin抗体、抗p53抗体检测在喉癌中的诊断意义[D].重庆:重庆医科大学, 2011:1-47.
[16] Joffre P, Giron J, Fraqa J, et al. MRI/CT x-ray comparison in the pre-operative evaluation of cancer of the larynx[J]. J Radiol, 1988, 69(6-7):387-396.
[17] Thoeny H C, Delaere P R, Hermans R. Correlation of local outcome after partial laryngectomy with cartilage abnormalities on CT[J]. AJNR, 2005, 26(3):674-678.
[18] 屈艺华,余永忠,陈春林,等.螺旋CT仿真内镜成像在喉部的临床应用[J].中国现代影像学杂志,2006,3(2):131-132. QU Yihua, YU Yongzhong, CHEN Chunlin, et al. Spiral CT virtual endoscopy imaging clinical applications in the throat[J]. J Chin Modern Imaging, 2006, 3(2):131-132.
[19] 胡巧,朱尚勇,陈功泉,等.超声与MRI在喉癌诊断及临床分期中的对比分析[J].中国临床医学影像杂志,2011,22(2):83-85. HU Qiao, ZHU Shangyong, CHEN Gongquan, et al. Comparison of ultrasonography and MR imaging in diagnosing and staging of laryngeal carcinoma[J]. Chin Clin Med Imaging, 2011, 22(2):83-85.
[20] Duet M, Hugonnet F, Faraggi M. Role of positron emission tomog-raphy (PET) in head and neck cancer[J]. Euro Ann Otorhinolaryngol Head Neck Dis, 2010, 127(1):40-45.
[21] 张婵,洪珊珊,杨鹏飞,等.PET在头颈部肿瘤诊断与治疗中的应用进展[J].中国口腔颌面外科杂志,2011,9(5):430-434. ZHANG Chan, HONG Shanshan, YANG Pengfei, et al. Application and advancement of PET indiagnosis and radio therapy planning in patients with head and neck tumors[J]. Chin J Oral Maxillofacial Surg, 2011, 9(5):430-434.
[22] 王丹丹,皇甫辉.CT/MRI融合图像对喉癌外科手术治疗指导意义的研究[D].太原:山西医科大学, 2012:1-33.
[23] 倪晓光,贺舜,高黎,等.窄带成像内镜在喉咽癌早期诊断中的应用[J].中国耳鼻咽喉头颈外科,2009,16(10):550-554. NI Xiaoguang, HE Shun, GAO Li, et al. The application of narrow band imaging endoscopy in the early diagnosis of hypopharyngeal carcinoma[J]. Chin Arch Otolaryngol Head Neck Surg, 2009, 16(10):550-554.
[24] 黄冬雁,杨伟炎,于萍,等.动态喉镜及纤维喉镜诊断早期声带癌价值比较[J].听力学及言语疾病杂志,2005,13(6):416-418. HUANG Dongyan, YANG Weiyan, YU Ping, et al. Efficacy of videasteoboscopy and flesible laryngoscope in the diagnosis of early vocal cord cancer[J]. J Audiol Speech Pathol, 2005, 13(6):416-418.
[25] Kavaida M, Fukuda H, Kohno N. Observations of laryngeal lesions with a rhinolarynx electronic videoendoscope system and digital image processing[J]. Ann Otol Rhinol Laryngol, 1998, 107(10):855-859.
[26] 林素青,王继群,罗思瑾.电子喉镜在喉和下咽部肿瘤诊断中的应用[J].暨南大学学报,2005,26(2):265-266. LIN Suqing, WANG Jiqun, LUO Sijin. Application of video laryngoscope in larynx and hypopharynx cancer diagnosis[J]. J Jinan Univ, 2005, 26(2):265-266.
[27] 李勇,Arens C, Glanz H.接触性内镜在早期喉癌及其癌前病变诊断中的应用[J].中国中西医结合耳鼻咽喉科杂志,2005,13(5):265-267. LI Yong, Arens C, Glanz H. Contact endoscopy in the early diagnosis of laryngeal carcinoma and precancerous lesions[J]. Chin J Otorhinolaryngol Tra West Med, 2005, 13(5):265-267.
[28] Kraft M, Betz C S, Leunig A, et al. Value of fluorescence endoscopy for the early diagnosis of laryngeal cancer and its precursor lesions[J]. Head Neck, 2010, 33(7):941-948.
[29] 张革化, 黎景佳.自身荧光内镜在喉癌早期诊断中的应用[J].中国医学文摘·耳鼻咽喉科学,2011,26(4):205-206. ZHANG Gehua, LI Jingjia. Application of autofluorescence endoscopy in the early diagnosis of laryngeal carcinoma[J]. New Rev, 2011, 26(4):205-206.
[30] Arens C, Reussner D, Neubacher H, et al. Spectrometric measurement in laryngeal cancer[J]. Eur Arch Otorhinolaryngol, 2006, 263(11):1001-1007.
[31] 李勇,Christoph A, Hiltrud G.自身荧光内镜在早期喉癌及其癌前病变诊断中的应用[J].中华耳鼻咽喉头颈外科杂志, 2009, 40(9):696-700. LI Yong, Christoph A, Hiltrud G. Autofluorescence endoscopy for diagnosing early laryngeal cancer and its precursor lesions[J]. Chin Arch Otolaryngol Head Neck Surg, 2009, 40(9):696-700.
[32] Baletic N, Malicevic H, Petrovic Z, et al. Advantages and limitations of the autofluorescent diagnostics of the laryngeal cancer and precancerosis[J]. Eur Arch Otorhinolaryngol, 2010, 267(6):925-931.
[33] Larghi A, Lecca P G, Costamagna G. High-resolution narrow band imaging endoscopy[J]. Gut, 2008, 57(7):976-986.
[34] East J E, Tan E K, Bergman J J, et al. Meta-analysis:narrow band imaging for lesion characterization in the colon, oesophagus, duodenal ampulla and lung[J]. Aliment Pharmacol Ther, 2008, 28(7):854-867.
[35] Marcel K, Karolos F, Nicolas G, et al. Value of narrow band imaging in the early diagnosis of laryngeal cancer[J]. Head Neck, 2014. doi: 10.1002/hed.23838.[Epub ahead of print]
[36] Muto M, Horimatsu T, Ezoe Y, et al. Narrow-band imaging of the gastrointestinal tract[J]. Gastroenterol, 2009, 44(1):13-25.
[37] 邱建华,石力.窄带成像技术在喉癌早期诊断中的应用[J].中国医学文摘·耳鼻咽喉科学,2011,26(4):186-188. QIU Jianhua, SHI Li. Application of narrow band imaging in the early diagnosis of laryngeal carcinoma[J]. Chin ENT New Rev, 2011, 26(4):205-206.
[38] Piazza C, Dessouky O, Peretti G, et al. Narrow-band imaging: a new tool for evaluation of head and neck squamous cell carcinomas[J]. Acta Otorhinolaryngol Ital, 2008, 28(2): 49-54.
[39] Piazza C, Cocco D, De Benedetto L, et al. Role of narrow-band imaging and high-definition television in the surveillance of head and neck squamous cell cancer after chemo- and/or radiotherapy[J]. Euro Arch OtoRhinoLaryngol, 2010, 267(9):1423-1428.
[40] Piazza C, Del Bon F, Peretti G, et al. Narrow band imaging in endoscopic evaluation of the larynx[J]. Curr Opin Otolaryngol Head Neck Surg, 2012, 20(6):472-476.
[41] 李勇, 栾信庸.内窥镜图像技术在早期喉癌及其癌前病变诊断中的应用研究[D].济南:山东大学, 2003:1-57.
[42] Kraft M, Bruns N, Hügens-Penzel M, et al. Clinical value of endosonography in the assessment of laryngeal cancer[J]. Head Neck, 2013, 35(2):195-200.
[43] Kraft M, Lüeren K, Lubatschowski H, et al. Technique of optical coherence tomography of the larynx during microlaryngoscopy[J].Laryngoscope, 2007, 117(5):950-952.
[44] Kraft M, Glanz H, Von Gerlach S, et al. Clinical value of optical coherence tomography in laryngology[J]. Head Neck, 2008, 30(12):1628-1635.
[1] 程卓, 梁辉, 邢鲁民. 深度学习技术在咽喉内镜应用中的研究进展及前景分析[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 112-119.
[2] 刘一洁,卢秀珍,吴秋欣. 外泌体在眼病发病机制和诊疗中的研究进展[J]. 山东大学耳鼻喉眼学报, 2026, 40(1): 135-141.
[3] 马孝宝,沈佳丽,杨军,陈建勇,朱颂欢. 水平半规管扫视波的临床意义探究[J]. 山东大学耳鼻喉眼学报, 2025, 39(6): 40-45.
[4] 刘梓琪,黄佳丽,汪李琴,陈曦,张立庆,周涵. 窄带成像内镜联合嗓音声学分析在声带白斑鉴别诊断中的价值[J]. 山东大学耳鼻喉眼学报, 2025, 39(6): 87-96.
[5] 刘南仙,杨泽垠,韩琳,张爱英,赵宇亮,薛静,孙怡君,邵永良. 视频脑电图在儿童复发性眩晕诊断中的意义[J]. 山东大学耳鼻喉眼学报, 2025, 39(5): 20-25.
[6] 周之航,刘素茹,周静,陈丹,杨佳静,刘蕊,周立. 声门闭合不全的病因及诊疗研究进展[J]. 山东大学耳鼻喉眼学报, 2025, 39(3): 97-103.
[7] 吴玮,王磊,陈升,李连勇,王刚. 胃食管气道反流性疾病多学科研究及进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 1-14.
[8] 刘莲莲,李进让. 阻塞性睡眠呼吸暂停与咽喉反流[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 15-22.
[9] 李桂,杨艳丽,李东海,闫秀英. 成人眼眶黄色肉芽肿病临床病理分析及文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 80-85.
[10] 彭宇婷,李坚昊,王燕. 鼻-眼眶-颅底恶性肿瘤继发眶尖综合征1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 105-111.
[11] 李亚茹,许贞菊,王效军,付涛,袁玥,吴策. 双颈部及鼻咽部Rosai-Dorfman病1例相关病例回顾[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 108-114.
[12] 陈海燕,王平. 易误诊的后巩膜炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 126-130.
[13] 张玉焕,张俊波,尹国平,袁雪梅,曹鑫,孙宇,陈强,叶京英. 鼾症患者前后半夜多导睡眠监测参数的对比分析[J]. 山东大学耳鼻喉眼学报, 2023, 37(6): 112-117.
[14] 张锟艺,肖旭平. 妊娠期鼻炎患者临床治疗及用药方案的研究进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 175-183.
[15] 秦念,肖禹,张锟艺,李京鲲,肖旭平. 宏基因组二代测序技术在坏死性颈筋膜炎中应用进展[J]. 山东大学耳鼻喉眼学报, 2023, 37(5): 192-197.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!