山东大学耳鼻喉眼学报 ›› 2019, Vol. 33 ›› Issue (3): 9-13.doi: 10.6040/j.issn.1673-3770.1.2018.043

• 专家笔谈 • 上一篇    下一篇

慢性鼻窦炎的内表型研究进展及精准治疗

李华斌(),赖玉婷,姜文秀   

  1. 复旦大学附属眼耳鼻喉科医院耳鼻喉科，上海200031
  • 收稿日期:2018-12-03 修回日期:2019-04-11 出版日期:2019-05-20 发布日期:2019-08-07
  • 通讯作者: 李华斌 E-mail:noseli@163.com
  • 作者简介:李华斌, 医学博士, 主任医师，教授，博士研究生导师,复旦大学附属眼耳鼻喉科医院耳鼻喉科副主任、耳鼻喉科研究院副院长,国家杰出青年基金获得者。主要学术任职：中华医学会耳鼻咽喉头颈外科学分会青年委员会副主任委员，中国医疗保健国际交流促进会过敏科学分会和中华预防医学会过敏病预防与控制专业委员会常务委员，上海市医学会变态反应专科分会副主任委员。《Clinical Otolaryngology》《World Journal of Otolaryngology-Head and Neck Surgery》《中华耳鼻咽喉头颈外科杂志》《临床耳鼻咽喉头颈外科杂志》等期刊编委。长期从事鼻科和过敏性疾病的基础和临床研究，擅长鼻内镜微创手术。主持国家自然科学基金项目5项，在《Immunity》《Nature Communications》《Journal of Allergy and Clinical Immunology》《Proceedings of the National Academy of Sciences of the United States of America》等国内外专业期刊发表相关SCI论文50余篇。曾于2003~2007年在南京医科大学第一附属医院（江苏省人民医院）耳鼻咽喉科工作。
  • 基金资助:
    国家杰出青年基金(81725004)

Endotypes and precision medicine in chronic sinusitis treatment

Huabin LI(),Yuting LAI,Wenxiu JIANG   

  1. Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China
  • Received:2018-12-03 Revised:2019-04-11 Online:2019-05-20 Published:2019-08-07
  • Contact: Huabin LI E-mail:noseli@163.com

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摘要：

慢性鼻窦炎（CRS）是耳鼻咽喉头颈外科的常见疾病，其内在的病理机制复杂，目前治疗的主要方式有药物治疗和手术治疗，但对于某些特殊内表型的CRS，手术往往无效。近年在精准医学的倡导下，趋向于根据CRS的内表型，研制新的生物制剂，施予精准治疗方案，包括针对Ⅱ型炎症内表型、嗜酸粒细胞型内表型、上皮屏障功能和上皮来源细胞因子内表型等。

关键词: 慢性鼻窦炎, 病理机制, 内表型, 精准医学, 生物制剂

Abstract:

Chronic rhinosinusitis (CRS) is a common otolaryngologic disease, with a complex intrinsic pathological mechanism. Traditional medicine and surgery do not fully treat CRS. In recent years, precision medicine has been used to develop new biological agents to treat CRS based on its phenotype. This article reviews the current endotypes of CRS that have therapeutic significance, including type II inflammatory, eosinophilic, epithelial barrier function, and epithelium-derived cytokine endotypes, and those that are still in the theoretical stage of research, including the non-type II inflammatory phenotype and tissue remodeling.

Key words: Chronic rhinosinusitis, Pathogenesis, Endotype, Precision medicine, Biologic products

中图分类号: 

  • R765.41
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