基质金属蛋白酶对慢性鼻窦炎组织重塑的影响

doi:10.6040/j.issn.1673-3770.0.2023.338

摘要/Abstract

摘要： 慢性鼻窦炎是具有高度异质性的鼻窦黏膜的炎性疾病,其发病机制尚不完全清楚。鼻黏膜组织重塑在其发病中起关键作用,主要表现为上皮黏膜损伤、基膜增厚、新生血管形成、成纤维细胞增殖等,即细胞外基质的生成与降解失衡。基质金属蛋白酶是降解细胞外基质的重要酶类之一,基质金属蛋白酶及其组织抑制因子通过影响细胞外基质的平衡进而影响组织重塑,抑制基质金属蛋白酶对组织重塑的影响是慢性鼻窦炎的一种潜在的治疗方法。论文就关于基质金属蛋白酶及其组织抑制因子对慢性窦炎组织重塑影响的研究进展进行综述。

关键词: 慢性鼻窦炎, 鼻息肉, 基质金属蛋白酶, 组织重塑, 基质金属蛋白酶组织抑制物

Abstract: The pathogenesis of chronic rhinosinusitis, a highly heterogeneous inflammatory disease of the sinus mucosa, is not fully understood. Tissue remodeling, which is the main factor in the pathogenesis of chronic rhinosinusitis, is characterized by features such as epithelial mucosal damage, basement membrane thickening, neovascularization, and fibroblast proliferation, aiming toward the generation and degradation disorder of extracellular matrix. Matrix metalloproteinases are one of the important enzymes that degrade extracellular matrix. Matrix metalloproteinases and tissue metalloproteinase inhibitors influence tissue remodeling by influencing extracellular matrix metabolism. Inhibition of the effects of these matrix metalloproteinases on tissue remodeling is a potential therapeutic approach. This article reviews the research progress of the effects of inhibitors of matrix metalloproteinases and tissue metalloproteinases on tissue remodeling in chronic sinusitis.

Key words: Chronic rhinosinusitis, Nasal polyps, Matrix metalloproteinase, Tissue remodeling, Tissue inhibitor of matrix metalloproteinases

中图分类号:

R765.41

张诗涵,刘红兵. 基质金属蛋白酶对慢性鼻窦炎组织重塑的影响[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 116-123.

ZHANG Shihan, LIU Hongbing. Effect of matrix metalloproteinase on tissue remodeling in chronic rhinosinusitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(3): 116-123.

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