JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (6): 36-38.doi: 10.6040/j.issn.1673-3770.0.2015.202

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Expression of tumor suppressor in lung cancer 1 in laryngeal squamous cell carcinoma and its significance

LI Fu1, ZHAO Shuyou2   

  1. 1. Department of Otolaryngology, First Affiliated Hospital of Baotou Medical College, Baotou 014010, Inner Mongolia, China;
    2. Department of Otolaryngology & Head and Neck Surgery, Qingdao Municipal Hospital, Qingdao 266011, Shandong, China
  • Received:2015-05-25 Online:2015-12-16 Published:2015-12-16

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Abstract: Objective To investigate the correlation of tumor suppressor in lung cancer 1 (TSLC1) and laryngeal squamous cell carcinoma, in order to provide a theoretic basis of oncogenesis, diagnosis and treatment of laryngeal cancer. Methods Paraffin-embedded specimens were collected from 45 cases of laryngeal squamous cell carcinoma, 8 of which had lymphatic metastasis. Another 20 specimens from normal adjacent tissues served as controls. The expression of TSLC1 was detected with immunohistochemical staining (PV-6000). The relation between TSLC1 expression and other clinicopathological parameters was analyzed with SPSS 10.0. Results The positive expression of TSLC1 was 17/45 (37.8%) in specimens of laryngeal squamous cell carcinoma, which was significantly lower than in specimens of normal adjacent tissues (15/20, 75%), (χ2=7.68, P<0.01). Loss of TSLC1 expression was correlated with the clinical stage, tumor differentiation and lymph node metastasis (χ2=4.15, 6.11, 4.11, P<0.05), but not correlated with patients' age, gender, or location of primary laryngeal carcinoma (χ2= 0.25, 0.09, 1.0, P>0.05). Conclusion Loss of TSLC1 expression is frequently observed in laryngeal squamous cell carcinoma, which is significantly correlated to the clinical stage, tumor differentiation and lymph node metastasis. The down-regulation of TSLC1 expression may correlate with the occurrence and invasion of laryngeal squamous cell carcinoma, but more studies are needed to verify the hypothesis.

Key words: Laryngeal carcinoma, Tumor suppressor in lung cancer 1, Immunohistochemistry

CLC Number: 

  • R739.65
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