山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (5): 160-164.doi: 10.6040/j.issn.1673-3770.0.2023.153

• 综述 • 上一篇    

M受体信号通路在近视发生发展中作用的研究进展

张金木1,郭滨1,2,蒋文君3,刘冬梅4   

  1. 1.山东中医药大学 眼科与视光医学院, 山东 济南 250355;
    2.山东中医药大学博士后流动站, 山东 济南 250355;
    3.山东省眼病防治研究院实验中心/山东省中西医结合眼病防治重点实验室, 山东 济南 250002 ;
    4.山东中医药大学附属眼科医院 白内障科, 山东 济南 250002
  • 发布日期:2024-09-25
  • 通讯作者: 刘冬梅. E-mail:13854191223@163.com

Research progress on the role of M receptor signaling pathway in the occurrence and development of myopia

ZHANG Jinmu1, GUO Bin1,2, JIANG Wenjun3, LIU Dongmei4   

  1. 1. College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China2.Postdoctoral Station of Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China3.Shandong Academy of Eye Disease Prevention and Therapy/Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Eye Disease, Jinan 250002, Shandong, China4. Department of Cataract, Eye Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong, China
  • Published:2024-09-25

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摘要： M受体参与调节众多眼组织生理活动。研究表明,M受体可通过调节睫状肌收缩、调控视网膜和脉络膜中近视相关神经递质(如多巴胺)和生长因子(如转化生长因子β2)的表达来影响巩膜成纤维细胞增殖和基质金属蛋白酶2水平,进而影响巩膜重塑和眼轴增长,最终影响近视的发生发展。近年来,大量动物实验及临床研究均证实M受体拮抗剂可有效延缓近视进展。论文就不同眼组织(睫状肌、视网膜、脉络膜和巩膜)中M受体信号通路在近视发生发展中的作用进行简要综述,以期为近视相关机制研究及临床治疗提供思路。

关键词: 近视, M受体, 睫状肌, 视网膜, 脉络膜, 巩膜

Abstract: M receptors participate in regulating numerous physiological activities in eye tissues. Studies have shown that M receptors can regulate ciliary muscle contraction, regulate the expression of myopia-related neurotransmitters(such as dopamine)and growth factors(such as transforming growth factor β2)in the retina and choroid, and affect scleral fibroblast proliferation and matrix metalloproteinase-2 expression, which in turn affects scleral remodeling and axial growth, ultimately affecting the occurrence and development of myopia. In recent years, a large number of animal experiments and clinical studies have confirmed that M receptor antagonists effectively delay the progression of myopia.This article provides a brief review of the role of the M receptor signaling pathway in the occurrence and development of myopia in different eye tissues(ciliary muscle, retina, choroid, and sclera), to provide ideas for the studing of myopia-related mechanisms and clinical treatment.

Key words: Myopia, M receptor, Ciliary muscle, Retina, Choroid, Sclera

中图分类号: 

  • R778.1+1
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