山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (5): 160-164.doi: 10.6040/j.issn.1673-3770.0.2023.153

• 综述 • 上一篇    

M受体信号通路在近视发生发展中作用的研究进展

张金木1,郭滨1,2,蒋文君3,刘冬梅4   

  1. 1.山东中医药大学 眼科与视光医学院, 山东 济南 250355;
    2.山东中医药大学博士后流动站, 山东 济南 250355;
    3.山东省眼病防治研究院实验中心/山东省中西医结合眼病防治重点实验室, 山东 济南 250002 ;
    4.山东中医药大学附属眼科医院 白内障科, 山东 济南 250002
  • 发布日期:2024-09-25
  • 通讯作者: 刘冬梅. E-mail:13854191223@163.com

Research progress on the role of M receptor signaling pathway in the occurrence and development of myopia

ZHANG Jinmu1, GUO Bin1,2, JIANG Wenjun3, LIU Dongmei4   

  1. 1. College of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China2.Postdoctoral Station of Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, China3.Shandong Academy of Eye Disease Prevention and Therapy/Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Eye Disease, Jinan 250002, Shandong, China4. Department of Cataract, Eye Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong, China
  • Published:2024-09-25

PDF (PC)

9

摘要： M受体参与调节众多眼组织生理活动。研究表明,M受体可通过调节睫状肌收缩、调控视网膜和脉络膜中近视相关神经递质(如多巴胺)和生长因子(如转化生长因子β2)的表达来影响巩膜成纤维细胞增殖和基质金属蛋白酶2水平,进而影响巩膜重塑和眼轴增长,最终影响近视的发生发展。近年来,大量动物实验及临床研究均证实M受体拮抗剂可有效延缓近视进展。论文就不同眼组织(睫状肌、视网膜、脉络膜和巩膜)中M受体信号通路在近视发生发展中的作用进行简要综述,以期为近视相关机制研究及临床治疗提供思路。

关键词: 近视, M受体, 睫状肌, 视网膜, 脉络膜, 巩膜

Abstract: M receptors participate in regulating numerous physiological activities in eye tissues. Studies have shown that M receptors can regulate ciliary muscle contraction, regulate the expression of myopia-related neurotransmitters(such as dopamine)and growth factors(such as transforming growth factor β2)in the retina and choroid, and affect scleral fibroblast proliferation and matrix metalloproteinase-2 expression, which in turn affects scleral remodeling and axial growth, ultimately affecting the occurrence and development of myopia. In recent years, a large number of animal experiments and clinical studies have confirmed that M receptor antagonists effectively delay the progression of myopia.This article provides a brief review of the role of the M receptor signaling pathway in the occurrence and development of myopia in different eye tissues(ciliary muscle, retina, choroid, and sclera), to provide ideas for the studing of myopia-related mechanisms and clinical treatment.

Key words: Myopia, M receptor, Ciliary muscle, Retina, Choroid, Sclera

中图分类号: 

  • R778.1+1
[1] 刘凌, 张美霞. 近视的药物治疗[J]. 山东大学耳鼻喉眼学报, 2021, 35(4): 123-128. doi: 10.6040/j.issn.1673-3770.0.2020.313 LIU Ling, ZHANG Meixia. Drug therapy for myopia[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(4): 123-128. doi: 10.6040/j.issn.1673-3770.0.2020.313
[2] Mathis U, Feldkaemper M, Wang M, et al. Studies on retinal mechanisms possibly related to myopia inhibition by atropine in the chicken[J]. Albrecht Von Graefes Arch Fur Klin Und Exp Ophthalmol, 2020, 258(2): 319-333. doi:10.1007/s00417-019-04573-y
[3] Chiang ST, Phillips JR. Effect of atropine eye drops on choroidal thinning induced by hyperopic retinal defocus[J]. J Ophthalmol, 2018: 8528315. doi:10.1155/2018/8528315
[4] Yam JC, Jiang YN, Lee J, et al. The association of choroidal thickening by atropine with treatment effects for myopia: two-year clinical trial of the low-concentration atropine for myopia progression(LAMP)study[J]. Am J Ophthalmol, 2022, 237: 130-138. doi:10.1016/j.ajo.2021.12.014
[5] 李佳芹, 毕爱玲, 毕宏生. 睫状肌功能结构异常与近视的关系研究进展[J]. 山东医药, 2023, 63(6): 111-114. doi:10.3969/j.issn.1002-266X.2023.06.027 LI Jiaqin, BI Ailing, BI Hongsheng. Research progress on the relationship between abnormal functional structure of ciliary muscle and myopia[J]. Shandong Medical Journal, 2023, 63(6): 111-114. doi:10.3969/j.issn.1002-266X.2023.06.027
[6] Company V, Moreno-Bravo JA, Perez-Balaguer A, et al. The amniote oculomotor complex[J]. Anat Rec, 2019, 302(3): 446-451. doi:10.1002/ar.23827
[7] Tong LY, Cui DM, Zeng JW. Effects of topical pilocarpine on ocular growth and refractive development in rabbits[J]. Eur J Ophthalmol, 2021, 31(4): 2107-2115. doi:10.1177/1120672120934962
[8] Tran HDM, Tran YH, Tran TD, et al. A review of myopia control with atropine[J]. J Ocul Pharmacol Ther, 2018, 34(5): 374-379. doi:10.1089/jop.2017.0144
[9] Nickla DL, Jordan K, Yang J, et al. Effects of time-of-day on inhibition of lens-induced myopia by quinpirole, pirenzepine and atropine in chicks[J]. Exp Eye Res, 2019, 181: 5-14. doi:10.1016/j.exer.2019.01.008
[10] Yam JC, Li FF, Zhang XJ, et al. Two-year clinical trial of the low-concentration atropine for myopia progression(LAMP)study: phase 2 report[J]. Ophthalmology, 2020, 127(7): 910-919. doi:10.1016/j.ophtha.2019.12.011
[11] Yam JC, Jiang YN, Tang SM, et al. Low-concentration atropine for myopia progression(LAMP)study: a randomized, double-blinded, placebo-controlled trial of 0.05%, 0.025%, and 0.01% atropine eye drops in myopia control[J]. Ophthalmology, 2019, 126(1): 113-124. doi:10.1016/j.ophtha.2018.05.029
[12] 陈辉. 毒蕈碱拮抗剂减缓近视发展的研究进展[J]. 中华实验眼科杂志, 2017, 35(6): 556-560. doi:10.3760/cma.j.issn.2095-0160.2017.06.015 CHEN Hui. Advances of muscarinic antagonists slowing the progression of myopia[J]. Chinese Journal of Experimental Ophthalmology, 2017, 35(6): 556-560. doi:10.3760/cma.j.issn.2095-0160.2017.06.015
[13] Ruan Y, Patzak A, Pfeiffer N, et al. Muscarinic acetylcholine receptors in the retina-therapeutic implications[J]. Int J Mol Sci, 2021, 22(9): 4989. doi:10.3390/ijms22094989
[14] 张立华, 闫东升, 周翔天, 等. 毒蕈碱1型受体在人视网膜色素上皮细胞表达的研究[J]. 中华眼科杂志, 2006(12): 1109-1112. doi:10.3760/j: issn: 0412-4081.2006.12.011 ZHANG Lihua, YAN Dongsheng, ZHOU Xiangtian, et al. Expression of muscarinic acetylcholine receptor-1 in human retinal pigment epithelium[J]. Chinese Journal of Ophthalmology, 2006(12): 1109-1112. doi:10.3760/j: issn: 0412-4081.2006.12.011
[15] Laspas P, Zhutdieva MB, Brochhausen C, et al. The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice[J]. Sci Rep, 2019, 9(1): 5222. doi:10.1038/s41598-019-41425-5
[16] Liu AL, Liu YF, Wang G, et al. The role of ipRGCs in ocular growth and myopia development[J]. Sci Adv, 2022, 8(23): eabm9027. doi:10.1126/sciadv.abm9027
[17] Tao Y, Li XL, Sun LY, et al. Effect of green flickering light on myopia development and expression of M1 muscarinic acetylcholine receptor in guinea pigs[J]. Int J Ophthalmol, 2018, 11(11): 1755-1760. doi:10.18240/ijo.2018.11.04
[18] 王玲, 沙芳, 吴建峰, 等. 电针对负透镜诱导型近视豚鼠视网膜M1受体表达的影响[J]. 眼科新进展, 2015, 35(11): 1001-1004. doi:10.13389/j.cnki.rao.2015.0274 WANG Ling, SHA Fang, WU Jianfeng, et al. Effects of electroacupuncture stimulation on levels of retinal acetylcholine receptors M1 in guinea pig model of lens-induced myopia[J]. Recent Advances in Ophthalmology, 2015, 35(11): 1001-1004. doi:10.13389/j.cnki.rao.2015.0274
[19] Carr BJ, Nguyen CT, Stell WK. Alpha2-adrenoceptor agonists inhibit form-deprivation myopia in the chick[J]. Clin Exp Optom, 2019, 102(4): 418-425. doi:10.1111/cxo.12871
[20] Troilo D, Smith EL 3rd, Nickla DL, et al. IMI - report on experimental models of emmetropization and myopia[J]. Invest Ophthalmol Vis Sci, 2019, 60(3): M31-M88. doi:10.1167/iovs.18-25967
[21] Mathis U, Feldkaemper M, Wang M, et al. Studies on retinal mechanisms possibly related to myopia inhibition by atropine in the chicken[J]. Albrecht Von Graefes Arch Fur Klin Und Exp Ophthalmol, 2020, 258(2): 319-333. doi:10.1007/s00417-019-04573-y
[22] Thomson K, Kelly T, Karouta C, et al. Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release[J]. Br J Pharmacol, 2021, 178(22): 4501-4517. doi:10.1111/bph.15629
[23] 向小玲, 杨琴, 兰长骏, 等. 多巴胺能与胆碱能通路在近视发生发展中的作用研究进展[J]. 国际眼科杂志, 2022, 22(9): 1500-1503. doi:10.3980/j.issn.1672-5123.2022.9.16 XIANG Xiaoling, YANG Qin, LAN Changjun, et al. Research progress of the dopaminergic and cholinergic signaling pathways in myopia[J]. International Eye Science, 2022, 22(9): 1500-1503. doi:10.3980/j.issn.1672-5123.2022.9.16
[24] Carr BJ, Mihara K, Ramachandran R, et al. Myopia-inhibiting concentrations of muscarinic receptor antagonists block activation of Alpha2A-adrenoceptors in vitro[J]. Invest Ophthalmol Vis Sci, 2018, 59(7): 2778-2791. doi:10.1167/iovs.17-22562
[25] Troilo D, Smith EL 3rd, Nickla DL, et al. IMI- report on experimental models of emmetropization and myopia[J]. Invest Ophthalmol Vis Sci, 2019, 60(3): M31-M88. doi:10.1167/iovs.18-25967
[26] Li T, Zhou XD, Li B, et al. Effect of MT3 on retinal and choroidal TGF-β2 and HAS2 expressions in form deprivation myopia of guinea pig[J]. J Ophthalmol, 2017, 2017: 5028019. doi:10.1155/2017/5028019
[27] Qian LF, Zhao H, Li XX, et al. Pirenzepine inhibits myopia in guinea pig model by regulating the balance of MMP-2 and TIMP-2 expression and increased tyrosine hydroxylase levels[J]. Cell Biochem Biophys, 2015, 71(3): 1373-1378. doi:10.1007/s12013-014-0359-9
[28] Tong LY, Cui DM, Zeng JW. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits[J]. Ophthalmic Physiol Opt, 2020, 40(5): 567-576. doi:10.1111/opo.12717
[29] McBrien NA, Jobling AI, Truong HT, et al. Expression of muscarinic receptor subtypes in tree shrew ocular tissues and their regulation during the development of myopia[J]. Mol Vis, 2009, 15: 464-475
[30] 周翔天, 张立华, 吕帆, 等. 毒蕈碱受体Ⅰ型受体在人眼巩膜成纤维细胞中的表达[J]. 中华眼科杂志, 2005, 41(11): 995-999. doi:10.3760/j: issn: 0412-4081.2005.11.009 ZHOU Xiangtian, ZHANG Lihua, Lü Fan, et al. Expression of muscarinic acetylcholine receptor-1 in human scleral fibroblasts[J]. Chinese Journal of Ophthalmology, 2005, 41(11): 995-999. doi:10.3760/j: issn: 0412-4081.2005.11.009
[31] Liu Q, Wu J, Wang XM, et al. Changes in muscarinic acetylcholine receptor expression in form deprivation myopia in guinea pigs[J]. Mol Vis, 2007, 13: 1234-1244
[32] Barathi VA, Kwan JL, Tan QS, et al. Muscarinic cholinergic receptor(M2)plays a crucial role in the development of myopia in mice[J]. Dis Model Mech, 2013, 6(5): 1146-1158. doi:10.1242/dmm.010967
[33] Barathi VA, Beuerman RW. Molecular mechanisms of muscarinic receptors in mouse scleral fibroblasts: prior to and after induction of experimental myopia with atropine treatment[J]. Mol Vis, 2011, 17: 680-692
[34] Zhao F, Zhou QY, Reinach PS, et al. Cause and effect relationship between changes in scleral matrix metallopeptidase-2 expression and myopia development in mice[J]. Am J Pathol, 2018, 188(8): 1754-1767. doi:10.1016/j.ajpath.2018.04.011
[35] Wu PC, Chuang MN, Choi J, et al. Update in myopia and treatment strategy of atropine use in myopia control[J]. Eye, 2019, 33(1): 3-13. doi:10.1038/s41433-018-0139-7
[36] Vishweswaraiah S, Swierkowska J, Ratnamala U, et al. Epigenetically dysregulated genes and pathways implicated in the pathogenesis of non-syndromic high myopia[J]. Sci Rep, 2019, 9(1): 4145. doi:10.1038/s41598-019-40299-x
[1] 张莉苑,郭颖卓,陈蛟,王华,钟定娟. 650 nm低能量红光联合角膜塑形镜控制近视的临床效果[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 52-57.
[2] 辛梦,纪芳,代春华,张靖,刘澍. 医用透明质酸钠与平衡盐溶液在微创玻璃体手术中对眼表保护的影响[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 58-65.
[3] 王东芳,张清雨,宋继科,毕宏生. 基于CONSORT声明和STRICTA清单评价针刺防控儿童青少年近视随机对照试验的报告质量[J]. 山东大学耳鼻喉眼学报, 2024, 38(5): 66-79.
[4] 陈海燕,王平. 易误诊的后巩膜炎1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 126-130.
[5] 张莉苑,钟定娟,王华. 非手术的近视管理方法与脉络膜的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 149-153.
[6] 艾朝晖, 张杰. 色素失禁症相关性眼病诊疗研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(4): 166-174.
[7] 鲍莹,刘志高,姜鹏飞,崔文轩,郑晓霞,杨梦瑶,司明威,王玉,王红. 康柏西普治疗糖尿病合并CRVO-ME高反射点的临床观察[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 55-60.
[8] 李飏,刘鸫,曹文捷. 红光治疗对近视儿童等效球镜度、眼轴长度及脉络膜厚度影响的Meta分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 74-81.
[9] 卢松,夏逸帆,李子晔,魏菁. 无视网膜脱离的儿童Stickler综合征1例并文献复习[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 97-101.
[10] 常威威,焦万珍,崔艳艳,赵杰,刘兆强,赵博军. 糖尿病性黄斑缺血的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 130-136.
[11] 胡亚柔,赵欣予,吴桢泉,范梓欣,余震,刘亚玲,陈婷毅,曾键,张国明. 早产儿屈光状态与眼部生物特征的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(3): 144-150.
[12] 何静,雷春燕,张美霞. 糖化血红蛋白变异指数与糖尿病视网膜病变严重程度的相关性研究[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 34-40.
[13] 吴丽丽,曲毅. OCTA在病理性近视脉络膜新生血管应用及其在人工智能的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 144-149.
[14] 王新钰,高丽芬,路晖,宋文琦,杨钰. 帕金森疾病的相关视网膜表现[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 156-162.
[15] 伦英俊,陈晨,高宏程,范清琳,邰仁清. TLR4/NF-κB通道在糖尿病视网膜病变中的作用[J]. 山东大学耳鼻喉眼学报, 2024, 38(2): 163-168.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
网站版权所有 © 2018 《山东大学耳鼻喉眼学报》编辑部　
地址：山东省济南市山大南路27号（250100）电话：+86-0531-88366912 E-mail: ebhxb@sdu.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发