山东大学耳鼻喉眼学报 ›› 2024, Vol. 38 ›› Issue (3): 151-156.doi: 10.6040/j.issn.1673-3770.0.2023.413
• 综述 • 上一篇
叶强1,洛松巴宗2,南苏亭1,王浩1,马进海3,律鹏1,张文芳1
YE Qiang1, LUOSONG Bazong2, NAN Suting1, WANG Hao1, MA Jinhai3, LYU Peng1, ZHANG Wenfang1
摘要: 干眼是目前严重危害人类视觉生活质量的眼表疾病之一,近年其发病率逐年升高,但具体发病机制目前尚未明确。眼表炎症反应、氧化应激、眼表细胞凋亡、营养保护因子减少等因素在干眼发生中的作用备受关注。色素上皮衍生因子(pigment epithelial derived factor, PEDF)是一种天然的新生血管抑制剂,具有抑制炎症反应、抗氧化应激反应、抗细胞凋亡及神经营养和细胞保护等生物学功能。最新的研究表明PEDF在干眼的发病机制中发挥重要作用。本文主要对PEDF在干眼发生、发展中发挥的机制及潜在的治疗作用做简要概述,为进一步研究PEDF在干眼中的作用并为干眼的治疗提供新思路。
中图分类号:
[1] 亚洲干眼协会中国分会, 海峡两岸医药卫生交流协会眼科学专业委员会眼表与泪液病学组, 中国医师协会眼科医师分会眼表与干眼学组. 中国干眼专家共识:免疫性疾病相关性干眼(2021年)[J]. 中华眼科杂志, 2021, 57(12): 898-907. doi:10.3760/cma.j.cn112142-20210929-00466 [2] 韦庆波, 林佳, 顾嘉凌, 等. 针灸治疗干眼症的临床与机制研究现状[J]. 中华中医药杂志, 2021, 36(1): 319-323 WEI Qingbo, LIN Jia, GU Jialing, et al. Current situation of the clinical and mechanism research of acupuncture therapy treating ophthalmoxerosis[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2021, 36(1): 319-323 [3] 许静. 中西医结合治疗干眼症的研究进展[J]. 内蒙古中医药, 2022, 41(8): 162-164. doi:10.16040/j.cnki.cn15-1101.2022.08.067 XU Jing. Research progress of xerophthalmia treated by combination of traditional Chinese and western medicine[J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2022, 41(8): 162-164. doi:10.16040/j.cnki.cn15-1101.2022.08.067 [4] Liu XM, Liu H, Lu XX, et al. PEDF attenuates ocular surface damage in diabetic mice model through its antioxidant properties[J]. Curr Eye Res, 2021, 46(3): 302-308. doi:10.1080/02713683.2020.1805770 [5] Ma BK, Zhou YF, Liu RJ, et al. Pigment epithelium-derived factor(PEDF)plays anti-inflammatory roles in the pathogenesis of dry eye disease[J]. Ocul Surf, 2021, 20: 70-85. doi:10.1016/j.jtos.2020.12.007 [6] Singh RB, Blanco T, Mittal SK, et al. Pigment epithelium-derived factor enhances the suppressive phenotype of regulatory T cells in a murine model of dry eye disease[J]. Am J Pathol, 2021, 191(4): 720-729. doi:10.1016/j.ajpath.2021.01.003 [7] Wang YZ, Liu XC, Quan XY, et al. Pigment epithelium-derived factor and its role in microvascular-related diseases[J]. Biochimie, 2022, 200: 153-171. doi:10.1016/j.biochi.2022.05.019 [8] Abooshahab R, Al-Salami H, Dass CR. The increasing role of pigment epithelium-derived factor in metastasis: from biological importance to a promising target[J]. Biochem Pharmacol, 2021, 193: 114787. doi:10.1016/j.bcp.2021.114787 [9] Bagdadi N, Sawaied A, AbuMadighem A, et al. The expression levels and cellular localization of pigment epithelium derived factor(PEDF)in mouse testis: its possible involvement in the differentiation of spermatogonial cells[J]. Int J Mol Sci, 2021, 22(3): 1147. doi:10.3390/ijms22031147 [10] Brook N, Brook E, Dharmarajan A, et al. Pigment epithelium-derived factor regulation of neuronal and stem cell fate[J]. Exp Cell Res, 2020, 389(2): 111891. doi:10.1016/j.yexcr.2020.111891 [11] Bascuas T, Zedira H, Kropp M, et al. Human retinal pigment epithelial cells overexpressing the neuroprotective proteins PEDF and GM-CSF to treat degeneration of the neural retina[J]. Curr Gene Ther, 2022, 22(2): 168-183. doi:10.2174/1566523221666210707123809 [12] Bai MG, Yu HM, Chen C, et al. Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex[J]. Neurosci Lett, 2022, 771: 136423. doi:10.1016/j.neulet.2021.136423 [13] 金梅, 罗晓燕, 曲利利. 19例合并2型糖尿病的干眼症患者干眼症症状、角膜神经病变观察及相关性分析[J]. 山东医药, 2022, 62(12): 64-67. doi:10.3969/j.issn.1002-266X.2022.12.015 JIN Mei, LUO Xiaoyan, QU Lili. Observation and correlation analysis of symptoms of dry eye and corneal neuropathy in 19 patients with dry eye complicated with type 2 diabetes mellitus[J]. Shandong Medical Journal, 2022, 62(12): 64-67. doi:10.3969/j.issn.1002-266X.2022.12.015 [14] Huang XB, Zhang P, Zou XR, et al. Two-year incidence and associated factors of dry eye among residents in Shanghai communities with type 2 diabetes mellitus[J]. Eye Contact Lens, 2020, 46(1): S42-S49. doi:10.1097/ICL.0000000000000626 [15] 栾莉, 邓菲, 贾凡, 等. PEDF-MSCs对糖尿病大鼠角膜上皮损伤的修复作用及其对上皮下神经表达改变的影响[J]. 潍坊医学院学报, 2020, 42(2): 88-91. doi:10.16846/j.issn.1004-3101.2020.02.002 LUAN Li, DENG Fei, JIA Fan, et al. Effect of PEDF MSCs on the repair of corneal epithelial injury in diabetic rats and the change of subepithelial nerve expression[J]. Acta Academiae Medicinae Weifang, 2020, 42(2): 88-91. doi:10.16846/j.issn.1004-3101.2020.02.002 [16] 葛瑞春, 王召格. LASIK术后干预与干眼症发生的相关性研究[J]. 内蒙古医科大学学报, 2020, 42(6): 617-620. doi:10.16343/j.cnki.issn.2095-512x.2020.06.014 GE Ruichun, WANG Zhaoge. Correlation between intervention after LASIK and dry eye[J]. Journal of Inner Mongolia Medical University, 2020, 42(6): 617-620. doi:10.16343/j.cnki.issn.2095-512x.2020.06.014 [17] 段练, 孟凡兰, 党光福. 干眼对屈光性白内障手术的影响[J]. 山东大学耳鼻喉眼学报, 2022, 36(6): 1-6. doi:10.6040/j.issn.1673-3770.0.2022.381 DUAN Lian, MENG Fanlan, DANG Guangfu. Effect of dry eye on refractive cataract surgery[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 1-6. doi:10.6040/j.issn.1673-3770.0.2022.381 [18] 万晨阳, 张东蕾, 卢山. 干眼症的发病机制及中医药治疗研究进展[J]. 实用中医内科杂志, 2020, 34(4): 36-43. doi:10.13729/j.issn.1671-7813.Z20191282 WAN Chenyang, ZHANG Donglei, LU Shan. Pathogenesis of dry eye and research progress of traditional Chinese medicine treatment[J]. Journal of Practical Traditional Chinese Internal Medicine, 2020, 34(4): 36-43. doi:10.13729/j.issn.1671-7813.Z20191282 [19] Alam J, Yazdanpanah G, Ratnapriya R, et al. IL-17 producing lymphocytes cause dry eye and corneal disease with aging in RXRα mutant mouse[J]. Front Med, 2022, 9: 849990. doi:10.3389/fmed.2022.849990 [20] 狄宇, 李莹. 干眼炎症反应机制及抗炎治疗的研究进展[J]. 山东大学耳鼻喉眼学报, 2022, 36(2): 144-150. doi:10.6040/j.issn.1673-3770.0.2020.484 DI Yu, LI Ying. Research progress in the inflammatory reaction and anti-inflammatory treatments in dry eye[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 144-150. doi:10.6040/j.issn.1673-3770.0.2020.484 [21] Chen YH, Shao CY, Fan NW, et al. The functions of IL-23 and IL-2 on driving autoimmune effector T-helper 17 cells into the memory pool in dry eye disease[J]. Mucosal Immunol, 2021, 14(1): 177-186. doi:10.1038/s41385-020-0289-3 [22] 王方, 万咪咪, 乐艳芝, 等. 淫羊藿总黄酮对干眼症雄兔泪腺中Bax和Bcl-2表达的作用研究[J]. 眼科新进展, 2020, 40(9): 817-821. doi:10.13389/j.cnki.rao.2020.0186 WANG Fang, WAN Mimi, LE Yanzhi, et al. Effect of epimedium total flavonoids on Bax and Bcl-2 expression based on male rabbit of dry eye syndrome[J]. Recent Advances in Ophthalmology, 2020, 40(9): 817-821. doi:10.13389/j.cnki.rao.2020.0186 [23] Shang ZY, Li CX, Liu XM, et al. PEDF gene deletion disrupts corneal innervation and ocular surface function[J]. Invest Ophthalmol Vis Sci, 2021, 62(7): 18. doi:10.1167/iovs.62.7.18 [24] He JC, Pham TL, Kakazu A, et al. Recovery of corneal sensitivity and increase in nerve density and wound healing in diabetic mice after PEDF plus DHA treatment[J]. Diabetes, 2017, 66(9): 2511-2520. doi:10.2337/db17-0249 [25] Fan NW, Ho TC, Lin EH, et al. Pigment epithelium-derived factor peptide reverses mouse age-related meibomian gland atrophy[J]. Exp Eye Res, 2019, 185: 107678. doi:10.1016/j.exer.2019.05.018 [26] 陆海,马一平. 干眼症的临床治疗进展[J]. 天津药学, 2020, 32(4): 62-66. doi:10.3969/j.issn.1006-5687.2020.04.022 LU Hai, MA Yiping. Progress in the clinical treatment of xerophthalmia[J]. Tianjin Pharmacy, 2020, 32(4): 62-66. doi:10.3969/j.issn.1006-5687.2020.04.022 [27] 韦振宇, 刘含若, 梁庆丰. 我国干眼流行病学的研究进展[J]. 中华眼科医学杂志(电子版), 2020, 10(1): 46-50. doi:10.3877/cma.j.issn.2095-2007.2020.01.008 WEI Zhenyu, LIU Hanruo, LIANG Qingfeng. Advances on the epidemiology of the dry eye[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2020, 10(1): 46-50. doi:10.3877/cma.j.issn.2095-2007.2020.01.008 [28] Vereertbrugghen A, Galletti JG. Corneal nerves and their role in dry eye pathophysiology[J]. Exp Eye Res, 2022, 222: 109191. doi:10.1016/j.exer.2022.109191 [29] Lasagni Vitar RM, Rama P, Ferrari G. The two-faced effects of nerves and neuropeptides in corneal diseases[J]. Prog Retin Eye Res, 2022, 86: 100974. doi:10.1016/j.preteyeres.2021.100974 [30] 张燕, 国希云, 邓娴, 等. 色素上皮衍生因子抗炎机制的相关研究进展[J]. 中国心血管杂志, 2020, 25(3): 286-289. doi:10.3969/j.issn.1007-5410.2020.03.018 ZHANG Yan, GUO Xiyun, DENG Xian, et al. Research progress on anti-inflammatory mechanism of pigment epithelium-derived factor[J]. Chinese Journal of Cardiovascular Medicine, 2020, 25(3): 286-289. doi:10.3969/j.issn.1007-5410.2020.03.018 [31] Ling JW, Chan BC, Tsang MS, et al. Current advances in mechanisms and treatment of dry eye disease: toward anti-inflammatory and immunomodulatory therapy and traditional Chinese medicine[J]. Front Med, 2021, 8: 815075. doi:10.3389/fmed.2021.815075 [32] He JC, Neumann D, Kakazu A, et al. PEDF plus DHA modulate inflammation and stimulate nerve regeneration after HSV-1 infection[J]. Exp Eye Res, 2017, 161: 153-162. doi:10.1016/j.exer.2017.06.015 [33] Tian X, Wang TS, Zhang SM, et al. PEDF reduces the severity of herpetic simplex keratitis in mice[J]. Invest Ophthalmol Vis Sci, 2018, 59(7): 2923-2931. doi:10.1167/iovs.18-23942 [34] Liu YL, Leo LF, McGregor C, et al. Pigment epithelium-derived factor(PEDF)peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita)mice[J]. Mol Med, 2012, 18(1): 1387-1401. doi:10.2119/molmed.2012.00008 [35] Singh RB, Blanco T, Mittal SK, et al. Pigment Epithelium-derived Factor secreted by corneal epithelial cells regulates dendritic cell maturation in dry eye disease[J]. Ocul Surf, 2020, 18(3): 460-469. doi:10.1016/j.jtos.2020.05.002 [36] Fan NW, Dohlman TH, Foulsham W, et al. The role of Th17 immunity in chronic ocular surface disorders[J]. Ocul Surf, 2021, 19: 157-168. doi:10.1016/j.jtos.2020.05.009 [37] Chen YH, Dana R. Autoimmunity in dry eye disease - An updated review of evidence on effector and memory Th17 cells in disease pathogenicity[J]. Autoimmun Rev, 2021, 20(11): 102933. doi:10.1016/j.autrev.2021.102933 [38] Ho TC, Fan NW, Yeh SI, et al. The therapeutic effects of a PEDF-derived short peptide on murine experimental dry eye involves suppression of MMP-9 and inflammation[J]. Transl Vis Sci Technol, 2022, 11(10): 12. doi:10.1167/tvst.11.10.12 [39] 李威, 张斌. 优化脉冲光联合睑板腺按摩治疗睑板腺功能障碍的临床效果观察[J]. 山东大学耳鼻喉眼学报, 2021, 35(2): 105-109. doi:10.6040/j.issn.1673-3770.0.2020.341 LI Wei, ZHANG Bin. Effects of optimal pulse technology combined with meibomian gland massage to treat meibomian gland dys-function[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(2): 105-109. doi:10.6040/j.issn.1673-3770.0.2020.341 [40] Qazi Y, Kheirkhah A, Blackie C, et al. Clinically relevant immune-cellular metrics of inflammation in meibomian gland dysfunction[J]. Invest Ophthalmol Vis Sci, 2018, 59(15): 6111-6123. doi:10.1167/iovs.18-25571 [41] Pinto RDP, Abe RY, Gomes FC, et al. Meibomian gland dysfunction and dry eye in keratoconus[J]. Arq Bras Oftalmol, 2021, 85(4): 406-410. doi:10.5935/0004-2749.20220056 |
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