表观遗传学在慢性鼻窦炎伴鼻息肉发病机制中的作用

doi:10.6040/j.issn.1673-3770.0.2021.562

摘要/Abstract

摘要： 慢性鼻窦炎伴鼻息肉其确切的发病机制尚未完全明确。表观遗传学(Epigenetics)主要指基于非基因序列改变所致基因表达水平的变化,包括DNA甲基化、组蛋白修饰和非编码RNA调控等。就相关基因的表观遗传学修饰及其引起的相应细胞因子和蛋白质等的表达改变在CRS发病机制中的作用作一综述,从全新的角度认识CRS,为明确其发病过程、探究治疗方法提供新的方向。

关键词: 慢性鼻窦炎, 鼻息肉, 表观遗传学, 甲基化, 发病机制

Abstract: The pathogenesis of chronic rhinosinusitis(CRS)with nasal polyps has not been fully elucidated. Epigenetics mainly refers to changes in gene expression levels based on non-gene sequence changes, such as DNA methylation, histone modification, and microRNA regulation. In this review, the role of epigenetic modification of CRS-related genes and changes in the expression levels of corresponding cytokines and other related proteins in the pathogenesis of CRS are discussed. The aim of this review is to provide new directions for research on the pathogenesis of CRS and the development of therapeutic methods.

Key words: Chronic Rhinosinusitis, Nasal Polyps, Epigenetics, Methylation, Pathogenesis

中图分类号:

R765.4

李佳倪,朱冬冬,孟粹达. 表观遗传学在慢性鼻窦炎伴鼻息肉发病机制中的作用[J]. 山东大学耳鼻喉眼学报, 2022, 36(3): 84-91.

LI Jiani, ZHU Dongdong,MENG Cuida. The role of epigenetics in the pathogenesis of chronic rhinosinusitis with nasal polyps[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 84-91.

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