ISSN 1673-3770 CN 37-1437/R
山东大学耳鼻喉眼学报 ›› 2026, Vol. 40 ›› Issue (1): 142-148.doi: 10.6040/j.issn.1673-3770.0.2024.066
• 综述 • 上一篇
孙凡敏1,张娟美2,高杰1,赵军2
SUN Fanmin1, ZHANG Juanmei2, GAO Jie1, ZHAO Jun2
摘要： Shh、PI3K/AKT、MMP-2是在机体中广泛表达的重要调控信号通路,与胚胎发育、细胞生长、增殖和分化密切相关。越来越多的研究发现Shh、PI3K/AKT、MMP-2信号通路在维持眼球的正常生长发育、眼部各组织再生和修复以及眼部多种疾病的发生发展过程中发挥着至关重要的作用。在近视的发生发展过程中均存在Shh、PI3K/AKT、MMP-2信号通路的异常表达,这表明Shh、PI3K/AKT、MMP-2信号通路对近视的发生发展尤为重要。寻找近视发病机制的相关信号通路也成为当下的热点话题,因此探索Shh、PI3K/AKT、MMP-2信号通路在近视发生发展中的表达变化以及关联性具有重要的意义。本文总结了Shh、PI3K/AKT、MMP-2信号通路在近视中的表达变化,并在此基础上对各通路之间的关联性进行探讨。
中图分类号:
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